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1. 发明专利

CA1340603C TRI-AZA MACROCYCLES AND METAL COMPLEXES THEREOF 未知
公开(公告)号：CA1340603C
公开(公告)日：1999-06-22
申请号：CA574629
申请日：1988-08-12
申请人： PARKER DAVID PARKER DAVID , MILLICAN THOMAS ANDREW MILLICA
发明人： PARKER DAVID PARKER DAVID , MILLICAN THOMAS ANDREW MILLICA
IPC分类号： C07H17/02 , A61K31/395 , A61K39/395 , A61K47/22 , A61K47/24 , A61K47/48 , A61K49/00 , A61P35/00 , C07D255/02 , C07D401/06 , C07F9/6515 , C07K1/13 , C07K16/00 , A61K51/04 , A61K51/10
摘要： Tri-aza macrocycles of formula (1) (see fig. I) wherein m and n, which may be the same of different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R1, R2 and R3, which may be the same or different, is each a hydrogen atom or an alkyl, alkoxyalkyl, -CO2H, -SO3H, PO3H2 or aryl group; L is a covalent bond or linker group; Z is a hydrogen atom or a reactive functional group, with the proviso that when L is a covalent bond Z is a reactive functional group; and metal complexes and/or salts thereof; are described together with processes for their preparation and compositions containing them. The compounds are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and are particularly suitable for coupling to other molecules such as proteins for use in diagnosis and therapy.

2. 发明专利

CA1341102C TETRA-AZA MACROCYCLES AND METAL COMPLEXES THEREOF 未知
公开(公告)号：CA1341102C
公开(公告)日：2000-09-26
申请号：CA574630
申请日：1988-08-12
申请人： MILLICAN THOMAS ANDREW MILLICA , PARKER DAVID PARKER DAVID
发明人： MILLICAN THOMAS ANDREW MILLICA , PARKER DAVID PARKER DAVID
IPC分类号： G01N33/532 , A61K31/395 , A61K31/44 , A61K31/4427 , A61K39/395 , A61K47/48 , A61K49/00 , A61P35/00 , C07D257/02 , C07D401/00 , C07D401/12 , C07F5/00 , C07K17/02 , A61K39/44
摘要： Tetra-aza macrocycles of formula (1) (see formula I) wherein m and n , which may be the same of different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R1, R2 and R3, which may be the same or different, is each a hydrogen atom or an alkyl, alkoxyalkyl, -CO2H, -SO3H, PO3H2 or aryl group; L is a covalent bond or linker group; Z is a hydrogen atom or a reactive functional group, with the proviso that when L is a covalent bond Z is a reactive functional group; and metal complexes and/or salts thereof; are described together with processes for their preparation and compositions containing them. The compounds are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and are particularly suitable for coupling to other molecules such as proteins for use in diagnosis and therapy.

3. 发明公开

EP2903993A4 IMPROVED LIQUID FORMULATIONS OF UREASE INHIBITORS FOR FERTILIZERS 审中-公开
标题翻译：脲酶抑制剂的改善现金配方专用肥
公开(公告)号：EP2903993A4
公开(公告)日：2016-06-15
申请号：EP13844259
申请日：2013-05-08
申请人： MCKNIGHT GARY DAVID , PARKER DAVID BRUCE , ZEHNI YANG , PERKINS RAY , XU WEI
发明人： MCKNIGHT GARY DAVID , PARKER DAVID BRUCE , ZEHNI YANG , PERKINS RAY , XU WEI
IPC分类号： C07F9/22 , C05C9/00 , C05G3/08
CPC分类号： C05G3/08 , C05C9/00 , C05C9/005 , C05G3/0041 , C05G3/0064 , C07F9/224 , C09K15/28
摘要： An improved solvent system for the formulation and application of N-alkyl thiophosphoric triamide urease inhibitors. These formulations provide safety and performance benefits relative to existing alternatives and enable storage, transport and subsequent coating or blending with urea based or organic based fertilizers. These formulations are comprised primarily of environmentally friendly aprotic and protic solvents (particularly dimethyl sulfoxide and alcohols/polyols) to stabilize the urease inhibitor.

