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41. 发明申请

US20150297674A1 SUBSTANCES AND METHODS FOR THE TREATMENT OF CEREBRAL AMYLOID ANGIOPATHY RELATED CONDITIONS OR DISEASE 审中-公开
标题翻译：用于治疗骨髓淀粉样变性相关病症或疾病的物质和方法
公开(公告)号：US20150297674A1
公开(公告)日：2015-10-22
申请号：US14382402
申请日：2013-03-12
申请人： Loma Linda University Medical Center
发明人： Wolff M. Kirsch , Andrew Crofton , Tanya Freeman , Charles Glabe , SAmuel M. Hudson , Matthew Schrag , Harry Vinters , Matthew Zabel
IPC分类号： A61K38/17 , A61K47/48
CPC分类号： A61K38/177 , A61K39/395 , A61K47/6891 , A61K47/6939 , C07K16/18
摘要： A substance for treating a cerebral amyloid angiopathy related condition or disease affecting cerebrovasculature in a patient, comprising an inhibitor that causes inhibition of the formation of membrane attack complex of the complement system; and a vehicle for transporting the inhibitor into the cerebrovasculature; where the inhibition by the inhibitor is sufficient to decrease the incidence of or to prevent the incidence of cytolysis of the smooth muscle cells. A method for treating a cerebral amyloid angiopathy related condition or disease affecting cerebrovasculature in a patient, comprising: a) identifying a patient with a cerebral amyloid angiopathy related condition or disease; b) providing one or more than one substance that comprises an inhibitor that causes inhibition of the formation of membrane attack complex of the complement system, c) administering one or more than one dose of the one or more than one substance to the patient.
摘要翻译：一种用于治疗患有脑血管病变的脑淀粉样血管病相关病症或疾病的物质，其包含抑制补体系膜分子复合物形成的抑制剂; 以及用于将抑制剂输送到脑血管系统中的载体; 其中抑制剂的抑制足以降低平滑肌细胞的细胞溶解的发生率或防止其发生。一种治疗患者脑淀粉样血管病相关病症或影响脑血管系统疾病的方法，包括：a）鉴定患有脑淀粉样血管病相关病症或疾病的患者; b）提供一种或多于一种物质，其包含抑制剂，所述抑制剂引起所述补体系统的膜侵袭复合物的形成的抑制，c）向所述患者施用一种或多于一种的所述一种或多种物质。

42. 发明申请

US20150198543A1 SYSTEMS, DEVICES AND METHODS RELATED TO CALIBRATION OF A PROTON COMPUTED TOMOGRAPHY SCANNER 有权
标题翻译：与计算机计算机扫描仪校准相关的系统，设备和方法
公开(公告)号：US20150198543A1
公开(公告)日：2015-07-16
申请号：US14492894
申请日：2014-09-22
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER
发明人： Reinhard W. Schulte , R. Ford Hurley
IPC分类号： G01N23/04 , G01N35/00
CPC分类号： G01T7/005 , A61B6/032 , A61B6/035 , A61B6/4258 , A61B6/548 , A61B6/583 , A61B6/585 , G01N23/04 , G01N23/046 , G01N35/00693 , G01N2223/107 , G01T1/169 , G01T1/2985
摘要： Disclosed are systems, devices and methodologies related to calibration of an ion based imaging apparatus such as a proton computed tomography scanner. In some implementations, energy degrader plates having known water-equivalent thickness (WET) values can be introduced to an ion beam to introduce different energy degradation settings. Energy detector responses to individual ions subject to such energy degradation settings can be obtained. Such responses can be normalized and correlated to water-equivalent path lengths (WEPL) of the ions based on the known WET values. Such calibration utilizing degrader plates can be performed relatively quickly and can yield accurate WEPL values that facilitate estimation of, for example, a CT image based on relative stopping power of an object.
摘要翻译：公开了与基于离子的成像装置如质子计算机断层摄影扫描仪的校准相关的系统，装置和方法。在一些实施方案中，具有已知水当量厚度（WET）值的能量降解板可被引入离子束以引入不同的能量降解设置。可以获得能量检测器对受到这种能量劣化设置影响的个体离子的响应。这些响应可以根据已知的WET值被归一化并且与离子的水当量路径长度（WEPL）相关。利用降解板的这种校准可以相对快速地进行，并且可以产生准确的WEPL值，其有助于基于对象的相对停止功率来估计例如CT图像。

