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41. 发明申请

US20100256480A1 METHODS, SYSTEMS AND DEVICES FOR LOCAL MAGNETIC RESONANCE IMAGING 有权
标题翻译：用于局部磁共振成像的方法，系统和装置
公开(公告)号：US20100256480A1
公开(公告)日：2010-10-07
申请号：US12521570
申请日：2007-12-31
申请人： Paul A. Bottomley , Shashank Sathyanarayana
发明人： Paul A. Bottomley , Shashank Sathyanarayana
IPC分类号： A61B5/055 , G01R33/48 , G01R33/32 , H01P11/00
CPC分类号： G01R33/285 , G01R33/34053 , G01R33/34084 , G01R33/3685 , G01R33/421 , G01R33/422 , G01R33/445 , G01R33/4833 , Y10T29/49016
摘要： Featured are a device with localized sensitivity to magnetic resonance signals, an imaging system using such a device and MRI methods for performing internal MRI or MRI Endoscopy. Such an MRI method includes introducing an MRI antenna or probe into the specimen to be imaged, the antenna being configured in accordance with the devices described herein, so that the spatial coordinate frame of imaging is inherently locked or defined with respect to the introduced antenna thereby providing imaging of the specimen from the point of view of the antenna. Further such imaging is conducted so that the MRI signal is confined substantially to a volume with respect to a particular region of the antenna or probe.
摘要翻译：特色是对磁共振信号具有局部敏感性的装置，使用这种装置的成像系统和用于执行内部MRI或MRI内窥镜检查的MRI方法。这样的MRI方法包括将MRI天线或探针引入待成像的样本中，天线根据本文所述的装置来配置，使得成像的空间坐标系相对于引入的天线固有地被锁定或定义，从天线的角度提供样本的成像。进一步进行这样的成像，使得MRI信号基本上被限制在相对于天线或探针的特定区域的体积。

42. 发明授权

US5192909A Spectroscopic localization using pinwheel NMR excitation pulses 失效
标题翻译：使用PINHEEL NMR激发脉冲进行光谱定位
公开(公告)号：US5192909A
公开(公告)日：1993-03-09
申请号：US637910
申请日：1991-01-07
申请人： Christopher J. Hardy , Paul A. Bottomley , Harvey E. Cline
发明人： Christopher J. Hardy , Paul A. Bottomley , Harvey E. Cline
IPC分类号： A61B5/055 , G01R33/48
CPC分类号： G01R33/446
摘要： An NMR system performs in vivo localized NMR spectroscopy. A two-dimensional selective RF excitation pulse is used to localize to a cylindrical region of interest, and either phase encoding or slice selective inversion is used to localize to a disk in the cylindrical region of interest. The two-dimensional selective RF excitation is performed in a series of pulse sequences rather than a single pulse sequence, and the resulting series of acquired NMR signals are summed together to substantially cancel signal conributions from outside the cylindrical region of interest.
摘要翻译： NMR体系进行体内局部NMR光谱。使用二维选择性RF激励脉冲来定位到感兴趣的圆柱形区域，并且使用相位编码或切片选择性反转来定位到感兴趣的圆柱形区域中的盘。二维选择性RF激励以一系列脉冲序列而不是单个脉冲序列执行，并且所得到的一系列获取的NMR信号被相加在一起以基本上消除来自感兴趣的圆柱体区域的信号。

43. 发明授权

US4973908A NMR probe with multiple isolated coplanar surface coils 失效
标题翻译：具有多个隔离的共面表面线圈的NMR探针
公开(公告)号：US4973908A
公开(公告)日：1990-11-27
申请号：US370518
申请日：1989-06-23
申请人： Paul A. Bottomley , Christopher J. Hardy
发明人： Paul A. Bottomley , Christopher J. Hardy
IPC分类号： G01R33/36 , A61B5/055 , G01R33/32 , G01R33/34 , G01R33/341
CPC分类号： G01R33/341
摘要： An NMR antenna probe has at least one substantially circular surface coil arranged in a plane and a surface coil having substantially a Figure-8 shape, substantially coplanar with the at least one circular surface coil. The Figure-8 coil has a cross-over portion which is located substantially coaxial with the axis of the at least one circular surface coil. The coil corresponding to the least-NMR-sensitive nucleus is circular, while the non-circular coil corresponds to the most-NMR-sensitive nucleus. The circular coil is positioned on the side of the NMR probe closest to the subject to be studied.

