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41. 发明申请

US20130261125A1 INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS 有权
标题翻译：用作ERK抑制剂的INDAZOLE衍生物
公开(公告)号：US20130261125A1
公开(公告)日：2013-10-03
申请号：US13994224
申请日：2011-12-16
申请人： Gerald W. Shipps, JR. , Xiaohua Huang , Yongqi Deng , Liang Zhu , Alan B. Cooper , Binyuan Sun , Abdelghani Achab , Sie-Mun Lo
发明人： Gerald W. Shipps, JR. , Xiaohua Huang , Yongqi Deng , Liang Zhu , Alan B. Cooper , Binyuan Sun , Abdelghani Achab , Sie-Mun Lo
IPC分类号： A61K31/4439 , C07D471/04 , A61K31/437 , C07D401/04
CPC分类号： A61K31/4439 , A61K31/416 , A61K31/437 , A61K45/06 , C07D231/56 , C07D401/04 , C07D401/14 , C07D403/14 , C07D417/04 , C07D471/04 , A61K2300/00
摘要： The present invention provides a compound of the Formula I, or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, m and are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions that comprise the above compounds, and methods of treating cancer using the same.
摘要翻译：本发明提供式I化合物或其药学上可接受的盐，溶剂化物或酯，其中R，R 1，R 2，R 3，m如本文所定义。这些化合物是ERK抑制剂。还公开了包含上述化合物的药物组合物和使用其的癌症治疗方法。

42. 发明申请

US20130158020A1 INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS 有权
标题翻译：用作ERK抑制剂的INDAZOLE衍生物
公开(公告)号：US20130158020A1
公开(公告)日：2013-06-20
申请号：US13819366
申请日：2011-08-29
申请人： Yongqi Deng , Gerald W. Shipps, JR. , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Kiran Muppalla
发明人： Yongqi Deng , Gerald W. Shipps, JR. , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Kiran Muppalla
IPC分类号： A61K31/541 , A61K31/5377 , A61K45/06 , C07D401/14 , A61K31/4545 , A61K31/496 , C07D413/14 , C07D417/14
CPC分类号： A61K31/541 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/113
摘要： The present invention provides a compound of the Formula I: Formula I or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, R4, X, m and n are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译：本发明提供式I化合物：式I或其药学上可接受的盐，溶剂合物或酯，其中R，R 1，R 2，R 3，R 4，X，m和n如本文所定义。这些化合物是ERK抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。

43. 发明申请

US20130096084A1 NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHBITORS 有权
标题翻译：新型杂环化合物作为ERK抑制剂
公开(公告)号：US20130096084A1
公开(公告)日：2013-04-18
申请号：US13703250
申请日：2011-06-22
申请人： Yongqi Deng , Liang Zhu , Gerald W. Shipps, JR. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
发明人： Yongqi Deng , Liang Zhu , Gerald W. Shipps, JR. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
IPC分类号： C07D401/14 , A61K45/06 , C07D405/14 , A61K31/454 , A61K31/55 , A61K31/551 , C07D401/12 , C07D409/14 , C07D417/14 , A61K31/506 , C07D471/04 , C07F7/18 , A61K31/695 , C07D413/14 , A61K31/5377 , A61K31/4545
CPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/1804
摘要： The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译：本发明提供了式I化合物：（式I应在此插入）或其药学上可接受的盐，溶剂化物或酯，其中R，R 1，R 2和R 3如本文所定义。这些化合物是ERK抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。

44. 发明申请

US20110212942A1 INHIBITORS OF POLO-LIKE KINASE 有权
标题翻译：类似激素的抑制剂
公开(公告)号：US20110212942A1
公开(公告)日：2011-09-01
申请号：US12974401
申请日：2010-12-21
申请人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
发明人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
IPC分类号： A61K31/55 , C07D475/00 , C07D471/14 , C07D487/14 , C07D498/14 , A61K31/4985 , A61K31/5383 , A61P35/00 , A61P25/28 , A61P25/16 , A61P35/02 , A61P35/04
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译：本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，X，R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。

