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41. 发明申请

US20090005721A1 PACKAGED IONTOPHORESIS SYSTEM 审中-公开
标题翻译：包装IOPOPHORESIS系统
公开(公告)号：US20090005721A1
公开(公告)日：2009-01-01
申请号：US12135901
申请日：2008-06-09
申请人： Mizuo Nakayama , Takehiko Matsumura , Tsutomu Shibata , Akihiro Ryuka
发明人： Mizuo Nakayama , Takehiko Matsumura , Tsutomu Shibata , Akihiro Ryuka
IPC分类号： A61N1/30
CPC分类号： B65D75/58 , A61N1/303
摘要： Provided is a packaged iontophoresis system 15 including: an iontophoresis system 10 including an apparatus body 50 for transdermally delivering an ionized drug by iontophoresis, and a connection part 70 extended from the apparatus body 50 and connected to the apparatus body 50 and a power source 60, the power source 60 supplying power to the apparatus body 50; a package material 80 hermetically packaging the apparatus body 50 and a portion of the connection part 70, by at least a part thereof being welded to the connection part 70; and a cutting guide 400 guiding a cutting line of the package material 80 so that the part of the package material 80 welded to the connection part 70 remains at the connection part 70 when the package material 80 is opened.
摘要翻译：提供了一种封装的离子电渗系统15，其包括：离子电渗系统10，其包括用于通过离子电渗法透皮地递送离子化药物的装置主体50;以及从装置主体50延伸并连接到装置主体50的连接部70和电源60 向设备主体50供电的电源60; 包装材料80将装置主体50和连接部70的一部分密封地包封，其至少一部分被焊接到连接部70; 以及导向包装材料80的切割线的切割引导件400，使得当包装材料80打开时，焊接到连接部70的包装材料80的一部分保留在连接部70。

42. 发明申请

US20120090222A1 FUEL MANUFACTURING METHOD 审中-公开
标题翻译：燃料制造方法
公开(公告)号：US20120090222A1
公开(公告)日：2012-04-19
申请号：US13259037
申请日：2009-03-25
申请人： Takehiko Matsumura , Noritaka Hirose , Takako Izumi
发明人： Takehiko Matsumura , Noritaka Hirose , Takako Izumi
IPC分类号： C10L1/02
CPC分类号： C10L1/02 , C10G2300/1014 , C10G2300/1018 , C10G2300/805 , Y02E50/30 , Y02P30/20
摘要： The objective is to obtain fuel having high combustion calorie and superior handleability from a crude glycerin or a fatty acid mixture that have been discarded as industrial waste products. Disclosed is a fuel comprising a water-insolublized fatty acid substance obtained by water-insolubilizing a fatty acid that is contained in a crude glycerin or fatty acid mixtures that are produced as by-products in the process of producing a biofuel from an animal/plant-derived fat/oil. The water-insolublized fatty acid substance is preferably a water-insoluble fatty acid salt, particularly preferably a salt of a fatty acid with a divalent or trivalent metal ion.
摘要翻译：目的是获得作为工业废弃物被丢弃的粗甘油或脂肪酸混合物获得具有高燃烧热量和优异操作性的燃料。公开了一种燃料，其包含水不溶性脂肪酸物质，所述脂肪酸物质通过水分不溶于粗制甘油或脂肪酸混合物中所含的脂肪酸，所述粗甘油或脂肪酸混合物在从动物/植物生产生物燃料的过程中作为副产物生产得到的脂肪/油。水不溶性脂肪酸物质优选为水不溶性脂肪酸盐，特别优选为具有二价或三价金属离子的脂肪酸的盐。

