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41. 发明授权

US08251981B2 Regulator 有权
公开(公告)号：US08251981B2
公开(公告)日：2012-08-28
申请号：US10862768
申请日：2004-06-07
申请人： James M. Olsen
发明人： James M. Olsen
IPC分类号： A61K9/22
CPC分类号： A61K9/0024 , A61M5/14276 , A61M5/16881
摘要： A flow regulator (19, 208, 308, 408) may be used in a drug delivery system 10. The regulator includes a chamber that is divided by a diaphragm (111, 211, 311, 411) into a first and second subchamber. A third subchamber is in fluid communication with the first subchamber. A valve (26, 217, 317, 417) is operatively connected to the diaphragm, wherein pressure differences between the first subchamber and second subchamber result in movement of the diaphragm and movement of the diaphragm controls operation of the valve. A flow restrictor (116, 216, 316, 416) is in fluid communication between the first and second subchambers. Flow of a drug (11, 101) is thereby regulated.

42. 发明授权

US08219207B2 Thermal switch for implantable medical devices 有权
标题翻译：用于植入式医疗设备的热开关
公开(公告)号：US08219207B2
公开(公告)日：2012-07-10
申请号：US11683907
申请日：2007-03-08
申请人： James M. Olsen
发明人： James M. Olsen
IPC分类号： A61N1/08
CPC分类号： A61N1/056 , A61N1/086
摘要： An implantable medical device includes an electrode having a thermal switch. The thermal switch is configured to electrically decouple components of the implantable medical device when in contact with tissue at temperatures above normal body temperature.
摘要翻译：可植入医疗装置包括具有热开关的电极。热开关被配置为在与正常体温以上的温度接触时，将可植入医疗装置的部件电气去耦。

43. 发明申请

US20120130461A1 RADIOPAQUE MARKERS FOR IMPLANTABLE MEDICAL LEADS, DEVICES, AND SYSTEMS 有权
标题翻译：可植入医疗领域，设备和系统的放射性标记
公开(公告)号：US20120130461A1
公开(公告)日：2012-05-24
申请号：US13265283
申请日：2010-04-28
申请人： James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham , Bruce R. Mehdizadeh , Michael J. Kern , Jay K. Lahti
发明人： James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham , Bruce R. Mehdizadeh , Michael J. Kern , Jay K. Lahti
IPC分类号： A61N1/05
CPC分类号： A61N1/08 , A61B90/39 , A61B2090/3966 , A61N1/05 , A61N1/0551 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582 , A61N2001/086 , Y10T29/49016 , Y10T29/49117 , Y10T29/4921 , Y10T29/49227 , Y10T29/49826
摘要： Radiopaque markers represent that a lead is suitable for a particular medical procedure such as a magnetic resonance image scan and are added to the lead or related device. The markers may be added after implantation of the lead in various ways including suturing, gluing, crimping, or clamping a radiopaque tag to the lead or to the device. The markers may be added by placing a radiopaque coil about the lead, and the radiopaque coil may radially contract against the lead to obtain a fixed position. The markers may be added by placing a polymer structure onto the lead where the polymer structure includes a radiopaque marker within it. The polymer structure may include a cylindrical aperture that contracts against the lead to fix the position of the structure. The polymer structure may form a lead anchor that includes suture wings that can be sutured to the lead.
摘要翻译：不透射线标记表示引线适用于特定的医学过程，例如磁共振图像扫描，并且被添加到引线或相关器件。可以以各种方式植入引线之后添加标记物，包括缝合，胶合，卷曲或夹紧不透射线标签到引线或器件。可以通过在引线周围放置不透射线的线圈来添加标记，并且不透射线圈可以径向地与引线收缩以获得固定位置。可以通过将聚合物结构放置在引线上来添加标记，其中聚合物结构在其内包括不透射线的标记。聚合物结构可以包括一个圆柱形的孔，该圆柱形的孔与引线收缩以固定结构的位置。聚合物结构可以形成引线锚，其包括可以缝合到引线的缝合翼。