45. 发明申请

US20110178156A1 Method of suppressing pRb deficiency-induced tumor formation 审中-公开
标题翻译：抑制pRb缺陷诱导的肿瘤形成的方法
公开(公告)号：US20110178156A1
公开(公告)日：2011-07-21
申请号：US12930861
申请日：2011-01-19
申请人： Liang Zhu
发明人： Liang Zhu
IPC分类号： A61K31/713 , A61P35/00 , C12Q1/48 , G01N33/53
CPC分类号： C12Q1/485 , A61K31/00 , A61K31/713
摘要： The present invention provides methods of determining a putative agent that inhibits tumorigenesis in retinoblastoma protein deficient cells, the methods comprising determining whether the putative agent decreases phosphorylation of threonine residue 187 of p27, decreases S-phase kinase-associated protein 2 interaction with p27 having a phosphorylated threonine residue 187, or an increase in apoptosis of retinoblastoma protein deficient cells. The present invention also provides the agent, the pharmaceutical composition, and methods of inhibiting, preventing and treating tumorigenesis in retinoblastoma deficient cells, the method comprising administration of the agent that decreases phosphorylation of threonine residue 187 of p27 or the S-phase kinase-associated protein 2 interaction with p27 having a phosphorylated threonine residue 187.
摘要翻译：本发明提供了确定抑制视网膜母细胞瘤蛋白质缺陷细胞中的肿瘤发生的推定剂的方法，所述方法包括确定推定剂是否降低p27的苏氨酸残基187的磷酸化，降低与p27的S期激酶相关蛋白2相互作用磷酸化苏氨酸残基187，或视网膜母细胞瘤蛋白缺陷细胞凋亡的增加。本发明还提供了抑制，预防和治疗视网膜母细胞瘤缺陷细胞中的肿瘤发生的药剂，药物组合物和方法，所述方法包括施用降低p27苏氨酸残基187的磷酸化或S期激酶相关蛋白质2与具有磷酸化苏氨酸残基的p27的相互作用。

46. 发明申请

US20100288689A1 MICROFLUIDIC FILTRATION UNIT, DEVICE AND METHODS THEREOF 审中-公开
标题翻译：微流体过滤装置，装置及其方法
公开(公告)号：US20100288689A1
公开(公告)日：2010-11-18
申请号：US12438505
申请日：2006-08-22
申请人： Liang Zhu , Wen-Tso Liu , Hanhua Feng , Hong Miao Ji , William Cheng Yong Teo , Ramana Murthy Badam
发明人： Liang Zhu , Wen-Tso Liu , Hanhua Feng , Hong Miao Ji , William Cheng Yong Teo , Ramana Murthy Badam
IPC分类号： B81B1/00 , B01D29/03 , B01D29/50
CPC分类号： B01D61/147 , B01L3/5027 , G01N1/4077
摘要： A microfluidic filtration unit for trapping particles of a predetermined nominal size present in a fluid is provided. The unit comprises a fluid chamber connected to an inlet for introducing the fluid to be filtered and an outlet for discharging filtered fluid, a filtration barrier arranged within the fluid chamber, said filtration barrier comprising a plurality of pillars arranged substantially perpendicular to the path of fluid flow when fluid is introduced into the fluid chamber, said pillars being aligned to form at least one row extending across said path of fluid flow, wherein each of said at least one row of pillars in the filtration barrier comprises at least one fine filtration section comprising a group of pillars that are spaced apart to prevent particles to be filtered from the fluid from moving between adjacent pillars, and at least one coarse filtration section comprising a group of pillars that are spaced apart to permit the movement of particles between adjacent pillars.
摘要翻译：提供了用于捕获存在于流体中的预定公称尺寸的微粒的微流体过滤单元。该单元包括连接到入口的流体室，用于引入要过滤的流体和用于排出过滤流体的出口，布置在流体室内的过滤阻挡层，所述过滤屏障包括基本上垂直于流体路径布置的多个柱当流体被引入到流体室中时，所述柱被对准以形成跨越所述流体流动路径延伸的至少一排，其中所述过滤阻挡层中的所述至少一排柱中的每一个包括至少一个精细过滤部分，其包括间隔开的一组支柱，以防止颗粒从流体中过滤，以在相邻的柱之间移动;以及至少一个粗过滤部分，其包括间隔开的一组支柱，以允许颗粒在相邻支柱之间移动。

