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41. 发明申请

WO2008110456A3 METHOD OF TREATING CELLULOSIC MATERIALS WITH HYDROPHOBINS 审中-公开
公开(公告)号：WO2008110456A3
公开(公告)日：2008-09-18
申请号：PCT/EP2008/052333
申请日：2008-02-27
申请人： CIBA HOLDING INC. , GABOR, Esther , BUTHE, Andreas , ECK, Jürgen , KAUFMANN, Franz , KOCH, Hans-Jörg , MEURER, Guido
发明人： GABOR, Esther , BUTHE, Andreas , ECK, Jürgen , KAUFMANN, Franz , KOCH, Hans-Jörg , MEURER, Guido
IPC分类号： D21C5/00 , D21H17/22 , D06M15/15 , B27K3/34
摘要： By treatment with hydrophobins, cellulosic materials such as paper, cardboard, cotton or, especially, wood-based materials, such as solid wood, glued wood products or particle board, can be effectively protected against absorption of and attack by water and/or moisture.

42. 发明申请

WO2007115797A3 A GROUP OF NOVEL ENANTIOSELECTIVE MICROBIAL NITRILE HYDRATASES WITH BROAD SUBSTRATE SPECIFICITY 审中-公开
公开(公告)号：WO2007115797A3
公开(公告)日：2007-10-18
申请号：PCT/EP2007/003114
申请日：2007-04-05
申请人： B.R.A.I.N. AG , ECK, Jürgen , LIEBETON, Klaus , FISCHER, Lutz , LUTZ-WAHL, Sabine , HENSEL, Martina , EWERT, Christian , WÄLZ, Marcus
发明人： ECK, Jürgen , LIEBETON, Klaus , FISCHER, Lutz , LUTZ-WAHL, Sabine , HENSEL, Martina , EWERT, Christian , WÄLZ, Marcus
IPC分类号： C12N9/14 , C12N9/78 , C12N1/20 , C12P13/02 , C12P41/00 , C07K14/195
摘要： The present invention provides a polynucleotide or a pair of polynucleotides encoding an enzyme having nitrile hydratase (NHase) [E. C. 4.2.1.84] activity. Furthermore, a vector and a host comprising the disclosed polynucleotide or pair of polynucleotides and methods for the production of the same are provided. Moreover, the invention relates to a pair of polypeptides or a fusion protein having NHase activity, an antibody specifically binding to the pair of polypeptides or fusion protein, a primer or probe, which specifically hybridizes under stringent conditions to the disclosed polynucleotide or either one of the pair of polynucleotides, a composition comprising the polynucleotide or pair of polynucleotides, the pair of polypeptides or fusion protein, the antibody and/or one or more primers or probes of the invention and a method for the production of amides comprising the enantioselective conversion of nitriles.

43. 发明申请

WO2003042412A1 RECA-NEGATIVE AND RHAB-NEGATIVE MICROORGANISM 审中-公开
标题翻译： RECA阴性和RHAB阴性微生物
公开(公告)号：WO2003042412A1
公开(公告)日：2003-05-22
申请号：PCT/EP2002/011979
申请日：2002-11-11
申请人： DEGUSSA AG , MAY, Oliver , LIEBETON, Klaus , ECK, Jürgen
发明人： MAY, Oliver , LIEBETON, Klaus , ECK, Jürgen
IPC分类号： C12R1/19
CPC分类号： C12R1/19 , C12N15/68 , C12N15/70 , C12P13/04 , C12P21/02 , C12P41/006
摘要： The present invention describes new microorganisms specifically for use as expression systems for rhamnose-inducible promoters. Due to the combination of rhamnose and recombination deficiency artificially created in these organisms, expression systems which require less of the expensive rhamnose for induction and therefore can be induced more inexpensively, and have a higher genetic stability are obtained.
摘要翻译：本发明描述了专门用作鼠李糖诱导型启动子表达系统的新微生物。由于在这些生物体中人造产生的鼠李糖和重组缺陷的组合，需要较少昂贵的鼠李糖用于诱导并因此可以更廉价地诱导并具有较高遗传稳定性的表达系统。

