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41. 发明申请

US20100201988A1 Transmitting/Reflecting Emanating Light With Time Variation 有权
标题翻译：发射/反射发光随时间变化
公开(公告)号：US20100201988A1
公开(公告)日：2010-08-12
申请号：US12762702
申请日：2010-04-19
申请人： Peter Kiesel , Markus Beck , Noble M. Johnson , Michael Bassler
发明人： Peter Kiesel , Markus Beck , Noble M. Johnson , Michael Bassler
IPC分类号： G01N21/25 , G01N21/85
CPC分类号： G01N21/05 , G01N21/255 , G01N21/645 , G01N2021/0346
摘要： A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences. The filter arrangement, in a practical commercial embodiment, can be manufactured to be disposable, and used in a point-of-care device for use practically anywhere, at low cost, and can also be implemented in an in-line monitoring system.
摘要翻译：滤波器装置可以发射和/或反射从移动物体发出的光，使得发射光具有时间变化，并且时间变化可以包括关于物体的信息，例如其类型。例如，可以通过路径的区段发出光，并通过过滤器组件的位置进行透射/反射，并且位置的透射函数可以充分地不同，从而在区间之间的发光中发生时间变化。或者发射来自光束的光可以通过其中叠加更简单的透射函数的滤光器部件被透射/反射，使得根据两个更简单的不均匀透射函数的叠加在发射光中发生时间变化。可以使用许多过滤装置，例如过滤器组件可以包括过滤器组件，其可以具有更简单的不均匀传输功能之一。可以比较感测结果中的时变波形，以获得光谱差异。在实用的商业实施例中，过滤器装置可以制造为一次性的，并且用于实际上在任何地方，以低成本使用的点护理装置，并且也可以在在线监测系统中实现。

42. 发明申请

US20100155577A1 Obtaining Sensing Results Indicating Time Variation 有权
标题翻译：获取传感结果指示时间变化
公开(公告)号：US20100155577A1
公开(公告)日：2010-06-24
申请号：US12337737
申请日：2008-12-18
申请人： Peter Kiesel , Joerg Martini , Michael Bassler , Markus Beck , Noble M. Johnson
发明人： Peter Kiesel , Joerg Martini , Michael Bassler , Markus Beck , Noble M. Johnson
IPC分类号： G01J1/42 , G06F15/00 , G01N21/00
CPC分类号： G01N15/1429 , G01N15/1056 , G01N15/12 , G01N15/1459 , G01N2015/1006 , G01N2015/1037 , G01N2015/1075
摘要： In response to objects having relative motion within an encoding/sensing region relative to an encoder/sensor that, e.g., photosenses emanating light or performs impedance-based sensing, sensing results can indicate sensed time-varying waveforms with information about the objects, about their relative motion, about excitation characteristics, about environmental characteristics, and so forth. An encoder/sensor can include, for example, a non-periodic arrangement of sensing elements; a longitudinal sequence of sensing elements with a combined sensing pattern that approximates a superposition or scaled superposition of simpler sensing patterns; and/or IC-implemented sensing elements that include photosensing arrays on ICs and readout/combine circuitry that reads out photosensed quantities from cells in groups in accordance with cell-group sensing patterns and combines the readout photosensed quantities to obtain the sensing results. Objects can move fluidically as in flow cytometry, through scanning movement as in document scanning, or in other ways.
摘要翻译：响应于在编码/感测区域内相对于编码器/传感器具有相对运动的物体，例如，发出光的光照或执行基于阻抗的感测，感测结果可以指示感测到的具有关于物体的信息的时变波形，关于它们相对运动，关于激发特性，关于环境特性等。编码器/传感器可以包括例如感测元件的非周期性布置; 具有组合感测图案的感测元件的纵向序列，其近似于更简单的感测图案的叠加或缩放叠加; 和/或IC实现的感测元件，其包括IC上的光敏阵列和读出/组合电路，其根据单元组感测图案从组中的单元读出光照量，并组合读出的光照量以获得感测结果。物体可以像流式细胞仪一样流动地进行扫描运动，如文档扫描或其他方式。