4. 发明公开

EP2903993A1 IMPROVED LIQUID FORMULATIONS OF UREASE INHIBITORS FOR FERTILIZERS 审中-公开
标题翻译： VERBESSERTEFLÜSSIGEFORMULIERUNGEN VON UREASEINHIBITORENFÜRDÜNGER
公开(公告)号：EP2903993A1
公开(公告)日：2015-08-12
申请号：EP13844259.5
申请日：2013-05-08
申请人： Mcknight, Gary, David , Parker, David, Bruce , Zehni, Yang , Perkins, Ray , Xu, Wei
发明人： Mcknight, Gary, David , Parker, David, Bruce , Zehni, Yang , Perkins, Ray , Xu, Wei
IPC分类号： C07F9/22
CPC分类号： C05G3/08 , C05C9/00 , C05C9/005 , C05G3/0041 , C05G3/0064 , C07F9/224 , C09K15/28
摘要： An improved solvent system for the formulation and application of N-alkyl thiophosphoric triamide urease inhibitors. These formulations provide safety and performance benefits relative to existing alternatives and enable storage, transport and subsequent coating or blending with urea based or organic based fertilizers. These formulations are comprised primarily of environmentally friendly aprotic and protic solvents (particularly dimethyl sulfoxide and alcohols/polyols) to stabilize the urease inhibitor.
摘要翻译：用于制备和应用N-烷基硫代磷酸三酰胺脲酶抑制剂的改进的溶剂体系。这些配方相对于现有的替代品提供了安全性和性能方面的优点，并且能够与尿素或有机基肥料进行储存，运输和随后的包衣或混合。这些制剂主要由环境友好的非质子和质子溶剂（特别是二甲基亚砜和醇/多元醇）组成，以稳定脲酶抑制剂。

5. 发明公开

EP3137435A1 INCREASED LONGEVITY OF NITROGEN CONTENT OF SOIL THROUGH IMPROVED LIQUID DELIVERY FORMULATIONS OF NITRIFICATION INHIBITORS TO FERTILIZERS 审中-公开
标题翻译：硝化抑制剂现金和给药的制剂肥料土壤氮含量增加LIFE
公开(公告)号：EP3137435A1
公开(公告)日：2017-03-08
申请号：EP15786758.1
申请日：2015-05-02
申请人： Mcknight, Gary, David , Rayborn, Randall, Linwood , Parker, David, Bruce , Xu, Wei , Perkins, Raymond, Patrick , Yang, Zehui
发明人： Mcknight, Gary, David , Rayborn, Randall, Linwood , Parker, David, Bruce , Xu, Wei , Perkins, Raymond, Patrick , Yang, Zehui
IPC分类号： C05D9/02
CPC分类号： C05G3/08 , C09K15/20 , C09K15/28 , C09K15/30 , Y02P60/218
摘要： Increasing longevity of the nitrogen content of soil through improved liquid delivery formulations of nitrification inhibitors. The liquid, formulation can also be comprised of nitrification inhibitors and urease inhibitors that are co-dissolved or blended solutions of each These novel formulations are designed to apply to fertilizers, especially area and manure based fertilizers These delivery formulations provide an environmentally sound and inherently safe solvating system that improves the storage stability of the urease inhibitors by utilizing liquid organic non-water containing solvents, maintain the nitrification inhibitors in solution to storage temperatures of at least 10°C and provides improved application to fertilizer of nitrification inhibitors. These delivery formulations enable safe storage, transport and subsequent application or blending with urea based or manure based fertilizers that can be applied to soil in either a liquid or granular form to provide improved nitrogen retention in the soil for uptake for plant life.
摘要翻译：通过硝化抑制剂的改进的液体输送式灰增加土壤中的氮含量的寿命。因此，该液体制剂可包括硝化抑制剂和脲酶抑制剂的那样是共溶解或每个论文新颖式蒸发散被设计成适用于肥料的混合解决方案，爱尤其尿素和基于肥料的肥料论文输送式蒸发散提供关于对环境无害和固有安全的溶剂化系统确实改善由利用液体有机非水溶剂含有的脲酶抑制剂的储存稳定性，保持在溶液中的硝化抑制剂到至少10℃的储存温度下，并提供改进的应用程序，以硝化抑制剂的肥料。这些递送式Ti能够安全储存，运输和随后的应用程序或与基于并可以应用到土壤中以液体或粒状形式，以提供在土壤中摄取为植物生命改进的氮保留基于尿素肥料或肥料混合。

