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41. 发明申请

US20100087011A1 Detection and/or Characterisation of Oligomers 审中-公开
标题翻译：低聚物的检测和/或表征
公开(公告)号：US20100087011A1
公开(公告)日：2010-04-08
申请号：US12531419
申请日：2008-03-17
申请人： Matthew Cooper
发明人： Matthew Cooper
IPC分类号： G01N33/53 , G06F19/00
CPC分类号： G01N29/022 , G01N29/036 , G01N29/4418 , G01N29/4454 , G01N33/54373 , G01N2291/012 , G01N2291/015 , G01N2291/018 , G01N2291/0255 , G01N2291/0256 , G01N2291/02809 , G01N2333/4709 , G01N2800/2821 , G01N2800/2828 , G01N2800/2835
摘要： Disclosed is a method of detecting the presence of an oligomer analyte in a liquid sample, the method comprising the steps of: (a) contacting a sample comprising the oligomer or aggregate with an oscillating sensor surface, which surface may optionally be coated with a receptor that binds directly or indirectly to at least one component of the oligomer or aggregate, so as to cause direct or indirect binding of the oligomer or aggregate to the surface; (b) using a detection circuit to measure or calculate at least two of the following parameters: series resonance frequency (f0), and hence the series resonance frequency shift (ΔF); motional resistance (RM), and hence the motional resistance shift ΔR; motional inductance (LM); motional capacitance (CM); parallel capacitance (C0); frequency half-band half-width (Γ); Q-factor (=f/(2Γ); dissipative factor (1/Q); impedance or admittance phase (φ) and hence phase shift (Δφ); and impedance or admittance amplitude (Z, or Y) and hence amplitude change (ΔZ, or ΔY); (c) and analysing the calculated values to derive data which vary according to the presence and/or amount of oligomer in the sample; (d) and, optionally, repeating the measurements continuously or intermittently to derive data which vary according to the presence and/or amount of oligomer or aggregate in the sample to be calculated as a function of elapsed time.
摘要翻译：公开了一种检测液体样品中低聚物分析物的存在的方法，该方法包括以下步骤：（a）使包含低聚物或聚集体的样品与振荡传感器表面接触，该表面可任选地被一个受体其直接或间接地结合至低聚物或聚集体的至少一种组分，以便使低聚物或聚集体与表面直接或间接结合; （b）使用检测电路来测量或计算以下参数中的至少两个：串联谐振频率（f0），因此串联谐振频移（＆Dgr; F）; 运动阻力（RM），因此运动阻力位移＆Dgr; R; 运动电感（LM）; 运动电容（CM）; 并联电容（C0）; 频率半带半宽（＆Ggr;）; Q因子（= f /（2＆Ggr;）;耗散因子（1 / Q）;阻抗或导纳相位（＆phgr），因此相移（＆Dgr;＆phgr;）;阻抗或导纳幅度（Z或Y）因此振幅变化（＆Dgr; Z，或＆Dgr; Y）;（c）并分析计算值以导出根据样品中低聚物的存在和/或量而变化的数据;（d）和任选地重复测量连续或间歇地导出根据待测时间的函数计算的样品中低聚物或聚集体的存在和/或量的变化而变化的数据。

42. 发明申请

US20090275721A1 Coating Surfaces 审中-公开
标题翻译：涂层表面
公开(公告)号：US20090275721A1
公开(公告)日：2009-11-05
申请号：US12225107
申请日：2007-03-16
申请人： Matthew Cooper , Xin Li
发明人： Matthew Cooper , Xin Li
IPC分类号： B05D3/00 , C07K17/08
CPC分类号： G01N33/54353 , C08B37/0021 , C08H1/00 , C09D105/02 , C09D189/00
摘要： Disclosed is a method of attaching, indirectly, a member of a specific binding pair (or sbp) to a surface, the method comprising the steps of: (a) contacting the surface with a solution, preferably an aqueous solution, of a polymer, having side chains according to the formula X-Y-Z-R, wherein X is a spacer group; Y is a sulphur, selenium or tellurium atom; Z is a sulphur, selenium or tellurium atom, any of which may be bonded to one or two oxygen atoms; and wherein R is any suitable moiety such that -Z-R constitutes a leaving group; such that at least some of the -Z-R groups are displaced and the polymer becomes bound to the surface by X-Y groups; and (b) contacting a polymer-coated surface resulting from step (a) with a solution, preferably an aqueous solution, comprising an sbp member, so as to cause the polymer to react with the sbp member, so as to attach the sbp member, indirectly, to the surface.
摘要翻译：公开了一种将特定结合对（或sbp）的成员间接附着到表面的方法，所述方法包括以下步骤：（a）使表面与聚合物的溶液，优选水溶液接触，具有根据式XYZR的侧链，其中X是间隔基; Y是硫，硒或碲原子; Z是硫，硒或碲原子，其中任何一个可以键合到一个或两个氧原子上; 并且其中R是任何合适的部分，使得-Z-R构成离去基团; 使得-Z-R基团中的至少一些位移并且聚合物通过X-Y基团与表面结合; 和（b）使由步骤（a）得到的聚合物涂覆的表面与包含sbp构件的溶液，优选水溶液接触，以使聚合物与sbp构件反应，从而将sbp构件，间接地到表面。

