专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明公开

EP1429792A1 STRONTIUM COMPOUND FOR TREATMENT OF SUB-DERMAL SOFT TISSUE PAIN 有权
标题翻译：锶连接对于皮下软组织疼痛的治疗
公开(公告)号：EP1429792A1
公开(公告)日：2004-06-23
申请号：EP02765057.1
申请日：2002-09-27
申请人： Santosolve AS , Cockbain, Julian
发明人： JELLUM, EgilSantosolve AS , FAGERLUND, Bjorn JarlSantosolve AS , KJ LBERG, Clas MagneSantosolve AS , KLAVENESS, JoSantosolve AS
IPC分类号： A61K33/24 , A61P25/02
CPC分类号： A61K33/14 , A61K31/192 , A61K31/194 , A61K31/196 , A61K31/198 , A61K31/20 , A61K31/28 , A61K31/375 , A61K31/60 , A61K33/24 , Y10S514/936 , Y10S514/946 , Y10S514/947
摘要： The invention provides a method of treatment of a human or non-human subject to combat sub-dermal soft tissue pain therein, said method comprising administering to a said subject in need thereof an effective amount of a physiologically tolerable strontium compound.

42. 发明公开

EP1401896A1 POLYMERIZATION PROCESS FOR PRODUCING PROPYLENE COPOLYMERS 有权
标题翻译：聚合制备丙烯
公开(公告)号：EP1401896A1
公开(公告)日：2004-03-31
申请号：EP02720305.8
申请日：2002-05-03
申请人： Borealis Technology Oy , Cockbain, Julian
发明人： LEHMUS, Petri , HAKALA, Kimmo , PITKÄNEN, Päivi , ARNOLD, Manfred , MEINECKE, Andreas , STEHLING, Udo Manfred
IPC分类号： C08F210/06 , C08F2/14
CPC分类号： C08F210/06 , C08F4/65912 , C08F4/65916 , Y10S526/943 , C08F2/14 , C08F4/65927 , C08F210/14 , C08F2500/12 , C08F210/08 , C08F2500/03 , C08F2500/20
摘要： The invention provides a process for the preparation of a propylene polymer in which propylene and a comonomer copolymerizable therewith and of greater molecular weight than propylene are polymerized in a single site catalyst catalized polymerization reaction,, characterised in that said polymerization reaction is effected at least in part at a temperature of at least 70° C.

43. 发明公开

EP1105739A1 ASSAY METHOD FOR CARDIOVASCULAR DISEASE 审中-公开
标题翻译：诊断步骤心血管疾病
公开(公告)号：EP1105739A1
公开(公告)日：2001-06-13
申请号：EP99940374.4
申请日：1999-08-19
申请人： AXIS-SHIELD ASA , Cockbain, Julian
发明人： SUNDREHAGEN, Erling
IPC分类号： G01N33/68 , G01N33/82
CPC分类号： G01N33/6893 , G01N33/82 , G01N2800/32 , Y10T436/142222 , Y10T436/145555
摘要： The present invention relates to an assay method for detecting potential cardiovascular disease (CVD) in a vascularised subject, e.g. a human or non-human animal. The assay method comprises the assessment of the concentration of holo-transcobalamin II (holo-TCII) in a sample from said subject, abnormally low levels of holo-TCII being indicative of CVD or susceptibility to CVD.

44. 发明公开

EP0989906A1 SURFACTANT COMPOSITIONS 失效
标题翻译：表面活性化合物：
公开(公告)号：EP0989906A1
公开(公告)日：2000-04-05
申请号：EP98930875.4
申请日：1998-06-17
申请人： NYCOMED IMAGING AS , Cockbain, Julian
发明人： NA, George, C. , YUAN, Barbara, O. , STEVENS, Harold, Jack
IPC分类号： B01F17/00
CPC分类号： B01F17/0028
摘要： It has been found that block copolymer surfactants can be stabilized by the presence of small quantities of certain metal ions and/or a polyalkyleneglycol. The metal ions afford block copolymer surfactant stability at very low concentration of metal ion and safety advantages over conventional stabilizing techniques. The present invention is all the more surprising in view of the prior art which clearly indicates that metal ions would be expected to accelerate autoxidative degradation.

