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41. 发明申请

US20050096705A1 Multi-site ventricular pacing therapy with parasympathetic stimulation 有权
标题翻译：多部位心室起搏治疗与副交感神经刺激
公开(公告)号：US20050096705A1
公开(公告)日：2005-05-05
申请号：US10700368
申请日：2003-11-03
申请人： Joseph Pastore , Zoe Harris-Hajenga , Julio Spinelli
发明人： Joseph Pastore , Zoe Harris-Hajenga , Julio Spinelli
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： A61N1/36114 , A61N1/3622 , A61N1/3627 , A61N1/368
摘要： A method and device for delivering multi-site ventricular pacing therapy in conjunction with parasympathetic stimulation for reducing ventricular wall stress. Such reduction in ventricular wall stress is useful in reversing or preventing the ventricular remodeling which can occur in heart failure patients.
摘要翻译：结合副交感神经刺激减少心室壁应力的方法和装置，用于多局部心室起搏治疗。心室壁应激的这种减少可用于逆转或预防心力衰竭患者发生的心室重塑。

42. 发明授权

US09221301B1 System and method for a removable wheel device for a field game goal 有权
标题翻译：用于野战游戏目标的可移动轮装置的系统和方法
公开(公告)号：US09221301B1
公开(公告)日：2015-12-29
申请号：US14262136
申请日：2014-04-25
申请人： Joseph Pastore
发明人： Joseph Pastore
IPC分类号： A63B63/00 , B60B33/02
CPC分类号： B60B33/02 , A63B63/004 , A63B2071/025 , A63B2102/14 , A63B2210/50 , B60B33/0005 , B60B33/001 , B60B33/0018 , B60B33/0023 , B60B33/0039 , B60B33/0049 , Y10T16/184 , Y10T29/49826
摘要： A removable wheel device which slides onto the base of a sports field goal. The wheel device allows one person to move a goal across a field without using excessive force by sliding one wheel device onto the base of each goalpost and using leverage to tilt the goal and push or pull it for a distance. When inserted onto the base of the goal, the wheel device does not require any type of fastening to remain in place, but rather uses its own unique shape to hold onto the goal. Because field goals vary in structure, so too do each of the embodiments of the removable wheel device. Some of these variances include the angle of the axle, the location and structure of the notch, the use of a protrusion, and the use of a removable pin to secure the goalpost in place.
摘要翻译：滑动到运动场目标基座上的可移动轮装置。车轮装置允许一个人通过将一个车轮装置滑动到每个门柱的基座上并且使用杠杆来倾斜目标并将其推或拉一段距离，而不用过度的力量移动目标。当插入到目标的底部时，轮装置不需要任何类型的紧固件保持在适当位置，而是使用其自己独特的形状来保持目标。因为场目标的结构不同，所以可拆卸轮装置的每个实施例也是如此。这些方差中的一些包括轴的角度，凹口的位置和结构，突起的使用，以及使用可移除的销将球柱固定到位。

43. 发明授权

US09221300B1 System and method for a removable wheel device for a field game goal 有权
标题翻译：用于野战游戏目标的可移动轮装置的系统和方法
公开(公告)号：US09221300B1
公开(公告)日：2015-12-29
申请号：US14026602
申请日：2013-09-13
申请人： Joseph Pastore
发明人： Joseph Pastore
IPC分类号： A63B63/00 , B60B33/00
CPC分类号： B60B33/00 , A63B63/004 , A63B2071/025 , A63B2102/14 , A63B2210/50 , B60B33/0005 , B60B33/001 , B60B33/0023 , B60B33/0026 , B60B33/0039 , B60B33/0049 , Y10T16/184 , Y10T29/49826
摘要： A removable wheel device which slides onto the base of a sports field goal. The wheel device allows one person to move a goal across a field without using excessive force by sliding one wheel device onto the base of each goalpost and using leverage to tilt the goal and push or pull it for a distance. When inserted onto the base of the goal, the wheel device does not require any type of fastening to remain in place, but rather uses its own unique shape to hold onto the goal. Because field goals vary in structure, so too do each of the embodiments of the removable wheel device. Some of these variances include the angle of the axle, the location and structure of the notch, and the use of a protrusion.
摘要翻译：滑动到运动场目标基座上的可移动轮装置。车轮装置允许一个人通过将一个车轮装置滑动到每个门柱的基座上并且使用杠杆来倾斜目标并将其推或拉一段距离，而不用过度的力量移动目标。当插入到目标的底部时，轮装置不需要任何类型的紧固件保持在适当位置，而是使用其自己独特的形状来保持目标。因为场目标的结构不同，所以可拆卸轮装置的每个实施例也是如此。这些方差中的一些包括轴的角度，凹口的位置和结构以及突起的使用。

