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41. 发明专利

AT536184T 未知
公开(公告)号：AT536184T
公开(公告)日：2011-12-15
申请号：AT05809765
申请日：2005-10-14
申请人： CENTRE NAT RECH SCIENT , UNIV POITIERS
发明人： BECQ FREDERIC , MEIJER LAURENT , KUNICK CONRAD
IPC分类号： A61K31/55 , A61P11/12
摘要： The invention relates to paullone derivatives for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells, said derivatives being of general formula (1): wherein X-C-O, C-S-CH3, C-S, -C-NHOH, Z-C or N, Y- with the adjacent ring, a phenyl or thienyl group, the ring(s) of said derivatives being optionally substituted with one or more halogen atoms, hydroxy, alkylenehydroxy, alkynealkylenehydroxy, alkynehydroxycyclohexyl, alkyl, alkoxy, alkylenealkoxy, or alkylenecyano groups where the alkylene group is either saturated or unsaturated, the groups having a straight or branched chain with C1 to C18, said chain being optionally substituted with one or more hydroxy or amino groups, or one or more trifluoromethyl, -COM, -COOM, or -CH2COOM groups (where M=H, C1 to C18 straight or branched chain alkyl, optionally substituted with one or more hydroxy and/or amino groups) nitroso, or cyano, R5-H, or C1 to C5 alkyl and R12-H, or -C-CO2-(CH3)3 and the physiologically-acceptable salts and derivatives thereof.

42. 发明专利

AT529402T 未知
公开(公告)号：AT529402T
公开(公告)日：2011-11-15
申请号：AT08161646
申请日：2008-08-01
申请人： CENTRE NAT RECH SCIENT
发明人： MEIJER LAURENT , SKALTSOUNIS LEANDROS , MIKROS EMMANUEL , MAGIATIS PROKOPIOS , JOHNSON CARL
IPC分类号： C07D209/40 , A61K31/404 , A61P25/00 , A61P35/00
摘要： Indirubin derivatives of formula I wherein R represents -(A) n - R 1 or -CO-N(R 2 ,R 3 ) with €¢ A being C1-C5 alkylene group, optionally substituted by one or several A 1 radical, A 1 being an halogen Br, OH, OR 4 or NH 2 , R 4 being C1-C5 alkyl; €¢ R 1 being halogen, OH, N(R 2 , R 3 ); R 2 and R 3 , identical or different, being C1-C5 alkyl, optionally substituted by A 1 such as above defined, or R 2 and R 3 are part of a cycle with 5 or 6 elements optionally comprising another heteroatom such as O or N; €¢ n = 1-5. It also relates to the biological application thereof.

43. 发明专利

DK1308447T3 Purin-derivat til anvendelse i behandlingen af en proliferativ sygdom 未知
公开(公告)号：DK1308447T3
公开(公告)日：2011-06-20
申请号：DK02293256
申请日：1996-11-29
申请人： CENTRE NAT RECH SCIENT , INST BOTAN EXPERIMENTALE
发明人： MEIJER LAURENT , BISAGNI EMILE , LEGRAVEREND MICHEL , STRNAD MIROSLAV
IPC分类号： C07D473/16 , A01N43/90 , A61K31/00 , A61K31/52 , A61K31/522 , A61P17/00 , A61P17/06 , A61P25/28 , A61P31/00 , A61P31/10 , A61P33/00 , A61P35/00 , C07D473/18 , C07D473/32 , C07D473/40

45. 发明专利

FR2876584B1 未知
公开(公告)号：FR2876584B1
公开(公告)日：2007-04-13
申请号：FR0410961
申请日：2004-10-15
申请人： CENTRE NAT RECH SCIENT CNRSE , UNIV POITIERS
发明人： BECQ FREDERIC , MEIJER LAURENT , KUNICK CONRAD
IPC分类号： A61K31/55 , A61P11/00 , A61P29/00
摘要： The invention relates to paullone derivatives for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells, said derivatives being of general formula (1): wherein X-C-O, C-S-CH3, C-S, -C-NHOH, Z-C or N, Y- with the adjacent ring, a phenyl or thienyl group, the ring(s) of said derivatives being optionally substituted with one or more halogen atoms, hydroxy, alkylenehydroxy, alkynealkylenehydroxy, alkynehydroxycyclohexyl, alkyl, alkoxy, alkylenealkoxy, or alkylenecyano groups where the alkylene group is either saturated or unsaturated, the groups having a straight or branched chain with C1 to C18, said chain being optionally substituted with one or more hydroxy or amino groups, or one or more trifluoromethyl, -COM, -COOM, or -CH2COOM groups (where M=H, C1 to C18 straight or branched chain alkyl, optionally substituted with one or more hydroxy and/or amino groups) nitroso, or cyano, R5-H, or C1 to C5 alkyl and R12-H, or -C-CO2-(CH3)3 and the physiologically-acceptable salts and derivatives thereof.

