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41. 发明公开

EP2768840A1 DERIVES AMINOSTEROIDIENS ANTI-DIABETIQUES 审中-公开
标题翻译：抗真菌药物氨基转移酶
公开(公告)号：EP2768840A1
公开(公告)日：2014-08-27
申请号：EP12787771.0
申请日：2012-10-16
申请人： Université Nice Sophia Antipolis , Université d'Aix-Marseille , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique
发明人： GOVERS, Roland Marinus Theodorus , BRUNEL, Jean Michel
IPC分类号： C07J41/00 , A61K31/575 , A61P31/10
CPC分类号： C07J43/003 , C07J41/0005
摘要： The present invention concerns new aminosteroid derivatives substituted in positions 3 and/or 6, and the use thereof in the context of the treatment of type 2 diabetes and insulin resistance.

42. 发明公开

EP2525224A1 VDAC1-S as a cell marker 审中-公开
标题翻译： VDAC1-S als ein Zellmarker
公开(公告)号：EP2525224A1
公开(公告)日：2012-11-21
申请号：EP11166799.4
申请日：2011-05-19
申请人： Centre National de la Recherche Scientifique , Université Nice Sophia Antipolis
发明人： Mazure, Nathalie
IPC分类号： G01N33/50 , G01N33/574
CPC分类号： G01N33/57492 , G01N33/6872 , G01N2500/10 , G01N2800/52 , G01N2800/56
摘要： The instant invention relates to the use of C-terminally truncated form of VDAC1 as a cell marker of apoptosis-resistance phenotype of hypoxic cancer cells.
摘要翻译：本发明涉及使用C-末端截短形式的VDAC1作为缺氧癌细胞的细胞凋亡抗性表型的细胞标志物。

43. 发明公开

EP2300043A1 EFFETS ANALGESIQUES DE LA TOXINE PEPTIDIQUE APETX2 有权
标题翻译：毒素肽APETX2镇痛作用
公开(公告)号：EP2300043A1
公开(公告)日：2011-03-30
申请号：EP09757702.7
申请日：2009-06-04
申请人： Centre National de la Recherche Scientifique - CNRS , Université Nice Sophia Antipolis
发明人： DEVAL , Emmanuel , DIOCHOT, Sylvie , LAZDUNSKI, Michel , LINGUEGLIA, Eric , NOEL, Jacques
IPC分类号： A61K38/16 , A61P29/00 , A61P17/04
CPC分类号： A61K38/16
摘要： The invention relates to the use of the peptide toxin APETx2 that blocks the ASIC3 cationic channels and that is derived from the Anthopleura elegantissima sea anemone, and to the use of the analogs and derivatives thereof as a drug, particularly as an analgesic against pain associated with the activation of ASIC3 (Acid Sensing Ion Channel 3) channels, in particular pain occurring upon an inflammation and potentially upon any painful situation associated with tissue acidosis (ischemiae, fractures, hematoma, oedema, phlyctena, local infections, tissue lesions, ocular wounds, tumours, etc.)

46. 发明公开

EP3356551A1 METHODS FOR DETERMINING THE METABOLIC STATUS OF LYMPHOMAS 有权转让
公开(公告)号：EP3356551A1
公开(公告)日：2018-08-08
申请号：EP16775236.9
申请日：2016-09-29
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Nice Sophia Antipolis , Assistance Publique-Hôpitaux de Paris (APHP)
发明人： RICCI, Jean-Ehrland , CHICHE, Johanna , THIEBLEMONT, Catherine
IPC分类号： C12Q1/68
摘要： The invention relates to an in vitro method for determining the metabolic status of a lymphoma comprising a step of determining the level of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression in lymphoma cells, wherein a low level of GAPDH expression is indicative of oxidative phosphorylation (OXPHOS) status. The invention also relates to an in vitro method for predicting the responsiveness of a patient afflicted with a lymphoma to a treatment with a metabolic inhibitor selected from the group consisting of mitochondrial metabolic inhibitors and glutamine metabolism inhibitors comprising a step of determining the level of GAPDH expression in lymphoma cells obtained from said patient, wherein a low level of GAPDH expression is predictive of a response to a treatment with a metabolic inhibitor.