44. 发明申请

WO2003002711A2 EINE NEUE GRUPPE VON $G(A)-AMYLASEN SOWIE EIN VERFAHREN ZUR IDENTIFIZIERUNG UND GEWINNUNG NEUER $G(A)-AMYLASEN 审中-公开
标题翻译：新群组识别与提取新的美元G（A）的淀粉酶的DOLLAR G（A）淀粉酶和方法的
公开(公告)号：WO2003002711A2
公开(公告)日：2003-01-09
申请号：PCT/EP2002/006842
申请日：2002-06-20
申请人： HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN , BREVES, Roland , KOTTWITZ, Beatrix , MAURER, Karl-Heinz , ECK, Jürgen , LORENZ, Patrick , ZINKE, Holger
发明人： BREVES, Roland , KOTTWITZ, Beatrix , MAURER, Karl-Heinz , ECK, Jürgen , LORENZ, Patrick , ZINKE, Holger
IPC分类号： C12N
CPC分类号： C12N9/2417 , C07K2319/00 , C12Y302/01001 , Y02E50/17
摘要： Die vorliegende Erfindung betrifft eine neue Gruppe von α-Am ylasen, die einem gemeinsamen Sequenzraum angehören, sowie zu diesen α-Amylasen hinreichend ähnliche Proteine mit amylolytischer Funktion, Verfahren zu deren Herstellung und diverse Einsatzmöglichkeiten für diese amylolytischen Proteine, insbesondere in Wasch- und Reinigungsmitteln. Sie betrifft auch ein PCR-basiertes Verfahren zur Identifizierung und Gewinnung neuer α-Amylasen aus isolierter genomischer DNA, insbesondere aus isolierter DNA von Sammlungen von Mikroorganismen sowie bestimmte Primer-Oligonukleotide und deren Anwendung in einem solchen Verfahren.
摘要翻译：本发明涉及到属于一个共同的序列空间，以及这些α-淀粉酶与淀粉分解功能足够相似的蛋白，其制备各种用途对这些淀粉分解蛋白质的方法，特别是在洗涤剂和清洁剂的α--Am ylasen的一个新组，它也涉及一种基于PCR的方法用于鉴定和从分离的基因组DNA获得的新α-淀粉酶，在来自微生物的集合以及某些引物寡核苷酸和它们在这样的方法中应用特定分离DNA。

45. 发明申请

WO2009103500A1 MEANS AND METHODS FOR CONTROLLING COMMENSALES 审中-公开
标题翻译：用于控制通信的手段和方法
公开(公告)号：WO2009103500A1
公开(公告)日：2009-08-27
申请号：PCT/EP2009/001135
申请日：2009-02-18
申请人： B.R.A.I.N. , DECHERT, Ute , ECK, Jürgen
发明人： DECHERT, Ute , ECK, Jürgen
IPC分类号： A61K8/35 , A61Q19/10 , A61P17/10 , A61Q19/00
CPC分类号： A61K8/35 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/404 , A61Q17/005
摘要： The present invention relates to a cosmetic composition for the cleaning of the skin, said composition comprising or consisting of one or more compounds of formula (I) wherein (formula II) represents a single bond or double bond; R 1 and R 2 are independently selected from H, linear or branched C 1 to C 4 alkyl, linear or branched C 1 to C 4 alkenyl, linear or branched C 1 to C 4 alkinyl, and linear or branched C 1 to C 4 alkanoyl; R 4 is selected from H, linear or branched C 1 to C 4 alkyl, linear or branched C 1 to C 4 alkenyl, and linear or branched C 1 to C 4 alkinyl; and R 3 and R 5 are independently selected from H, OH and halogen, or R 3 and R 5 together are O to form an epoxid, wherein (formula II) represents a single bond in case R 3 and R 5 together are O. Also provided are means and methods for the prevention or reduction of biofilm formation on an intracorporeal device and/or for the removal of biofilm from an intracorporeal device, wherein said biofilm comprises or consists of bacteria of the genus Propionibacterium. Furthermore provided is an intracorporeal device which is coated and/or loaded with one or more compounds as defined above.
摘要翻译：本发明涉及一种用于清洁皮肤的化妆品组合物，所述组合物包含一种或多种式（I）化合物或由其组成，其中（式II）表示单键或双键; R 1和R 2独立地选自H，直链或支链C 1至C 4烷基，直链或支链C 1至C 4烯基，直链或支链C 1至C 4炔基，和直链或支链C 1至C 4烷酰基; R4选自H，直链或支链C1至C4烷基，直链或支链C1至C4烯基，直链或支链C1至C4炔基; 并且R 3和R 5独立地选自H，OH和卤素，或者R 3和R 5一起为O以形成环氧化物，其中（式II）在情况R3和R5一起为O时表示单键。还提供了手段和方法用于预防或减少在体内装置上生物膜形成和/或从体内装置中除去生物膜，其中所述生物膜包含丙酸杆菌属的细菌或由其构成。此外，提供了一种体外装置，其被涂覆和/或加载一种或多种如上所定义的化合物。