6. 发明授权

EP1237600B1 IMPROVEMENTS IN OR RELATING TO HYPODERMIC SYRINGES 有权
标题翻译：与之相关的改进皮下SPLASH
公开(公告)号：EP1237600B1
公开(公告)日：2006-11-29
申请号：EP00988968.4
申请日：2000-12-14
申请人： Parker, David William , Burgess, Colin Hamilton
发明人： Parker, David William , Burgess, Colin Hamilton
IPC分类号： A61M5/32
CPC分类号： A61M5/3234 , A61M5/3202 , A61M5/34 , A61M5/344 , A61M2005/3241 , A61M2005/3242
摘要： A hypodermic syringe includes a housing (1), a plunger (2) with an associated piston (3), a needle carrier (4) with a needle (5) covered by a removable sheath (6). A vacuum is formed between the plunger (2) and piston (3). When the plunger (2) is operated, the piston (3) engages the needle carrier and a coupling between the plunger and piston is broken, so that the vacuum withdraws the piston (3) into the plunger (2), together with the needle carrier, so as to retract the needle into the housing (1). The needle carrier (4) is rectangular in cross-section and is received in a corresponding rectangular sectioned housing opening (1.2) in order to prevent rotation of the needle carrier relative to the housing. This facilitates removal of the needle sheath, without the risk of a needle stick injury prior to use of the syringe, and allows for the separate and external fitting of a needle.

7. 发明公开

EP0248016A1 A VEHICLE ROAD WHEEL LOCKING DEVICE 失效
标题翻译： LOCKING安排车辆。
公开(公告)号：EP0248016A1
公开(公告)日：1987-12-09
申请号：EP86901737.0
申请日：1986-03-05
申请人： PARKER, David, Henry , COWAN, James, Thornton
发明人： RUSSELL-HEAD, David, Stephen , HOPPER, William, Robb , KELSO, Richard, Malcolm
IPC分类号： B60R25
CPC分类号： B60R25/093
摘要： Un dispositif de verrouillage de la roue d'un véhicule comprend un support cylindrique (10) ayant un premier élément de mors (16) rigidement fixé à une des ses extrémités. Un deuxième élément de mors (22) est soutenu par l'autre extrémité du support (10) de façon à glisser axialement et à tourner sur celle-ci. Chaque élément de mors comprend un mors (24, 26) transversal par rapport au support (10). Un ou les deux mors (24, 26) se terminent par une protubérance (28, 30). Le moraillon (44) du cadenas (46) peut s'encastrer dans des orifices (42) du support et du deuxième élément de mors (22) pour bloquer le deuxième élément de mors (22) par rapport au support (10), les deux mors (24, 26) étant placés sur le même plan, ce qui permet de fixer le mécanisme axialement sur la périphérie d'un ensemble de roue et de pneu. Les protubérances (28, 30) de mors enclenchent des côtés opposés de la jante de la roue, ce qui empêche le mécanisme d'être enlevé.

