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41. 发明申请

WO2008009663A1 TREATMENT OF PAIN 审中-公开
标题翻译：治疗疼痛
公开(公告)号：WO2008009663A1
公开(公告)日：2008-01-24
申请号：PCT/EP2007/057343
申请日：2007-07-17
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , ROSENBURG, Ronald , MILLER, Jeffrey
发明人： ROSENBURG, Ronald , MILLER, Jeffrey
IPC分类号： A61K31/416 , A61K31/197 , A61P29/00
CPC分类号： A61K31/197 , A61K31/416 , A61K2300/00
摘要： The invention relates to a new medicamentation for the treatment of pain, in particular fibromyalgia. The medicamentation comprises the administration of pramipexole in combination with an analgesic of the class of chemical compounds structurally related with gamma aminobutyric acid (GABA) selected from the group of pregabaline and gabapentine. The medicamentation is either a combination of pramipexole and pregabaline or a combination of pramipexole and gabapentine, both of which may be used in a fixed dose combination as well as in a free dose combination. The invention further is related to the manufacture of a medicament for the treatment of pain, in particular fibromyalgia comprising said medicamentation and a method of treatment of pain, in particular fibromyalgia comprising said medicamentation.
摘要翻译：本发明涉及用于治疗疼痛，特别是纤维肌痛的新药物。所述药物包括将普拉克索与与选自普瑞卡班和加巴喷丁组的γ-氨基丁酸（GABA）结构相关的化学化合物类别的镇痛药组合施用。药物化学是普拉克索和普瑞卡班的组合或普拉克索与加巴喷丁的组合，两者均可以固定剂量组合以及游离剂量组合使用。本发明还涉及用于治疗疼痛的药物的制备，特别是包括所述药物的纤维肌痛和治疗疼痛的方法，特别是包含所述药物化学的纤维肌痛。

42. 发明申请

WO2007079169A2 TREATMENT FOR ACUTE MYELOID LEUKEMIA 审中-公开
标题翻译：急性髓性白血病治疗
公开(公告)号：WO2007079169A2
公开(公告)日：2007-07-12
申请号：PCT/US2006049466
申请日：2006-12-28
申请人： 3M INNOVATIVE PROPERTIES CO , MILLER JEFFREY S , YUNIS CARLA
发明人： MILLER JEFFREY S , YUNIS CARLA
IPC分类号： A61K31/47 , A61K31/4738 , A61P35/02
CPC分类号： A61K31/47 , A61K31/4738
摘要： The present invention provides a method of treating acute myeloid leukemia. Generally, the method includes administering to a patient with AML an amount of a TLR agonist compound effective to decrease the percentage of leukemic cells in the patient's peripheral blood or bone marrow.
摘要翻译：本发明提供治疗急性骨髓性白血病的方法。通常，该方法包括向患者施用一定量的有效降低患者外周血或骨髓中白血病细胞百分比的TLR激动剂化合物。

43. 发明申请

WO2006121610A2 PERSONAL CARE COMPOSITIONS AND METHODS FOR THEIR USE 审中-公开
标题翻译：个人护理组合物及其使用方法
公开(公告)号：WO2006121610A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/015711
申请日：2006-04-25
申请人： GENENCOR INTERNATIONAL, INC. , COLLIER, Katherine, D. , DAY, Anthony , DE NOBEL, Hans , ESTELL, David, A. , GANSHAW, Grant, C. , KOLKMAN, Marc , LAD, Raj , MILLER, Jeffrey, V. , MURRAY, Christopher, J. , POWER, Scott, D. , SCHMIDT, Brian , VAN KIMMENADE, Anita , VOGTENTANZ, Gudrun
发明人： COLLIER, Katherine, D. , DAY, Anthony , DE NOBEL, Hans , ESTELL, David, A. , GANSHAW, Grant, C. , KOLKMAN, Marc , LAD, Raj , MILLER, Jeffrey, V. , MURRAY, Christopher, J. , POWER, Scott, D. , SCHMIDT, Brian , VAN KIMMENADE, Anita , VOGTENTANZ, Gudrun
CPC分类号： A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
摘要： The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments, the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. In alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.
摘要翻译：本发明提供用于治疗各种疾病和病症的肽和负载肽。在特别优选的实施方案中，本发明提供用于个人护理的组合物和方法。在一些实施方案中，本发明提供用于皮肤和/或头发护理以及化妆品组合物的组合物。在替代的特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载的肽，例如红斑痤疮。在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。在一些最优选的实施方案中，支架蛋白包含BBI。

