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41. 发明申请

WO1990004605A1 CALCITONIN GENE RELATED PEPTIDE ANALOGUES 审中-公开
标题翻译： CALCITONIN基因相关肽类似物
公开(公告)号：WO1990004605A1
公开(公告)日：1990-05-03
申请号：PCT/GB1989001249
申请日：1989-10-20
申请人： CELLTECH LIMITED , EATON, Michael, Anthony, William , BEELEY, Nigel, Robert, Arnold , BOSE, Christopher, Cyril
发明人： CELLTECH LIMITED
IPC分类号： C07K07/10
CPC分类号： C07K14/57527 , A61K38/00
摘要： Novel analogues of calcitonin gene related peptide comprise analogues of natural CGRPs modified at at least two of positions 3, 22 and 25. These compounds are of general formula NH2-Ala-Cys-A-aaα-B-C-Lys-D-aa?β-CONH¿2, wherein A is a carboxylate or amide substituted amino acid or amino acid analogue; aaα is substantially the amino acid sequence of a CGRP from position 4 to position 21; B is a hydrocarbyl or thio substituted amino acid or amino acid analogue; C is valine or glycine; D is an amine or hydroxyl substituted amino acid or amino acid analogue. The novel analogues may comprise natural amino acid residues. Preferably A is aspartate or asparagine, B is valine or methionine, C is valine and D is asparagine or serine. The analogues exhibit desirable cardiovascular properties and are potentially useful in therapy, e.g. for treatment of deficiencies in cerebral blood supply.

42. 发明申请

WO1990001553A1 TRYPTOPHAN PRODUCTION 审中-公开
标题翻译： TRYPTOPHAN生产
公开(公告)号：WO1990001553A1
公开(公告)日：1990-02-22
申请号：PCT/GB1989000907
申请日：1989-08-09
申请人： CELLTECH LIMITED , FROUD, Stephen, James , LITTLE, Stephen, John , ROBINSON, Martyn, Kim , LILLEY, Gerald
发明人： CELLTECH LIMITED
IPC分类号： C12P13/22
CPC分类号： C12N9/88 , C12P13/227
摘要： A multi-stage microbial process for the production of tryptophan is described where the biocatalyst production and bioconversion stages are separated. In the biocatalyst production stage bacterial host cells are transformed with a vector containing a DNA sequence coding for tryptophanase wherein the expression of the tryptophanase gene is directly controllable; the transformed host cells are induced to synthesise tryptophanase; and then in a subsequent bioconversion stage the reaction substrates for tryptophan synthesis are added and the tryptophan which accumulates in the reaction mixture is optionally isolated.
摘要翻译：描述了用于生产色氨酸的多级微生物方法，其中分离生物催化剂生产和生物转化阶段。在生物催化剂生产阶段，用含有编码色氨酸酶的DNA序列的载体转化细菌宿主细胞，其中色氨酸酶基因的表达是直接可控的; 诱导转化的宿主细胞合成色氨酸酶; 然后在随后的生物转化阶段中，加入用于色氨酸合成的反应底物，任选分离积聚在反应混合物中的色氨酸。

43. 发明申请

WO1989009825A1 METHOD FOR PRODUCING RECOMBINANT DNA PROTEINS 审中-公开
标题翻译：生产重组DNA蛋白的方法
公开(公告)号：WO1989009825A1
公开(公告)日：1989-10-19
申请号：PCT/GB1989000399
申请日：1989-04-17
申请人： CELLTECH LIMITED , WINTER, Gregory, Paul , RIECHMANN, Lutz , YARRANTON, Geoffrey, Thomas , BODMER, Mark, William , OWENS, Raymond, John
发明人： CELLTECH LIMITED
IPC分类号： C12N15/00
CPC分类号： C07K16/40 , C07K16/00 , C07K2317/24 , C07K2317/56
摘要： The present invention provides a method for producing Fv fragments comprising: transforming a eukaryotic host cell with a eukaryotic expression vector comprising an operon having a DNA sequence which encodes the variable domain only of an antibody light or heavy chain, culturing the transformed host cell under conditions which cause the protein encoded by the DNA sequence to be synthesised; and collecting the synthesised protein.