43. 发明申请

US20150050349A1 SYSTEMS AND METHODS FOR PARTICLE RADIATION ENHANCED DELIVERY OF THERAPY 审中-公开
标题翻译：粒子辐射增强治疗方法的系统与方法
公开(公告)号：US20150050349A1
公开(公告)日：2015-02-19
申请号：US14336924
申请日：2014-07-21
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER
发明人： Reinhard Schulte , Gilmer Valdes-Diaz
IPC分类号： A61K9/14 , A61K47/02 , C07K16/18
CPC分类号： A61K9/14 , A61K47/02 , A61N5/1042 , A61N2005/1052 , A61N2005/1061 , A61N2005/1087 , A61N2005/1098 , C07K16/18
摘要： Systems and methods for enhancing the selective targeting of agents for preferential action at a target with reduced action with healthy tissue distal the target tissue. One or more agents can be combined with nano scale structures/particles for delivery to the target tissue. Appropriate bombardment with accelerated particle radiation, such as proton radiation, induces the release of the agents at the target site. Nano carriers can be combined with therapeutic and/or imaging enhancement agents. Imaging of the target tissue can provide a verification of the delivered dose of particle radiation. Nanocarriers can be provided with an outer shell selected for biocompatibility and durability in the in vivo environment and further selected to provide a feedback mechanism in the treatment environment to accelerate the release of the agent and reduce a total radiation dose needed for that release.
摘要翻译：用于增强靶标选择性靶向的系统和方法，用于在目标组织远端的健康组织减少作用的靶上优先作用。一种或多种药剂可以与纳米级结构/颗粒结合以递送至靶组织。用加速的粒子辐射（例如质子辐射）进行适当的轰击诱导药剂在目标部位的释放。纳米载体可与治疗和/或成像增强剂组合。目标组织的成像可以提供粒子辐射的递送剂量的验证。纳米载体可以具有选择用于体内环境中的生物相容性和耐久性的外壳，并进一步选择在治疗环境中提供反馈机制以加速药剂的释放并减少该释放所需的总辐射剂量。

44. 发明授权

US08932521B2 Chitosan-based hemostatic textile 有权
标题翻译：基于壳聚糖的止血纺织品
公开(公告)号：US08932521B2
公开(公告)日：2015-01-13
申请号：US14097151
申请日：2013-12-04
申请人： Loma Linda University Medical Center
发明人： Wolff M. Kirsch , Samuel Hudson
IPC分类号： A61L2/00 , A61L26/00 , A61L33/08 , A61L15/28 , A61L24/00 , A61L24/08 , A61L31/04 , A61L2/20 , A61L2/08
CPC分类号： A61L15/28 , A61L2/081 , A61L2/14 , A61L2/20 , A61L15/42 , A61L24/0036 , A61L24/08 , A61L26/0023 , A61L31/042 , A61L33/08 , A61L2400/04 , C08L5/08
摘要： A microfibrillar high molecular weight chitosan-based textile can be used as a hemostat. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan textile. A single or multiple such treatments may be employed. For example, the chitosan textile may be irradiated under nitrogen using γ-irradiation, treated under a nitrogen plasma, or both.
摘要翻译：可以使用微原纤维高分子量壳聚糖类织物作为止血剂。壳聚糖通过施加能量以在壳聚糖纺织品中和周围离子化氮在氮气田中进行处理。可以使用单次或多次这样的治疗。例如，壳聚糖纺织品可以在氮气下用氮气照射，氮气等离子体处理或二者均照射。

45. 发明申请

US20140316183A1 METHOD AND DEVICE FOR REGISTRATION AND IMMOBILIZATION 审中-公开
标题翻译：用于注册和固定的方法和设备
公开(公告)号：US20140316183A1
公开(公告)日：2014-10-23
申请号：US13934120
申请日：2013-07-02
申请人： Loma Linda University Medical Center
发明人： Michael F. Moyers
IPC分类号： A61N5/10
CPC分类号： A61N5/10 , A61B5/055 , A61B6/037 , A61B90/18 , A61N5/1039 , A61N5/1049 , A61N2005/1087 , A61N2005/1089 , A61N2005/1097
摘要： Support devices and pods for the head and neck region of patients undergoing radiation therapy are provided herein. The pod generally includes a support shell shaped to generally conform to the shape of the head and neck region of the patient, a foam insert that conforms to the head and neck region of the patient, and an immobilization facemask attached directly to the shell, thereby facilitating close placement of the radiation beam delivery device to the patient and reducing any attenuation and perturbation of radiation doses directed at the patient. The components of the pod are made from materials having properties that reduce any attenuation and perturbation of prescribed radiation doses.
摘要翻译：本文提供了用于接受放射治疗的患者的头颈部区域的支撑装置和荚。所述荚通常包括形状为大致符合患者的头部和颈部区域的形状的支撑壳体，符合患者的头部和颈部区域的泡沫插入物以及直接附接到壳体上的固定面罩，由此促进辐射束输送装置向患者的近距离放置，并减少针对患者的辐射剂量的任何衰减和扰动。荚的组件由具有减少规定辐射剂量的任何衰减和扰动性质的材料制成。

