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41. 发明专利

UA98926C2 ИНГИБИТОР МИТОТИЧЕСКИХ КИНЕЗИНОВ И ЕГО ИСПОЛЬЗОВАНИЕ 未知
公开(公告)号：UA98926C2
公开(公告)日：2012-07-10
申请号：UAA200705497
申请日：2005-10-18
申请人： ARRAY BIOPHARMA INC
发明人： HANS JEREMY , WALLACE ELI M , ZHAO QIAN , LYSSIKATOS JOSEPH P , AICHER TOM , LAIRD ELLEN , ROBINSON JOHN , ALLEN SHELLEY
IPC分类号： A61K38/04 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/496 , A61K31/675 , C07D413/04 , C07D417/04
摘要： Этоизобретениекасаетсяингибиторовмитотическихкинезинов, вчастности KSP, испособовполученияэтихингибиторов. Изобретениетакжеобеспечиваетфармацевтическиекомпозиции, которыесодержатингибиторысогласноизобретению, ииспользованиеэтихингибиторови фармацевтическихкомпозицийв лечениии предупрежденииразличныхнарушений.

43. 发明专利

ES2372955T3 CICLOPENTA[D]PIRIMIDINAS COMO INHIBIDORES DE LA PROTEINA CINASA AKT. 未知
公开(公告)号：ES2372955T3
公开(公告)日：2012-01-30
申请号：ES07799329
申请日：2007-07-05
申请人： ARRAY BIOPHARMA INC , GENENTECH INC
发明人： MITCHELL IAN S , BLAKE JAMES F , XU RUI , KALLAN NICHOLAS C , XIAO DENGMING , SPENCER KEITH LEE , BENCSIK JOSEF R , LIANG JUN , SAFINA BRIAN , LI JUN , CHABOT CHRISTINE , BANKA ANNA L , WALLACE ELI M , SCHLACHTER STEPHEN T
IPC分类号： C07D239/70 , A61K31/517 , A61P35/00 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D409/12 , C07D409/14
摘要： Un compuesto de la Fórmula: y sus enantiómeros y sales, en los que: R1 y R1a se seleccionan de manera independiente entre H, Me, Et, CH=CH2. CH2OH, CF3, CHF2 o CH2F; R2 y R2a se seleccionan de manera independiente entre H o F; R5 es H, Me, Et, o CF3; A es en la que G es fenilo opcionalmente sustituido con de uno a cuatro grupos R9 o un heteroarilo monocíclico de 5-6 miembros o bicíclico de 9 miembros opcionalmente sustituido por un halógeno; R6 y R7 son de manera independiente H, (cicloalquilo C3-C6 )-(CH2), (cicloalquilo C3-C6 )-(CH2CH2), V-(CH2)0-1 en el que V es un heteroarilo de 5-6 miembros , W-(CH2)1-2 en el que W es fenilo opcionalmente sustituido con F, Cl, Br, I OMe, CF3 o Me, cicloalquilo C3-C6, hidroxi-(cicloalquilo C3-C6), fluoro-(cicloalquilo C3-C6), CH(CH3)CH(OH)fenilo, heterociclo de 4-6 miembros opcionalmente sustituido con F, OH, ciclopropilmetilo, alquilo C1-C3 o C(=O)(alquilo C1- C3) o alquilo C1-C6 opcionalmente sustituido con de uno o más grupos seleccionados de manera independiente entre OH, oxo, O(alquilo C1C6), CN, F, NH2, NH(alquilo C1-C6), N(alquilo C1-C6)2, tetrahidropiranilo, tetrahidrofuranilo, morfolinilo, oxetanilo, piperidinilo y pirrolidinilo, o R6 y R7 junto con el nitrógeno al cual se unen forman un anillo heterocíclico de 3-6 miembros opcionalmente sustituido con de uno o más grupos seleccionados de manera independiente entre OH, halógeno, oxo, CF3, CH2CF3, CH2CH2OH, C(=O)CH3 y alquilo(C1-C3); Ra y Rb son H, o Ra es H y Rb y R6 junto con los átomos a los cuales se unen forman un anillo heterocíclico de 5-6 miembros que tiene uno o dos átomos de nitrógeno en el anillo; Rc y Rd son H o Me, o Rc y Rd junto con el átomo al cual se unen forman un anillo ciclopropilo; o R8 es H, Me, u OH, o R8 y R6, junto con los átomos a los cuales se unen forman un anillo heterocíclico de 5-6 miembros que tiene uno o dos átomos en el anillo; cada uno de R9 es de manera independiente halógeno, alquilo C1-C6, cicloalquilo C3-C6, O-(alquilo C1-C6-), CF3, OCF3, S(alquilo C6C1), CN, OCH2-fenilo, CH2O-fenilo, NH2, NO 5 2 NH-(alquilo C1-C6), N-(alquilo C1-C6)2, piperidina, pirrolidina, CH2F, CHF2, OCH2F, OCHF2, OH, SO2(alquilo C1-C6), C(O)NH2, C(O)NH(alquilo C1-C6) y C(O)N(alquilo C1-C6)2; y m, n y p son de manera independiente 0 o 1.