46. 发明申请

WO2007128496A2 A NOVEL GROUP OF ESTERASES FOR THE ENANTIOSELECTIVE PRODUCTION OF FINE AND SPECIALITY CHEMICALS 审中-公开
标题翻译：一种新的精选和特种化学品生产的新一代产品
公开(公告)号：WO2007128496A2
公开(公告)日：2007-11-15
申请号：PCT/EP2007/003919
申请日：2007-05-03
申请人： B.R.A.I.N. AG , LIEBETON, Klaus , ECK, Jürgen , BORNSCHEUER, Uwe , BÖTTCHER, Dominique , LANGER, Peter , BELLUR, Esen
发明人： LIEBETON, Klaus , ECK, Jürgen , BORNSCHEUER, Uwe , BÖTTCHER, Dominique , LANGER, Peter , BELLUR, Esen
IPC分类号： C12N9/18 , C12N15/55 , C07K16/40 , C12N5/10
CPC分类号： C12N9/18
摘要： The present invention relates to a polynucleotide encoding an enzyme having carboxylesterase [E. C. 3.1.1.1] activity, wherein the coding sequence is selected from the group consisting of (a) a polynucleotide encoding an amino acid sequence as depicted in any one of SEQ ID NOs: 2, 4, 6, 8, 10 and 12; (b) a polynucleotide having or comprising a nucleotide sequence encoding an enzyme, wherein the nucleic acid sequence is as shown in any one of SEQ ID NOs: 1, 3, 5, 7, 9 and 11; (c) a polynucleotide having or comprising a nucleotide sequence encoding a fragment or derivative of an enzyme encoded by a polynucleotide of (a) or (b), wherein in said derivative one or more amino acid residues are conservatively substituted compared to the amino acid sequence of (a); (d) a polynucleotide encoding an enzyme having carboxylesterase activity which polynucleotide is at least 66% identical to a polynucleotide encoding an enzyme as shown in one of SEQ ID NOs: 2, 4, 6, 8, 10 and 12; (e) a polynucleotide having or comprising a nucleotide sequence the complementary strand of which hybridizes to a polynucleotide as defined in any one of (a) to (d); and (T) a polynucleotide having or comprising a nucleotide sequence being degenerate to the nucleotide sequence of the polynucleotide of (d) or (e); or the complementary strand of such a polynucleotide of (a) to (f) or fragments thereof useful as specific probes or primers. The present invention also relates to a host genetically engineered with the polynucleotide of the present invention or the vector of the present invention. The present invention also relates to a process for producing a polypeptide having carboxylesterase [E. C. 3.1.1.1] activity, comprising culturing the host of the present invention and recovering the polypeptide produced by said host. Moreover, The present invention also relates to a process for producing bacteria or eukaryotic cells capable of expressing a polypeptide having carboxylesterase [E. C. 3.1.1.1] activity, the process comprising genetically engineering bacteria or eukaryotic cells with the vector of the present invention. Finally, the present invention relates to (poly)peptides, antibodies, compositions and various methods for the production of optically active compounds.
摘要翻译：本发明涉及编码具有羧酸酯酶[E. 3.1.1.1]活性，其中编码序列选自（a）编码SEQ ID NO：2,4,6,8,10和12中任一个所示的氨基酸序列的多核苷酸 ; （b）具有或包含编码酶的核苷酸序列的多核苷酸，其中所述核酸序列如SEQ ID NO：1,3,5,7,9和11中任一个所示; （c）具有或包含编码由（a）或（b）的多核苷酸编码的酶的片段或衍生物的核苷酸序列的多核苷酸，其中在所述衍生物中，与氨基酸相比，一个或多个氨基酸残基被保守取代（a）的顺序; （d）编码具有羧酸酯酶活性的多核苷酸的多核苷酸与编码如SEQ ID NO：2,4,6,8,10和12之一所示的酶的多核苷酸至少66％相同; （e）具有或包含核苷酸序列的多核苷酸，其互补链与（a）至（d）中任一项所定义的多核苷酸杂交; 和（T）具有或包含与（d）或（e）的多核苷酸的核苷酸序列退化的核苷酸序列的多核苷酸; 或（a）至（f）的这种多核苷酸或其片段的互补链用作特异性探针或引物。本发明还涉及用本发明的多核苷酸或本发明的载体进行遗传工程改造的宿主。本发明还涉及产生具有羧酸酯酶[E. 3.1.1.1]活性，包括培养本发明的宿主并回收由所述宿主产生的多肽。此外，本发明还涉及能够表达具有羧酸酯酶[E]的多肽的细菌或真核细胞的生产方法。 3.1.1.1]活性，该方法包括用本发明的载体将细菌或真核细胞遗传工程化。最后，本发明涉及（多）肽，抗体，组合物和用于制备光学活性化合物的各种方法。

