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41. 发明申请

WO1995009146A1 PARENTERAL NUTRIENTS BASED ON WATER SOLUBLE GLYCEROL BISACETOACETATES 审中-公开
标题翻译：基于水溶性甘油二磺酸酯的营养营养
公开(公告)号：WO1995009146A1
公开(公告)日：1995-04-06
申请号：PCT/US1994010966
申请日：1994-09-29
申请人： EASTMAN CHEMICAL COMPANY , MEDICAL COLLEGE OF OHIO
发明人： EASTMAN CHEMICAL COMPANY , MEDICAL COLLEGE OF OHIO , BIRKHAHN, Ronald, H. , CLEMENS, Robert, J. , HUBBS, John, C.
IPC分类号： C07C69/72
CPC分类号： A61K31/22 , A23L33/10 , A23V2002/00 , C07C69/72 , A23V2200/132 , A23V2250/30
摘要： Novel parenteral nutrient compositions are disclosed. These compositions are sterile aqueous solutions containing an effective amount of at least one glycerol bisacetoacetate of formula (I) wherein one R group is hydrogen, and two R groups are -(COCH2COCH3). These compositions are useful as a substitute for glucose in intravenous feeding.
摘要翻译：公开了新型肠外营养组合物。这些组合物是含有有效量的式（I）的至少一种甘油双乙酰乙酸酯的无菌水溶液，其中一个R基团是氢，两个R基团是 - （COCH 2 COCH 3）。这些组合物可用作静脉内给药中葡萄糖的替代物。

42. 发明申请

WO1995008949A1 USE OF PHOTODYNAMIC THERAPY TO TREAT PROSTATIC TISSUE 审中-公开
标题翻译：使用光化疗治疗前列腺组织
公开(公告)号：WO1995008949A1
公开(公告)日：1995-04-06
申请号：PCT/US1994007755
申请日：1994-07-08
申请人： MEDICAL COLLEGE OF OHIO
发明人： MEDICAL COLLEGE OF OHIO , SELMAN, Steven, H.
IPC分类号： A61B06/08
CPC分类号： A61K41/0057 , A61B2018/2261 , A61M25/10 , A61M2025/1075 , A61N5/0601 , A61N5/062 , A61N2005/061
摘要： The present invention provides a method for diagnosing or treating prostatic tissue in a human or animal patient which comprises sensitizing the prostatic tissue with an effective amount of a photosensitive composition which accumulates in the prostatic tissue and exposing the sensitized tissue to a source of light energy for a predetermined time and intensity sufficient to cause cellular and/or tissue function of the sensitized prostatic tissue to diminish or cease.
摘要翻译：本发明提供一种用于诊断或治疗人或动物患者中的前列腺组织的方法，其包括用有效量的积累在前列腺组织中的感光组合物对前列腺组织进行敏化，并将敏化组织暴露于光能来源足以引起致敏的前列腺组织的细胞和/或组织功能减少或停止的预定时间和强度。

43. 发明申请

WO2003080646A2 MODIFIED PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 AND METHODS BASED THEREON 审中-公开
标题翻译：改良的PLASMINOGEN激活剂抑制剂类型1及其方法
公开(公告)号：WO2003080646A2
公开(公告)日：2003-10-02
申请号：PCT/US2003/006679
申请日：2003-03-04
申请人： MEDICAL COLLEGE OF OHIO , SWIERCZ, Rafal , SELMAN, Steven, H. , JANKUN, Jerzy
发明人： SWIERCZ, Rafal , SELMAN, Steven, H. , JANKUN, Jerzy
IPC分类号： C07K
CPC分类号： C07K14/8132 , A61K38/00
摘要： The present invention is based upon the discovery that modified plasminogen activator inhibitor type-I (PAI-1) in which two or more amino acid residues that do not contain a sulfliydryl group have been replaced with amino acid residues that contain a sulfhydryl group and, therefore, forms intramolecular disulfide bonds, have increased in vivo half-life. Also disclosed are the modified PAI-1 proteins, derivatives and analogs thereof, specific antibodies, nucleic acid molecules and host cells. Methods for producing modified PAI-1, derivatives and analogs are also provided. The invention further relates to Therapeutics, pharmaceutical compositions and method of using the composition for treatment. The invention may be used to inhibit angiogenesis in a subject, thereby treating diseases or conditions associated with undesired angiogenesis and cell proliferation. Such conditions include psoriasis, chronic inflammation, tumor invasion and metastasis and conditions in which angiogenesis is pathogenic. The modified PAI-1 molecules of the present invention are useful for the treatment, prophylaxis, management and amelioration of cardiovascular diseases such as, but not limited to those that are related to hyerfibrinolysis, hemophilia, and vessel leakage syndrome.
摘要翻译：本发明基于以下发现：其中两个或更多个不含磺酰基基团的氨基酸残基已经被含有巯基的氨基酸残基替代的修饰的纤溶酶原激活物抑制剂I型（PAI-1）因此，形成分子内二硫键，体内半衰期有所增加。还公开了修饰的PAI-1蛋白，其衍生物和类似物，特异性抗体，核酸分子和宿主细胞。还提供了生产改性PAI-1，衍生物和类似物的方法。本发明还涉及使用该组合物进行治疗的治疗剂，药物组合物和方法。本发明可以用于抑制受试者的血管生成，从而治疗与不期望的血管生成和细胞增殖相关的疾病或病症。这些病症包括牛皮癣，慢性炎症，肿瘤浸润和转移以及血管发生是致病性的病症。本发明的修饰的PAI-1分子可用于治疗，预防，治疗和改善心血管疾病，例如但不限于与血纤维蛋白溶解，血友病和血管渗漏综合征相关的那些。

