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1. 发明专利

AU2017273720A1 Compositions and methods to expedite antibody-based exchange imaging 未知
公开(公告)号：AU2017273720A1
公开(公告)日：2018-12-20
申请号：AU2017273720
申请日：2017-06-01
申请人： ULTIVUE INC
发明人： CHEN XI
IPC分类号： G01N21/64 , C07K16/12 , C12N15/115 , C12Q1/68 , G01N33/533 , G01N33/58 , G01N33/68
摘要： A method and kit for exchange imaging of at least two targets in a sample comprises (a) providing at least two or more target-recognizing antibodies, each bound to a corresponding MTAB-DM reagent capable of binding monovalently to the target-recognizing antibodies, (b) incubating a sample with the two or more target-recognizing antibodies, each bound to a corresponding MTAB-DM reagent, (c) applying at least two imager moieties corresponding to the MTAB-DM, either in series, in batches, or in parallel, and (d) imaging the at least two imager moieties either in series, in batches, or in parallel.

2. 发明专利

AU2019397157A1 Methods and compositions for sequentially detecting targets 未知
公开(公告)号：AU2019397157A1
公开(公告)日：2021-05-27
申请号：AU2019397157
申请日：2019-12-13
申请人： ULTIVUE INC
发明人： MOHAMMED ABDUL MAJEED , MANESSE MAEL , SCHERMER MACK J , BOBROW MARK N , NATAN MICHAEL JULES
IPC分类号： C12Q1/6818 , C12Q1/6804 , C12Q1/6823 , C12Q1/6841
摘要： Compositions, kits and methods for detecting a plurality of targets are provided herein. A probe-set composition is provided, including one or more first probes and one or more second probes. Each of the first probe includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a first label, and a cleavage site for a first cleavage agent, wherein the first cleavage agent is capable of releasing the first label. Each of the second probes includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a second label, a quench moiety that renders the second label undetectable, and a cleavage site for the first cleavage agent. The first cleavage agent is capable of releasing the quench moiety, whereby the second label is rendered detectable.

3. 发明专利

CA3098722A1 MULTIPLEXED CATALYZED REPORTER DEPOSITION 未知
公开(公告)号：CA3098722A1
公开(公告)日：2019-12-12
申请号：CA3098722
申请日：2019-06-06
申请人： ULTIVUE INC
发明人： BOBROW MARK , HENNEK STEPHANIE , MANESSE MAEL
IPC分类号： C12Q1/6804 , C12Q1/682
摘要： A method for testing a sample for the presence of one or more targets comprises multiplexed catalyzed reporter deposition (CARD) is provided.

4. 发明申请

WO2019236841A1 MULTIPLEXED CATALYZED REPORTER DEPOSITION 审中-公开
公开(公告)号：WO2019236841A1
公开(公告)日：2019-12-12
申请号：PCT/US2019/035785
申请日：2019-06-06
申请人： ULTIVUE, INC.
发明人： BOBROW, Mark , HENNEK, Stephanie , MANESSE, Mael
IPC分类号： C12Q1/6804 , C12Q1/682
摘要： A method for testing a sample for the presence of one or more targets comprises multiplexed catalyzed reporter deposition (CARD) is provided.

5. 发明申请

WO2020014036A1 METHODS FOR MULTICOLOR MULTIPLEX IMAGING 审中-公开
公开(公告)号：WO2020014036A1
公开(公告)日：2020-01-16
申请号：PCT/US2019/040235
申请日：2019-07-02
申请人： ULTIVUE, INC.
发明人： WOOD, Douglas , BOBROW, Mark , MANESSE, Mael , WHEELER, Eloise , BOISVERT, Heike
IPC分类号： G01N33/543 , G01N33/58
摘要： Methods for multicolor multiplex imaging are provided herein in order to increase the number of targets that may be imaged given the number of fluorophores available or desired for use.

6. 发明专利

AU2019280824A1 Multiplexed catalyzed reporter deposition 未知
公开(公告)号：AU2019280824A1
公开(公告)日：2020-11-26
申请号：AU2019280824
申请日：2019-06-06
申请人： ULTIVUE INC
发明人： BOBROW MARK , HENNEK STEPHANIE , MANESSE MAEL
IPC分类号： C12Q1/6804 , C12Q1/682
摘要： A method for testing a sample for the presence of one or more targets comprises multiplexed catalyzed reporter deposition (CARD) is provided.