44. 发明申请

WO1989008460A1 ANTIBODIES FOR USE IN ANTILYMPHOCYTE ANTIBODY THERAPY 审中-公开
标题翻译：抗体用于抗精神病药物治疗的抗体
公开(公告)号：WO1989008460A1
公开(公告)日：1989-09-21
申请号：PCT/GB1989000254
申请日：1989-03-13
申请人： CELLTECH LIMITED , BUURMAN, Wim
发明人： CELLTECH LIMITED
IPC分类号： A61K39/395
CPC分类号： C07K16/2809 , A61K38/00 , C07K16/241
摘要： The use of antibodies against human alpha tumour necrosis factor in antilymphocyte antibody therapy is described. The anti-human alpha tumour necrosis factor antibodies may be used to prevent or treat shock-related conditions arising from antilymphocyte antibody therapy. Also described are compositions containing anti-human alpha tumour necrosis factor antibodies and antilymphocyte antibodies, as well as recombinant anti-human alpha tumour necrosis factor antibodies.
摘要翻译：描述了在抗淋巴细胞抗体治疗中使用针对人α肿瘤坏死因子的抗体。抗人α肿瘤坏死因子抗体可用于预防或治疗由抗淋巴细胞抗体治疗产生的休克相关病症。还描述了含有抗人α肿瘤坏死因子抗体和抗淋巴细胞抗体以及重组抗人α肿瘤坏死因子抗体的组合物。

45. 发明申请

WO1989004866A1 BACILLUS CELLS 审中-公开
标题翻译： BACILLUS细胞
公开(公告)号：WO1989004866A1
公开(公告)日：1989-06-01
申请号：PCT/GB1988001026
申请日：1988-11-25
申请人： CELLTECH LIMITED , MOUNTAIN, Andrew
发明人： CELLTECH LIMITED
IPC分类号： C12N01/20
CPC分类号： C12R1/125 , C12N15/75
摘要： A triple mutant strain of Bacillus is described. The mutant strain has at least the phenotype Apr , Npr SpoOH and shows a reduced level of extracellular proteases. The reduction in the level of the extracellular proteases secreted by the Bacillus cell makes it a useful host for the expression of heterologous polypeptides.
摘要翻译：描述了芽孢杆菌的三重突变菌株。该突变体菌株至少具有表型Apr - ，Npr - SpoOH - ，并显示细胞外蛋白酶水平的降低。由芽孢杆菌细胞分泌的细胞外蛋白酶水平的降低使其成为表达异源多肽的有用宿主。

46. 发明申请

WO1989001783A2 RECOMBINANT ANTIBODY AND METHOD 审中-公开
标题翻译：重组抗体和方法
公开(公告)号：WO1989001783A2
公开(公告)日：1989-03-09
申请号：PCT/GB1988000731
申请日：1988-09-05
申请人： CELLTECH LIMITED , BODMER, Mark, William , ADAIR, John, Robert , WHITTLE, Nigel, Richard
发明人： CELLTECH LIMITED
IPC分类号： A61K39/395
CPC分类号： C07K16/3015 , C07K16/00 , C07K16/30 , Y10S424/801 , Y10S530/867
摘要： The present invention provides a humanised antibody molecule (HAM) having specificity for the TAG-72 antigen and having an antigen binding site wherein at least the complementarity determining regions (CDRs) of the variable domain are derived from the mouse monoclonal antibody B72.3 (B72.3 MAb) and the remaining immunoglobulin-derived parts of the HAM are derived from a human immunoglobulin and a process for its production.
摘要翻译：本发明提供了对TAG-72抗原具有特异性且具有抗原结合位点的人源化抗体分子（HAM），其中至少可变区的互补决定区（CDR）源自小鼠单克隆抗体B72.3（ B72.3MAb），剩余的来自HAM的免疫球蛋白衍生部分来自人免疫球蛋白及其生产方法。