44. 发明申请

WO0032209A3 SUBMUCOSA MODULATION OF MAMMALIAN IMMUNE RESPONSE 审中-公开
标题翻译：潜蝇对哺乳动物免疫应答的调节
公开(公告)号：WO0032209A3
公开(公告)日：2000-12-28
申请号：PCT/US9928302
申请日：1999-12-01
申请人： PURDUE RESEARCH FOUNDATION , MEDICAL COLLEGE OF OHIO AT TOL , BADYLAK STEPHEN F , MCPHERSON TIMOTHY B , METZGER DENNIS
发明人： BADYLAK STEPHEN F , MCPHERSON TIMOTHY B , METZGER DENNIS
IPC分类号： A61K35/12 , A61K35/34 , A61K35/36 , A61K35/38 , A61P37/06
CPC分类号： A61K35/38
摘要： A composition and method for locally suppressing the cell mediated immune response of a vertebrate species is described. The method comprises contacting the site in need of immune suppression with a composition comprising vertebrate submucosa.
摘要翻译：描述了用于局部抑制脊椎动物物种的细胞介导的免疫应答的组合物和方法。该方法包括使需要免疫抑制的部位与包含脊椎动物粘膜下层的组合物接触。

45. 发明申请

WO1994000118A1 PRODUCTION AND USE OF IMINES OF PORPHYRINS 审中-公开
标题翻译：生产和使用吡啶的方法
公开(公告)号：WO1994000118A1
公开(公告)日：1994-01-06
申请号：PCT/US1993005727
申请日：1993-06-16
申请人： THE UNIVERSITY OF TOLEDO , MEDICAL COLLEGE OF OHIO
发明人： THE UNIVERSITY OF TOLEDO , MEDICAL COLLEGE OF OHIO , SKALKOS, Dimitris , SELMAN, Steven, H. , HAMPTON, James, A.
IPC分类号： A61K31/40
CPC分类号： C07D487/22 , A61K31/40 , A61K31/555
摘要： Purified imines of porphyrins, chlorins, bacteriochlorins, chlorophylls, bacteriochlorophylls, purpurins, reduced purpurins, verdins, Diels Alder adducts, benzochlorins and metal complexes of the foregoing imines are disclosed. The formulas of the benzochlorinimines and of the benzochlorinimine metal complexes are set forth (1) and (2). In specific examples, M in the metal complexes is a copper cation that is complexed with two of the nitrogens of the benzochlorinimine R' and R"" are methyl, and R1 through R8 are ethyl.
摘要翻译：公开了卟啉，二氢卟酚，细菌二氢卟酚，叶绿素，细菌叶绿素，紫草素，还原紫草素，葡蛋白，狄尔斯lder木加合物，苯并二氢卟酚和前述亚胺的金属络合物的亚胺。（1）和（2）列出了苯并氯嘧啶和苯并氯亚胺金属络合物的配方。在具体实例中，金属络合物中的M是与两个苯并氯嘧啶R'的氮络合的铜阳离子，R“”是甲基，R 1至R 8是乙基。

46. 发明授权

EP0998581B1 METHOD FOR QUANTITATIVE MEASUREMENT OF GENE EXPRESSION USING MULTIPLEX COMPETITIVE REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION 失效
标题翻译：法进行基因表达的定量测定使用MULTIPLEXING COMPETITIVEN逆转录聚合酶链反应
公开(公告)号：EP0998581B1
公开(公告)日：2004-05-19
申请号：EP98929076.2
申请日：1998-06-15
申请人： MEDICAL COLLEGE OF OHIO
发明人： WILLEY, James, C. , CRAWFORD, Erin, L. , DEMUTH, Jeffery, P. , JACKSON, Clara, M. , WEAVER, David, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , B01D57/02 , C12Q1/686 , C12Q2531/113 , C12Q2545/107 , C12Q2525/204 , C12Q2537/143 , C12Q2521/107

47. 发明公开

EP0998581A2 METHOD FOR QUANTITATIVE MEASUREMENT OF GENE EXPRESSION USING MULTIPLEX COMPETITIVE REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION 失效
标题翻译：法进行基因表达的定量测定使用MULTIPLEXING COMPETITIVEN逆转录聚合酶链反应
公开(公告)号：EP0998581A2
公开(公告)日：2000-05-10
申请号：EP98929076.2
申请日：1998-06-15
申请人： MEDICAL COLLEGE OF OHIO
发明人： WILLEY, James, C. , CRAWFORD, Erin, L. , DEMUTH, Jeffery, P. , JACKSON, Clara, M. , WEAVER, David, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , B01D57/02 , C12Q1/686 , C12Q2531/113 , C12Q2545/107 , C12Q2525/204 , C12Q2537/143 , C12Q2521/107
摘要： A method and apparatus for quantitative measurement of gene expression through multiplex competitive reverse transcriptase polymerase chain reaction amplification are disclosed. The method and apparatus are especially useful for analysis of small specimens of cells and tissues.