8. 发明公开

EP1316331A1 Method for determining the remaining adsorption capacity of a carbon dioxide scrubber and associated apparatus 有权
标题翻译：一种用于确定系统的吸附容量用于去除二氧化碳和相关联的装置的方法
公开(公告)号：EP1316331A1
公开(公告)日：2003-06-04
申请号：EP02258125.0
申请日：2002-11-26
申请人： Parker, Martin John , Parker, David
发明人： Parker, Martin John
IPC分类号： A62B7/02 , B63C11/24 , B01D53/04
CPC分类号： B01D53/0438 , A62B9/006 , A62B19/00 , B01D53/0415 , B01D2256/12 , B01D2257/504 , B01D2259/4533 , B63C11/24 , Y02C10/08
摘要： A breathing apparatus of the type in which exhaled gas is passed through a body of re-agent material for removal of at least a proportion of the carbon dioxide content from the exhaled gas prior to or following injection of a determined quantity of oxygen or a mixture of oxygen and other gases to the gas and presentation of the gas for re-breathing. The apparatus comprises an exhaled air treatment system (19) which comprises a cylindrical container (32) having an inner cartridge (39). The inner cartridge contains the re-agent material. The apparatus further comprises a plurality of temperature sensors (70) disposed in or adjacent to the re-agent material for measuring the temperature difference between at least two locations during carbon dioxide removal by the filter. A processor means is provided for determining the remaining carbon dioxide absorbing capacity of the remaining active re-agent material in accordance with the measured temperature difference from the sensors. A method for determining the remaining carbon dioxide absorbing capacitiy of the re-agent material in accordance with the data provided by the sensors (70).
摘要翻译：在哪个呼出气体通过重新剂材料的主体通过去除至少一个中的二氧化碳含量的从呼出气体之前比例或以下的氧的确定性开采量或它们的混合物的喷射的类型的呼吸装置的氧气和其它气体的气体和气体的呈现用于再呼吸。呼出的空气处理系统（19），其包括具有上内筒（39）的圆柱形容器（32）的所述装置包括。内套筒包含重剂材料。该装置还包括设置在或邻近于重剂材料二氧化碳去除由过滤器期间测量在至少两个位置之间的温度差的温度传感器（70）的复数。一种处理器装置，用于确定性采矿剩余二氧化碳吸收在雅舞蹈与来自传感器的测量温度差的剩余活性重新剂材料的容量。一种用于确定性采矿方法的剩余二氧化碳吸收重新剂材料的capacitiy与由传感器（70）提供的数据雅舞蹈。

9. 发明授权

EP1015077B1 SELF-CONTAINED BREATHING APPARATUS 有权
标题翻译：自综合呼吸器
公开(公告)号：EP1015077B1
公开(公告)日：2003-04-09
申请号：EP98942946.9
申请日：1998-09-17
申请人： Parker, Martin John , Parker, David , Parker, Angela Margaret
发明人： PARKER, Martin John
IPC分类号： A62B7/02 , B63C11/24
CPC分类号： B63C11/24 , A62B7/02

10. 发明公开

EP1115439A1 IMPROVEMENTS IN OR RELATING TO HYPODERMIC SYRINGES 审中-公开
标题翻译：与超声波注射器有关的改进或与超声波注射器有关的改进
公开(公告)号：EP1115439A1
公开(公告)日：2001-07-18
申请号：EP99949131.9
申请日：1999-09-22
申请人： Parker, David William , Burgess, Colin Hamilton
发明人： Parker, David William , Burgess, Colin Hamilton
IPC分类号： A61M5/32
CPC分类号： A61M5/3234 , A61M5/31501 , A61M5/3202 , A61M2005/3104 , A61M2005/3231 , A61M2005/3235 , A61M2005/3241 , A61M2005/342 , Y10S128/919
摘要： A disposable hypodermic syringe which is provided with the needle fitted and sheathed and which provides automatic retraction of the needle after use. The syringe may be supplied pre-charged with an injectant. In this invention the completion of the injection stroke attaches the piston (3) to the needle carrier (8) and subsequently dislodges a retaining ring (6) thereby freeing the piston (3) from the plunger (2) and releasing stored energy of the spring (4) to draw the piston (3) and needle carrier (8) into the plunger (2). The plunger (2) is positively retained inside the housing (1) by the interaction of rings (1.2) and (2.2). Alternative methods of locating the needle carrier (8) during use and of attaching the piston (3) to the needle carrier (8) to enable retraction are shown. An alternative method of retaining the piston (3) on the plunger (2) is also shown. A further configuration is shown affording the use of an off-set needle. The syringe has optional features to prevent unwanted inward movement of the plunger (2) and to prevent seepage of liquid after use.
摘要翻译：一种一次性皮下注射器，其装有并套有针头并在使用后自动缩回针头。注射器可以预先装有注射剂。在本发明中，注射冲程的完成将活塞（3）连接到针托架（8）上，随后移动保持环（6），由此使活塞（3）从柱塞（2）释放并释放储存的弹簧（4）将活塞（3）和针座（8）拉入柱塞（2）。柱塞（2）通过环（1.2）和（2.2）的相互作用而可靠地保持在壳体（1）内。示出了在使用期间定位针托架（8）并且将活塞（3）附接到针托架（8）以实现回缩的可选方法。还示出了将柱塞（3）保持在柱塞（2）上的替代方法。示出了提供使用偏置针的另一种构造。注射器具有可选特征以防止柱塞（2）的不希望的向内移动并防止使用后的液体渗漏。

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