47. 发明公开

EP3325452A1 SUBSTITUTED HYDROPHOBIC BENZENE SULFONAMIDE THIAZOLE COMPOUNDS FOR USE IN TREATING CANCER 有权转让
公开(公告)号：EP3325452A1
公开(公告)日：2018-05-30
申请号：EP16741632.0
申请日：2016-07-22
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Nice Sophia Antipolis , Centre National de la Recherche Scientifique (CNRS)
发明人： ROCCHI, Stéphane , BENHIDA, Rachid , BALLOTTI, Robert , PLAISANT, Magali , RONCO, Cyril , MILLET, Antoine
IPC分类号： C07D277/46 , A61K31/426 , A61P35/00
CPC分类号： C07D277/46 , A61P35/00
摘要： The present invention relates to compound of general formula (I) R1 is selected from H, aryl and alkyl, R2 is selected from H, alkyl, aryl and CO-R6; R3 is selected from H, halogen, alkyl, alkenyl, alkynyl, aryl, NHR7, NR7R8, OR7 and SR7; R4 is selected from(C6-C12) alkyl, (C2-C12) alkenyl, (C2-C12) alkynyl and (C6-C10) aryl, R5 represents H, R6, aryl, OH, OR6, O-aryl, SH, SR6, S-aryl, CN, NO2, CF3, COOR6, SO2NR6R7, CONR6R7, NH2, NHR6, NH-aryl, NR6R7, NHCOR6 or aminoacyl; R6 is alkyl optionally substituted with halogen, OH, SH, NH2, O-alkyl, S-alkyl, NH- alkyl or NH-di(alkyl); R7 and R8 identical or different are H or alkyl optionally substituted with halogen, OH, SH, NH2, O-alkyl, S-alkyl, NH-alkyl or NH-di (alkyl), their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof. The compounds are useful for the treatment of cancers.

48. 发明公开

EP3274662A1 CAPTEUR A FIBRE OPTIQUE DISTRIBUE D'ETAT DE CONTRAINTE 有权
标题翻译：光纤传感器从应变状态分布
公开(公告)号：EP3274662A1
公开(公告)日：2018-01-31
申请号：EP16714782.6
申请日：2016-03-17
申请人： Thales , Centre National de la Recherche Scientifique , Université Nice Sophia Antipolis
发明人： MOLIN, Stéphanie , DOISY, Martine , PEIGNE, Arnaud , RESIDORI, Stefania , BORTOLOZZO, Umberto , HUIGNARD, Jean-Pierre , BOUFFARON, Renaud , DOLFI, Daniel
IPC分类号： G01D5/353 , G01H9/00
摘要： The invention concerns a distributed optical fibre sensor for sensing dynamic stress state, comprising: - an optical assembly configured to generate a series of optical pulses (l
pi ); - an optical fibre (FO) of optical length L; - an optical system configured to: o inject, via said first end (E
x1 ), at least said series of optical pulses (l
pi ); o receive, at said end (E
x1 ), at least one series of output optical pulses, from said input pulses after propagation and back-propagation in the fibre; o generate at least one continuous reference beam (Fr) or reference optical pulses (l
pri ) from said optical assembly or said output optical pulses (I
psi ); o produce a series of interference zones corresponding to the interference between said reference beam (Fr) or a reference pulse (lpri) and a signal optical pulse (l
psiS ) from an output optical pulse (l
psi ); - a holographic detector (HD) comprising: o a liquid crystal optical valve (LCLV), said valve (LCLV) being arranged in such a way as to at least partially cover said interference zones, and producing holograms from said interference zones; o at least one optical detector (PD) configured to detect output optical signals diffracted by said holograms.