48. 发明公开

EP0728214A1 STABLE CELL LINES CAPABLE OF EXPRESSING THE ADENO-ASSOCIATED VIRUS REPLICATION GENE 失效
标题翻译：稳定的细胞系，将能够给复制基因ADENOASSOZIERTENVIRUS来表达
公开(公告)号：EP0728214A1
公开(公告)日：1996-08-28
申请号：EP95900505.0
申请日：1994-11-03
申请人： MEDICAL COLLEGE OF OHIO , TARGETED GENETICS CORPORATION
发明人： TREMPE, James, P. , YANG, Qicheng
IPC分类号： C12N15 , C07K14 , C12N5 , C12N7 , C12P21 , C12R1
CPC分类号： C12N15/86 , C12N2750/14143
摘要： Stable packaging cell lines derived from human 293 cells which are transfected with an AAV vector having the AAV rep gene operably linked to a heterologous transcription promoter, such as the metallothionein promoter, or an AAV Rep78 insensitive homologous promoter and which are capable of producing AAV Rep proteins and being useful for packaging recombinant AAV vectors containing target polynucleotides.

49. 发明授权

EP0256036B1 PRODUCTION AND USE OF PURPURINS, CHLORINS AND PURPURIN- AND CHLORIN-CONTAINING COMPOSITIONS 有权
标题翻译：丙酮，氯林和含有丙酮和氯的组合物的生产和使用
公开(公告)号：EP0256036B1
公开(公告)日：1993-04-07
申请号：EP87900613.8
申请日：1986-12-31
申请人： THE UNIVERSITY OF TOLEDO , THE MEDICAL COLLEGE OF OHIO , SAINT VINCENT MEDICAL CENTER
发明人： MORGAN, Alan, R. , SELMAN, Steven, H. , KREIMER-BIRNBAUM, Martha
IPC分类号： A61K31/40 , C07D487/22
CPC分类号： C07D487/22 , A61K31/40 , C07D519/00
摘要： A family of chlorins, a family of purpurins and metal complexes thereof are disclosed. The purpurins have the formula of Fig. 5 of the attached drawings; their metal complexes have the formula of Fig. 1. The chlorins have the formula of Fig. 6 of the attached drawings; their metal complexes have the formula of Fig. 2. Solutions of the purpurins, chlorins and metal complexes which are physiologically acceptable for intravenous administration are also disclosed, as are emulsions or suspensions of the solutions. The solvent for the solutions can be a product of the reaction of ethylene oxide with castor oil. A method for detecting and treating tumors in human and animal patients is also disclosed. The method comprises administering one of the purpurins, chlorins or metal complexes to the patient. For detection, the tumor area is then illuminated with ultra violet light; for treatment, the tumor area is illuminated with visible light of a wavelength at which the purpurin, chlorin or complex administered shows an absorption peak.

50. 发明公开

EP0189326A3 Derivatives of arginine vasopressin antagonists 失效
标题翻译： ARGININE VASOPRESSIN拮抗剂的衍生物
公开(公告)号：EP0189326A3
公开(公告)日：1988-10-26
申请号：EP86300463
申请日：1986-01-23
申请人： Medical College of Ohio , The Trustees of Columbia University
发明人： Manning, Maurice , Sawyer, Wilbur Henderson
IPC分类号： C07K07/16
CPC分类号： C07K7/16 , A61K38/00 , Y10S514/807 , Y10S930/15
摘要： Compounds acting as antagonists of the antidiuretic/ and or vasopressor activity of arginine vasopressin have the formula
wherein n is 4 or 5; X is (D- or L-)Tyr (R), (in which R is C 1 -C 4 alkyl, D-Phe, D-Val, D-Leu, D-Ile, D-Nva, D-Nle, D-Cha, D-Abu, D-Thr, D-Asn, D-Gln or D-Met; Y is Val, Ile, Thr, Ala, Lys, Cha, Nva, Met, Nle, Orn, Ser, Asn, Gin, Phe, Tyr, Gly, Abu or Leu; Z is (D-or L-)Arg, Orn or Lys; and Q is Orn(NH 2 ), NHCH 2 CH 2 NH 2 Val(NH 2 ), Phe(NH 2 ), Ile(NH 2 ), Thr(NH 2 ), Pro(NH 2 ) or Tyr(NH 2 ), provided that when Y is Val or Gin, R is also H.

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