43. 发明授权

US07569905B2 Systems and methods for electrical contacts to arrays of vertically aligned nanorods 失效
标题翻译：用于电接触垂直排列的纳米棒阵列的系统和方法
公开(公告)号：US07569905B2
公开(公告)日：2009-08-04
申请号：US11015663
申请日：2004-12-20
申请人： Thomas Hantschel , Noble M. Johnson , Peter Kiesel , Christian G. Van De Walle , William S. Wong
发明人： Thomas Hantschel , Noble M. Johnson , Peter Kiesel , Christian G. Van De Walle , William S. Wong
IPC分类号： H01L29/84
CPC分类号： B82Y10/00 , G01N27/127 , H01L27/307 , H01L29/0665 , H01L29/0673 , H01L29/0676 , H01L51/0048 , H01L51/441 , Y02E10/549 , Y10S977/762
摘要： Systems and methods may provide electrical contacts to an array of substantially vertically aligned nanorods. The nanorod array may be fabricated on top of a conducting layer that serves as a bottom contact to the nanorods. A top metal contact may be applied to a plurality of nanorods of the nanorod array. The contacts may allow I/V (current/voltage) characteristics of the nanorods to be measured.
摘要翻译：系统和方法可以向基本上垂直排列的纳米棒阵列提供电触点。纳米棒阵列可以制造在用作纳米棒的底部接触的导电层的顶部上。顶部金属接触可以应用于纳米棒阵列的多个纳米棒。触点可以允许测量纳米棒的I / V（电流/电压）特性。

44. 发明申请

US20090156917A1 Controlling Transfer of Objects Affecting Optical Characteristics 有权
标题翻译：控制影响光学特性的物体的传输
公开(公告)号：US20090156917A1
公开(公告)日：2009-06-18
申请号：US11957610
申请日：2007-12-17
申请人： Jorg Martini , Jeffrey Roe , Peter Kiesel , Michael Bassler , Alan Bell , Richard H. Bruce , Noble M. Johnson
发明人： Jorg Martini , Jeffrey Roe , Peter Kiesel , Michael Bassler , Alan Bell , Richard H. Bruce , Noble M. Johnson
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/14532 , G01N21/03 , G01N21/39 , G01N21/8507
摘要： An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.
摘要翻译：诸如制品，装置或系统的可植入产品可以包括可以作为光腔操作的部件中的分析物和非分析物容器。该产品还可以包括流体组件，例如过滤器组件，其控制影响或移动光谱特征或特性的物体的转移，例如通过移动透射模式峰值或反射模式谷，移动相位，减小最大值或对比度，或增加中等强度宽度，作为全宽半最大值（FWHM）。分析物，例如葡萄糖分子可以主要包括在一组物体中，其比其它物体更快地转移到分析物容器中，并且可以具有可忽略或零速率的转移到非分析物容器中; 将更快速地转移到非分析物容器中的物体可以包括比分析物小的物体或一组选定类型的分子，包括例如氯化钠。因此，来自容器的输出光包括关于分析物的信息。

45. 发明授权

US07479625B2 Sensing photons from object in channels 有权
标题翻译：从通道中的物体感应光子
公开(公告)号：US07479625B2
公开(公告)日：2009-01-20
申请号：US12098584
申请日：2008-04-07
申请人： Peter Kiesel , Meng H. Lean , Oliver Schmidt , Armin R. Volkel , Noble M. Johnson
发明人： Peter Kiesel , Meng H. Lean , Oliver Schmidt , Armin R. Volkel , Noble M. Johnson
IPC分类号： G01J3/50
CPC分类号： G01N21/05 , G01N21/645 , G01N21/65 , G01N21/658 , G01N2021/0346 , G01N2021/1734 , G01N2021/6421 , G01N2021/6482
摘要： A fluidic structure includes a channel and along the channel is a series of sensing components to obtain information about objects traveling within the channel, such as droplets or other objects carried by fluid. At least one sensing component includes a set of cells of a photosensor array. The set of cells photosense a range of photon energies that emanate from objects, and include a subset of cells that photosense within subranges. A processor can receive information about objects from the sensing components and use it to obtain spectral information. The processor can perform an initial analysis using information from one set of sensing components and, based on the results, control a fluidic device in the channel, such as a gate, to retain objects, such as for concentration and more detailed analysis by other sensing components, or to purge objects from the channel.
摘要翻译：流体结构包括通道，并且沿着通道是一系列感测部件，以获得关于在通道内行进的物体的信息，例如由流体携带的液滴或其它物体。至少一个感测组件包括一组光电传感器阵列的单元。该组细胞照射从物体发出的一系列光子能量，并且包括在子范围内的光密度的子集。处理器可以从感测组件接收关于对象的信息，并使用它来获得光谱信息。处理器可以使用来自一组感测组件的信息来执行初始分析，并且基于该结果，控制通道（例如门）中的流体装置以保持对象，例如通过其他感测的浓度和更详细的分析组件，或从通道清除对象。