44. 发明申请

US20070005114A1 Therapy control based on the rate of change of intracardiac impedance 有权
标题翻译：基于心内阻抗变化率的治疗控制
公开(公告)号：US20070005114A1
公开(公告)日：2007-01-04
申请号：US11169339
申请日：2005-06-29
申请人： Rodney Salo , Joseph Pastore , Jeffrey Stahmann , Jesse Hartley
发明人： Rodney Salo , Joseph Pastore , Jeffrey Stahmann , Jesse Hartley
IPC分类号： A61N1/00
CPC分类号： A61N1/36521 , A61N1/30
摘要： A system comprising a medical device that includes an impedance measurement circuit adapted to be coupled to implantable electrodes to obtain an intracardiac impedance signal between electrodes, a therapy circuit operable to deliver a therapy to a subject, and a controller circuit coupled to the impedance measurement circuit and the therapy circuit. The controller circuit determines a time rate of change of the intracardiac impedance signal and adjusts at least one parameter related to therapy in a manner that alters the rate of change.
摘要翻译：一种包括医疗装置的系统，该医疗装置包括阻抗测量电路，该阻抗测量电路适于耦合到可植入电极以获得电极之间的心内阻抗信号，可操作以将治疗递送给受试者的治疗电路，以及耦合到所述阻抗测量电路和治疗电路。控制器电路确定心内阻抗信号的时间变化率，并且以改变变化率的方式调节与治疗相关的至少一个参数。

45. 发明申请

US20060167511A1 Apparatus and method for temporary treatment of acute heart failure decompensation 有权
公开(公告)号：US20060167511A1
公开(公告)日：2006-07-27
申请号：US11044971
申请日：2005-01-27
申请人： Joseph Pastore , Qingsheng Zhu
发明人： Joseph Pastore , Qingsheng Zhu
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/368
摘要： A system for providing temporary therapy, such as cardiac resynchronization therapy, to a patient suffering a decompensation event. The system can include a device having an external module for generating electrical stimuli, a first lead coupled to the module and implanted into an atrial region of a patient's heart, and a second lead coupled to the module and implanted into a ventricular region of the patient's heart. The device can also include a storage module coupled to the external module to store data associated with physiological data measured by the device. The external module is configured to temporarily generate electrical stimuli that are delivered by at least one of the first and second leads to provide therapy cardiac resynchronization therapy to the heart. A network can be coupled to the device to allow data stored in the device to be downloaded through the network to a central repository.

46. 发明申请

US20060134079A1 Implantable medical devices comprising isolated extracellular matrix 有权
标题翻译：可植入医疗器械包括分离的细胞外基质
公开(公告)号：US20060134079A1
公开(公告)日：2006-06-22
申请号：US11017432
申请日：2004-12-20
申请人： Haris Sih , Joseph Pastore
发明人： Haris Sih , Joseph Pastore
IPC分类号： A61K48/00 , A61K38/19 , C12N5/08 , A61N1/00
CPC分类号： A61K38/30 , A61K35/545 , A61K38/18 , A61K38/1833 , A61K38/193 , A61K38/39 , A61K48/00 , A61N1/05 , A61N1/375
摘要： Implantable devices containing extracellular matrix and methods of using the devices are provided.
摘要翻译：提供了含有细胞外基质的植入式装置和使用该装置的方法。

47. 发明申请

US20050149129A1 Baropacing and cardiac pacing to control output 审中-公开
标题翻译：支架和心脏起搏来控制输出
公开(公告)号：US20050149129A1
公开(公告)日：2005-07-07
申请号：US10746135
申请日：2003-12-24
申请人： Imad Libbus , Joseph Pastore
发明人： Imad Libbus , Joseph Pastore
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/362 , A61N1/36114
摘要： One aspect of the present subject matter relates to an implantable medical system. An embodiment of the system includes a baroreflex stimulator and a cardiac stimulator. The baroreflex stimulator applies a baroreflex stimulation signal through an electrode and provides a signal indicating that the baroreflex signal is being applied. The cardiac stimulator applies a pacing therapy with a pacing rate, receives the signal from the baroreflex stimulator, and increases the pacing rate of the pacing therapy to compensate for cardiac output compromised by applying the baroreflex stimulation signal. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及可植入医疗系统。系统的一个实施例包括压力反射刺激器和心脏刺激器。压力反射刺激器通过电极施加压力反射刺激信号，并提供指示正在施加压力反射信号的信号。心脏刺激器应用起搏速率的起搏治疗，接收来自压力反射刺激器的信号，并增加起搏治疗的起搏速率，以补偿通过应用压力反射刺激信号而损害的心输出量。本文提供了其他方面。

