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41. 发明申请

US20190120767A1 Super-Resolution Fluorescence Microscopy Method Using Improved Drift Compensation Markers 审中-公开
公开(公告)号：US20190120767A1
公开(公告)日：2019-04-25
申请号：US16096073
申请日：2017-04-25
申请人： Ultivue, Inc.
发明人： Michael Jules NATAN , Stephanie Rae HENNEK , Mael MANESSE
IPC分类号： G01N21/64 , G01N21/65
摘要： A super-resolution fluorescence microscopy method comprises (a) providing a drift compensation marker, wherein (i) the drift compensation marker comprises a coated plasmonic particle; (ii) the drift compensation marker comprises an anisotropic plasmonic particle; and/or (iii) the drift compensation marker comprises a plasmonic particle comprising at least one reporter molecule on the surface of the plasmonic particle or on the surface of a coating; (b) performing super-resolution fluorescence microscopy; (c) using the drift compensation marker to improve the resolution of the super-resolution fluorescence microscopy. A super-resolution fluorescence microscopy method alternatively comprises (a) providing a drift compensation marker comprising a nonplasmonic Raman-active particle and wherein optionally the drift compensation marker comprises a coated nonplasmonic Raman-active particle and/or optionally the drift compensation marker comprises an anisotropic nonplasmonic Raman-active particle; (b) performing super-resolution fluorescence microscopy; (c) using the drift compensation marker to improve the resolution of the super-resolution fluorescence microscopy.

42. 发明申请

US20180371532A1 MULTIPLEXED IMAGING USING STRAND DISPLACEMENT 审中-公开
公开(公告)号：US20180371532A1
公开(公告)日：2018-12-27
申请号：US16117194
申请日：2018-08-30
申请人： Ultivue, Inc.
发明人： Xi CHEN , Stephanie HENNEK
IPC分类号： C12Q1/6806 , C12Q1/6855 , C12Q1/6869
摘要： The present disclosure describes various improved methods for imaging at least one target in a sample, including methods employing an adapter strand oligonucleotide and a bridge strand oligonucleotide. Some methods also employ bouncer oligonucleotides and/or blocker oligonucleotides. Some methods also use two partial docking strands to detect proximity of the partial docking strands to each other.

43. 发明申请

US20180348214A1 COMPOSITIONS FOR MULTIPLEX IMAGING USING LABELED NUCLEIC ACID IMAGING AGENTS 审中-公开
公开(公告)号：US20180348214A1
公开(公告)日：2018-12-06
申请号：US16059166
申请日：2018-08-09
申请人： Ultivue, Inc.
发明人： Stephanie Rae HENNEK , Mael MANESSE , Abdul MOHAMMED , Xi CHEN , Michael Jules NATAN
IPC分类号： G01N33/543 , G01N33/58 , C12Q1/6874 , C12Q1/68 , C12Q1/6823 , C12Q1/682 , C12Q1/6818 , C12Q1/6816 , C12Q1/6806 , C12Q1/6804 , C12Q1/6832
CPC分类号： G01N33/54386 , C12Q1/68 , C12Q1/6804 , C12Q1/6806 , C12Q1/6816 , C12Q1/6818 , C12Q1/682 , C12Q1/6823 , C12Q1/6832 , C12Q1/6874 , G01N33/543 , G01N33/54306 , G01N33/54333 , G01N33/58 , G01N33/587 , C12Q2531/125 , C12Q2537/143 , C12Q2563/179
摘要： The present application provides compositions for multiplexed imaging using labeled nucleic acid imaging agents.

44. 发明公开

US20240242353A1 Validation Methods for Multiplexed Imaging Method 审中-公开
公开(公告)号：US20240242353A1
公开(公告)日：2024-07-18
申请号：US18435336
申请日：2024-02-07
申请人： Ultivue, Inc.
发明人： Douglas Wood
IPC分类号： G06T7/00 , C12Q1/6804 , G01N21/64 , G01N33/569 , G06T3/14
CPC分类号： G06T7/0014 , G01N21/64 , G01N21/6458 , G01N33/56966 , G06T3/14 , C12Q1/6804 , G01N2333/7051 , G01N2458/10 , G06T2207/10056 , G06T2207/10064 , G06T2207/10081 , G06T2207/30024
摘要： A quantitative method of validating at least one candidate imaging method or candidate imaging reagent for use in evaluating a biological sample for the presence of one or more targets is described relying upon cross-correlation calculations.

45. 发明申请

US20220370633A1 Compositions and Methods to Expedite Antibody-Based Exchange Imaging 有权
公开(公告)号：US20220370633A1
公开(公告)日：2022-11-24
申请号：US17835026
申请日：2022-06-08
申请人： Ultivue, Inc.
发明人： Xi Chen
IPC分类号： A61K47/68 , G01N33/58 , C07K16/12 , G01N33/68 , C07K16/42 , G01N33/536
摘要： A method for exchange imaging of at least two targets in a sample includes (a) incubating a sample with at least two or more target-recognizing antibodies, each bound to a corresponding monovalent tight antibody binder-docketing moiety (MTAB-DM) reagent capable of binding monovalently to the target-recognizing antibodies, (b) applying at least two imager moieties corresponding to the MTAB-DM, either in series, in batches, or in parallel, and (d) imaging the at least two imager moieties either in series, in batches, or in parallel.