46. 发明授权

US07456953B2 Method and apparatus for improved light distribution in an anti-resonant waveguide sensor 有权
标题翻译：用于改善反谐振波导传感器中的光分布的方法和装置
公开(公告)号：US07456953B2
公开(公告)日：2008-11-25
申请号：US11777976
申请日：2007-07-13
申请人： Oliver Schmidt , Michael Bassler , Peter Kiesel , Patrick Y Maeda , Noble M Johnson
发明人： Oliver Schmidt , Michael Bassler , Peter Kiesel , Patrick Y Maeda , Noble M Johnson
IPC分类号： G01J3/30 , G01N21/64
CPC分类号： G02B6/10 , G01N21/03 , G01N21/0303 , G01N21/33 , G01N21/35 , G01N21/3577 , G01N21/64 , G01N21/65 , G01N2021/651 , G02B6/032 , G02B6/34
摘要： An improved method of analyzing target analytes in a sample is described. The method is based on creating an approximately homogeneous distribution of light in an anti-resonant guided optical waveguide to improve light-target interaction in a target-containing medium. The light-target interaction can be monitored by many different means to determine characteristics of the target analyte.
摘要翻译：描述了一种分析样品中目标分析物的改进方法。该方法基于在反谐振引导光波导中产生大致均匀的光分布，以改善含靶介质中的光 - 目标相互作用。光靶相互作用可以通过许多不同的手段来监测，以确定目标分析物的特征。

47. 发明申请

US20080186483A1 Implanting optical cavity structures 有权
标题翻译：植入光腔结构
公开(公告)号：US20080186483A1
公开(公告)日：2008-08-07
申请号：US11702329
申请日：2007-02-05
申请人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
发明人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
IPC分类号： G01N1/10
CPC分类号： G01N21/03 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B5/1459 , G01N21/0303 , G01N21/274 , G01N21/31
摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.
摘要翻译：可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。第二部分包括封闭的容器并且包含参考流体。可植入产品还可以包括光源组件和感光组件中的一个或两个。可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

48. 发明授权

US09029800B2 Compact analyzer with spatial modulation and multiple intensity modulated excitation sources 有权
标题翻译：紧凑型分析仪，具有空间调制和多重强度调制激励源
公开(公告)号：US09029800B2
公开(公告)日：2015-05-12
申请号：US13206436
申请日：2011-08-09
申请人： Peter Kiesel , Joerg Martini
发明人： Peter Kiesel , Joerg Martini
IPC分类号： G01J1/58 , G01N21/64 , G01J3/36 , G01N21/05 , G01N21/65 , G01J3/10 , G01N15/14 , G01N15/10
CPC分类号： G01J3/36 , G01J2003/104 , G01N15/1459 , G01N21/05 , G01N21/6428 , G01N21/65 , G01N2015/1006 , G01N2015/145 , G01N2021/6419 , G01N2201/0691
摘要： A compact analyzer includes a flow cell having a flow channel through which a sample is made to pass. First and second light sources are arranged to emit first and second excitation light into first and second overlapping portions of the flow channel, respectively. The first excitation light stimulates a first light emission from particles of a first particle type that may be present in the sample; the second excitation light stimulates a second light emission from particles of a second particle type. A detector receives the first and second light emission from the corresponding particles present in the sample in a detection portion of the flow channel, and provides a detector output based on the received light emission. The light sources are modulated at different frequencies so that a frequency analysis of the detector output can provide separate information about the first and second particle types.
摘要翻译：紧凑型分析器包括具有流通通道的流通池，样品通过该流路通过。第一和第二光源分别布置成将第一和第二激发光发射到流动通道的第一和第二重叠部分。第一激发光刺激可能存在于样品中的第一颗粒类型的颗粒的第一光发射; 第二激发光刺激来自第二粒子类型的颗粒的第二光发射。检测器在流动通道的检测部分中接收来自样品中存在的相应颗粒的第一和第二光发射，并且基于接收到的光发射提供检测器输出。光源以不同的频率被调制，使得检测器输出的频率分析可以提供关于第一和第二粒子类型的单独的信息。

