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41. 发明申请

US20060121467A1 Method and nucleic acids for the improved treatment of breast cell proliferative disorders 有权
标题翻译：用于改善乳腺增生性疾病治疗的方法和核酸
公开(公告)号：US20060121467A1
公开(公告)日：2006-06-08
申请号：US10517741
申请日：2003-10-01
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Armin Schmitt , Manfred Schmitt , Maxime Look , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Armin Schmitt , Manfred Schmitt , Maxime Look , Almuth Marx , Heinz Hoefler
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译：本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与乳腺组织的细胞增殖性病症的反应的方法，进行内分泌治疗。

42. 发明申请

US20060084056A1 Methods for selecting treatment regimens and predicting outcomes in cancer patients 审中-公开
标题翻译：选择治疗方案和预测癌症患者结局的方法
公开(公告)号：US20060084056A1
公开(公告)日：2006-04-20
申请号：US10504287
申请日：2003-02-13
申请人： Nadia Harbeck , Manfred Schmitt , John Foekens , Ronald Kates
发明人： Nadia Harbeck , Manfred Schmitt , John Foekens , Ronald Kates
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57415 , G01N2800/52 , Y02A90/26
摘要： The present invention relates to methods for determining a treatment regimen beyond surgical removal of tumor tissue for node negative or node positive breast cancer patient. The method comprises measuring the levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in a subject, preferably a tumor; and, based upon the values, predicting the expected benefit including disease-free survival and/or overall survival for the patient without treatment (beyond the surgical removal of tumor tissue) or with a particular treatment and using that information to select a treatment regimen for the subject. High risk subject is identified by high levels of both uPA and PAI-1, high level of uPA and low level of PAI-1 or, low level of uPA and high level of PAI-1. Treatment options for high risk subjects include, but are not limited to, adjuvant CMF chemotherapy, adjuvant non-CMF chemotherapy, adjuvant endocrine therapy, adjuvant anthracyclin-containing chemotherapy, radiation therapy, and gene therapy. Treatment options for low risk subjects include, but are not limited to, no treatment, radiation, and adjuvant endocrine therapy.
摘要翻译：本发明涉及用于确定除了手术切除淋巴结阴性或淋巴结阳性乳腺癌患者的肿瘤组织之外的治疗方案的方法。该方法包括测量受试者，优选肿瘤中尿激酶型纤溶酶原激活物（uPA）和纤溶酶原激活物抑制剂-1（PAI-1）的水平; 并且基于这些值，预测未经治疗的患者（超过手术切除肿瘤组织）或特定治疗的患者的无病生存期和/或总生存期的预期益处，并且使用该信息来选择治疗方案主题。 uPA和PAI-1水平高，uPA水平高，PAI-1水平低，uPA水平低，PAI-1水平高。高风险患者的治疗方案包括但不限于辅助性CMF化疗，辅助性非CMF化疗，辅助内分泌治疗，含蒽环类化疗，放射治疗和基因治疗。低风险患者的治疗方案包括但不限于治疗，放射和辅助内分泌治疗。

43. 发明申请

US20060024684A1 Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients 审中-公开
公开(公告)号：US20060024684A1
公开(公告)日：2006-02-02
申请号：US11011332
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Aspects of the present invention provide compositions and methods for prognosis of, and/or predicting the estrogen treatment outcome of breast cell proliferative disorder patients, and in particular of patients with breast carcinoma. In preferred embodiments, this is achieved, at least in part, by determining the expression level of PITX2, and/or the genetic or the epigenetic modifications of the genomic DNA associated with the gene PITX2. Additional aspects of the invention provide novel sequences, oligomers (e.g., oligonucleotides or peptide nucleic acid (PNA)-oligomers), and antibodies, which have substantial utility in the described inventive methods and compositions.

44. 发明申请

US20050205683A1 Cooling circuit for an internal combustion engine 审中-公开
标题翻译：内燃机冷却回路
公开(公告)号：US20050205683A1
公开(公告)日：2005-09-22
申请号：US10507038
申请日：2003-02-18
申请人： Manfred Schmitt , Karsten Mann , Oliver Kaefer , Herbert Windisch
发明人： Manfred Schmitt , Karsten Mann , Oliver Kaefer , Herbert Windisch
IPC分类号： F01P3/02 , F01P5/10 , F01P7/14 , F01P7/16 , B60H1/02
CPC分类号： F01P7/165 , F01P7/162 , F01P2003/024 , F01P2005/105 , F01P2007/146 , F01P2037/02 , F01P2060/08
摘要： A cooling circuit for an internal combustion engine includes a first coolant circuit and a second coolant circuit, the cooling circuit being able to be operated by a distributor so that the internal combustion engine reaches its operating temperature as quickly as possible, and a heat exchanger used to heat the vehicle interior is operational as quickly as possible. The return channel from the second coolant circuit is connectable to either the return channel or the flow channel of the first coolant circuit.
摘要翻译：用于内燃机的冷却回路包括第一冷却剂回路和第二冷却剂回路，该冷却回路能够由分配器操作，使得内燃机尽可能快地达到其工作温度，并使用热交换器加热车辆内部尽可能快地运行。来自第二冷却剂回路的返回通道可连接到第一冷却剂回路的返回通道或流动通道。