47. 发明申请

US20100256365A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 有权
公开(公告)号：US20100256365A1
公开(公告)日：2010-10-07
申请号：US12616079
申请日：2009-11-10
申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
IPC分类号： C07D413/14 , C07D401/14 , C07F7/02 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

48. 发明申请

US20100068814A1 MULTI-MICRORNA METHODS AND COMPOSITIONS 失效
标题翻译：多微波方法和组合物
公开(公告)号：US20100068814A1
公开(公告)日：2010-03-18
申请号：US12312616
申请日：2007-11-28
申请人： Liang Zhu , Daqian Sun
发明人： Liang Zhu , Daqian Sun
IPC分类号： C07H21/04 , C12N5/10 , C12N15/63
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2320/10
摘要： Provided are DNAs comprising a polynucleotide that encodes at least a first modified miR-30 precursor and a second modified miR-30 precursor. Also provided are vectors comprising the the DNAs, where the vector can replicate in a host cell. Additionally, specific lentiviral vectors comprising the above-described DNA are provided, as are methods of inhibiting expression of a target gene in a eukaryotic cell.
摘要翻译：提供了包含编码至少第一修饰的miR-30前体和第二修饰的miR-30前体的多核苷酸的DNA。还提供了包含DNA的载体，其中载体可以在宿主细胞中复制。此外，提供了包含上述DNA的特定慢病毒载体，以及抑制靶基因在真核细胞中的表达的方法。

49. 发明授权

US07501526B2 Synthesis of polyamine compounds 失效
标题翻译：多胺化合物的合成
公开(公告)号：US07501526B2
公开(公告)日：2009-03-10
申请号：US11039283
申请日：2005-01-20
申请人： Chien-Huang Wu , Jia-Liang Zhu , Chen-Tso Tseng , Chi-Feng Yen , Kak-Shan Shia , Yibin Xiang , Gholam Hossein Hakimelahi , Ming-Chen Chou
发明人： Chien-Huang Wu , Jia-Liang Zhu , Chen-Tso Tseng , Chi-Feng Yen , Kak-Shan Shia , Yibin Xiang , Gholam Hossein Hakimelahi , Ming-Chen Chou
IPC分类号： C07D235/06 , C07D235/10
CPC分类号： C07D403/02
摘要： This invention relates to methods of preparing the compounds of formula (V): Each variable in this formula is defined in the specification.
摘要翻译：本发明涉及制备式（V）化合物的方法：该式中的每个变量在本说明书中定义。

50. 发明授权

US06576816B2 Heavy metal phytoremediation 失效
公开(公告)号：US06576816B2
公开(公告)日：2003-06-10
申请号：US09933549
申请日：2001-08-20
申请人： Norman Terry , Elizabeth Pilon-Smits , Yong Liang Zhu
发明人： Norman Terry , Elizabeth Pilon-Smits , Yong Liang Zhu
IPC分类号： C12N1509
CPC分类号： C12N9/93 , B09C1/105 , C12N15/8259
摘要： The invention provides methods and compositions for heavy metal phytoremediation, including plants which are genetically engineered to overexpress glutamylcysteine synthetase (ECS) and thereby provide enhanced heavy metal accumulation. In various embodiments, the plants comprise a gene encoding ECS operably linked to a heterologous promoter, the plant is a member of the Brassicaceae family. In general, the methods comprise the steps of growing such plants in a medium such as soil or water comprising a heavy metal, under conditions wherein ECS is overexpressed, whereby the plant provides enhanced accumulation of the heavy metal, whereby the heavy metal content of the medium is decreased.

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