45. 发明公开

EP0971747A2 CONTRAST AGENTS 失效
标题翻译：对比剂
公开(公告)号：EP0971747A2
公开(公告)日：2000-01-19
申请号：EP97910516.0
申请日：1997-10-28
申请人： NYCOMED IMAGING AS , COCKBAIN, Julian
发明人： KLAVENESS, Jo , NAEVESTAD, Anne , CUTHBERTSON, Alan
IPC分类号： A61K49/00 , A61K51/08
CPC分类号： A61K49/0056 , A61K49/0021 , A61K49/0043 , A61K49/0052 , A61K49/0091 , A61K49/10 , A61K49/103 , A61K49/223 , A61K51/04 , A61K51/0453 , A61K51/0478 , A61K51/0497 , A61K51/1255
摘要： The invention provides a composition of matter of the formula (I): V-L-R where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body, with the provisos that where V is angiotension or a peptidic angiotensin derivative or analog then V-L-R is other than a non-metal radionuclide substituted peptide (e.g. 125I substituted angiotensin II) and L-V is other than simply a peptide with a chelating agent amide bonded to a side chain thereof. This composition of matter may be used to image cardiovascular diseases and disorders.
摘要翻译：本发明提供式（I）的物质组合物：VLR，其中V是对血管紧张素II受体位点具有结合亲和力的有机基团，L是接头部分或键，并且R是在体内成像中可检测的部分条件是当V是血管紧张素或肽类血管紧张素衍生物或类似物时，则VLR不是非金属放射性核素取代的肽（例如125 I取代的血管紧张素II）而LV不是简单的肽，而是与其侧链结合的螯合剂酰胺。这种物质组合物可以用于成像心血管疾病和病症。

46. 发明公开

EP0953149A1 DIAGNOSTIC SYSTEM 失效
标题翻译：诊断系统
公开(公告)号：EP0953149A1
公开(公告)日：1999-11-03
申请号：EP98900897.0
申请日：1998-01-15
申请人： Axis Biochemicals ASA , COCKBAIN, Julian Roderick Michaelson
发明人： SUNDREHAGEN, Erling , BREMNES, Dag
IPC分类号： G01J3 , G01N21
CPC分类号： G01N21/8483 , G01N21/82
摘要： There is described a diagnostic system comprising a desk-top, flat-bed optical colour scanner (101) which scans a substrate, such as a urine stick (107), which has been dipped in a container of analyte (105). The substrate (107) carries an image result generated by a chemical diagnostic assay and the scanner (101) generates a digitised record of the image. A personal computer (103) coupled to the scanner (101) is arranged to perform a colour analysis of the image by analysis of the digitised record and provides a quantified result for the diagnostic assay.

47. 发明公开

EP0815091A1 POLYAZACYCLOALKANE COMPOUNDS 失效
标题翻译：聚氮杂环烷烃化合物
公开(公告)号：EP0815091A1
公开(公告)日：1998-01-07
申请号：EP96904204.0
申请日：1996-03-01
申请人： NYCOMED IMAGING AS , COCKBAIN, Julian Roderick Michaelson
发明人： SCHULTZE, Lisa , BULLS, Alan, Ray
IPC分类号： C07D257
CPC分类号： C07D257/02
摘要： The present invention relates to tribenzylcyclen compounds of formula (I) (where R is hydrogen, or a C1-12 alkyl group optionally substituted by hydroxy, alkoxy or aryl groups or R is an amphiphilic aralkyl group comprising a N, S, O or P interrupted C2-25alkylene chain, e.g. a polyalkylene oxide chain or R provides a bridge to a second tribenzylcyclen group, but with the proviso that R is other than benzyl; X is CHR1, or where R is hydrogen two X groups may each represent CO groups; and R1 is hydrogen, a C1-6alkyl group optionally substituted by hydroxy, alkoxy or carboxy groups or an aralkyl group having 1 to 6 carbons in the alkyl moiety and optionally substituted in the aryl moiety by alkyl, alkoxy, hydroxy or isothiocyanate groups). These compounds are useful in the preparation of DO3A, N-substituted-1,4,7,10-tetraazacyclododecane-N',N',N'''-triacetic acids, and the phosphonic acid analogs.
摘要翻译：本发明涉及式（I）的三苄基环化合物（其中R为氢或任选被羟基，烷氧基或芳基取代的C 1-12烷基或R 2为包含N，S，O或P的两亲性芳烷基中断的C2-25亚烷基链，例如聚亚烷基氧链或R提供桥接到第二个三苄基环庚基，但条件是R不是苄基; X是CHR1，或其中R是氢，两个X基团可各自代表CO基团 ;并且R 1为氢，任选被羟基，烷氧基或羧基取代的C 1-6烷基或在烷基部分具有1-6个碳原子并且在芳基部分任选被烷基，烷氧基，羟基或异硫氰酸酯基团取代的芳烷基）。这些化合物可用于制备DO3A，N-取代-1,4,7,10-四氮杂环十二烷-N'，N'，N“' - 三乙酸和膦酸类似物。