46. 发明授权

US11382986B2 Compositions and methods to expedite antibody-based exchange imaging 有权
公开(公告)号：US11382986B2
公开(公告)日：2022-07-12
申请号：US16129895
申请日：2018-09-13
申请人： Ultivue, Inc.
发明人： Xi Chen
IPC分类号： A61K47/68 , C07K16/42 , G01N33/536 , G01N33/58 , C07K16/12 , G01N33/68
摘要： A method for exchange imaging of at least two targets in a sample includes (a) incubating a sample with at least two or more target-recognizing antibodies, each bound to a corresponding monovalent tight antibody binder-docketing moiety (MTAB-DM) reagent capable of binding monovalently to the target-recognizing antibodies, (b) applying at least two imager moieties corresponding to the MTAB-DM, either in series, in batches, or in parallel, and (d) imaging the at least two imager moieties either in series, in batches, or in parallel.

47. 发明申请

US20210396760A1 Super-Resolution Immunofluorescence with Diffraction-Limited Preview 有权
$Super-Resolution Immunofluorescence with Diffraction-Limited Preview$
公开(公告)号：US20210396760A1
公开(公告)日：2021-12-23
申请号：US17363416
申请日：2021-06-30
申请人： Ultivue, Inc.
发明人： Xi Chen
IPC分类号： G01N33/58 , G01N21/64 , C07K16/18 , G01N33/533
摘要： An imaging agent comprises (a) at least one target recognition moiety; (b) at least one observable moiety non-transiently bound to the target recognition moiety, and (c) at least one docking moiety bound to the target recognition moiety, wherein the docking moiety is capable of transiently binding at least one observable moiety. In some embodiments, the at least one target recognition moiety is an antibody or antigen binding fragment thereof.

48. 发明申请

US20200371097A1 Methods for Multiplex Imaging Using Labeled Nucleic Acid Imaging Agents 审中-公开
公开(公告)号：US20200371097A1
公开(公告)日：2020-11-26
申请号：US16992654
申请日：2020-08-13
申请人： Ultivue, Inc.
发明人： Stephanie Rae HENNEK , Mael MANESSE , Abdul MOHAMMED , Xi CHEN , Michael Jules NATAN
IPC分类号： G01N33/543 , C12Q1/6816 , G01N33/58 , C12Q1/6823 , C12Q1/6818 , C12Q1/6806 , C12Q1/68 , C12Q1/6874 , C12Q1/6832 , C12Q1/6804 , C12Q1/682
摘要： The present application provides certain advantageous ways of conducting multiplexed imaging.

49. 发明授权

US10246738B2 DNA-antigen exchange and amplification 有权
公开(公告)号：US10246738B2
公开(公告)日：2019-04-02
申请号：US15941770
申请日：2018-03-30
申请人： Ultivue, Inc.
发明人： Stephanie Rae Hennek , Mael Manesse
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/682 , C12Q1/6804 , G01N33/58 , C12Q1/6844 , G01N33/53
摘要： Methods for imaging are described, including, but not limited to a method comprising: (1) contacting a sample being tested for the presence of one or more targets with one or more target-specific binding partners, wherein each target-specific binding partner is linked to a docking strand, and wherein target-specific binding partners of different specificity are linked to different docking strands, (2) optionally removing unbound target-specific binding partners, (3) contacting the sample with antigen-bound imager strands and antigen-specific binding partners linked (directly or indirectly) to optical labels, wherein the antigen-bound imager strands have complementarity to a docking strand, directly or indirectly, and wherein each antigen-specific binding partner is linked to one or more optical labels, and wherein antigen-specific binding partners of different specificity are linked to distinct optical labels, (4) optionally removing unbound antigen-bound imager strands and/or antigen-specific binding partners, (5) imaging the sample to detect bound labeled antigen-specific binding partners, (6) optionally removing/extinguishing signal from the optical labels, and (7) optionally repeating steps (1)-(7), or any subset thereof.

50. 发明申请

US20180164308A1 METHODS FOR MULTIPLEX IMAGING USING LABELED NUCLEIC ACID IMAGING AGENTS 审中-公开
公开(公告)号：US20180164308A1
公开(公告)日：2018-06-14
申请号：US15836322
申请日：2017-12-08
申请人： Ultivue, Inc.
发明人： Stephanie Rae WALTER , Mael MANESSE , Abdul MOHAMMED , Xi CHEN , Michael Jules NATAN
IPC分类号： G01N33/543 , G01N33/58 , C12Q1/6832 , C12Q1/6874 , C12Q1/6804
摘要： The present application provides certain advantageous ways of conducting multiplexed imaging.

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