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41. 发明专利

CA2515453C METHODS FOR PREVENTING AND TREATING TISSUE DAMAGE ASSOCIATED WITH ISCHEMIA-REPERFUSION INJURY 未知
公开(公告)号：CA2515453C
公开(公告)日：2013-09-24
申请号：CA2515453
申请日：2004-02-20
申请人： TANOX INC
发明人： FUNG SEK CHUNG
IPC分类号： A61K39/395 , A61K38/00 , C07K16/18
摘要： A method for preventing or treating tissue damage associated with ischemia-reperfusion injury and thoraco-abdominal aortic aneurysm (TAAA) repair by administering a tissue damage preventing or treating amount of a complement inhibitor to a patient likely to suffer from or suffering from tissue damage associated with ischemia-reperfusion injury or TAAA repair. The complement inhibitors are preferably antibodies that bind to and inhibit complement proteins involved in the formation of the membrane attach complex, preferably antibodies that inhibit MBL, MASP1, MASP2, and MASP3 in the lectin pathway. The complement inhibitors can be used alone or in combination to decrease the morbidity and mortality caused by tissue damage associated with ischemia-reperfusion injury or TAAA repair.

42. 发明专利

AU2011202021B2 High affinity anti-human IgE antibodies 未知
公开(公告)号：AU2011202021B2
公开(公告)日：2013-08-29
申请号：AU2011202021
申请日：2011-05-03
申请人： TANOX INC
发明人： FOSTER CATHERINE , SINGH SANJAYA , WU HERREN
IPC分类号： C07K16/00 , C07K16/42
摘要： High Affinity Anti-Human IgE Antibodies Abstract 5 The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

43. 发明专利

CA2524534C METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF SEPSIS 未知
公开(公告)号：CA2524534C
公开(公告)日：2012-12-11
申请号：CA2524534
申请日：2004-05-14
申请人： TANOX INC , MEDINNOVA AS
发明人： FUNG SEK CHUNG , MOLLNES TOM EIRIK
IPC分类号： A61K39/395 , A01N37/18 , A61K20060101 , A61K38/00 , A61P31/04 , C07K16/18 , C07K16/28
摘要： A method for preventing or treating sepsis by administering in conjunction a sepsis preventing or treating amount of one or more complement inhibitors and a sepsis preventing or treating amount of one or more CD14 pathway inhibitors to a patient. The complement inhibitors are preferably antibodies that bind to and inhibit complement proteins such as C5a and the CD14 pathway inhibitors are preferably antibodies that bind to and inhibit CD14 pathway components such as CD14 and LPS.

44. 发明专利

AU2004209638B2 High affinity anti-human IgE antibodies 未知
公开(公告)号：AU2004209638B2
公开(公告)日：2011-02-03
申请号：AU2004209638
申请日：2004-02-02
申请人： TANOX INC
发明人： FOSTER CATHERINE , SINGH SANJAYA , WU HERREN
IPC分类号： C07K16/00 , C07K16/42

45. 发明专利

DE60219801T2 未知
公开(公告)号：DE60219801T2
公开(公告)日：2008-01-17
申请号：DE60219801
申请日：2002-08-17
申请人： TANOX INC
发明人： FUNG MICHAEL S , SUN CECILY , LU MEISHENG , SUN WILLIAM
IPC分类号： A61K39/395 , G01N33/53 , A61K45/00 , A61P7/00 , A61P9/10 , A61P13/12 , A61P29/00 , A61P31/04 , A61P37/00 , C07K16/18 , C07K16/36 , C07K16/46 , C07K19/00 , C12N5/10 , C12N5/12 , C12P21/08
摘要： The invention relates to inhibitors that bind to C5 and C5a, but which do not prevent the activation of C5 and do not prevent formation of or inhibit the activity of C5b. One example of such an inhibitor molecule is the monoclonal antibody designated MAb137-26, which binds to a shared epitope of human C5 and C5a. These inhibitors may be used to inhibit the activity of C5a in treating diseases and conditions mediated by excessive or uncontrolled production of C5a. The inhibitor molecules are also useful for diagnostic detection of the presence/absence or amount of C5 or C5a.