47. 发明申请

WO1989001476A1 TETRA-AZA MACROCYCLES AND METAL COMPLEXES THEREOF 审中-公开
标题翻译： TETRA-AZA MACROCYCLES及其金属复合物
公开(公告)号：WO1989001476A1
公开(公告)日：1989-02-23
申请号：PCT/GB1988000671
申请日：1988-08-12
申请人： CELLTECH LIMITED , PARKER, David , MILLICAN, Thomas, Andrew
发明人： CELLTECH LIMITED
IPC分类号： C07D257/02
CPC分类号： C07D401/12 , A61K47/6887 , A61K49/0002 , C07D257/02
摘要： Tetra-aza macrocycles of formula (1), wherein m and n, which may be the same or different, is each zero or an integer 1, 2, or 3; d is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R , R and R , which may be the same or different, is each a hydrogen atom or an alkyl, alkoxyalkyl, -CO2H, -SO3H, PO3H2 or aryl group; L is a covalent bond or linker group; Z is a hydrogen atom or a reactive functional group, with the proviso that when L is a covalent bond Z is a reactive functional group; and metal complexes and/or salts thereof; are described together with processes for their preparation and compositions containing them. The compounds are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and are particularly suitable for coupling to other molecules, such as proteins for use in diagnosis and therapy.
摘要翻译：式（1）的四氮杂大环，其中m和n可以相同或不同，分别为零或整数1,2或3; d为零或整数1或2; q为0或1〜6的整数; R 1，R 2和R 3可以相同或不同，分别为氢原子或烷基，烷氧基烷基，-CO 2 H，-SO 3 H，PO 3 H 2或芳基; L是共价键或连接基团; Z是氢原子或反应性官能团，条件是当L是共价键时，Z是反应性官能团; 和金属络合物和/或其盐; 与其制备方法和含有它们的组合物一起描述。所述化合物可用于成像和治疗异常细胞病症，例如治疗肿瘤，并且特别适用于与其它分子（例如用于诊断和治疗的蛋白质）的偶联。

48. 发明申请

WO1988005433A1 THIOL-REACTIVE CROSS-LINKING REAGENTS 审中-公开
标题翻译： THIOL反应性交联试剂
公开(公告)号：WO1988005433A1
公开(公告)日：1988-07-28
申请号：PCT/GB1988000028
申请日：1988-01-15
申请人： CELLTECH LIMITED , ALEXANDER, Rikki, Peter , EATON, Michael, Anthony, William , MILLICAN, Thomas, Andrew , TITMAS Richard, Charles, Dominic
发明人： CELLTECH LIMITED
IPC分类号： C07D213/30
CPC分类号： C07D213/30
摘要： Cross-linking reagents which are highly specific for sulphydryl groups and react with thiols at an excellent rate. The essential feature of the reagents is at least one vinyl group conjugated with an aromatic nitrogen heterocycle. Particular examples include vinyl pyridines, vinyl pyrimidines and vinyl triazines.
摘要翻译：对巯基高度特异的交联试剂，以极好的速率与硫醇反应。试剂的基本特征是至少一个与芳族氮杂环共轭的乙烯基。具体实例包括乙烯基吡啶，乙烯基嘧啶和乙烯基三嗪。

49. 发明申请

WO1987004462A1 RECOMBINANT DNA SEQUENCES, VECTORS CONTAINING THEM AND METHOD FOR THE USE THEREOF 审中-公开
标题翻译：重组DNA序列，含有它们的载体及其使用方法
公开(公告)号：WO1987004462A1
公开(公告)日：1987-07-30
申请号：PCT/GB1987000039
申请日：1987-01-23
申请人： CELLTECH LIMITED , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW , WILSON, Richard, Harris , BEBBINGTON, Christopher, Robert
发明人： CELLTECH LIMITED , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
IPC分类号： C12N15/00
CPC分类号： C12N9/93 , C12N9/6459 , C12N15/85 , C12Y304/21069
摘要： Recombinant DNA sequences which encode the complete amino acid sequence of a glutamine synthetase, vectors containing such sequences, and methods for their use, in particular as dominant selectable markers, for use in co-amplification of non-selected genes and in transforming host cell lines to glutamine independence.
摘要翻译：编码谷氨酰胺合成酶的完整氨基酸序列的重组DNA序列，含有此类序列的载体及其使用方法，特别是作为显性选择性标记，用于非选择基因的共扩增和转化宿主细胞系谷氨酰胺独立。

50. 发明申请

WO1987001729A1 POLYPEPTIDE PRODUCTION 审中-公开
标题翻译：多肽生产
公开(公告)号：WO1987001729A1
公开(公告)日：1987-03-26
申请号：PCT/GB1986000559
申请日：1986-09-19
申请人： CELLTECH LIMITED , EATON, Michael, Anthony, William , TITMAS, Richard, Charles, Dominic , RHIND, Stephen, Keith
发明人： CELLTECH LIMITED
IPC分类号： C12P21/02
CPC分类号： C12N9/0071 , C12Y114/17003
摘要： A process for the production of a polypeptide having a C-terminal amide group where the polypetide has one or more cysteine or cystine amino acid residues. A second polypetide comprising the amino acid sequence of the first polypeptide and a C-terminal glycine amino acid residue and where the cysteine or cystine sulphur group or groups is or are protected is reacted with an amidating enzyme capable of converting the C-terminal glycine amino acid residue to an amide.

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