43. 发明申请

US20110273955A1 LIQUID MIXING DEVICE 审中-公开
标题翻译：液体混合装置
公开(公告)号：US20110273955A1
公开(公告)日：2011-11-10
申请号：US13107581
申请日：2011-05-13
申请人： Takehiko Matsumura , Yoshihiko Uchino
发明人： Takehiko Matsumura , Yoshihiko Uchino
IPC分类号： G05D11/02 , B01F3/08
CPC分类号： B01F5/0685 , B01F3/0807 , B01F5/0688 , B01F5/0689 , B01F13/1027 , B01F2215/0088 , C10L1/328 , F23K5/12
摘要： Provided is a liquid mixing device capable of mixing together two or more kinds of liquids successively in an accurate ratio. The liquid mixing device includes: a first supply system for supplying a first liquid; a second supply system for supplying a second liquid; and a liquid mixing system that receives supply of the first liquid and second liquid from the first supply system and the second supply system, respectively, in which: the first supply system communicates to the liquid mixing system through a first flow rate regulation unit having a first path sectional area; the second supply system is connected to the liquid mixing system through a second flow rate regulation unit having a second path sectional area; and the first liquid in an amount corresponding to the first path sectional area and the second liquid in an amount corresponding to the second path sectional area are allowed to flow into the liquid mixing system, respectively, by making an inside pressure of the liquid mixing system negative.
摘要翻译：本发明提供一种液体混合装置，能够以两种或更多种液体连续地将其精确地混合在一起。液体混合装置包括：用于供应第一液体的第一供应系统; 用于供应第二液体的第二供应系统; 以及液体混合系统，其分别接收来自第一供应系统和第二供应系统的第一液体和第二液体的供应，其中：第一供应系统通过第一流量调节单元与液体混合系统连通，所述第一流量调节单元具有第一路径截面积; 第二供应系统通过具有第二路径截面积的第二流量调节单元连接到液体混合系统; 并且分别通过使液体混合系统的内部压力分别将与第一路径截面面积相对应的量的第一液体和对应于第二路径截面面积的量分别流入液体混合系统负。

44. 发明申请

US20070073212A1 IONTOPHORESIS APPARATUS AND METHOD TO DELIVER ACTIVE AGENTS TO BIOLOGICAL INTERFACES 审中-公开
标题翻译： IOPOPHORESIS设备和将活性剂递送到生物界面的方法
公开(公告)号：US20070073212A1
公开(公告)日：2007-03-29
申请号：US11532049
申请日：2006-09-14
申请人： Takehiko Matsumura
发明人： Takehiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/0436 , A61N1/0444 , A61N1/0448
摘要： An iontophoresis device includes active and counter electrode assemblies. The active electrode assembly includes an active electrode element, an outermost ion selective membrane caching an active agent and a further active agent carried by an outer surface of the outermost ion selective membrane. The active electrode assembly may also include an inner active agent reservoir storing additional active agent, an electrolyte reservoir storing electrolyte, an inner ion selective membrane positioned between the electrolyte reservoir and the active agents. The active electrode may also include an inner withdrawable sealing liner between the electrolyte reservoir and the active agents. An outer release liner may protectively cover or overlay the further active agent and/or outer surface prior to use.
摘要翻译：离子电渗装置包括有源和对电极组件。活性电极组件包括活性电极元件，最外层的离子选择性膜缓冲活性剂和由最外层离子选择性膜的外表面承载的另外的活性剂。有源电极组件还可以包括存储附加活性剂的内部活性剂储存器，储存电解质的电解质储存器，位于电解质储存器和活性剂之间的内部离子选择性膜。活性电极还可以包括在电解质储存器和活性剂之间的内部可抽出的密封衬垫。外释放衬垫可以在使用之前保护性地覆盖或覆盖另外的活性剂和/或外表面。