44. 发明申请

US20120041528A1 TERMINATION OF A SHIELD WITHIN AN IMPLANTABLE MEDICAL LEAD 有权
标题翻译：在可植入医疗领域终止护理
公开(公告)号：US20120041528A1
公开(公告)日：2012-02-16
申请号：US13265313
申请日：2010-04-27
申请人： Bruce R. Mehdizadeh , Brian T. Stolz , Michael R. Klardie , Michael J. Kern , James M. Olsen , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
发明人： Bruce R. Mehdizadeh , Brian T. Stolz , Michael R. Klardie , Michael J. Kern , James M. Olsen , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61B90/39 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582
摘要： A shield located within an implantable medical lead may be terminated in various ways at a metal connector. The shield may be terminated by various joints including butt, scarf, lap, or other joints between insulation layers surrounding the lead and an insulation extension. The shield may terminate with a physical and electrical connection to a single metal connector. The shield may terminate with a physical and electrical connection by passing between an overlapping pair of inner and outer metal connectors. The metal connectors may include features such as teeth or threads that penetrate the insulation layers of the lead. The shield may terminate with a physical and electrical connection by exiting a jacket of a lead adjacent to a metal connector and lapping onto the metal connector.
摘要翻译：位于可植入医疗引线内的护罩可以以各种方式在金属连接器处终止。屏蔽层可以由围绕引线的绝缘层和绝缘延伸部之间的各种接头（包括对接，围巾，搭接或其他接头）终止。屏蔽可以通过与单个金属连接器的物理和电连接终止。屏蔽可以通过在重叠的一对内部和外部金属连接器之间通过物理和电连接终止。金属连接器可以包括贯穿引线的绝缘层的诸如齿或螺纹的特征。通过离开与金属连接器相邻的引线的护套并且研磨到金属连接器上，屏蔽件可以通过物理和电连接终止。

45. 发明申请

US20120035694A1 GROUNDING OF A SHIELD WITHIN AN IMPLANTABLE MEDICAL LEAD 有权
标题翻译：在可植入医疗领域接触皮肤
公开(公告)号：US20120035694A1
公开(公告)日：2012-02-09
申请号：US13264093
申请日：2010-04-28
申请人： James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
发明人： James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
IPC分类号： A61N1/05 , H01R43/00
CPC分类号： A61N1/08 , A61B90/39 , A61B2090/3966 , A61N1/05 , A61N1/0551 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582 , A61N2001/086 , Y10T29/49016 , Y10T29/49117 , Y10T29/4921 , Y10T29/49227 , Y10T29/49826
摘要： Grounding of a shield that is located in an implantable medical lead may be done in many ways. The shield may be grounded directly to tissue from the lead body at one or more points along the lead body. The pathway for grounding may be a direct current pathway or be capacitively coupled. The pathway for grounding may utilize an exposed or nearly exposed shield at one or more points along the lead body. A jacket forming the lead body may have an outer layer removed at these points to provide the RF pathway to ground. Alternatively, the jacket may be doped with conductive particles at these points. Metal conductors such as ring electrodes and/or lead anchors may be attached to the lead at one or more points to provide the RF pathway to ground.
摘要翻译：位于植入式医疗引线中的护罩的接地可以以许多方式进行。屏蔽件可以沿着引线主体的一个或多个点从引线体直接接地到组织。用于接地的途径可以是直流电路或电容耦合。用于接地的路径可以沿着引线主体在一个或多个点处利用暴露或几乎暴露的屏蔽。形成引线体的护套可以在这些点处具有去除的外层，以将RF通路提供到地面。或者，夹套可以在这些点处掺杂导电颗粒。诸如环形电极和/或引线锚的金属导体可以在一个或多个点附接到引线，以将RF通路提供到地。

46. 发明授权

US07981107B2 Low profile inlet valve for a piston pump therapeutic substance delivery device 有权
标题翻译：用于活塞泵治疗物质输送装置的低轮廓入口阀
公开(公告)号：US07981107B2
公开(公告)日：2011-07-19
申请号：US11435582
申请日：2006-05-17
申请人： James M. Olsen
发明人： James M. Olsen
IPC分类号： A61M1/00 , A61M31/00 , A61M37/00 , A61K9/22
CPC分类号： A61M5/14276 , A61M5/14216 , A61M39/22
摘要： Low profile inlet valve embodiments for a piston pump therapeutic substance infusion device are disclosed that reduce dead volume, occupies little residential space, operates rapidly, and have many other improvements. The therapeutic substance infusion device has a housing, a therapeutic substance reservoir, a power source carried in the housing, electronics, a piston pump, and an inlet valve. The piston pump is configured for pumping therapeutic substance from the therapeutic substance reservoir through an infusion port at a programmed rate. The inlet valve is in fluid communication with a reservoir outlet to control the flow of therapeutic substance into the piston pump. The inlet valve has a substantially coplanar valve surface and valve spring. Many embodiments of the low profile inlet valve and its methods of operation are possible.
摘要翻译：公开了一种用于活塞泵治疗物质输注装置的低轮廓入口阀实施例，其减少死体积，占用少量住宅空间，快速操作，并且具有许多其它改进。治疗物质输注装置具有壳体，治疗物质储存器，承载在壳体中的电源，电子器件，活塞泵和入口阀。活塞泵被配置为以编程速率从治疗物质储存器通过输注端口泵送治疗物质。入口阀与储存器出口流体连通以控制治疗物质流入活塞泵的流动。入口阀具有基本上共面的阀表面和阀弹簧。薄型入口阀的许多实施例及其操作方法是可能的。

