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41. 发明申请

WO2005049056A3 IMMUNE MODULATOR COMPRISING WHOLE CELL RHODOCOCCUS, GORDONIA, NOCARDIA, DIETZIA, TSUKAMURELLA OR NOCARDIOIDES BACTERIA 审中-公开
标题翻译：包含全细胞RHODOCOCCUS，GORDONIA，NOCARDIA，DIETZIA，TSUKAMURELLA或NOCARDIOIDES BACTERIA的免疫调节剂
公开(公告)号：WO2005049056A3
公开(公告)日：2005-11-03
申请号：PCT/GB2004004783
申请日：2004-11-12
申请人： UCL BIOMEDICA PLC , MCINTYRE GRAHAM , STANFORD JOHN LAWSON , STANFORD CYNTHIA ANN , BOTTASSO OSCAR ADELMO
发明人： MCINTYRE GRAHAM , STANFORD JOHN LAWSON , STANFORD CYNTHIA ANN , BOTTASSO OSCAR ADELMO
IPC分类号： A61K35/74 , A61K39/00 , A61K39/39 , A61P9/00 , A61P37/00 , A61P37/06
CPC分类号： A61K39/39 , A61K35/74 , A61K39/0008 , A61K2039/55594 , A61K2039/57
摘要： Use of an immune modulator composition and/or pharmaceutical composition comprising a whole cell of a bacterium from the genera Rhodococcus, Gordonia, Nocardia, Dietzia, Tsukamurella and Nocardioides, for use in the manufacture of a medicament for the treatment of an autoimmune disease or autoimmune disorder, including certain vascular disorders.
摘要翻译：使用免疫调节剂组合物和/或药物组合物，其包含来自红球菌属，戈多尼氏菌属，诺卡氏菌属，Dietzia属，冢卡那霉素属和诺卡氏菌属的细菌的全细胞，用于制备用于治疗自身免疫疾病或自身免疫的药物障碍，包括某些血管疾病。

42. 发明申请

WO2005049056A2 IMMUNE MODULATOR 审中-公开
标题翻译：免疫调节剂
公开(公告)号：WO2005049056A2
公开(公告)日：2005-06-02
申请号：PCT/GB2004/004783
申请日：2004-11-12
申请人： UCL BIOMEDICA PLC , MCINTYRE, Graham , STANFORD, John, Lawson , STANFORD, Cynthia, Ann , BOTTASSO, Oscar, Adelmo
发明人： MCINTYRE, Graham , STANFORD, John, Lawson , STANFORD, Cynthia, Ann , BOTTASSO, Oscar, Adelmo
IPC分类号： A61K35/74
CPC分类号： A61K39/39 , A61K35/74 , A61K39/0008 , A61K2039/55594 , A61K2039/57
摘要： Use of an immune modulator composition and/or pharmaceutical composition comprising a whole cell of a bacterium from the genera Rhodococcus, Gordonia , Nocardia, Dietzia , Tsukamurella and Nocardioides , for use in the manufacture of a medicament for the treatment of an autoimmune disease or autoimmune disorder, including certain vascular disorders.
摘要翻译：使用免疫调节剂组合物和/或药物组合物，其包含来自红球菌属，戈多尼氏菌属，诺卡氏菌属，Dietzia属，冢卡那霉素属和诺卡氏菌属的细菌的全细胞，用于制备用于治疗自身免疫疾病或自身免疫的药物障碍，包括某些血管疾病。