43. 发明授权

US07440947B2 System and method for identifying query-relevant keywords in documents with latent semantic analysis 有权
标题翻译：在具有潜在语义分析的文档中识别查询相关关键词的系统和方法
公开(公告)号：US07440947B2
公开(公告)日：2008-10-21
申请号：US10987377
申请日：2004-11-12
申请人： John E. Adcock , Matthew Cooper , Andreas Girgensohn , Lynn D. Wilcox
发明人： John E. Adcock , Matthew Cooper , Andreas Girgensohn , Lynn D. Wilcox
IPC分类号： G06F7/00
CPC分类号： G06F17/2795 , G06F17/2785 , G06F17/30613 , Y10S707/99933 , Y10S707/99936 , Y10S707/99937
摘要： A system and method for identifying query-related keywords in documents found in a search using latent semantic analysis. The documents are represented as a document term matrix M containing one or more document term-weight vectors d, which may be term-frequency (tf) vectors or term-frequency inverse-document-frequency (tf-idf) vectors. This matrix is subjected to a truncated singular value decomposition. The resulting transform matrix U can be used to project a query term-weight vector q into the reduced N-dimensional space, followed by its expansion back into the full vector space using the inverse of U.To perform a search, the similarity of qexpanded is measured relative to each candidate document vector in this space. Exemplary similarity functions are dot product and cosine similarity. Keywords are selected with the highest values in qexpanded that are also comprised in at least one document. Matching keywords from the query may be highlighted in the search results.
摘要翻译：用于使用潜在语义分析在搜索中发现的文档中识别查询相关关键字的系统和方法。这些文件被表示为包含一个或多个文档术语权重向量d的文档术语矩阵，其可以是术语频率（tf）向量或术语频率逆文档频率（tf） -idf）载体。该矩阵经受截断的奇异值分解。所得到的变换矩阵 U可用于将查询项权重向量q投影到缩小的N维空间中，然后使用 U。为了执行搜索，相对于该空间中的每个候选文档向量测量q _{expanded 的相似度。示例性相似度函数是点积和余弦相似度。关键字被选择，其中也包含在至少一个文档中的q 扩展的最高值。查询中的匹配关键字可能会在搜索结果中突出显示。}

44. 发明申请

US20080026486A1 Assay Methods, Materials and Preparations 审中-公开
标题翻译：测定方法，材料和制剂
公开(公告)号：US20080026486A1
公开(公告)日：2008-01-31
申请号：US11662081
申请日：2005-09-08
申请人： Matthew Cooper , Xin Li
发明人： Matthew Cooper , Xin Li
IPC分类号： C08B37/00 , A61K41/00 , G01N33/543
CPC分类号： C08B37/0021 , C08B5/02 , C08B11/12 , C08B37/0039 , C08B37/0072 , C08F228/02 , C08F228/06 , C08L1/18 , C08L1/286 , C08L5/02 , C08L5/08 , C08L5/12 , G01N33/54373 , Y10T428/31678 , Y10T428/31971
摘要： Disclosed is a polymer comprising covalently bound side chains of the formula —X—Y—Z—R wherein X is a spacer group; is a sulphur, selenium or tellurium atom; Z is a sulphur, selenium or tellurium atom any of which may be bonded to one or two oxygen atoms; and wherein R is any suitable moiety such that —Z—R constitutes a leaving group.
摘要翻译：公开了包含式-X-Y-Z-R的共价结合侧链的聚合物，其中X是间隔基; 是硫，硒或碲原子; Z是硫，硒或碲原子，其中任何一个可以键合到一个或两个氧原子上; 并且其中R是任何合适的部分，使得-Z-R构成离去基团。