45. 发明授权

US06900561B2 Electric machine, especially a generator for motor vehicles 有权
标题翻译：电机，特别是汽车发电机
公开(公告)号：US06900561B2
公开(公告)日：2005-05-31
申请号：US10399837
申请日：2002-06-20
申请人： Johannes Vlemmings , Manfred Schmitt , Karsten Mann , Oliver Kaefer
发明人： Johannes Vlemmings , Manfred Schmitt , Karsten Mann , Oliver Kaefer
IPC分类号： H02K5/18 , H02K5/20 , H02K9/19 , H02K9/00
CPC分类号： H02K5/20 , H02K5/18
摘要： An electric machine, particularly a generator for motor vehicles, includes a housing and a casing enclosing the housing concentrically, the casing, together with the housing, bounding an annular space that is sealed in a fluid-tight manner and is connected to a coolant outflow and a coolant inflow. To achieve a uniform circumflow of the housing with sufficient cooling capacity, even given low volumetric flow of the coolant, a plurality of axial guide bars are arranged in the annular space, so that the coolant restrictedly flows in an axially wide-strip manner through the annular space within space segments arranged in a row in the circumferential direction, with an opposing flow direction in successive space segments.
摘要翻译：一种电动机，特别是用于机动车辆的发电机，包括壳体和壳体，其同心地围绕壳体，壳体与壳体一起限定环形空间，该环形空间以流体密封的方式被密封并连接到冷却剂流出和冷却剂流入。为了实现具有足够的冷却能力的壳体的均匀的环流，即使给定冷却剂的低体积流量，多个轴向导杆布置在环形空间中，使得冷却剂以轴向宽带方式受限地流过在圆周方向上排列成一行的空间段内的环形空间，在相继的空间段中具有相反的流动方向。

46. 发明授权

US06899162B2 Device for cooling and heating a motor vehicle 失效
标题翻译：用于冷却和加热机动车辆的装置
公开(公告)号：US06899162B2
公开(公告)日：2005-05-31
申请号：US10450986
申请日：2002-07-18
申请人： Reiner Hohl , Manfred Schmitt , Karsten Mann , Oliver Kaefer
发明人： Reiner Hohl , Manfred Schmitt , Karsten Mann , Oliver Kaefer
IPC分类号： F01P3/18 , F01P3/20 , F01P7/14 , F01P7/16 , B60H3/00
CPC分类号： F01P7/165 , F01P7/164 , F01P2003/187 , F01P2007/146 , F01P2023/08 , F01P2050/24 , F01P2050/30 , F01P2060/02 , F01P2060/08 , F01P2060/185 , F01P2070/00
摘要： The current invention relates to an apparatus for cooling and/or heating a motor vehicle, with at least one coolant pump for circulating a coolant in a cooling and heating system, with a main cooler segment, which has a main cooler inlet and a main cooler outlet, wherein the main cooler inlet is at least intermittently connected to at least one coolant outlet of an engine to be cooled, in particular an internal combustion engine, of the vehicle, and its main cooler outlet is connected to at least one coolant inlet of the engine, and with at least one other, secondary cooler segment provided in addition to the main cooler segment and at least one other unit to be cooled, which is connected to the cooling and heating system, and the apparatus have at least one bypass line with a bypass valve, which is associated with the at least one secondary cooler segment and is disposed parallel to this secondary cooler segment in the cooling and heating system of the motor vehicle.
摘要翻译：本发明涉及一种用于冷却和/或加热机动车辆的装置，具有至少一个用于在冷却和加热系统中循环冷却剂的冷却剂泵，主冷却器段具有主冷却器入口和主冷却器出口，其中主冷却器入口至少间歇地连接到车辆的待冷却发动机，特别是内燃机的至少一个冷却剂出口，并且其主冷却器出口连接到至少一个冷却剂入口发动机，以及除了主冷却器段和要冷却的至少另一个其它单元之外还设置有至少另一个第二冷却器段，其连接到冷却和加热系统，并且该设备具有至少一个旁路管线其具有与所述至少一个次级冷却器段相关联的旁通阀，并且与所述机动车辆的冷却和加热系统中的所述次级冷却器段平行设置。