43. 发明申请

WO2005045067A1 IMPROVEMENTS RELATING TO SEMEN PRESERVATION 审中-公开
标题翻译：关于SEMEN保存的改进
公开(公告)号：WO2005045067A1
公开(公告)日：2005-05-19
申请号：PCT/GB2004/004683
申请日：2004-11-08
申请人： UCL BIOMEDICA PLC , MICHAEL, Anthony , THURSTON, Lisa
发明人： MICHAEL, Anthony , THURSTON, Lisa
IPC分类号： C12Q1/32
CPC分类号： C12Q1/32 , G01N33/5005 , G01N33/689 , G01N2800/367
摘要： The present invention provides a method for determining the suitability of a sample of mammalian semen for cooling and/or cryopreservation or storage, which comprises: (a) providing said sample of semen; (b) determining the level of a hydrophobic stimulator of 11β-HSD activity in said sample; and (c) assessing, from the level of 11β-HSD stimulator determined, the suitability of the semen sample for cooling and/or cryopreservation or storage. The present invention also provides a method of obtaining a hydrophobic product that improves the tolerance of mammalian semen to cooling and/or cryopreservation or storage, a method of improving the survival rate of sperm intended for cooling and/or cryopreservation or storage and a method of performing an assisted conception/reproductive procedure comprising contacting an oocyte with sperm obtained by a method according to the present invention.
摘要翻译：本发明提供了一种用于确定用于冷却和/或冷冻保存或储存的哺乳动物精液样品的适合性的方法，其包括：（a）提供所述精液样品; （b）确定所述样品中11beta-HSD活性的疏水刺激剂的水平; 和（c）从确定的11beta-HSD刺激剂的水平评估精液样品用于冷却和/或冷冻保存或储存的适用性。本发明还提供了获得提高哺乳动物精液对冷却和/或冷冻保存或储存的耐受性的疏水产物的方法，提高用于冷却和/或冷冻保存或储存的精子存活率的方法和执行辅助受孕/繁殖程序，包括使卵母细胞与通过根据本发明的方法获得的精子接触。

44. 发明申请

WO2005031357A3 CELL SAMPLE ANALYSIS 审中-公开
公开(公告)号：WO2005031357A3
公开(公告)日：2005-04-07
申请号：PCT/GB2004/004010
申请日：2004-09-21
申请人： UCL BIOMEDICA PLC. , JANOSSY, George
发明人： JANOSSY, George
IPC分类号： G01N33/569
摘要： The present invention provides a flow cytometric method for analysing a cell sample by enumeration of the CD4+, CD38+ and CD8+ populations of the cell sample. The method is particularly useful for monitoring HIV infection. The present invention also provides a method for gating CD8+ T cells into normal CD38+ cells and pathogenic CD38++ cells in a flow cytometric method, by indentifying the monocyte population in a reference cell sample and setting a gate based on the CD38 expression of this population.

45. 发明申请

WO2004089456A1 GUIDE WIRE STRUCTURE FOR INSERTION INTO AN INTERNAL SPACE 审中-公开
标题翻译：导线插入内部空间的导线结构
公开(公告)号：WO2004089456A1
公开(公告)日：2004-10-21
申请号：PCT/US2004/009982
申请日：2004-04-01
申请人： ETHICON ENDO-SURGERY, INC. , UCL BIOMEDICA PLC
发明人： SWAIN, Christopher, Paul , LONG, Gary, L.
IPC分类号： A61M25/01
CPC分类号： A61B18/14 , A61M25/01 , A61M25/09
摘要： A method is described of inserting guide wires into a lumen, for example into the human gastrointestinal tract. A guide wire structure is employed which comprises at least two guide wires (1, 2) each having a leading end portion which terminates in a leading end, the guide wires being connected to one another by a junction (3) at or adjacent their leading ends, the guide wires have a first position in which the leading end portions are substantially parallel to one another, a second position in which theleading end portions are curved, and a third position in which at least one of the leading end portions forms a loop. The guide wire structure is steered through the gastrointestinal tract by selectively advancing or retracting a single guide wire or advancing more than one guide wire simultaneously, according to the path which is required to be followed.
摘要翻译：描述了将引导线插入管腔，例如插入人胃肠道中的方法。引导线结构被使用，其包括至少两根引导线（1,2），每个引导线（1,2）具有终止于前端的前端部分，引导线通过接合部（3）彼此连接在其前端导丝具有第一位置，其中前端部基本上彼此平行，第二位置，其中，顶端部弯曲;第三位置，其中至少一个前端部形成环。根据需要遵循的路径，引导线结构通过选择性地前进或后退单根导丝或同时推进多根导丝而转向胃肠道。

