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41. 发明专利

AU1682400A 4-oxoimidazolidine-2-spiro-nitrogenous heterocycle compounds 未知
公开(公告)号：AU1682400A
公开(公告)日：2000-06-26
申请号：AU1682400
申请日：1999-12-09
申请人： BANYU PHARMA CO LTD
发明人： SATOH ATSUSHI , KAWAMOTO HIROSHI , OZAKI SATOSHI , ITO YOSHIKI , IWASAWA YOSHIKAZU
IPC分类号： A61P25/04 , C07D471/10 , A61K31/407 , A61K31/438 , A61P3/04 , A61P9/02 , A61P13/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/36 , A61P43/00 , C07D487/10

42. 发明专利

AU7453298A 2-oxoimidazole derivatives 未知
公开(公告)号：AU7453298A
公开(公告)日：1998-12-30
申请号：AU7453298
申请日：1998-05-27
申请人： BANYU PHARMA CO LTD
发明人： OZAKI SATOSHI , KAWAMOTO HIROSHI , ITO YOSHIKI , HIRANO KAORI , HAYASHI KYOKO , IWASAWA YOSHIKAZU
IPC分类号： C07D401/04 , C07D403/04 , C07D451/06 , C07D453/06 , A61K31/415 , A61K31/435 , A61K31/445
摘要： The present invention relates to a compound represented by Formula ÄIÜ Äwherein represents an aromatic carbo- or heterocyclic ring which may have a substituent; Cy represents a mono-, bi- or tricyclic aliphatic carbocyclic group having 3 to 20 carbon atoms, which may have a substituent; represents a mono- or bicyclic aliphatic nitrogen-containing heterocyclic group having 3 to 14 carbon atoms, which may have a substituent; R represents a hydrogen atom, a lower alkenyl group, a lower alkynyl group, a cyclo(lower alkyl) group, an amino group, a lower alkylamino group, a di(lower alkyl)amino group, a hydroxyl group, a lower alkoxy group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group or a di(lower alkyl)carbamoyl group, or a lower alkyl group which may have a substituent; and R represents a hydrogen atom or a lower alkyl groupÜ, a salt or ester thereof, a production process for the same, and an analgesic, a reliever against tolerance to a narcotic analgesic represented by morphine, a reliever against dependence on a narcotic analgesic represented by morphine, an analgesic enhancer, an antiobestic, a drug for ameliorating brain function, a remedy for schizophrenia, a remedy for Parkinsonism, a remedy for chorea, an antidepressant, a remedy for diabetes insipidus, a remedy for polyuria, or a remedy for hypotension, comprising an effective ingredient of the same.

43. 发明专利

CA2291094A1 2-OXOIMIDAZOLE DERIVATIVE 未知
公开(公告)号：CA2291094A1
公开(公告)日：1998-12-03
申请号：CA2291094
申请日：1998-05-27
申请人： BANYU PHARMA CO LTD
发明人： OZAKI SATOSHI , KAWAMOTO HIROSHI , HIRANO KAORI , ITOH YOSHIKI , IWASAWA YOSHIKAZU , HAYASHI KYOKO
IPC分类号： C07D401/04 , C07D403/04 , C07D451/06 , C07D453/06 , A61K31/415 , A61K31/435 , A61K31/445
摘要： Compounds represented by general formula (I), their salts or esters; processes for producing the same; and analgesics, antagonists against tolerance to narcotic analgesics typified by morphine, antagonists against dependence on narcotic analgesics typified by morphine, analgesic enhancers, antiobestics, drugs for ameliorating brain function, remedies for schizophrenia, remedies for Parkinson's disease, remedies for chorea, antidepressive drugs, remedies for diabetes insipidus, remedies for polyuria, or remedies for hypotension, each drug containing the above compounds as the active ingredient. In said formula, (a) represents an optionally substituted aromatic carbon ring or heterocycle; Cy represents an optionally substituted, mono-, di- or tricyclic C3-20 aliphatic carbon ring; (b) represents an optionally substituted, monoor di-cyclic C3-14 aliphatic heterocycle containing nitrogen; R1 represents hydrogen, lower alkenyl, lower alkynyl, lower cycloalkyl, amino, lower alkylamino, di(lower alkyl)amino, hydroxy, lower alkoxy, carboxy, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, di(lower alkyl)carbamoyl or optionally substituted lower alkyl; and R2 represents hydrogen or lower alkyl.