45. 发明申请

US20110166135A1 AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE 审中-公开
标题翻译：含有硝酸的六元环化合物及其用途
公开(公告)号：US20110166135A1
公开(公告)日：2011-07-07
申请号：US13062841
申请日：2009-09-09
申请人： Hiroshi Morimoto , Toshiaki Sakamoto , Toshiyuki Himiyama , Eiji Kawanishi , Takehiko Matsumura
发明人： Hiroshi Morimoto , Toshiaki Sakamoto , Toshiyuki Himiyama , Eiji Kawanishi , Takehiko Matsumura
IPC分类号： A61K31/5377 , C07D401/14 , C07D487/04 , C07D413/14 , A61K31/517 , A61K31/506 , A61K31/497 , A61K31/519 , A61P25/18 , A61P25/24 , A61P25/22 , A61P25/16 , A61P25/28
CPC分类号： C07D401/14 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12
摘要： The present invention provides aromatic nitrogen-containing 6-membered ring compounds having excellent PDE10 inhibitory activity. The present invention relates to an aromatic nitrogen-containing 6-membered ring compound represented by the following formula [I0] or a pharmaceutically acceptable salt thereof, a method for preparing the same, and use of said compounds for PDE10 inhibitors, and a pharmaceutical composition comprising said compounds as an active ingredient: Formula [I0] wherein: X1, X2 and X3 each independently are N or CH, and at least two of X1, X2 and X3 are N; A is *—CH═CH—, *—C(Alk)=CH—, *—CH2—CH2— or *—O—CH2— (* is a bond with R1); Alk is a lower alkyl group; Ring B is an optionally substituted nitrogen-containing aliphatic heterocyclic group; R1 is an optionally substituted nitrogen-containing heterocyclic group, a nitrogen-containing heterocyclic moiety of which is a moiety selected from the group consisting of quinoxalinyl, quinolyl, isoquinolyl, quinazolinyl, pyrazinyl, pyrimidinyl and a moiety thereof fused with a 5 to 6-membered aliphatic ring thereto; Y0 is a group selected from the group consisting of the following (1) to (5): (1) an optionally substituted phenyl or an optionally substituted aromatic monocyclic 5 to 6-membered heterocyclic group; (2) an optionally substituted aminocarbonyl; (3) an optionally substituted amino lower alkyl; (4) —O—R2 wherein R2 is hydrogen, an optionally substituted lower alkyl, lower cycloalkyl, aliphatic monocyclic 5 to 6-membered heterocyclic group, or Formula [AA]; (5) mono- or di-substituted amino; provided that, when Y0 is mono- or di-substituted amino, the nitrogen-containing heterocyclic moiety of R1 is not quinoxalinyl or quinolyl.
摘要翻译：本发明提供具有优异的PDE10抑制活性的芳香族含氮6元环化合物。本发明涉及由下式[I0]表示的含芳族含氮的6元环化合物或其药学上可接受的盐，其制备方法以及所述化合物用于PDE10抑制剂的用途和药物组合物包括所述化合物作为活性成分：式[I0]其中：X1，X2和X3各自独立地为N或CH，X1，X2和X3中的至少两个为N; A是* -CH = CH-，* -C（Alk）= CH-，* -CH2-CH2-或* -O-CH2-（*是与R1的键）; Alk是低级烷基; 环B是任选取代的含氮脂族杂环基; R1是任选取代的含氮杂环基团，其含氮杂环部分是选自喹喔啉基，喹啉基，异喹啉基，喹唑啉基，吡嗪基，嘧啶基及其部分与5至6位稠合的部分，元环脂族环; Y0是选自下列（1）至（5）的基团：（1）任选取代的苯基或任选取代的芳族单环5至6元杂环基; （2）任选取代的氨基羰基; （3）任选取代的氨基低级烷基; （4）-O-R2，其中R2是氢，任选取代的低级烷基，低级环烷基，脂族单环5至6元杂环基或式[AA]; （5）单取代或二取代氨基; 条件是当Y 0是单取代或二取代的氨基时，R 1的含氮杂环部分不是喹喔啉基或喹啉基。

46. 发明申请

US20110160206A1 TRI-SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS 审中-公开
标题翻译：三取代的吡咯烷酮化合物及其作为PDE10抑制剂的用途
公开(公告)号：US20110160206A1
公开(公告)日：2011-06-30
申请号：US13062074
申请日：2009-09-03
申请人： Eiji Kawanishi , Takehiko Matsumura
发明人： Eiji Kawanishi , Takehiko Matsumura
IPC分类号： A61K31/5377 , C07D403/14 , A61K31/498 , A61K31/506 , C07D413/14 , A61P25/18 , A61P25/22 , A61P25/28
CPC分类号： C07D405/14 , C07D403/14 , C07D409/14 , C07D413/14
摘要： The present invention provides a tri-substituted pyrimidine compound having an excellent PDE10 inhibitory activity. The present invention relates to a tri-substituted pyrimidine compound represented by the following formula [I0] or a pharmaceutically acceptable salt thereof, a method for preparing the same, and use of said compound for PDE10 inhibitor, and a pharmaceutical composition comprising said compounds as an active ingredient: wherein: either one of X1 and X2 is N, and the other of X1 and X2 is CH; A is *-CH═CH—, *-C(Alk)=CH—, *-CH2—CH2— or *-O—CH2— (* is a bond with R1); Alk is a lower alkyl group; Ring B is an optionally substituted nitrogen-containing aliphatic heterocyclic group; R1 is an optionally substituted quinoxalinyl or an optionally substituted quinolyl; Y0 is mono- or di-substituted amino group, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有优异的PDE10抑制活性的三取代嘧啶化合物。本发明涉及由下式[I0]表示的三取代嘧啶化合物或其药学上可接受的盐，其制备方法，以及所述化合物用于PDE10抑制剂的用途，以及包含所述化合物作为活性成分：其中：X1和X2中的任一个为N，X1和X2中的另一个为CH; A是* -CH = CH-，* -C（Alk）= CH-，* -CH2-CH2-或* -O-CH2-（*是与R1的键）; Alk是低级烷基; 环B是任选取代的含氮脂族杂环基; R1是任选取代的喹喔啉基或任选取代的喹啉基; Y0是单取代或二取代的氨基，或其药学上可接受的盐。

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