46. 发明专利

DE60219801D1 未知
公开(公告)号：DE60219801D1
公开(公告)日：2007-06-06
申请号：DE60219801
申请日：2002-08-17
申请人： TANOX INC
发明人： FUNG MICHAEL S , SUN CECILY , LU MEISHENG , SUN WILLIAM
IPC分类号： A61K39/395 , G01N33/53 , A61K45/00 , A61P7/00 , A61P9/10 , A61P13/12 , A61P29/00 , A61P31/04 , A61P37/00 , C07K16/18 , C07K16/36 , C07K16/46 , C07K19/00 , C12N5/10 , C12N5/12 , C12P21/08
摘要： The invention relates to inhibitors that bind to C5 and C5a, but which do not prevent the activation of C5 and do not prevent formation of or inhibit the activity of C5b. One example of such an inhibitor molecule is the monoclonal antibody designated MAb137-26, which binds to a shared epitope of human C5 and C5a. These inhibitors may be used to inhibit the activity of C5a in treating diseases and conditions mediated by excessive or uncontrolled production of C5a. The inhibitor molecules are also useful for diagnostic detection of the presence/absence or amount of C5 or C5a.

47. 发明专利

HK1085771A1 HIGH AFFINITY ANTI-HUMAN IGE ANTIBODIES 未知
公开(公告)号：HK1085771A1
公开(公告)日：2006-09-01
申请号：HK06107957
申请日：2006-07-17
申请人： TANOX INC
发明人： SINGH SANJAYA , FOSTER CATHERINE , WU HERREN
IPC分类号： A61K20060101 , C07K16/00 , C07K16/42 , C12P20060101 , C12Q20060101 , G01N20060101

48. 发明专利

AU2006200377A1 Tissue factor antagonists and methods of use thereof 未知
公开(公告)号：AU2006200377A1
公开(公告)日：2006-02-23
申请号：AU2006200377
申请日：2006-01-27
申请人： TANOX INC
发明人： LUEPSCHEN LAWRENCE K , WONG HING C , NIEVES ESPERANZA L , TAYLOR DEAN P , JIAO JIN-AN
IPC分类号： A61K31/00

49. 发明专利

AT315643T 未知
公开(公告)号：AT315643T
公开(公告)日：2006-02-15
申请号：AT95904808
申请日：1994-11-30
申请人： TANOX INC
发明人： KIEFER MICHAEL C , BARR PHILIP J
IPC分类号： A01K67/027 , A61K38/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/85 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/53 , C12N15/12 , A61K38/17 , C12N1/21
摘要： The present invention provides a novel family of apoptosis-modulating proteins. Nucleotide and amino acid residue sequences and methods of use thereof are also provided.

50. 发明专利

CA2568427A1 METHOD FOR PREVENTING AND TREATING MAST CELL MEDIATED DISEASES 未知
公开(公告)号：CA2568427A1
公开(公告)日：2006-01-12
申请号：CA2568427
申请日：2005-05-26
申请人： TANOX INC
发明人： YAO YHENGBIN , HU GUANGHUI , WANG SHEN-WU
IPC分类号： A61K39/395
摘要： A system clock signal generator circuit comprising a first PLL circuit that is frequency and phase locked to a wobble signal; a frequency and phase comparator for comprising a first output signal from the first PLL circuit with a system clock signal as frequency divided by M and for outputting a second output signal based on the differences in frequency and in phase; a PLL filter for providing a predetermined cutoff to the second output signal to output a third output signal; a pulse width modulating circuit for generating a pulse wave, the carrier frequency of which is a second reference clock signal, and for outputting a fourth output signal obtained by modulating the pulse width of the pulse wave by the third output signal; a low pass filter for smoothing the fourth output signal to output a fifth output signal; a VCO circuit the control voltage of which is the fifth output signal; a first frequency divider circuit for frequency dividing an output signal of the VCO circuit by N to output a system clock signal; and a second frequency divider circuit for frequency dividing, by M, and feeding the system clock signal back to the frequency and phase comparator.

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