7. 发明专利

CA3017945A1 SUPER-RESOLUTION IMMUNOFLUORESCENCE WITH DIFFRACTION-LIMITED PREVIEW 未知
公开(公告)号：CA3017945A1
公开(公告)日：2017-11-02
申请号：CA3017945
申请日：2017-04-25
申请人： ULTIVUE INC
发明人： CHEN XI
IPC分类号： C07K16/18 , C07K19/00 , C12Q1/00 , G01N21/64 , G01N21/78 , G01N33/542
摘要： An imaging agent comprises (a) at least one target recognition moiety; (b) at least one observable moiety non-transiently bound to the target recognition moiety, and (c) at least one docking moiety bound to the target recognition moiety, wherein the docking moiety is capable of transiently binding at least one observable moiety. In some embodiments, the at least one target recognition moiety is an antibody or antigen binding fragment thereof. A method of performing super-resolution imaging on a sample comprises (a) contacting the sample with at least one imaging agent comprising (i) a target-recognizing molecule non-transiently attached to at least one observable moiety and (ii) a target-recognizing molecule attached to at least one docking moiety, wherein the docking moiety is capable of transiently binding at least one observable moiety; (b) imaging the target-recognizing molecule non-transiently bound to at least one observable moiety; and (c) providing at least one observable moiety capable of transiently binding to the docking moiety and imaging the observable moiety transiently bound to the docking moiety.

8. 发明申请

WO2018183876A1 DNA-ANTIGEN EXCHANGE AND AMPLIFICATION 审中-公开
公开(公告)号：WO2018183876A1
公开(公告)日：2018-10-04
申请号：PCT/US2018/025444
申请日：2018-03-30
申请人： ULTIVUE, INC.
发明人： WALTER, Stephanie Rae , MANESSE, Mael
IPC分类号： C07K16/18 , C07K19/00 , C12Q1/68 , G01N33/53 , G01N33/533 , G01N33/58
摘要： Methods for imaging are described, including, but not limited to a method comprising: (1) contacting a sample being tested for the presence of one or more targets with one or more target-specific binding partners, wherein each target-specific binding partner is linked to a docking strand, and wherein target-specific binding partners of different specificity are linked to different docking strands, (2) optionally removing unbound target-specific binding partners, (3) contacting the sample with antigen-bound imager strands and antigen-specific binding partners linked (directly or indirectly) to optical labels, wherein the antigen-bound imager strands have complementarity to a docking strand, directly or indirectly, and wherein each antigen-specific binding partner is linked to one or more optical labels, and wherein antigen-specific binding partners of different specificity are linked to distinct optical labels, (4) optionally removing unbound antigen-bound imager strands and/or antigen-specific binding partners, (5) imaging the sample to detect bound labeled antigen-specific binding partners, (6) optionally removing/extinguishing signal from the optical labels, and (7) optionally repeating steps (1)-(7), or any subset thereof.

9. 发明申请

WO2017210387A1 COMPOSITIONS AND METHODS TO EXPEDITE ANTIBODY-BASED EXCHANGE IMAGING 审中-公开
标题翻译：基于抗体的交换成像的组合物和方法
公开(公告)号：WO2017210387A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035375
申请日：2017-06-01
申请人： ULTIVUE, INC.
发明人： CHEN, Xi
IPC分类号： G01N21/64 , G01N33/68 , G01N33/58 , G01N33/533 , C07K16/12 , C12Q1/68 , C12N15/115
摘要： A method and kit for exchange imaging of at least two targets in a sample comprises (a) providing at least two or more target-recognizing antibodies, each bound to a corresponding MTAB-DM reagent capable of binding monovalently to the target-recognizing antibodies, (b) incubating a sample with the two or more target-recognizing antibodies, each bound to a corresponding MTAB-DM reagent, (c) applying at least two imager moieties corresponding to the MTAB-DM, either in series, in batches, or in parallel, and (d) imaging the at least two imager moieties either in series, in batches, or in parallel.
摘要翻译：用于样品中至少两个靶标的交换成像的方法和试剂盒包括（a）提供至少两种或更多种靶标识别抗体，每种靶标识别抗体各自与能够结合的相应MTAB-DM试剂结合（b）将样品与两种或更多种识别目标的抗体一起孵育，每种抗体与相应的MTAB-DM试剂结合，（c）施用至少两种对应于MTAB-DM的成像剂部分，（d）串联，分批或平行对所述至少两个成像部分进行成像。

10. 发明专利

CA3117944A1 METHODS AND COMPOSITIONS FOR SEQUENTIALLY DETECTING TARGETS 未知
公开(公告)号：CA3117944A1
公开(公告)日：2020-06-18
申请号：CA3117944
申请日：2019-12-13
申请人： ULTIVUE INC
发明人： MOHAMMED ABDUL MAJEED , MANESSE MAEL , SCHERMER MACK J , BOBROW MARK N , NATAN MICHAEL JULES
IPC分类号： C12Q1/6804 , C12Q1/68 , C12Q1/6823 , C12Q1/6841 , C40B30/04 , C40B70/00 , G01N33/53
摘要： Compositions, kits and methods for detecting a plurality of targets are provided herein. A probe-set composition is provided, including one or more first probes and one or more second probes. Each of the first probe includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a first label, and a cleavage site for a first cleavage agent, wherein the first cleavage agent is capable of releasing the first label. Each of the second probes includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a second label, a quench moiety that renders the second label undetectable, and a cleavage site for the first cleavage agent. The first cleavage agent is capable of releasing the quench moiety, whereby the second label is rendered detectable.

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