49. 发明授权

US08723140B2 Particle analyzer with spatial modulation and long lifetime bioprobes 有权
标题翻译：具有空间调制和长寿命生物探针的粒子分析仪
公开(公告)号：US08723140B2
公开(公告)日：2014-05-13
申请号：US13206439
申请日：2011-08-09
申请人： Peter Kiesel , Richard H. Bruce , Michael Bassler
发明人： Peter Kiesel , Richard H. Bruce , Michael Bassler
IPC分类号： F21V9/16
CPC分类号： G01N21/6408 , G01N21/05 , G01N2021/6413
摘要： An analyzer includes a flow cell having a flow channel through which a sample passes. A light source excites at least a first particle type in the sample in one or more excitation region(s), and a detector detects light emitted by the excited particle. A spatial filter defines detection regions, wherein light emitted by the particle is transmitted to the detector, and interspersed shielded regions, wherein such light is at least partially blocked from reaching the detector. The light emitted by the excited particle has a response time τ1, and the sample may also contain a component that is excited by the light source and that has a response time τ2
摘要翻译：分析器包括具有样品通过的流动通道的流动池。光源在一个或多个激发区域中激发样品中的至少第一颗粒类型，并且检测器检测被激发颗粒发射的光。空间滤波器定义检测区域，其中由颗粒发射的光被传输到检测器和散布的屏蔽区域，其中这样的光被至少部分地阻挡到达检测器。由激发的粒子发射的光具有响应时间τ1，并且样品还可以包含由光源激发的并且具有响应时间τ2<τ1的分量。激励区域和检测区域被布置成在激发和检测之间提供时间延迟，所述时间延迟被定制以将由第一粒子发射的光与由该部件发射的光隔离。

50. 发明授权

US07741147B2 Method of field-controlled diffusion and devices formed thereby 失效
标题翻译：现场控制扩散方法及由此形成的器件
公开(公告)号：US07741147B2
公开(公告)日：2010-06-22
申请号：US11615331
申请日：2006-12-22
申请人： Peter Kiesel , Oliver Schmidt
发明人： Peter Kiesel , Oliver Schmidt
IPC分类号： H01L21/00 , H01L21/16 , H01L21/331 , H01L21/326
CPC分类号： H01L29/66848 , H01L29/22 , H01L29/66143 , H01L31/108 , H01L31/1828 , Y02E10/543 , Y02P70/521
摘要： A technique for creating high quality Schottky barrier devices in doped (e.g., Li+) crystalline metal oxide (e.g., ZnO) comprises field-controlled diffusion of mobile dopant atoms within the metal oxide crystal lattice. When heated (e.g., above 550 K) in the presence of an electric field (e.g., bias to ground of +/−50 V) the dopant atoms are caused to collect to form an ohmic contact, leaving a depletion region. The size of the depletion region controls the thickness of the Schottky barrier. Metal-semiconductor junction devices such as diodes, photo-diodes, photo-detectors, MESFETs, etc. may thereby be fabricated.
摘要翻译：在掺杂（例如Li +）结晶金属氧化物（例如ZnO）中产生高质量肖特基势垒器件的技术包括在金属氧化物晶格内的移动掺杂剂原子的场控扩散。当在存在电场（例如，+/- 50V的接地偏压）的情况下加热（例如，高于550K）时，引起掺杂剂原子以形成欧姆接触，留下耗尽区。耗尽区的大小控制肖特基势垒的厚度。因此可以制造诸如二极管，光电二极管，光电检测器，MESFET等的金属 - 半导体结器件。

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