44. 发明申请

WO2006092547A3 METHODS OF USING DRILLING FLUIDS CONTAINING BIODEGRADABLE ORGANOPHILIC CLAY 审中-公开
公开(公告)号：WO2006092547A3
公开(公告)日：2006-09-08
申请号：PCT/GB2006/000057
申请日：2006-01-09
申请人： HALLIBURTON ENERGY SERVICES, INC. , CURTIS, Philip, Anthony , MILLER, Jeffrey, J.
发明人： MILLER, Jeffrey, J.
IPC分类号： C09K8/14 , C09K8/32
摘要： Methods of treating a wellbore comprise displacing a drilling fluid comprising an organophilic clay treated with a quaternary ammonium surfactant having an amide linkage into the wellbore. Methods of drilling a wellbore comprise: applying torque to a bit within the wellbore and concurrently applying force to urge the bit to extend through the wellbore; and circulating a drilling fluid past the bit to remove cuttings therefrom, the drilling fluid comprising an organophilic clay treated with a quaternary ammonium surfactant having an amide linkage. Methods of preparing a drilling fluid comprise: forming an organophilic clay treated with a quaternary ammonium surfactant having an amide linkage; and combining the organophilic clay with an oil-based fluid.

45. 发明申请

WO2006079775A1 DRILLING FLUIDS CONTAINING BIODEGRADABLE ORGANOPHILIC CLAY 审中-公开
标题翻译：含有生物可降解有机粘土的钻井液
公开(公告)号：WO2006079775A1
公开(公告)日：2006-08-03
申请号：PCT/GB2006/000049
申请日：2006-01-09
申请人： HALLIBURTON ENERGY SERVICES, INC , CURTIS, Philip, Anthony , MILLER, Jeffrey, J.
发明人： MILLER, Jeffrey, J.
IPC分类号： C09K8/14 , C09K8/36
CPC分类号： C09K8/36 , C09K8/145
摘要： Drilling fluids are provided that comprise an organophilic clay treated with a quaternary ammonium surfactant having an amide linkage. The quaternary ammonium surfactant may comprise a compound generally represented by formula (I); where M" is an anion such as a chloride, methyl sulfate, bromide, acetate, or iodide ion; R 1 is an alkyl group such as a saturated hydrocarbon with 10 or more carbons; R 2 , R 3 , and R 4 are the same or different alkyl groups such as a methyl, ethyl, or benzyl group, and x is greater than or equal to 1. The organophilic clay treated in this manner is substantially biodegradable. In embodiments, the drilling fluids comprise the foregoing organophilic clay, an oil-based fluid and a weighting agent. In still more embodiments, the drilling fluids comprise the foregoing organophilic clay, an invert emulsion, an emulsifier, and a weighting agent.
摘要翻译：提供钻井液，其包含用具有酰胺键的季铵表面活性剂处理的亲有机物质粘土。季铵表面活性剂可以包含通常由式（I）表示的化合物; 其中M“是阴离子如氯化物，甲基硫酸盐，溴化物，乙酸盐或碘离子; R 1是烷基，例如具有10个或更多个碳的饱和烃; R 1， R 2，R 3和R 4是相同或不同的烷基，例如甲基，乙基或苄基，x大于或以这种方式处理的亲有机质的粘土基本上是可生物降解的，在实施方案中，钻井流体包括上述亲有机粘土，油基流体和加重剂。在更多实施方案中，钻井液包含上述亲有机质的粘土，反相乳液，乳化剂和加重剂。