44. 发明专利

CA2261633A1 CHEMOKINE RECEPTOR ANTAGONISTS 未知
公开(公告)号：CA2261633A1
公开(公告)日：1998-02-05
申请号：CA2261633
申请日：1997-07-23
申请人： BANYU PHARMA CO LTD
发明人： SAEKI TOSHIHIKO , OWADA YUFU , NAYA AKIRA , IWASAWA YOSHIKAZU , OHWAKI KENJI
IPC分类号： C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/14 , C07D471/08 , C07D409/14 , C07D417/14 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/54 , A61K31/55
摘要： Compounds represented by general formula (I), pharmaceutically acceptable anion-exchange products thereof, or hydrates of both, wherein R1 and R2 are the same or different and each represents hydrogen, halogeno, lower alkyl, etc.; X represents oxygen, sulfur or CH; Y represents CH or nitrogen; and A represents 1-substituted-4-piperidinyl, etc. Because of having chemokine receptor antagonism, these compounds are useful as remedies for various diseases related to chemokine, such as acute inflammatory diseases, chronic inflammatory diseases, human acquired immunological deficiency syndrome, cancer, ischemic reflow disorders and/or arteriosclerosis.

45. 发明专利

AU1619397A N,n-disubstituted amic acid derivatives 未知
公开(公告)号：AU1619397A
公开(公告)日：1997-08-28
申请号：AU1619397
申请日：1997-02-07
申请人： BANYU PHARMA CO LTD
发明人： IWASAWA YOSHIKAZU , AOYAMA TETSUYA , KAWAKAMI KUMIKO , ARAI SACHIE , SATOH TOSHIHIKO , MONDEN YOSHIAKI
IPC分类号： C07C233/01 , C07D213/56 , C07D307/66 , C07D405/12 , C07D407/12 , A61K31/34 , A61K31/35 , A61K31/44 , C07D307/68 , C07D405/06 , C07D407/06

46. 发明专利

AU1619297A Substituted amide derivatives 未知
公开(公告)号：AU1619297A
公开(公告)日：1997-08-28
申请号：AU1619297
申请日：1997-02-07
申请人： BANYU PHARMA CO LTD
发明人： IWASAWA YOSHIKAZU , AOYAMA TETSUYA , KAWAKAMI KUMIKO , ARAI SACHIE , SATOH TOSHIHIKO , MONDEN YOSHIAKI
IPC分类号： C07C233/01 , C07D307/68 , A61K31/27 , A61K31/34
摘要： Compounds represented by general formula (I), pharmacologically acceptable salts or esters thereof, and antitumor agents comprising these as the active ingredients, wherein Ar , Ar , and Ar each represents aryl or heteroaryl; A represents C1-6 hydrocarbyl or a group represented by -A -W -A - (where W represents oxygen, sulfur, ethynylene, cyclopropylene, or a group represented by -NR -); A represents C1-8 hydrocarbyl group; R represents lower alkyl, lower alkenyl, lower alkoxy, carboxy, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, a group represented by R COO- (where R represents hydrogen, amino, lower alkyl, lower alkoxy, or lower alkylamino) or by R CONR - (where R represents hydrogen, amino, lower alkyl, lower alkoxy, or lower alkylamino), or an alicyclic group; R represents lower alkyl; and X and Y each represents oxygen, sulfur, carbonyl, or a group represented by -CHR - or -NR -, or X and Y are bonded to each other to thereby form vinylene or ethynylene, provided that when one of X and Y represents oxygen, sulfur, or a group represented by -NR -, then the other represents carbonyl or a group represented by -CHR -.

47. 发明专利

AU1619097A Substituted amide derivatives 未知
公开(公告)号：AU1619097A
公开(公告)日：1997-08-28
申请号：AU1619097
申请日：1997-02-07
申请人： BANYU PHARMA CO LTD
发明人： IWASAWA YOSHIKAZU , AOYAMA TETSUYA , KAWAKAMI KUMIKO , ARAI SACHIE , SATOH TOSHIHIKO , MONDEN YOSHIAKI
IPC分类号： C07C233/47 , A61K31/195 , A61K31/27 , A61K31/34 , A61K31/36 , A61K31/38 , A61K31/54 , C07C235/12 , C07D265/32 , C07D307/79 , C07D317/60 , C07D333/20 , C07D333/66