44. 发明授权

US4783641A NMR radio frequecny field coil with distributed current 失效
标题翻译：具有分布电流的NMR无线电频率场线圈
公开(公告)号：US4783641A
公开(公告)日：1988-11-08
申请号：US84774
申请日：1987-08-13
申请人： Cecil E. Hayes , Thomas K. F. Foo , William H. Perman , Paul R. Moran , Paul A. Bottomley
发明人： Cecil E. Hayes , Thomas K. F. Foo , William H. Perman , Paul R. Moran , Paul A. Bottomley
IPC分类号： G01R33/341 , H01P7/08 , H01P7/00 , G01R33/20
CPC分类号： H01P7/082 , G01R33/341
摘要： A uniform surface current density is approximated in an RF transmitting/receiving NMR coil by employing a plurality of discrete conductors having a resonantly distributed current. Inductive and capacitive lines provide a sinusoidal current distribution with various resonant modes providing different magnetic field orientations. The distributed current reduces losses. In a second order resonant mode, decoupling of the surface coil from a transmit coil is achieved without a blocking network.
摘要翻译：通过采用具有共振分布电流的多个离散导体，在RF发射/接收NMR线圈中近似均匀的表面电流密度。电感和电容线提供具有提供不同磁场取向的各种谐振模式的正弦电流分布。分布式电流降低了损耗。在二阶谐振模式中，在没有阻塞网络的情况下实现了表面线圈与发射线圈的去耦。

45. 发明授权

US4733185A Methods for localization in NMR spectroscopy 失效
标题翻译： NMR光谱定位方法
公开(公告)号：US4733185A
公开(公告)日：1988-03-22
申请号：US056513
申请日：1987-06-01
申请人： Paul A. Bottomley
发明人： Paul A. Bottomley
IPC分类号： A61B10/00 , A61B5/055 , G01R33/48 , G01R33/483 , G01R33/20
CPC分类号： G01R33/483
摘要： A method for acquiring an NMR spectroscopy response signal from a portion of a sample located in a voxel at the junction of three planar surfaces, each in a plane at an angle to the planes of the other two surfaces, first excites the sample with a localization subsequence which selects values for the surfaces in only two of the three dimensions, to evoke a chemical-shift spectrum from voxels substantially along a line at the junction of the two selected planes; and then provides a readout subsequence including a NMR signal portion spatially-selective in the third dimension and selected to limit the received spectroscopy response signal substantially to the voxel of interest. Any necessary cycling of sequences to improve spatial localization is provided in the two dimensions of the preliminary localization subsequence; phase cycling or alternation is not used in the selective RF pulse of the data acquisition subsequence. The methods provide improvements in immunity to localization artifacts, as may be produced physiological motion, or by NMR relaxation between the localization and read-out subsequences.

46. 发明授权

US4689563A High-field nuclear magnetic resonance imaging/spectroscopy system 失效
标题翻译：高场核磁共振成像/光谱系统
公开(公告)号：US4689563A
公开(公告)日：1987-08-25
申请号：US743125
申请日：1985-06-10
申请人： Paul A. Bottomley , William A. Edelstein , Howard R. Hart, Jr. , John F. Schenck , Rowland W. Redington , William M. Leue
发明人： Paul A. Bottomley , William A. Edelstein , Howard R. Hart, Jr. , John F. Schenck , Rowland W. Redington , William M. Leue
IPC分类号： G01R33/36 , G01R33/38 , G01R33/485 , G01R33/20
CPC分类号： G01R33/381 , G01R33/3607 , G01R33/485 , G01R33/3815
摘要： A magnetic resonance system for both imaging and spectroscopy of a sample of non-magnetic material (such as a portion of the human anatomy and the like) at one static magnetic field magnitude in excess of 0.7 Tesla (T), utilizes a superconducting magnet having a room-temperature bore of diameter sufficiently large to place therein not only the desired sample but also a set of gradient magnetic field-producing coils and at least one radio-frequency coil for exciting and/or receiving response signals from the sample to be examined. The entire magnetic system has suitably-small temporal and positional field variations to allow imaging to be accomplished at the resonant frequencies of nuclei including .sup.1 H, .sup.13 C, .sup.19 F, .sup.23 Na and .sup.31 P. The system includes a novel interface subsystem, itself including a novel gradient signal switching circuit, for acquiring imaging data in relatively short time intervals.
摘要翻译：在超过0.7特斯拉（T）的一个静态磁场强度下，用于非磁性材料样品（例如人体解剖结构等的一部分）的成像和光谱学的磁共振系统利用具有直径足够大的室温孔，不仅放置所需的样品，而且还设置一组梯度磁场产生线圈和至少一个用于激发和/或接收来自待检样品的响应信号的射频线圈。整个磁系统具有适当小的时间和位置场变化，以允许在包括1H，13C，19F，23Na和31P的核的共振频率下实现成像。该系统包括一个新颖的接口子系统，本身包括一个新颖的梯度信号切换电路，用于以较短的时间间隔采集成像数据。