48. 发明公开

EP0756496A1 DENDRIMERIC COMPOUNDS 失效
标题翻译：树枝状化合物
公开(公告)号：EP0756496A1
公开(公告)日：1997-02-05
申请号：EP95915939.0
申请日：1995-04-20
申请人： NYCOMED SALUTAR INC. , COCKBAIN, Julian
发明人： MARGERUM, Larry , CAMPION, Brian , FELLMAN, Jere Douglas , GARRITY, Martha
IPC分类号： A61K47 , A61K49 , A61K51 , C08G79
CPC分类号： A61K49/124 , A61K47/60 , A61K49/085 , A61K51/065 , A61K2121/00 , A61K2123/00 , C08G79/00 , Y10S424/16
摘要： The invention provides a dendrimeric compound comprising a dendrimeric backbone moiety with linked thereto a plurality of diagnostically or therapeutically active moieties, characterised in that the molecular skeleton of said compound contains at least one biodegradable cleavage site such that on cleavage thereof said active moieties are released in renally excretable form.
摘要翻译：本发明提供了一种树枝状大分子化合物，其包含树枝状大分子骨架部分并连接有多个诊断或治疗活性部分，其特征在于所述化合物的分子骨架含有至少一个可生物降解的切割位点，使得其切割时所述活性部分被释放可以排泄的形式。

49. 发明公开

EP0637252A1 NHR CONTRAST AGENTS 失效
标题翻译： NHR造影剂
公开(公告)号：EP0637252A1
公开(公告)日：1995-02-08
申请号：EP93911859.0
申请日：1993-04-22
申请人： COCKBAIN, Julian Roderick Michaelson , NYCOMED IMAGING AS
发明人： KLAVENESS, Jo , BERG, Arne
IPC分类号： A61K49
CPC分类号： A61K49/06
摘要： The invention provides parenterally administrable, liver-specific MR imaging contrast media comprising Mn(II) chelates of N,N'-EDTA bisamides.
摘要翻译：本发明提供了包含N，N'-EDTA双酰胺的Mn（II）螯合物的肠胃外可施用的肝特异性MR成像造影剂。

50. 发明公开

EP0497926A1 MULTI-SITE METAL CHELATING AGENTS 失效转让
标题翻译：齿金属螯动物端接。
公开(公告)号：EP0497926A1
公开(公告)日：1992-08-12
申请号：EP91908157.0
申请日：1990-10-20
申请人： COCKBAIN, Julian Roderick Michaelson , SALUTAR, INC.
发明人： LOVE, David , DOW, William, C. , HIMMELSBACH, Richard, J. , WATSON, Alan, D. , ROCKLAGE, Scott, M.
IPC分类号： A61K , C07C , C07D , A61K49 , A61K51 , C07C237 , C07D241 , C07D257 , C07D295 , C07F3 , C07F5 , C07F7 , C07F9 , C07F11 , C07F15 , C07F19 , C07K2
CPC分类号： C07D241/06 , A61K49/06 , C07C237/06 , C07C237/10 , C07C237/12 , C07D257/02 , C07D295/185 , C07F19/005
摘要： On a mis au point des composés polychélateurs, c'est-à-dire des agents chélateurs métalliques multi-sites, ainsi que des chélates formés à l'aide de ceux-ci. Les polychélateurs et notamment leur polychélate de métal paramagnétique, de métal lourd ou de métal radioactif sont particulièrement adaptés à une utilisation en imagerie de diagnostique, en détoxification ou en radiothérapie à l'aide de métal lourd. Les polychélateurs ont une structure oligomère linéaire ou ramifiée, comprenant des fractions de chélateurs et de liaisons alternées, liées ensemble par des fractions d'amides ou d'esters, dont les groupes carbonyle sont adjacents aux fractions de chélateurs, chaque polychélateur comprenant au moins deux desdites fractions de chélateurs capables de transformer en complexe un ion de métal.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式