48. 发明申请

US20050102000A1 Linear stimulation of the heart for improved hemodynamic benefit 审中-公开
标题翻译：心脏的线性刺激改善血液动力学效益
公开(公告)号：US20050102000A1
公开(公告)日：2005-05-12
申请号：US10981019
申请日：2004-11-03
申请人： Joseph Pastore , Qingsheng Zhu , Rodney Salo
发明人： Joseph Pastore , Qingsheng Zhu , Rodney Salo
IPC分类号： A61N1/362 , A61N1/368 , A61N1/36
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and apparatus for linear stimulation of the heart to resynchronize contraction for improved hemodynamic benefit. Linear stimulation may be accomplished using a linear source, which may comprise an elongated electrode or plurality of electrodes arranged so as to linearly stimulate the heart. A linear source may be coupled to the left ventricle, and one or more additional electrodes may be positioned so as to stimulate a separate region of the left ventricle or one or more additional chambers of the heart as well. Application of an electrical stimulus by the linear source may function to stimulate a larger region of the heart, thereby enhancing the resynchronization effect as well as providing other hemodynamic benefits.
摘要翻译：用于线性刺激心脏以重新同步收缩以改善血液动力学益处的方法和装置。线性刺激可以使用线性源实现，线性源可以包括细长电极或多个电极，其布置成线性刺激心脏。线性源可以耦合到左心室，并且可以定位一个或多个附加电极，以便也刺激心脏的左心室或一个或多个另外的腔室的单独区域。通过线性源的电刺激的应用可以起到刺激心脏的较大区域的作用，从而增强再同步效应以及提供其它血液动力学优点。

49. 发明授权

US5228830A Wicket gate 失效
标题翻译：小门
公开(公告)号：US5228830A
公开(公告)日：1993-07-20
申请号：US627341
申请日：1990-12-14
申请人： Joseph Pastore
发明人： Joseph Pastore
IPC分类号： F03B3/18
CPC分类号： F03B3/183 , F05B2230/90 , F05B2280/4003 , Y02E10/223 , Y02P70/525 , Y10T29/49337
摘要： This invention relates to an improvement in an apparatus for directing the flow of water from the penstock to the vanes of a hydraulic turbine, generally referred to as a wicket gate, and a method for making the improved wicket gate. The improved wicket gate comprises a rotatable planar body made either of a high-strength plastic material or metal, onto which a viscoelastic material is affixed. The improvement lies in the application of the viscoelastic material to the rotatable planar body in such a way that the viscoelastic material becomes an integral component of the rotatable planar body. This improvement extends the maintenance life cycle by reducing marine growth, erosion and pitting caused by cavitation.
摘要翻译：本发明涉及用于将水从水管引导到水轮机的叶片（通常称为小门）的装置的改进以及用于制造改进的小门的方法。改进的门板门包括由高强度塑料材料或金属制成的可旋转平面体，粘合有粘弹性材料。改进在于将粘弹性材料应用于可旋转平面体，使得粘弹性材料成为可旋转平面体的整体部件。这种改进通过减少由气蚀导致的海洋生长，侵蚀和点蚀延长了维护生命周期。

50. 发明申请

US20130303597A1 SDF-1 DELIVERY FOR TREATING ISCHEMIC TISSUE 有权
标题翻译： SDF-1交付用于治疗组织组织
公开(公告)号：US20130303597A1
公开(公告)日：2013-11-14
申请号：US13912435
申请日：2013-06-07
申请人： Marc S. Penn , Rahul Aras , Joseph Pastore , Timothy J. Miller
发明人： Marc S. Penn , Rahul Aras , Joseph Pastore , Timothy J. Miller
IPC分类号： A61K48/00
CPC分类号： A61K38/19 , A61K9/0019 , A61K31/711 , A61K38/00 , A61K48/005 , C07K14/521 , C07K2319/02 , C07K2319/09
摘要： Provided herein are methods of treating a cardiomyopathy in a subject by administering directly to, or expressing locally in, a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification. Also provided are methods of treating critical limb ischemia in a subject by administering a DNA plasmid encoding human SDF-1 by direct injection into the affected limb.
摘要翻译：本文提供了通过直接施用或表达受试者心肌组织的弱化，缺血和/或梗死周围区域来治疗受试者的心肌病的方法，所述量的SDF-1有效引起功能改善在以下参数中的至少一个中：左心室容积，左心室面积，左心室尺寸，心脏功能，6分钟步行测试或纽约心脏协会（NYHA）功能分类。还提供了通过直接注射到受影响的肢体中来施用编码人SDF-1的DNA质粒来治疗受试者的关键性肢体缺血的方法。

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