46. 发明专利

CA2583363A1 UTILISATION DE DERIVES DE PYRROLO- PYRAZ INES POUR LE TRAITEMENT DE LA MUCOVISCIDOSE 未知
公开(公告)号：CA2583363A1
公开(公告)日：2006-04-27
申请号：CA2583363
申请日：2005-10-14
申请人： CENTRE NAT RECH SCIENT , UNIV POITIERS
发明人： METTEY YVETTE , MEIJER LAURENT , BECQ FREDERIC
IPC分类号： A61K31/4985 , A61P1/00 , A61P11/00

47. 发明专利

AU778735B2 Fused azepinone cyclin dependent kinase inhibitors 未知
公开(公告)号：AU778735B2
公开(公告)日：2004-12-16
申请号：AU4571499
申请日：1999-06-16
申请人： US GOV HEALTH & HUMAN SERV , KUNICK CONRAD , CENTRE NAT RECH SCIENT
发明人： KUNICK CONRAD , MEIJER LAURENT , ZAHAREVITZ DANIEL W , GUSSIO RICK , JALLURI RAVI K , SAUSVILLE EDWARD A
IPC分类号： A61K31/55 , A61P35/00 , A61P43/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D495/14
摘要： A new class of cyclin dependent kinase inhibitors that also have antiproliferative activity in human tumor cell line assays are described. Most of these compounds satisfy the formulawherein A is oxygen or sulfur coupled to the right by a single or double bond; R2 is selected from the group consisting of hydrogen, aryl, lower aliphatic substituents, particularly alkyl and lower alkyl ester; R4-R7 are independently selected from the group consisting of alkoxy, amino, acyl, aliphatic substituents, particularly alkyl, alkenyl and alkinyl substituents, aliphatic alcohols, particularly alkyl alcohols, aliphatic nitriles, particularly alkyl nitriles, cyano, nitro, carboxyl, halogen, hydrogen, hydroxyl, imino, and alpha, beta, unsaturated ketones; R8-R11 are independently selected from the group consisting of aliphatic substituents, particularly alkyl, alkenyl and alkinyl substituents, particularly lower aliphatic substituents, alipahatic alcohols, particularly alkyl alcohols, alkoxy, acyl, cyano, nitro, epoxy, haloalkyl groups, halogen, hydrogen and hydroxyl; R12 is selected from the group consisting of aliphatic groups, particularly lower alkyl groups, aliphatic alcohols, particularly alkyl alcohols, carboxylic acids and hydrogen. Compositions comprising effective amounts of such compounds also are described. These compounds and compositions can be used in a method for inhibiting the proliferation of living cells in a subject comprising administering an effective amount of the compound(s), or composition(s) comprising the compound(s), to a subject to inhibit the proliferation of living cells, such as neoplastic cells.

48. 发明专利

ES2213996T3 未知
公开(公告)号：ES2213996T3
公开(公告)日：2004-09-01
申请号：ES99403077
申请日：1999-12-08
申请人： CENTRE NAT RECH SCIENT
发明人： MEIJER LAURENT
IPC分类号： C07D487/04 , A61K31/55 , A61P3/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00

49. 发明专利

AU2003302747A1 MEANS FOR INDUCING DIFFERENTIATION OF SUPERNUMERARY HAIR CELLS AND DEITERS' CELLS IN THE DEVELOPING ORGAN OF CORTI. 未知
公开(公告)号：AU2003302747A1
公开(公告)日：2004-07-09
申请号：AU2003302747
申请日：2003-12-17
申请人： CENTRE NAT RECH SCIENT
发明人： KNOCKAERT MARIE , MALGRANGE BRIGITTE , MEIJER LAURENT
IPC分类号： A61K31/404 , A61K31/519 , A61P27/16
摘要： Use of at least one kinase inhibitor for making drugs for inducing differentiation of supernumerary hair cells and Deiters' cells in the developing organ of Corti.

50. 发明专利

CA2495060A1 PYRROLOPYRAZINES AS KINASE INHIBITORS 未知
公开(公告)号：CA2495060A1
公开(公告)日：2004-02-26
申请号：CA2495060
申请日：2003-08-08
申请人： CENTRE NAT RECH SCIENT
发明人： METTEY YVETTE , MEIJER LAURENT , VIERFOND JEAN-MICHEL
IPC分类号： A61K31/495 , A61P25/16 , A61P25/28 , A61P35/00 , C07D487/04 , C07D498/04
摘要： The invention relates to pyrrolo [2, 3b]-pyrazine derivatives having the general Formula (I) wherein R2 and R3 are identical or different and represe nt H, C1-C6 alkyl, said alkyl being a straight or branched - chain alkyl, which can be substituted, R6 is an optionally subsituted aromatic cycle Ar or a cycloalkyl, said cycloalkyl being optionally substituted by an aryl group which can also be substituted, R7 is H, C1-C6 alkyl, (alk.)n-hal., CH2-CH = CH2, CH2-cycloalkyl, CH2-Ar, with "alk." being a C1-C6 alkylene group, n bei ng 1-6, Z is H or CH3. Application as active principle of pharmaceutical compositions, particularly for treating or preventing neurodegenerative disorders and proliferative disorders.

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