46. 发明申请

WO2006052813A2 STABLE AND FILTERABLE ENVELOPED VIRUS FORMULATIONS 审中-公开
标题翻译：稳定和可过滤的包膜病毒制剂
公开(公告)号：WO2006052813A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040149
申请日：2005-11-04
申请人： WELLSTAT BIOLOGICS CORPORATION , CHEN, Tzer-Fen , JANG, Jouhn-Wern , MILLER, Jeffrey, A.
发明人： CHEN, Tzer-Fen , JANG, Jouhn-Wern , MILLER, Jeffrey, A.
IPC分类号： C12Q1/70 , C12N7/00
CPC分类号： A61K9/0019 , A61K47/26 , C12N7/00 , C12N2760/18151
摘要： Envelope viruses (e.g. Newcastle disease virus (NDV)) are formulated for storage at moderately cold temperatures (e.g. -20 °C). The formulation is an aqueous solution containing the enveloped virus at a concentration of from 10 6 PFU/mL to 10 12 PFU/mL; and a non-reducing saccharide (e.g. sucrose). When the non-reducing saccharide is a disaccharide it is present in the solution at a concentration of from 5% (w/v) to 50% (w/v), and when it is a monosaccharide it is present in the solution at a concentration of from 2.5% (w/v) to 25% (w/v). The solution has an osmotic pressure of about 250 mOs or higher, and has a pH of from 5 to 10.
摘要翻译：包膜病毒（例如新城疫病毒（NDV））被配制用于在中等低温（例如-20℃）下储存。该制剂是含有浓度为10 6 PFU / mL至10 12 PFU / mL的包膜病毒的水溶液; 和非还原糖（例如蔗糖）。当非还原性糖为二糖时，其以5％（w / v）至50％（w / v）的浓度存在于溶液中，当其为单糖时，其在溶液中以浓度从2.5％（w / v）到25％（w / v）。该溶液具有约250mOs或更高的渗透压，并具有5至10的pH。

47. 发明申请

WO2006028529A2 IONIC POLYMER MEMBRANES 审中-公开
标题翻译：离子聚合物膜
公开(公告)号：WO2006028529A2
公开(公告)日：2006-03-16
申请号：PCT/US2005017547
申请日：2005-05-19
申请人： BP CORP NORTH AMERICA INC , GEORGIA TECH RES INST , MILLER JEFFREY T , HUFF GEORGE A JR , KOROS WILLIAM JOHN , HOPPIN CHARLES RICHARD
发明人： MILLER JEFFREY T , HUFF GEORGE A JR , KOROS WILLIAM JOHN , HOPPIN CHARLES RICHARD
IPC分类号： B01D71/56
CPC分类号： B01D53/228 , B01D71/82
摘要： Compositions and processes are disclosed for economical separation of fluid mixtures. Broadly, the present invention discloses ionic polymer compositions that are useful for perm-selective membrane separations. More particularly, ionic polymers of the invention comprise a plurality of repeating structural units having as a constituent part thereof organic ionic moieties consisting of nitrogen containing anions and/or cations. In the form of non-porous membranes, ionic polymers of the invention facilitate recovery of purified organic and inorganic products from fluid mixtures by means of perm-selective membrane separations. The present invention also provides methods for forming the ionic polymers, for example by treating selected nitrogen-containing organic polymers with acids, or treating a polymeric material comprising a plurality of carboxylate groups with an amine. Ionic polymer compositions of the invention are particularly useful for simultaneous recovery of a permeate product of an increased concentration, and a desired non-permeate stream, from a fluid mixture containing at least two compounds of different boiling point temperatures.
摘要翻译：公开了用于经济地分离流体混合物的组合物和方法。广义地说，本发明公开了用于渗透选择性膜分离的离子聚合物组合物。更特别地，本发明的离子聚合物包含多个重复结构单元，所述重复结构单元具有作为其组成部分的由含氮阴离子和/或阳离子组成的有机离子部分。采用无孔膜的形式，本发明的离子聚合物利于通过选择性渗透膜分离从流体混合物中回收纯化的有机和无机产物。本发明还提供了用于形成离子聚合物的方法，例如通过用酸处理选定的含氮有机聚合物，或用胺处理包含多个羧酸盐基团的聚合物材料。本发明的离子聚合物组合物特别适用于从含有至少两种不同沸点温度的化合物的流体混合物中同时回收增加浓度的渗透产物和期望的非渗透物流。