47. 发明授权

US4614195A Method for reduction of motion artifacts in Fourier transform NMR imaging techniques 失效
标题翻译：傅里叶变换核磁共振成像技术中减少运动伪影的方法
公开(公告)号：US4614195A
公开(公告)日：1986-09-30
申请号：US683071
申请日：1984-12-18
申请人： Paul A. Bottomley , Gary H. Glover
发明人： Paul A. Bottomley , Gary H. Glover
IPC分类号： A61B10/00 , A61B5/055 , G01R33/48 , G01R33/54 , G01R33/567 , G06T1/00 , A61B5/05
CPC分类号： G01R33/482 , G01R33/56509 , G01R33/5676
摘要： A reduction in motion-induced image artifact, occurring when imaging moving subjects using Fourier transform (FT) NMR techniques, is achieved by recognizing that the greatest contribution to the artifacts is simple geometric motion (such as respiration). The method relies on avoiding the synchrony between the sequence repetition time of an FT pulse sequence, such as spin warp, and the period of the motion. In one preferred embodiment, the different amplitude values of the phase-encoding gradient are selected randomly, rather than sequentially. In another preferred embodiment, gradient amplitude values are selected by alternating high and low values in the temporal implementation of the pulse sequence.
摘要翻译：通过使用傅里叶变换（FT）NMR技术对移动物体进行成像时发生的运动诱导图像伪影的减少通过识别对人造物的最大贡献是简单的几何运动（例如呼吸）来实现。该方法依赖于避免FT脉冲序列的序列重复时间（例如自旋扭曲）与运动周期之间的同步。在一个优选实施例中，相位编码梯度的不同振幅值被随机地选择，而不是依次选择。在另一个优选实施例中，通过在脉冲序列的时间实现中交替高和低值来选择梯度振幅值。

48. 发明授权

US4585993A Method for selective NMR imaging of chemically-shifted nuclei 失效
标题翻译：化学位移核的选择性NMR成像方法
公开(公告)号：US4585993A
公开(公告)日：1986-04-29
申请号：US561381
申请日：1983-12-14
申请人： Paul A. Bottomley
发明人： Paul A. Bottomley
IPC分类号： A61B10/00 , A61B5/055 , G01N24/08 , G01R33/48 , G01R33/485 , G01R33/54 , G01R33/20
CPC分类号： G01R33/4828 , G01R33/485
摘要： A method for providing NMR images free of chemical shift artifacts, obtained from selected nuclei of a sample containing nuclei having chemically-shifted NMR frequencies is described. Non-selected nuclei of the sample are selectively saturated prior to applying an NMR imaging sequence by applying to the sample an RF pulse containing frequencies equal to the chemically-shifted frequencies of the non-selected nuclei and having a narrow frequency spectrum about the chemically-shifted frequencies. Alternatively, selected nuclei are directly excited during application of an NMR imaging sequence by applying to the sample an RF pulse containing frequencies equal to the chemically-shifted frequencies of the selected nuclei, and having a narrow frequency spectrum about the chemically-shifted frequencies so as to exclude signal contributions from the non-selected nuclei. These selective pulses are applied in the absence of the imaging magnetic field gradients.
摘要翻译：描述了提供从包含具有化学位移的NMR频率的核的样品的选定核获得的没有化学位移伪影的NMR图像的方法。在应用NMR成像序列之前，样品的未选择的核选择性饱和，通过向样品施加包含等于非选择核的化学位移频率的频率的RF脉冲，并且具有关于化学 - 移位频率。或者，通过向样品施加包含等于所选核的化学位移频率的频率并且具有关于化学位移频率的窄频谱的RF脉冲，在NMR成像序列的应用期间直接激发所选择的核以排除来自未选核的信号贡献。在不存在成像磁场梯度的情况下施加这些选择脉冲。