45. 发明申请

US20070153128A1 Smart cable for controlling video capture device 有权
标题翻译：用于控制视频采集设备的智能电缆
公开(公告)号：US20070153128A1
公开(公告)日：2007-07-05
申请号：US11324859
申请日：2006-01-04
申请人： John Adcock , Laurent Denoue , David Hilbert , Matthew Cooper
发明人： John Adcock , Laurent Denoue , David Hilbert , Matthew Cooper
IPC分类号： H04N5/268
CPC分类号： G11B31/00 , G11B33/10
摘要： An element, such as a plug on a VGA cable, can communicate with a media storage unit to enable or disable media storage.
摘要翻译：诸如VGA电缆上的插头的元件可以与媒体存储单元通信以启用或禁用媒体存储。

46. 发明申请

US20070072175A1 Nucleotide array containing polynucleotide probes complementary to, or fragments of, cynomolgus monkey genes and the use thereof 审中-公开
标题翻译：含有与食蟹猴基因互补或片段的多核苷酸探针的核苷酸阵列及其用途
公开(公告)号：US20070072175A1
公开(公告)日：2007-03-29
申请号：US11433832
申请日：2006-05-15
申请人： Matthew Cooper , Deborah Kinch , Michael Rosenberg , S. Subramaniam , Suzanne Szak , Huo Li , Raj Bandaru , Maher Derbel
发明人： Matthew Cooper , Deborah Kinch , Michael Rosenberg , S. Subramaniam , Suzanne Szak , Huo Li , Raj Bandaru , Maher Derbel
IPC分类号： C12Q1/70 , C12Q1/68 , C12M3/00
CPC分类号： C12Q1/6876 , C12Q1/6837 , C12Q2600/158
摘要： This invention relates to a nucleotide array containing polynucleotide probes complementary to, or fragments of, Cynomolgus monkey genes, and the use of such a nucleotide array to characterize the biological effects, including the actions, targets, and toxicities, of therapeutic agents in primates, e.g., a human, a Cynomolgus monkey, or a Rhesus monkey, in particular a nucleotide array to be used in identifying the toxicities of therapeutic agents administered to a non-human primate, e.g., a Cynomolgus monkey or a Rhesus monkey.
摘要翻译：本发明涉及含有与食蟹猴基因互补或片段的多核苷酸探针的核苷酸阵列，以及使用这种核苷酸阵列来表征灵长类动物中治疗剂的生物学作用，包括其作用，靶标和毒性，例如人，食蟹猴或恒河猴，特别是用于鉴定施用于非人灵长类动物（例如食蟹猴或恒河猴）的治疗剂的毒性的核苷酸阵列。

47. 发明公开

US20230314657A1 Climate risk and impact analytics at high spatial resolution and high temporal cadence 审中-公开
公开(公告)号：US20230314657A1
公开(公告)日：2023-10-05
申请号：US18129862
申请日：2023-04-02
申请人： Tristan Ballard , Matthew Cooper , Gopal Erinjippurath
发明人： Tristan Ballard , Matthew Cooper , Gopal Erinjippurath
IPC分类号： G01W1/10
CPC分类号： G01W1/10
摘要： Environmental information combined with satellite driven observations and ground observations to create a predictor for wildfire at high spatial resolution. Temperature and precipitation are bias corrected using modeling and processing techniques driven from reanalysis datasets. Such techniques can be used to provide projections of future climate risk data at high temporal cadence over individual addresses or over large regions using spatial aggregation using polygon processing techniques.

48. 发明申请

US20140099071A1 Systems and Methods for Instructional Video Navigation and Note Taking 有权
标题翻译：教学视频导航系统与方法及注意事项
公开(公告)号：US20140099071A1
公开(公告)日：2014-04-10
申请号：US13647248
申请日：2012-10-08
申请人： John Adcock , Scott Carter , Matthew Cooper , Laurent Denoue
发明人： John Adcock , Scott Carter , Matthew Cooper , Laurent Denoue
IPC分类号： H04N9/87
CPC分类号： H04N9/87 , H04N5/76 , H04N5/783 , H04N21/4334 , H04N21/44218 , H04N21/47217 , H04N21/8455 , H04N21/8456
摘要： A method for navigating instructional video presentations is disclosed. The method includes determining a pause mode of a video presentation, and playing the video presentation on a display device. The video presentation has one or more predetermined pause positions. The method also includes, while playing the video presentation, determining that the video presentation has reached one of the one or more pause positions. The method further includes, in accordance with a determination that the video presentation is in a first pause mode, pausing the video presentation at the one of the one or more pause positions and maintaining a display of a paused frame of the video presentation, and, in accordance with a determination that the video presentation is in a second pause mode distinct from the first pause mode, continuing to play the video presentation through the one of the one or more pause positions.
摘要翻译：公开了用于导航教学视频演示的方法。该方法包括确定视频呈现的暂停模式，以及在显示装置上播放视频呈现。视频呈现具有一个或多个预定的暂停位置。该方法还包括在播放视频呈现时确定视频呈现已经达到一个或多个暂停位置中的一个。所述方法还包括：根据所述视频呈现处于第一暂停模式的确定，暂停所述一个或多个暂停位置中的所述一个或多个暂停位置中的所述一个处的所述视频呈现，并且保持所述视频呈现的暂停帧的显示，根据与第一暂停模式不同的第二暂停模式的确定，继续通过一个或多个暂停位置中的一个播放视频呈现。