48. 发明申请

WO2005084190A2 METHODS AND COMPOSTIONS FOR TARGETED CLEAVAGE AND RECOMBINATION 审中-公开
标题翻译：用于目标清除和重构的方法和组合
公开(公告)号：WO2005084190A2
公开(公告)日：2005-09-15
申请号：PCT/US2005/003245
申请日：2005-02-03
申请人： SANGAMO BIOSCIENCES, INC. , MILLER, Jeffrey C. , ZHANG, Lei
发明人： MILLER, Jeffrey C. , ZHANG, Lei
IPC分类号： C07K14/435 , C07K14/47 , C07K14/715 , C12N9/14 , C12N9/22 , C12N15/62 , C12P19/34 , C12Q1/68
CPC分类号： A61K35/12 , C07K14/43595 , C07K14/4717 , C07K14/715 , C07K2319/00 , C07K2319/09 , C07K2319/81 , C12N9/14 , C12N9/22 , C12N15/62 , C12N15/85 , C12N2800/80
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, as well as polynucleotides encoding same. Fusion proteins comprising cleavage half-domains are used in pairs, to reconstitute a functional cleavage domain. In these fusion proteins, the zinc finger domain can be N-terminal to the cleavage half-domain, or the cleavage half-domain can be N-terminal to the zinc finger domain. The availability of fusion endonucleases having these different polarities allows targeting (and thereby binding) of zinc finger endonucleases either to opposite strands of the DNA target or to the same strand of the DNA target, thereby increasing the number of possible sequences which can be targeted and cleaved by the fusion proteins.
摘要翻译：本文公开了用于基因组序列的靶向切割，基因组序列的靶向改变以及基因组区域和与该基因组区域同源的外源多核苷酸之间的靶向重组的方法和组合物。组合物包括包含切割结构域（或切割半结构域）和工程化锌指结构域的融合蛋白，以及编码它们的多核苷酸。包含切割半结构域的融合蛋白成对使用，以重构功能性切割结构域。在这些融合蛋白中，锌指结构域可以是切割半结构域的N末端，或者切割半结构域可以是锌指结构域的N末端。具有这些不同极性的融合核酸内切酶的可得性允许锌指核酸内切酶与DNA靶的相对链或DNA靶的相同链靶向（从而结合），从而增加可靶向的可能序列的数目，被融合蛋白切割。

49. 发明申请

WO2005027920A1 2-ALKYLIDENE-19-NOR-VITAMIN D DERIVATIVES FOR THE TREATMENT OF RICKETS OR VITAMIN D DEFICIENCY 审中-公开
标题翻译：用于治疗叮咬或维生素D缺乏症的2-烷基-L-维生素D衍生物
公开(公告)号：WO2005027920A1
公开(公告)日：2005-03-31
申请号：PCT/IB2004/002925
申请日：2004-09-06
申请人： PFIZER PRODUCTS INC. , MILLER, Jeffrey, Wells , NDUAKA, Chudi, Ike
发明人： MILLER, Jeffrey, Wells , NDUAKA, Chudi, Ike
IPC分类号： A61K31/59
CPC分类号： A61K31/59
摘要： The present invention relates to methods of treating osteopenia or male osteoporosis, the methods comprising administering to a patient in need thereof a 2 alkylidene-19-nor-vitamin D derivative. Particularly, the present invention relates to methods of treating osteopenia or male osteoporosis, the methods comprising administering to a patient in need thereof 2-methylene-19-nor-20(S)-1a,25 dihydroxyvitamin D 3 .
摘要翻译：本发明涉及治疗骨质减少症或男性骨质疏松症的方法，所述方法包括向有需要的患者施用2亚烷基-19-维生素D衍生物。特别地，本发明涉及治疗骨质减少症或男性骨质疏松症的方法，所述方法包括向有需要的患者施用2-亚甲基-19-去甲-20（S）-1a，25二羟基维生素D3。

50. 发明申请

WO2004034228A3 A SYSTEM AND METHOD FOR REVENUE AND AUTHORIZATION MANAGEMENT 审中-公开
标题翻译：收入和授权管理的系统和方法
公开(公告)号：WO2004034228A3
公开(公告)日：2005-01-20
申请号：PCT/US0332255
申请日：2003-10-10
申请人： CONVERGYS INFORMATION MAN GROU , CLUBB IAN JAMES , CLARIDGE PHILIP GEOFFREY , SHUSTA THOMAS JOSEPH , MILLER JEFFREY M
发明人： CLUBB IAN JAMES , CLARIDGE PHILIP GEOFFREY , SHUSTA THOMAS JOSEPH , MILLER JEFFREY M
IPC分类号： G06Q20/10 , G06Q40/02 , G06F17/60
CPC分类号： G06Q40/02 , G06Q20/105
摘要： A system is disclosed for facilitating relationship-centric authorization of transactions in a manner which provides optimum scalability and availability by logically partitioning wallets in conjunction with partitioning a resource associated with a group of consumers (Fig. 1).
摘要翻译：公开了一种系统，用于以提供最佳可扩展性和可用性的方式促进以交易的关系为中心的授权，通过逻辑地划分钱包以及与消费者群组相关联的资源的划分（图1）。

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