46. 发明申请

US20140093421A1 CHITOSAN-BASED HEMOSTATIC TEXTILE 有权
标题翻译：基于CHITOSAN的HEMOSTATIC TEXTILE
公开(公告)号：US20140093421A1
公开(公告)日：2014-04-03
申请号：US14097151
申请日：2013-12-04
申请人： Loma Linda University Medical Center
发明人： Wolff M. Kirsch , Yong Hua Zhu , Samuel Hudson
IPC分类号： A61L26/00 , A61L2/08
CPC分类号： A61L15/28 , A61L2/081 , A61L2/14 , A61L2/20 , A61L15/42 , A61L24/0036 , A61L24/08 , A61L26/0023 , A61L31/042 , A61L33/08 , A61L2400/04 , C08L5/08
摘要： A microfibrillar high molecular weight chitosan-based textile can be used as a hemostat. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan textile. A single or multiple such treatments may be employed. For example, the chitosan textile may be irradiated under nitrogen using γ-irradiation, treated under a nitrogen plasma, or both.
摘要翻译：可以使用微原纤维高分子量壳聚糖类织物作为止血剂。壳聚糖通过施加能量以在壳聚糖纺织品中和周围离子化氮在氮气田中进行处理。可以使用单次或多次这样的治疗。例如，壳聚糖纺织品可以在氮气下用氮气照射，氮气等离子体处理或二者均照射。

47. 发明申请

US20130345489A1 CONFIGURATION MANAGEMENT AND RETRIEVAL SYSTEM FOR PROTON BEAM THERAPY SYSTEM 审中-公开
标题翻译：用于原子束治疗系统的配置管理和检索系统
公开(公告)号：US20130345489A1
公开(公告)日：2013-12-26
申请号：US13741018
申请日：2013-01-14
申请人： Loma Linda University Medical Center
发明人： Alexandre V. Beloussov , Michael A. Baumann , Howard B. Olsen , Dana Salem
IPC分类号： A61N5/10
CPC分类号： A61N5/1048 , A61N5/10 , A61N5/1077 , A61N5/1079 , A61N2005/1074 , A61N2005/1087 , H05H7/00
摘要： In a complex, multi-processor software controlled system, such as proton beam therapy system (PBTS), it may be important to provide treatment configurable parameters that are easily modified by an authorized user to prepare the software controlled systems for various modes of operation. This particular invention relates to a configuration management system for the PBTS that utilizes a database to maintain data and configuration parameters and also to generate and distribute system control files that can be used by the PBTS for treatment delivery. The use of system control files reduces the adverse effects of single point failures in the database by allowing the PBTS to function independently from the database. The PBTS accesses the data, parameters, and control settings from the database through the system control files, which insures that the data and configuration parameters are accessible when and if single point failures occur with respect to the database.
摘要翻译：在诸如质子束治疗系统（PBTS）的复杂的多处理器软件控制系统中，提供治疗可配置参数可能是重要的，该可配置参数由授权用户容易地修改以准备用于各种操作模式的软件控制系统。本发明涉及一种PBTS的配置管理系统，其利用数据库来维护数据和配置参数，并且还用于生成和分发可由PBTS用于治疗传递的系统控制文件。使用系统控制文件可以通过允许PBTS独立于数据库运行来减少数据库中单点故障的不利影响。 PBTS通过系统控制文件从数据库访问数据，参数和控制设置，确保当数据库和数据库发生单点故障时可以访问数据和配置参数。