44. 发明专利

NZ587190A Heterocyclic inhibitors of MEK and methods of use thereof wherein teh inhibitor compounds have a dihydropyridazine core 未知
公开(公告)号：NZ587190A
公开(公告)日：2011-11-25
申请号：NZ58719006
申请日：2006-05-17
申请人： ARRAY BIOPHARMA INC , ASTRAZENECA AB
发明人： MARLOW ALLISON L , WALLACE ELI M , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM , STOREY RICHARD ANTHONY , BOOTH REBECCA JANE , PITTMAN JOHN DAVID , LEONARD JOHN , FIELDING MARK RICHARD
IPC分类号： A61K31/44 , A61K31/50 , C07D213/63 , C07D213/84 , C07D231/14 , C07D237/12
摘要： Disclosed is a substituted 1,6-dihydropyridazine carboxamide compound of formula (I) where the substituents are as disclosed in the description. Also disclosed is the use of a compound of formula (I) in the manufacture of a medicament for treating hyperproliferative disorder or an inflammatory condition. Further disclosed is a method of producing a MEK inhibitory effect in a warm-blooded non-human animal in need of such treatment which comprises administering to said animal an effective amount of a compound of formula (I). Additional disclosed is a pharmaceutical composition comprising a compound of formula (I) with a pharmaceutically acceptable carrier. A method of preparing a compound of formula (I) is also disclosed.

45. 发明专利

PT1809280E INIBIDORES DE QUINESINA MITÓTICA E MÉTODOS PARA A SUA UTILIZAÇÃO 未知
公开(公告)号：PT1809280E
公开(公告)日：2011-11-15
申请号：PT05819172
申请日：2005-10-18
申请人： ARRAY BIOPHARMA INC
发明人： LYSSIKATOS JOSEPH P , WALLACE ELI M , ZHAO QIAN , HANS JEREMY , AICHER TOM , LAIRD ELLEN , ALLEN SHELLEY
IPC分类号： A61K31/4245 , C07D413/00 , C07D417/00

46. 发明专利

HK1149270A1 PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS 未知
公开(公告)号：HK1149270A1
公开(公告)日：2011-09-30
申请号：HK11103698
申请日：2011-04-13
申请人： ARRAY BIOPHARMA INC
发明人： BANKA ANNA , BENCSIK JOSEF R , BLAKE JAMES F , FONG KIN CHIU , HENTEMANN MARTIN F , MITCHELL IAN S , SAMMOND DOUGLAS MCCORD , TANG TONY P , WALLACE ELI M , XU RUI , GRAHAM JAMES
IPC分类号： C07D20060101 , A61K20060101 , A61P20060101

47. 发明专利

ZA201002206B PYRIDIN-2-TY-AMINO-I,2,4-THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS 未知
公开(公告)号：ZA201002206B
公开(公告)日：2011-06-29
申请号：ZA201002206
申请日：2010-03-29
申请人： ARRAY BIOPHARMA INC
发明人： TURNER TIMOTHY M , GUNAWARDANA INDRANI W , FISCHER JOHN P , FELL JAY BRADFORD , CONDROSKI KEVIN RONALD , CHICARELLI MARK JOSEPH , AICHER THOMAS DANIEL , BOYD STEVEN ARMEN , SINGH AJAY , HINKLIN RONALD JAY , WALLACE ELI M
摘要： Provided are compounds of Formula I wherein R 2 , R 3 , R 13 , L and D 2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.

49. 发明专利

NZ563707A Heterocyclic inhibitors of MEK and methods of use thereof 未知
公开(公告)号：NZ563707A
公开(公告)日：2011-01-28
申请号：NZ56370706
申请日：2006-05-17
申请人： ARRAY BIOPHARMA INC , ASTRAZENECA AB
发明人： MARLOW ALLISON L , WALLACE ELI M , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM , STOREY RICHARD ANTHONY , BOOTH REBECCA JANE , PITTMAN JOHN DAVID , LEONARD JOHN , FIELDING MARK RICHARD
IPC分类号： C07D213/63 , A61K31/4412 , A61K31/50 , C07D211/74 , C07D211/86 , C07D213/70 , C07D237/12 , C07D237/14
摘要： Disclosed herein are compounds of forumula IV and VI along with a crystalline form of a compound of formula XI, wherein substituents and characterizing peaks for the crystalline forms are as defined within the specification. Such compounds are MEK inhibitors which are useful in the treatment of hyperproliferative diseases such as cancer and inflammation in mammals and inflammatory conditions. Also discloses are methods of using such compounds in the treatment of hyperproliferative diseases in mammals, pharmaceutical compositions containing such compounds and methods for preparing compounds of formula IV, VI and XI.

50. 发明专利

HK1141976A1 N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS 未知
公开(公告)号：HK1141976A1
公开(公告)日：2010-11-26
申请号：HK10105717
申请日：2010-06-09
申请人： ARRAY BIOPHARMA INC
发明人： WALLACE ELI M , LYSSIKATOS JOSEPH P , HURLEY BRIAN T , MARLOW ALLISON L
IPC分类号： C07D235/08 , A61K20060101 , A61K31/4184 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P20060101 , A61P1/00 , A61P1/18 , A61P3/10 , A61P9/08 , A61P9/10 , A61P13/08 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D235/04 , C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
摘要： Pharmaceutical compositions comprising a compound of the formula I selected from 6-(4-bromo-2-fluoro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and pharmaceutically acceptable salts thereof, for use in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals.

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