47. 发明授权

US07931643B2 Miniature pump for drug delivery 有权
标题翻译：用于药物递送的微型泵
公开(公告)号：US07931643B2
公开(公告)日：2011-04-26
申请号：US11490876
申请日：2006-07-21
申请人： James M. Olsen , Mark S. Lent , James G. Skakoon , Richard T. Stone , Laetitia Mayor , Dale F. Seeley , Michael T. Hegland
发明人： James M. Olsen , Mark S. Lent , James G. Skakoon , Richard T. Stone , Laetitia Mayor , Dale F. Seeley , Michael T. Hegland
IPC分类号： A61K9/22 , A61M37/00 , A61F5/00
CPC分类号： A61M5/14276 , A61M5/14593 , A61M5/16881 , A61M39/0208 , A61M2039/0205 , A61M2205/0266
摘要： A miniature drug delivery pump utilizes a shape memory Ni—Ti alloy. A flow restrictor is provided and the pump is refillable.
摘要翻译：微型药物输送泵采用形状记忆Ni-Ti合金。提供了一个流量限制器，并且该泵是可再填充的。

48. 发明授权

US07766860B2 Catheter systems having flow restrictors 有权
标题翻译：具有流量限制器的导管系统
公开(公告)号：US07766860B2
公开(公告)日：2010-08-03
申请号：US11112077
申请日：2005-04-22
申请人： James M. Olsen , Mary M. Morris , Michael Hegland , Justin A. Blanco
发明人： James M. Olsen , Mary M. Morris , Michael Hegland , Justin A. Blanco
IPC分类号： A61M1/00
CPC分类号： A61M25/0021 , A61M5/14276 , A61M5/16813 , A61M25/00 , A61M25/0029 , A61M25/003 , A61M25/0043 , A61M25/0068 , A61M25/0071 , A61M25/0075 , A61M27/006 , A61M2025/0073 , A61M2039/1005 , A61M2205/15 , A61M2206/16
摘要： Catheter systems including one or more flow restrictors are disclosed. The catheter systems may include two or more delivery branches. The delivery branches may be connected to a supply catheter section using a branching catheter connector that may include one or more flow restrictors. The flow restrictors may include a restrictor body located within a lumen with a channel located between the restrictor body and interior surface of the lumen, the channel restricting flow through the lumen past the flow restrictor. The channel may be defined by a groove formed in the restrictor body and/or the interior surface of the lumen. Methods of providing pressure relief by flowing fluid past a flow restrictor are also disclosed.
摘要翻译：公开了包括一个或多个流量限制器的导管系统。导管系统可以包括两个或更多个输送分支。输送分支可以使用可包括一个或多个限流器的分支导管连接器连接到供应导管部分。限流器可以包括位于管腔内的节流体，通道位于限流器主体和内腔内表面之间，通道限制流经管腔的流经限流器。通道可以由形成在限流器主体中的凹槽和/或内腔的内表面限定。还公开了通过使流体流过限流器来提供压力释放的方法。