46. 发明申请

WO2004086984A1 A DEVICE FOR TRANSFIXING AND JOINING TISSUE 审中-公开
标题翻译：用于转运和接合组织的装置
公开(公告)号：WO2004086984A1
公开(公告)日：2004-10-14
申请号：PCT/GB2004/001350
申请日：2004-03-31
申请人： UCL BIOMEDICA PLC , SWAIN, Christopher, Paul , MOSSE, Charles, Alexander , FRITSCHER-RAVENS, Annette, Dora, Anna , MILLS, Timothy, Noel
发明人： SWAIN, Christopher, Paul , MOSSE, Charles, Alexander , FRITSCHER-RAVENS, Annette, Dora, Anna , MILLS, Timothy, Noel
IPC分类号： A61B17/11
CPC分类号： A61B17/11 , A61B17/0057 , A61B17/0401 , A61B17/0469 , A61B17/1114 , A61B2017/00557 , A61B2017/00637 , A61B2017/0417 , A61B2017/06052 , A61B2017/1107 , A61B2017/1139
摘要： A device is provided for use in joining together first and second tissue layers. The device comprises a catheter (7) with an inflatable balloon (8) mounted on the catheter adjacent one end thereof. An inflation channel is provided which is in fluid communication with the interior of the balloon (8) and with a source of inflation fluid, for introducing the inflation fluid into the interior of the balloon (8). The balloon (8) is inflated and engages an outwardly facing surface of the first tissue layer and a tissue-engaging member, for example a cup (10) or another balloon, engages an outwardly facing surface of the second tissue layer. The inwardly facing surfaces of the first and second tissue layers are thereby urged into engagement with one another.
摘要翻译：提供了用于将第一和第二组织层连接在一起的装置。该装置包括具有可靠气囊（8）的导管（7），所述气囊邻近其一端安装在导管上。提供了一种充气通道，其与球囊（8）的内部和膨胀流体源流体连通，用于将膨胀流体引入气囊（8）的内部。气球（8）膨胀并与第一组织层的面向外的表面接合，并且组织接合构件例如杯（10）或另一气囊与第二组织层的面向外的表面接合。因此，第一和第二组织层的面向内的表面被推动成彼此接合。

47. 发明申请

WO2004050914A1 CANCER ASSOCIATED PLEXINB1 MUTATIONS 审中-公开
标题翻译：癌症相关PLEXINB1突变
公开(公告)号：WO2004050914A1
公开(公告)日：2004-06-17
申请号：PCT/GB2003/005223
申请日：2003-11-28
申请人： UCL BIOMEDICA PLC , WILLIAMSON, Magali , MASTERS, John
发明人： WILLIAMSON, Magali , MASTERS, John
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , G01N33/57415 , G01N33/57434
摘要： The present inventors have identified cancer associated mutations in plexinB1, which is a transmembrane receptor that mediates semaphorin signalling. The frequency of plexinB1 mutations, in particular in prostate and breast cancer, indicates that plexinB1 may be useful in the screening and diagnosis of cancer and as a drug target in the development of anti-cancer therapeutics.
摘要翻译：本发明人已经鉴定了plexinB1中的癌症相关突变，其是介导信号素信号转导的跨膜受体。 plexinB1突变的频率，特别是在前列腺和乳腺癌中的频率表明，plexinB1可用于癌症的筛选和诊断以及作为抗癌治疗剂开发中的药物靶标。