48. 发明专利

ZA898464B SUBSTITUTED ALLYLAMINE DERIVATIVES,PROCESSES FOR PRODUCTION THEREOF AND USE THEREOF 未知
公开(公告)号：ZA898464B
公开(公告)日：1991-01-30
申请号：ZA898464
申请日：1989-11-07
申请人： BANYU PHARMA CO LTD
发明人： TAKEZAWA HIROSHI , HIROSHI TAKEZAWA , HAYASHI MASAHIRO , MASAHIRO HAYASHI , IWASAWA YOSHIKAZU , YOSHIKAZU IWASAWA , HOSOI MASAAKI , MASAAKI HOSOI , IIDA YOSHIAKI , YOSHIAKI IIDA , TSUCHIYA YOSKIMI , YOSKIMI TSUCHIYA , HORIE MASAHIRO , MASAHIRO HORIE , KAMEI TOSHIO , TOSHIO KAMEI
IPC分类号： C07D207/08 , C07D207/32 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/38 , C07D239/26 , C07D261/08 , C07D263/32 , C07D271/10 , C07D275/02 , C07D277/22 , C07D277/24 , C07D307/42 , C07D333/16 , C07D333/18 , C07D333/20 , C07D335/02 , C07D409/10 , C07D413/04 , C07D413/10 , C07D417/04 , C07D521/00 , C07F , A61K
摘要： Alk-2-en-4-ynamine derivatives of formula (I) and their non-toxic salts are new: where A1 and A2 are -CH=, N, O or S; Q1 and Q2 complete a 5 or 6 membered aromatic ring and may contain one or two N, O or S; X and Y are O, S, CO, -CHRa-or NRb- or together form vinylene or ethynylene; Ra is H or lower alkyl; Rb is H or lower alkyl; R1 is a 5 or 6 membered heterocyclic ring contg. 1-4N, O and/or S; R2 is lower alkyl, allyl, propargyl or cyclopropyl; R3 and R4 are lower alkyl or together complete a cycloalkane ring; R5 is H, lower alkyl or lower alkoxy; R6 and R7 are H, halogen, OH, CN, lower alkyl or lower alkoxy. When one of X and Y is O, S or -NRb-, then the other is -CO-or -CHRa-.

49. 发明专利

GR890100736A PROCESSES FOR PRODUCTION OF SUBTITUTED ALLYLAMINE DERIVATIVES AND USE THEREOF 未知
公开(公告)号：GR890100736A
公开(公告)日：1990-12-31
申请号：GR89100736
申请日：1989-11-07
申请人： BANYU PHARMA CO LTD
发明人： HAYASHI MASAHIRO , HORIE MASAHIRO , HOSOI MASAAKI , IIDA YOSHIAKI , IWASAWA YOSHIKAZU , KAMEI TOSHIO , TAKEZAWA HIROSHI , TSUCHIYA YOSHIMI
IPC分类号： C07D207/08 , C07D207/32 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/38 , C07D239/26 , C07D261/08 , C07D263/32 , C07D271/10 , C07D275/02 , C07D277/22 , C07D277/24 , C07D307/42 , C07D333/16 , C07D333/18 , C07D333/20 , C07D335/02 , C07D409/10 , C07D413/04 , C07D413/10 , C07D417/04 , C07D521/00 , C07D22/20
摘要： Alk-2-en-4-ynamine derivatives of formula (I) and their non-toxic salts are new: where A1 and A2 are -CH=, N, O or S; Q1 and Q2 complete a 5 or 6 membered aromatic ring and may contain one or two N, O or S; X and Y are O, S, CO, -CHRa-or NRb- or together form vinylene or ethynylene; Ra is H or lower alkyl; Rb is H or lower alkyl; R1 is a 5 or 6 membered heterocyclic ring contg. 1-4N, O and/or S; R2 is lower alkyl, allyl, propargyl or cyclopropyl; R3 and R4 are lower alkyl or together complete a cycloalkane ring; R5 is H, lower alkyl or lower alkoxy; R6 and R7 are H, halogen, OH, CN, lower alkyl or lower alkoxy. When one of X and Y is O, S or -NRb-, then the other is -CO-or -CHRa-.

50. 发明专利

NZ565026A N-dihydroxyalkyl-substituted 2-oxo-imidazole (benzimidazolone) derivatives 未知
公开(公告)号：NZ565026A
公开(公告)日：2010-09-30
申请号：NZ56502606
申请日：2006-07-11
申请人： BANYU PHARMA CO LTD
发明人： HASHIMOTO MASAYA , IWASAWA YOSHIKAZU , KAWAMOTO HIROSHI , OHTA HISASHI , OZAKI SATOSHI , SAGARA TAKESHI , SAKOH HIROKI , SATOH ATSUSHI
IPC分类号： C07D401/04 , A61K31/454 , A61P3/04 , A61P9/00 , A61P9/02 , A61P9/10 , A61P13/02 , A61P19/02 , A61P19/06 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P43/00
摘要： Disclosed is a piperidine-substituted benzimidazolone derivative of formula (I), wherein R is a di-hydroxy-substituted C1-6alkyl, and Cy is a spiro or bridged hydrocarbon ring group selected from the list given in the specification. Also described is the use of a compound as an analgesic, a reliever against tolerance to narcotic analgesics, a reliever against dependence on narcotic analgesics or against addiction, an analgesic enhancer; an antiobestic or appetite suppressor, or for treating cognitive impairment and dementia/amnesia in aging, cerebrovascular disease and Alzheimer's disease, developmental cognitive abnormality in attention deficit, hyperactivity disorder and learning disability, schizophrenia, neurodegenerative diseases such as Parkinsonism and chorea, affective disorder, diabetes insipidus, polyuria, or hypotension.

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