47. 发明申请

WO2005103239A2 NOVEL ALCOHOL DEHYDROGENASES 审中-公开
标题翻译：新型酒精脱水剂
公开(公告)号：WO2005103239A2
公开(公告)日：2005-11-03
申请号：PCT/EP2005/002557
申请日：2005-03-10
申请人： DEGUSSA AG , SCHULZE, Renate , LORENZ, Patrick , ECK, Jürgen , MAY, Oliver , GRÖGER, Harald , TRAUTHWEIN, Harald
发明人： SCHULZE, Renate , LORENZ, Patrick , ECK, Jürgen , MAY, Oliver , GRÖGER, Harald , TRAUTHWEIN, Harald
IPC分类号： C12N9/04
CPC分类号： C12P7/02 , C12N9/0006 , C12Y101/01002
摘要： The invention relates to novel polypeptides which have the biological activity of an NAD- or NADP-dependent alcohol dehydrogenase. The invention furthermore relates to nucleic acids encoding said polypeptides, to non-human hosts or host cells and to reaction systems which may be used for preparing desired products. The polypeptides of the invention are preferably used in the preparation, starting from aldehydes or ketones, of primary and enantiomerically pure secondary alcohol’s which may serve as intermediates for medicaments. Alternatively, the polypeptides of the invention may also be employed in the reverse reaction, i.e. the oxidation of alcohol’s with the formation of aldehydes or ketones.
摘要翻译：本发明涉及具有NAD-或NADP依赖性醇脱氢酶的生物活性的新型多肽。本发明还涉及编码所述多肽，非人宿主或宿主细胞的核酸和可用于制备所需产物的反应体系。本发明的多肽优选用于从醛或酮开始制备可以作为药物中间体的初级和对映异构纯的仲醇。或者，本发明的多肽也可以用于反向反应，即醇与醛或酮的形成的氧化。