49. 发明授权

EP2856153B1 PROCESS FOR MAKING A DIAGNOSIS OF INVASIVE CANCER 有权转让
标题翻译：进行侵入性癌症诊断的过程
公开(公告)号：EP2856153B1
公开(公告)日：2018-01-17
申请号：EP13724594.0
申请日：2013-05-23
申请人： Rarecells , Assistance Publique - Hôpitaux de Paris , Institut National de la Santé et de la Recherche Médicale , Université Paris Descartes , Université Nice Sophia Antipolis , Centre Hospitalier Universitaire de Nice
发明人： LAGET, Sophie , PATERLINI-BRECHOT, Patrizia , HOFMAN, Paul , CAPIOD, Thierry
IPC分类号： G01N33/50
CPC分类号： G01N33/5091 , C12Q1/6886
摘要： A process for isolating or extracting rare cells from a biological sample comprising filtering a biological sample, which may be treated or diluted, through a filter that has a pore size, pore density or other physical properties that retain rare cells, but which permits other kinds of cells to pass through the filter. This process also comprises multiple analyses performed on rare cells after their extraction or isolation by filtration to diagnostically identify the presence of rare cells in a biological sample and to use their diagnostic identification and molecular characterization for diagnostic purposes such as for early diagnosis of diseases, namely for early diagnosis of cancer and to select, guide, monitor treatments and in particular to select targeted treatments and to monitor the response and/or resistance to them. A kit comprising tools, equipment and/or reagents to accomplish both the filtration step and various kinds of multiple analyses performed after isolation and extraction of the rare cells by filtration.

50. 发明公开

EP3212176A1 PANICEIN COMPOUNDS, COMPOSITIONS AND USES THEREOF 有权
标题翻译： PANICEIN化合物，组合物及其用途
公开(公告)号：EP3212176A1
公开(公告)日：2017-09-06
申请号：EP15784956.3
申请日：2015-10-26
申请人： Centre National de la Recherche Scientifique , Université Nice Sophia Antipolis
发明人： MUS-VETEAU, Isabelle , THOMAS, Olivier , TRIBALAT, Marie-Aude , AZOULAY, Stéphane
IPC分类号： A61K31/05 , A61K31/11 , A61K31/353 , A61P35/00
摘要： The present invention relates to the fields of medicine and cancer treatment. The invention more specifically relates to the use of a panicein or a derivative thereof, to decrease or inhibit, in vitro or ex vivo, the Patched receptor drug efflux activity, in particular the chemotherapeutic drug efflux activity and chemotherapy resistance. The present disclosure further relates to uses of such compounds, in particular to prepare a pharmaceutical composition to allow or improve the efficiency of a therapy of cancer in a subject in need thereof. The compound of the invention can indeed be advantageously used, in combination with at least one chemotherapeutic drug, for treating cancer, for preventing cancer metastasis and/or for preventing cancer recurrence in a subject. The invention also discloses methods for preventing or treating cancer, cancer metastasis and/or cancer recurrence in a subject, as well as kits suitable for preparing a composition according to the present invention and/or for implementing the herein described methods.
摘要翻译：本发明涉及医学和癌症治疗领域。本发明更具体地涉及使用panicein或其衍生物来减少或抑制体外或离体Patched受体药物外排活性，特别是化疗药物外排活性和化疗耐受性。本公开还涉及此类化合物的用途，特别是用于制备药物组合物以允许或改善有需要的受试者中癌症疗法的效率。本发明的化合物确实可以有利地与至少一种化学治疗药物组合用于治疗癌症，预防癌症转移和/或预防受试者的癌症复发。本发明还公开用于预防或治疗受试者的癌症，癌症转移和/或癌症复发的方法，以及适用于制备根据本发明的组合物和/或用于实施本文所述方法的试剂盒。

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