47. 发明授权

US06872702B1 Inhibitors for urokinase receptor 失效
标题翻译：尿激酶受体抑制剂
公开(公告)号：US06872702B1
公开(公告)日：2005-03-29
申请号：US09402464
申请日：1999-04-14
申请人： Horst Kessler , Heinrich Graeff , Manfred Schmitt , Viktor Magdolen , Olaf G. Wilhelm , Christoph Riemer , Markus Bürgle
发明人： Horst Kessler , Heinrich Graeff , Manfred Schmitt , Viktor Magdolen , Olaf G. Wilhelm , Christoph Riemer , Markus Bürgle
IPC分类号： A61K38/00 , A61K38/04 , A61K38/49 , A61P9/00 , A61P9/10 , A61P19/10 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07K7/00 , C07K7/06 , C07K14/47 , C12N9/72 , A61K38/12
CPC分类号： C12N9/6462 , C12Y304/21073
摘要： The present invention concerns peptides as inhibitors of the binding of urokinase to the urokinase receptor. These peptides, which are preferably cyclic, are suitable as pharmaceutical agents for diseases that are mediated by urokinase and its receptor.
摘要翻译：本发明涉及作为尿激酶与尿激酶受体结合的抑制剂的肽。这些优选环状的肽适合作为由尿激酶及其受体介导的疾病的药剂。

48. 发明授权

US06229420B1 Proximity switches with mechanical decoupling of connection pins and connection insert 失效
标题翻译：接近开关，具有连接插针和连接插件的机械去耦
公开(公告)号：US06229420B1
公开(公告)日：2001-05-08
申请号：US09194214
申请日：1998-11-20
申请人： Alfred Bäuml , Manfred Schmitt , Robert Gassner
发明人： Alfred Bäuml , Manfred Schmitt , Robert Gassner
IPC分类号： H01H900
CPC分类号： H03K17/9505 , H05K1/182 , H05K3/403
摘要： A proximity switch including a connector insert (4) and connection pins (4) are not securely connected to one another. Apart from a potting compound which fills the housing, the connection pins are held only by a printed circuit board. This permits easy assembly, and no forces are transmitted to a sensor element via the printed circuit board.
摘要翻译：包括连接器插入件（4）和连接销（4）的接近开关彼此不牢固地连接。除了填充壳体的灌封组合物之外，连接销仅由印刷电路板保持。这允许容易组装，并且没有力通过印刷电路板传递到传感器元件。

49. 发明授权

US5607110A Device for discharging blowing air 失效
标题翻译：排风吹风装置
公开(公告)号：US5607110A
公开(公告)日：1997-03-04
申请号：US355962
申请日：1994-12-14
申请人： Manfred Schmitt
发明人： Manfred Schmitt
IPC分类号： B65H3/48 , B05B1/00
CPC分类号： B65H3/48
摘要： An adjustable discharge nozzle for blowing air is constructed in a structurally simple manner. A second pipe section is fit over a first pipe section substantially without play and it is fixed longitudinally but rotatable about the longitudinal axis. A relative rotation of the two pipe sections moves a blowing air discharge opening along a longitudinal direction defined by the pipes. The blowing air outlet is defined as an overlap between a longitudinal slit formed in the first pipe section and an oblique slit formed in the second pipe section. The oblique slit is inclined relative to the longitudinal slit.
摘要翻译：以结构简单的方式构造了用于吹送空气的可调排放喷嘴。第二管段基本上没有游隙地配合在第一管段上，并且其纵向固定而且可以围绕纵向轴线旋转。两个管段的相对旋转沿着由管道限定的纵向移动吹送空气排出口。吹风出口被定义为形成在第一管段中的纵向狭缝与形成在第二管段中的倾斜狭缝之间的重叠。倾斜狭缝相对于纵向狭缝倾斜。

50. 发明授权

US4901240A Method and apparatus for controlling the operating characteristic quantities of an internal combustion engine 失效
标题翻译：用于控制内燃机的工作特性量的方法和装置
公开(公告)号：US4901240A
公开(公告)日：1990-02-13
申请号：US6696
申请日：1987-01-21
申请人： Peter J. Schmidt , Manfred Schmitt
发明人： Peter J. Schmidt , Manfred Schmitt
IPC分类号： F02D45/00 , F02D41/14 , F02D41/24
CPC分类号： F02D41/2454
摘要： In a method and an apparatus for open-loop and closed-loop control of operating characteristic quantities of an internal combustion engine, it is proposed that the anticipatory or pilot control area, which is variable by means of learning, be embodied such that in a factor characteristic field associated with a basic characteristic field, not only the particular support point but with decreasing influence outward the area surrounding it as well are changed by the carry-over of an averaged regulating factor value. Alternatively, or preferably combined therewith, the factor characteristic field is replaced by at least two correcting characteristic fields, which have larger inclusion areas, overlapping one another, for each support point, so that even in the event of fluctuations of input quantities about a border of an area, at least one of the correcting characteristic fields will be addressed.
摘要翻译：在用于内燃机的工作特征量的开环和闭环控制的方法和装置中，提出通过学习可变的预期或先导控制区域被体现为在与基本特征场相关联的因子特征场，不仅特定的支持点，而且随着其周围的区域的减小也受到平均调节因子值的转移而改变。替代地，或优选地与其组合，因子特征字段被至少两个修正特征字段替换，所述校正特征字段对于每个支持点具有较大的包含区域，彼此重叠，使得即使在关于边界的输入量的波动的情况下的区域中，校正特征字段中的至少一个将被解决。

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