49. 发明授权

US06685452B2 Implantable drug delivery pump with desiccant humidity protection 失效
标题翻译：具有干燥剂湿度保护的植入式药物输送泵
公开(公告)号：US06685452B2
公开(公告)日：2004-02-03
申请号：US09925598
申请日：2001-08-09
申请人： Chris C. Christiansen , James M. Olsen
发明人： Chris C. Christiansen , James M. Olsen
IPC分类号： F04B3900
CPC分类号： A61M5/14276
摘要： A human body implantable drug delivery pump has a housing including at least a first shield and a second shield. The housing defines an interior within the shields. The pump further includes a fluid reservoir within the housing, a fluid conduit also within the housing from the reservoir, an outlet from the fluid conduit to the exterior of the housing, and a pump member in the housing adapted to move fluid through the fluid conduit to the outlet. The fluid in the reservoir and fluid conduit is isolated from the pump interior. The pump further has a desiccant in the pump interior, the desiccant absorbent of moisture in the pump interior, and preferably absorbent of substantially all the moisture in the pump interior. The desiccant also preferably has a moisture absorbent property dependent on temperature, being lessened at higher temperatures, the desiccant being pre-baked to improve its moisture absorbent property before being placed in the pump.
摘要翻译：人体可植入药物输送泵具有至少包括第一屏蔽和第二屏蔽的壳体。壳体限定了屏蔽内的内部。所述泵还包括在所述壳体内的流体贮存器，还存在从所述容器的壳体内的流体导管，从所述流体导管到所述壳体的外部的出口以及所述壳体中的泵构件，其适于将流体移动通过所述流体导管到出口。储存器和流体导管中的流体与泵内部隔离。泵还在泵内部具有干燥剂，泵内部的湿气的干燥剂吸收剂，并且优选地在泵内部基本上吸收所有的水分。干燥剂还优选具有取决于温度的吸湿性，在较高温度下减弱，干燥剂被预烘烤以在放入泵之前改善其吸湿性能。

50. 发明授权

US06228050B1 Overfill protection systems for implantable drug delivery devices 有权
标题翻译：用于可植入药物输送装置的溢出保护系统
公开(公告)号：US06228050B1
公开(公告)日：2001-05-08
申请号：US09303006
申请日：1999-04-30
申请人： James M. Olsen , Reginald D. Robinson , Chris Christiansen , Paul Kratoska
发明人： James M. Olsen , Reginald D. Robinson , Chris Christiansen , Paul Kratoska
IPC分类号： A61M1100
CPC分类号： A61M5/14276 , A61M39/22 , A61M2209/045
摘要： The displacement of refill valves in an implantable drug delivery device is reduced to permit the housings of a drug delivery device to remain compact in size while permitting reservoirs of increased depth to be used. In a preferred embodiment, a collapsible link is provided as a telescoping member incorporating a coil spring. As the valve is pulled into contact with its seat, a detectable pressure increase is sensed in the refill device. In accordance with the invention, as the drug supply contained in the reservoir depletes, the reservoir surface moves towards a collapsed position, compressing the coil spring and eventually contacting the valve stem, thereby lifting the valve from its seat. By virtue of telescoping link, the valve stem length and therefore the valve travel may be reduced as compared to prior art devices, thus eliminating the need for increased housing depth when deeper reservoirs are used. The collapsible link may be comprised of a second spring combined with a telescoping link. The second spring is situated on a side of the valve opposite the telescoping link, thereby providing a downward force on the valve and valve stem. As an other alternative, the invention provides a lever arm for actuating the refill valve. A pivot for the lever arm is situated near the refill valve and a distal end of the lever arm maintained in contact with the reservoir surface using a spring bias. An intermediate portion of the lever arm engages the valve stem. Thus, as the reservoir surface moves towards the collapsed position, the displacement of the valve is a fraction of the displacement of the distal end of the lever arm.
摘要翻译：可植入药物输送装置中的再填充阀的位移被减少以允许药物输送装置的壳体保持紧凑的尺寸，同时允许使用增加深度的储存器。在优选实施例中，可折叠连杆被提供为包括螺旋弹簧的伸缩构件。当阀被拉动与其座位接触时，在再填充装置中感测到可检测的压力增加。根据本发明，随着储存器中所含的药物供给消耗，贮存器表面向收缩位置运动，压缩螺旋弹簧并最终接触阀杆，从而将阀从其座上提起。通过伸缩连杆，与现有技术的装置相比，阀杆长度和阀行程可以减小，从而在使用更深的储存器时消除了增加壳体深度的需要。可折叠连杆可以由与伸缩连杆组合的第二弹簧构成。第二弹簧位于与伸缩连杆相对的阀的一侧，从而在阀和阀杆上提供向下的力。作为另一种替代方案，本发明提供一种用于致动再填充阀的杠杆臂。用于杠杆臂的枢轴位于补充阀附近，并且杠杆臂的远端使用弹簧偏压保持与储存器表面接触。杠杆臂的中间部分与阀杆接合。因此，当储存器表面朝向折叠位置移动时，阀的位移是杠杆臂的远端的位移的一部分。

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