49. 发明授权

US08556323B2 Motor vehicle seat 有权
标题翻译：汽车座椅
公开(公告)号：US08556323B2
公开(公告)日：2013-10-15
申请号：US12746361
申请日：2008-11-27
申请人： Ralf Hoge , Karim El Benaye , Lip-Min Ng , Matthew Cooper , Johan Skrabala
发明人： Ralf Hoge , Karim El Benaye , Lip-Min Ng , Matthew Cooper , Johan Skrabala
IPC分类号： B60N2/02
CPC分类号： B60N2/309 , B60N2/12 , B60N2/3045 , B60N2/3047
摘要： A folding seat arrangement comprising a first carrying structure (2) having a backrest (3) and guiding elements (11) for the removable attachment in guide rails (9) to a vehicle floor, a second carrying structure (5) pivotally mounted to the first carrying structure (2) and having a seat cushion (4), and a supporting structure (6; 31), on which in a first end region guiding elements (10) are provided for the removable attachment in guide rails (9) and which in a second region is mounted a carrying structure (2; 5) in an articulated manner such that the seat arrangement in the folded setting requires the least amount of space in the lower region of the expanded luggage compartment. This is achieved in that the guiding elements (11) on the first carrying structure (2) and the supporting structure (6; 31) can be moved relative to one another to pivot the supporting structure (6; 31).
摘要翻译：一种折叠座椅装置，包括具有靠背（3）的第一承载结构（2）和用于在车辆地板上的导轨（9）中的可移除附件的引导元件（11），第二承载结构（5），枢转地安装到第一承载结构（2）并具有座垫（4）和支撑结构（6; 31），在第一端部区域中设有引导元件（10），用于在导轨（9）中的可移除附件和其在第二区域中以铰接方式安装承载结构（2; 5），使得在折叠设置中的座椅装置在扩展的行李箱的下部区域中需要最少的空间。这是通过使第一承载结构（2）和支撑结构（6; 31）上的引导元件（11）相对于彼此移动以使支撑结构（6; 31）枢转来实现的。

50. 发明申请

US20130029350A1 BI-STABLE OSCILLATOR 有权
标题翻译：双稳态振荡器
公开(公告)号：US20130029350A1
公开(公告)日：2013-01-31
申请号：US13574135
申请日：2011-01-19
申请人： Matthew Cooper , Alexander Sleptsov , Richard John Hammond
发明人： Matthew Cooper , Alexander Sleptsov , Richard John Hammond
IPC分类号： G01N27/00 , G01N33/48
CPC分类号： H03B5/32 , G01N29/022 , G01N2291/02466
摘要： In accordance with the present invention there is provided a bi-stable oscillator circuit for detecting a load imparted to a surface. The bi-stable oscillator comprises an electrical amplifier, at least one resonator comprising an electrical transducer having a resonant frequency, a surface of the resonator forming the surface on which the load is to be detected and an impedance network having a resonant frequency. The resonator is arranged to be exposed to an environment under test, and the resonator and the impedance network are connected in parallel with the electrical amplifier such that when a load imparted to the surface exceeds a pre-determined threshold value the oscillator circuit oscillates at the resonant frequency of the impedance network and when a load imparted to the surface is less than the threshold value the oscillator circuit oscillates at the resonant frequency of the resonator, switching of the circuit oscillation frequency being indicative of the load crossing the predetermined threshold value.
摘要翻译：根据本发明，提供一种用于检测施加到表面的负载的双稳态振荡器电路。所述双稳态振荡器包括电放大器，至少一个谐振器包括具有谐振频率的电变换器，谐振器的形成要在其上检测负载的表面的表面和具有谐振频率的阻抗网络。谐振器被布置为暴露于被测环境，并且谐振器和阻抗网络与电放大器并联连接，使得当施加到表面的负载超过预定阈值时，振荡器电路在阻抗网络的谐振频率和施加到表面的负载小于阈值时，振荡器电路以共振器的谐振频率振荡，电路振荡频率的切换指示负载超过预定阈值的负载。

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