48. 发明申请

WO2005026338A1 ALCOHOL DEHYDROGENASES WITH INCREASED SOLVENT AND TEMPERATURE STABILITY 审中-公开
标题翻译：具有溶解度和温度稳定性的酒精脱氢剂
公开(公告)号：WO2005026338A1
公开(公告)日：2005-03-24
申请号：PCT/EP2004/052095
申请日：2004-09-08
申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. , STAMPFER, Wolfgang , KOSJEK, Birgit , KROUTIL, Wolfgang , FABER, Kurt , NIEHAUS, Frank , ECK, Jürgen
发明人： STAMPFER, Wolfgang , KOSJEK, Birgit , KROUTIL, Wolfgang , FABER, Kurt , NIEHAUS, Frank , ECK, Jürgen
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , C12P7/02 , C12P7/26 , C12P41/002
摘要： The invention relates to biocatalysts showing alcohol dehydrogenase activity obtainable from Rhodococcus ruber, their preparation, their use in the oxidation of secondary alcohols and/or the reduction of ketones, as well as nucleic acids coding for these alcohol dehydrogenases and microorganisms transformed with nucleic acids coding for these biocatalysts and their use for producing the biocatalyst or oxidizing secondary alcohols and/or reducing ketones.
摘要翻译：本发明涉及显示可从红球菌获得的醇脱氢酶活性的生物催化剂，其制备方法，它们在仲醇氧化和/或还原酮中的用途，以及编码这些醇脱氢酶的核酸和用编码的核酸转化的微生物这些生物催化剂及其用于生产生物催化剂或氧化仲醇和/或还原酮的用途。

49. 发明申请

WO2003054544A3 VERFAHREN ZUR BESTIMMUNG DER RESPONSIVITÄT EINES INDIVIDUUMS FÜR MISTELLEKTIN 审中-公开
公开(公告)号：WO2003054544A3
公开(公告)日：2003-07-03
申请号：PCT/EP2002/014682
申请日：2002-12-20
申请人： VISCUM AG , MÜTHING, Johannes , PETER-KATALINIC, Jasna , LANGER, Martin , MÖCKEL, Babette , ECK, Jürgen
发明人： MÜTHING, Johannes , PETER-KATALINIC, Jasna , LANGER, Martin , MÖCKEL, Babette , ECK, Jürgen
IPC分类号： G01N33/566
摘要： Beschrieben wird ein Verfahren zur Bestimmung der Responsivität eines Individuums auf Mistellektin oder für (eine) Mistellektin-Einzellkette(n), wobei die Expression eines membranständigen Rezeptors für Mistellektin charakteristisch für eine entsprechende Responsivität ist. Der Rezeptor ist gekennzeichnet durch eine endständige N-Acetyl-Neuraminsäure (Neu5Ac), die über eine glykosidische alpha2-6-Verknüpfung mit einer Galactose (Gal) verbunden ist. Ein anderes Verfahren zur Bestimmung der Responsivität auf Mistellektin wird auch offenbart, in dem es sich um den Nachweis eines Sialyltransferase handelt.

50. 发明申请

WO2003054177A3 NEUE GLYKOSYLHYDROLASEN 审中-公开
公开(公告)号：WO2003054177A3
公开(公告)日：2003-07-03
申请号：PCT/EP2002/014210
申请日：2002-12-13
申请人： HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN , B.R.A.I.N BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG , BREVES, Roland , MAURER, Karl-Heinz , ECK, Jürgen , LORENZ, Patrick , ZINKE, Holger
发明人： BREVES, Roland , MAURER, Karl-Heinz , ECK, Jürgen , LORENZ, Patrick , ZINKE, Holger
IPC分类号： C12N9/24
摘要： Die vorliegende Erfindung betrifft neue Glykosylhydrolasen mit amylolytischer Aktivität und die für diese Glykosylhydrolasen codierenden Nukleinsäuren, ein PCR-basiertes Verfahren zur Identifizierung und Gewinnung neuer Glykosylhydrolasen aus Metagenom-DNA sowie diverse technische Anwendungsmöglichkeiten für derartige Glykosylhydrolasen mit amylolytischer Aktivität. Hierunter sind Wasch- und Reinigungsmittel mit solchen Enzymen sowie entsprechende Verfahren und Verwendungsmöglichkeiten von besonderem Interesse.

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