49. 发明授权

US4521733A NMR Imaging of the transverse relaxation time using multiple spin echo sequences 失效
标题翻译：使用多个自旋回波序列的横向弛豫时间的NMR成像
公开(公告)号：US4521733A
公开(公告)日：1985-06-04
申请号：US497358
申请日：1983-05-23
申请人： Paul A. Bottomley , William A. Edelstein
发明人： Paul A. Bottomley , William A. Edelstein
IPC分类号： G01R33/50 , G01R33/56 , G01R33/561 , G01R33/08
CPC分类号： G01R33/56 , G01R33/5615 , G01R33/50 , G01R33/5617
摘要： Improved nuclear magnetic resonance (NMR) imaging methods based on a Carr-Purcell-Meiboom-Gill (CPMG) RF pulse sequence and pulsed magnetic field gradients applied to both multiple angle projection (MAP) imaging techniques, and to the two-dimensional Fourier transform (2DFT) or spin warp imaging techniques, are disclosed. The improved methods involve the generation of multiple spin echoes induced by a repetitive sequence of phase alternated 180.degree. nonselective pulses, wherein the resulting spin echoes are used to provide substantive improvements in the pixel signal to noise ratio, and/or to generate images which reflect substantially the transverse relaxation time T.sub.2. The improved imaging methods are particularly useful when directed to the detection and localization of various disease states of biological tissue, which exhibit altered T.sub.2 relaxation times indicative of changes at the molecular level.
摘要翻译：基于Carr-Purcell-Meiboom-Gill（CPMG）RF脉冲序列和应用于多角度投影（MAP）成像技术的脉冲磁场梯度的改进的核磁共振（NMR）成像方法，以及二维傅里叶变换（2DFT）或旋转翘曲成像技术。改进的方法涉及由相位交替的180度非选择性脉冲的重复序列引起的多个自旋回波的产生，其中所产生的自旋回波用于提供像素信噪比的实质性改进和/或产生反映基本上横向弛豫时间T2。当针对生物组织的各种疾病状态的检测和定位时，改进的成像方法特别有用，其表现出改变的T2松弛时间，指示分子水平的变化。

50. 发明授权

US4480228A Selective volume method for performing localized NMR spectroscopy 失效
标题翻译：用于进行局部NMR光谱的选择体积法
公开(公告)号：US4480228A
公开(公告)日：1984-10-30
申请号：US434688
申请日：1982-10-15
申请人： Paul A. Bottomley
发明人： Paul A. Bottomley
IPC分类号： A61B10/00 , A61B5/055 , G01R33/48 , G01R33/483 , G01R33/485 , G01R33/08
CPC分类号： G01R33/4833 , G01R33/485
摘要： Selective irradiation is used to isolate a planar slice of nuclear spins in a nuclear magnetic resonance (NMR) sample. Selective radio frequecy pulses, applied in the presence of magnetic field gradients, are then employed to define a smaller sensitive volume in a predetermined region of the isolated planar slice. An NMR spin echo signal produced by excited nuclear spins situated in the thusly localized volume is observed in the absence of magnetic field gradients and, upon Fourier transformation, yields the desired localized chemical shift spectra.
摘要翻译：选择性照射用于分离核磁共振（NMR）样品中核自旋的平面切片。然后采用在存在磁场梯度的情况下应用的选择性无线电频率脉冲来在孤立平面切片的预定区域中定义较小的灵敏体积。在没有磁场梯度的情况下观察到位于如此定位的体积中的激发的核自旋产生的NMR自旋回波信号，并且在傅里叶变换后，产生期望的局部化学位移谱。

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