48. 发明授权

US09555265B2 Intensity-modulated ion therapy 有权
标题翻译：强度调制离子治疗
公开(公告)号：US09555265B2
公开(公告)日：2017-01-31
申请号：US14945214
申请日：2015-11-18
申请人： Loma Linda University Medical Center
发明人： Reinhard W. Schulte
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61N5/1031 , A61N5/1077 , A61N2005/1087
摘要： The therapeutic treatment of a patient using intensity-modulated proton therapy is described. In one example, a method of creating a proton treatment plan is presented that divides volumes of interest into sub-volumes, applies dose constraints to the sub-volumes, finds one or more feasible configurations of a proton therapy system, and selects a proton beam configuration that improves or optimizes one or more aspects of proton therapy. In some implementations, the method of dividing volumes into sub-volumes includes creating fractional sub-volumes based at least in part on proximity to a target volume boundary. In some implementations, the method of finding an improved or optimal proton beam configuration from a set of feasible configurations includes finding a minimum of a cost function that utilizes weighting factors associated with treatment sites.
摘要翻译：描述了使用强度调制质子治疗的患者的治疗方法。在一个示例中，提出了一种创建质子治疗计划的方法，其将感兴趣的体积分成子体积，对子体积施加剂量约束，找到质子治疗系统的一个或多个可行配置，并选择质子束改善或优化质子治疗的一个或多个方面的配置。在一些实现中，将卷分割成子卷的方法包括至少部分地基于与目标卷边界的接近度来创建分数子卷。在一些实施方式中，从一组可行配置中找到改进或最佳质子束配置的方法包括找到利用与治疗部位相关联的加权因子的成本函数的最小值。

49. 发明申请

US20160077223A1 SYSTEMS AND METHODOLOGIES FOR PROTON COMPUTED TOMOGRAPHY 审中-公开
标题翻译：用于PROTON计算机图像的系统和方法
公开(公告)号：US20160077223A1
公开(公告)日：2016-03-17
申请号：US14799910
申请日：2015-07-15
申请人： University of Haifa , University of Wollongong , Loma Linda University Medical Center
发明人： Yair Censor , Scott N. Penfold , Reinhard W. Schulte
IPC分类号： G01T1/29 , A61B6/03 , A61B6/00 , G01T1/17
CPC分类号： G01T1/2985 , A61B6/032 , A61B6/4241 , A61B6/4258 , A61B6/4266 , A61B6/5205 , A61B6/583 , A61N5/10 , A61N2005/1087 , G01N23/046 , G01N2223/419 , G01T1/17 , G06F19/12 , G06F19/24 , G06T11/006
摘要： Disclosed are systems, devices and methodologies relating to proton computed tomography. In some implementations, detection of protons can yield track information before and after an object for each proton so as to allow determination of a likely path of each proton within the object. Further, measurement of energy loss experienced by each proton allows determination that a given likely path results in a given energy loss. A collection of such data allows characterization of the object. In the context of energy loss, such a characterization can include an image map of relative stopping power of the object. Various reconstruction methodologies for obtaining such an image, including but not limited to superiorization of a merit function such as total variation, are disclosed. In some implementations, various forms of total variation superiorization methodology can yield excellent results while being computationally efficient and with reduced computing time. In some implementations, such a methodology can result in high quality proton CT images using relatively low dose of protons.
摘要翻译：公开了与质子计算机断层摄影相关的系统，装置和方法。在一些实施方案中，质子的检测可以产生每个质子的物体之前和之后的轨道信息，以便允许确定物体内每个质子的可能路径。此外，每个质子经历的能量损失的测量允许确定给定的可能路径导致给定的能量损失。这样的数据的集合允许表征对象。在能量损失的上下文中，这种表征可以包括对象的相对停止力的图像映射。公开了用于获得这种图像的各种重建方法，包括但不限于诸如总变化的优点功能的优化。在一些实现中，各种形式的全变异优化方法可以产生优异的结果，同时在计算上有效并且具有减少的计算时间。在一些实施方案中，这种方法可以产生使用相对低剂量的质子的高质量质子CT图像。

50. 发明申请

US20160058904A1 CHITOSAN-BASED HEMOSTATIC TEXTILE 审中-公开
公开(公告)号：US20160058904A1
公开(公告)日：2016-03-03
申请号：US14933400
申请日：2015-11-05
申请人： Loma Linda University Medical Center , North Carolina State University
发明人： Wolff M. Kirsch , Yong Hua Zhu , Samuel Hudson
IPC分类号： A61L15/28 , A61L2/08 , A61L2/14 , A61L15/42
CPC分类号： A61L15/28 , A61L2/081 , A61L2/14 , A61L2/20 , A61L15/42 , A61L24/0036 , A61L24/08 , A61L26/0023 , A61L31/042 , A61L33/08 , A61L2400/04 , C08L5/08
摘要： A microfibrillar high molecular weight chitosan-based textile can be used as a hemostat. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan textile. A single or multiple such treatments may be employed. For example, the chitosan textile may be irradiated under nitrogen using γ-irradiation, treated under a nitrogen plasma, or both.

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