48. 发明申请

WO2004004577A2 IMPROVEMENTS IN AND RELATING TO THE FORMATION OF KNOTS 审中-公开
标题翻译：改进和关于形成知识的改进
公开(公告)号：WO2004004577A2
公开(公告)日：2004-01-15
申请号：PCT/GB2003/002847
申请日：2003-07-03
申请人： UCL BIOMEDICA PLC , BOSE, Ganendra, Coomer
发明人： BOSE, Ganendra, Coomer
IPC分类号： A61B17/04
CPC分类号： A61B17/062 , A61B17/0469 , A61B17/0483 , A61B2017/00349 , A61B2017/0474 , A61B2017/0475 , A61B2017/0477
摘要： The present invention is concerned with the formation of knots in filamentary material. The invention has particular application to the formation of knots in suturing and in ligating tubular structures, such as blood vessels. Devices are provided which carry at least one loop (22, 220, 230, 101, 116, 122) of filamentary material, such as suture material. The loop or loops can be used in the formation of sutures.
摘要翻译：本发明涉及在丝状材料中形成结。本发明特别适用于在缝合和结扎管状结构如血管中形成结。提供了装有丝线材料（例如缝合材料）的至少一个回路（22,220,230,101,116,122）的装置。环或环可用于形成缝合线。

49. 发明专利

CA2601197C METHOD 未知
公开(公告)号：CA2601197C
公开(公告)日：2017-06-06
申请号：CA2601197
申请日：2006-03-16
申请人： UCL BIOMEDICA PLC
发明人： LOWDELL MARK W
IPC分类号： C12N5/0783 , A61K35/17 , A61K39/00 , A61P35/00 , A61P37/02 , C12Q1/04
摘要： The present invention provides a method for activating a Natural Killer (NK) cell by contacting the NK cell in vitro with an activating tumour cell preparation (ATCP). The invention also provides an activated NK cell produced by such a method and its use in the treatment of cancer.

50. 发明专利

CA2556940C MODULATOR 未知
公开(公告)号：CA2556940C
公开(公告)日：2013-12-10
申请号：CA2556940
申请日：2005-02-21
申请人： UCL BIOMEDICA PLC
发明人： OKUYAMA MASAHIRO , SELWOOD DAVID , VISINTIN CRISTINA , BAKER DAVID , PRYCE GARETH
IPC分类号： C07C233/68 , A61K31/167 , A61K31/192 , A61K31/216 , A61K31/235 , C07C63/04 , C07C69/76 , C07C69/78 , C07C233/11 , C07C233/65 , C07C233/66 , C07C233/69 , C07C233/77 , C07C235/42 , C07C235/78 , C07C235/84 , C07C237/32 , C07C237/38 , C07C237/42 , C07C255/41
摘要： The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein Z is OR1 or NR1R2 wherein each of R1 and R2 is independently H, or a hydrocarbyl group; X is an alkylene, alkenylene, or alkynylene group, each of which may be optionally substituted by one or more substituents selected from alkyl, COOH, CO2-alkyl, alkenyl, CN, NH2, hydroxy, halo, alkoxy, CF3 and nitro; Y is a polar functional group selected from OH, NO2, CN, COR3, COOR3, NR3R4, CONR3R4, SO3H, SO2-R3, SO2NR3R4 and CF3, where each of R3 and R4 is independently H or a hydrocarbyl group; A is an aryl or heteroaryl group, each of which may be optionally substituted; and B is (CH2)n where n is 0, 1, 2, 3, 4 or 5; with the proviso that: (i) when A is phenyl, n is 0, and Z is OH, X-Y is other than meta-C.ident.-C-(CH2)2CO2H, meta-C.ident.-C-(CH2)2OH, meta-C.ident.C-(CH2)2CO2Me, meta-(CH2)4CO2H, ortho-CH2CO2H, ortho-(CH2)2CO2Hand ortho-(CH2)4CO2H; and (ii) when A is phenyl, n is 0, and Z is OMe, X-Y is other than meta-C.ident.C-(CH2)4OH. Further aspects of the invention relate to the use of such compounds in the preparation of a medicament for the treatment of a muscular disorder, a gastrointestinal disorder, or for controlling spasticity or tremors.

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