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    • 43. 发明专利
    • Nmr measurement device with temperature control element for sample vial
    • 具有温度控制元件的NMR测量装置
    • JP2014089178A
    • 2014-05-15
    • JP2013186333
    • 2013-09-09
    • Bruker Biospin Agブルーカー バイオシュピン アー・ゲー
    • PHILIPP GISLERDIRK WILHELMCHRISTOPH PFENNINGER
    • G01R33/31G01R33/32
    • G01R33/31
    • PROBLEM TO BE SOLVED: To provide an NMR measurement device with a temperature control element for a sample vial.SOLUTION: An NMR measurement device includes a temperature control element for a sample vial 1 where a temperature control fluid 8 brought under the temperature control of a heater 12 flows at its periphery. Further, the NMR measurement device is provided with a temperature sensor 9 such that a measurement head projects into a measurement space 14 spatially closely to the sample vial 1. A supply wire for the temperature sensor 9 is arranged in another space different from the measurement space 14. The temperature sensor 9 including the supply wire is surrounded with the sensor tube 15 at a radius distance, and a partial flow of the temperature control fluid 8 enters a free space 17 as a temperature control flow 16 from the measurement space 14 through a sensor flow entrance 26 and exits from the sensor tube 15 through a sensor flow exit 18 at an end on the opposite side from the sensor tube 15. Consequently, a temperature crossover and a temperature difference (ΔTp) between the temperature sensor 9 and sample vial 1 are both minimized.
    • 要解决的问题:提供具有用于样品瓶的温度控制元件的NMR测量装置。解决方案:NMR测量装置包括用于样品瓶1的温度控制元件,其中温度控制流体8在温度控制下 加热器12在其周边流动。 此外,NMR测量装置设置有温度传感器9,使得测量头在空间上突出到测量空间14中。温度传感器9的供应线布置在与测量空间不同的另一空间中 包括电源线的温度传感器9以半径距离被传感器管15包围,并且温度控制流体8的部分流动作为温度控制流16从测量空间14进入自由空间17,通过 传感器流入口26并通过传感器流出口18在传感器管15的相对侧的端部处从传感器管15离开。因此,温度传感器9和温度传感器9之间的温度差异(&Dgr; Tp) 样品瓶1都被最小化。
    • 45. 发明专利
    • Device for extremely precise synchronization of nmr transmission frequency to resonance frequency of nmr line taking into consideration non-constant rf phase, and synchronization system of the same
    • 用于核磁共振传输频率的极端精确同步的设备与考虑非常数RF相位的NMR线的共振频率及其同步系统
    • JP2010281812A
    • 2010-12-16
    • JP2010101022
    • 2010-04-26
    • Bruker Biospin Agブルーカー バイオシュピン アー・ゲー
    • SCHWILCH ARTHURSCHENKEL MICHAEL
    • G01R33/36
    • G01R33/31G01R33/36G01R33/3607G01R33/389
    • PROBLEM TO BE SOLVED: To highly precisely synchronize an NMR transmission frequency to a resonance frequency in consideration of a non-constant RF phase. SOLUTION: This device synchronizes the frequency fRF of an RF generator to the resonance frequency f0, repeatedly produces a train of excitation pulses of a frequency fm from the RF generator, semi-continuously excites a nuclear spin of a related specific resonance frequency, receives an NMR signal between the excitation pulses, selects period time 1/fm so that the relaxation time is shorter than 1/10, closed-loop-controls the value of the transmission frequency or the value of the B0 field using an NMR signal UD of a low frequency range from a first control loop, accurately matches the frequency of the RF generator and the NMR line with the phase, controls a phase shifter for rotating the high frequency phase of a transmission and reception system of the first control loop by value Δϕ by the second control loop, extracts a signal UD where the input signal of the second control loop is a saw-tooth AC component, produces the input signal in a signal extraction stage for keeping it at zero by the closed-loop-control, and improves the precision for synchronizing the resonance frequency. COPYRIGHT: (C)2011,JPO&INPIT
    • 要解决的问题:考虑到不恒定的RF相,将NMR传输频率高精度地同步到谐振频率。 解决方案:该装置将RF发生器的频率fRF与谐振频率f0同步,从RF发生器重复产生频率fm的一系列激励脉冲,半连续地激发相关特定谐振频率的核自旋 ,在激励脉冲之间接收NMR信号,选择周期时间1 / fm,使得弛豫时间短于1/10,闭环控制传输频率的值或使用NMR信号的B0场的值 来自第一控制回路的低频范围的UD与RF发生器和NMR线的频率精确地匹配相位,控制用于使第一控制回路的发送和接收系统的高频相位旋转的移相器, 通过第二控制回路获得值Δφ,提取信号UD,其中第二控制回路的输入信号是锯齿AC分量,在信号提取阶段产生输入信号以保持其 通过闭环控制为零,并且提高了谐振频率同步的精度。 版权所有(C)2011,JPO&INPIT
    • 46. 发明专利
    • Sn BASED ALLOY WITH FINE COMPOUND INCLUSION FOR Nb3Sn SUPERCONDUCTING WIRE
    • Sn基合金与Nb3Sn超导线的精细化合物包合
    • JP2010255115A
    • 2010-11-11
    • JP2010075464
    • 2010-03-29
    • Bruker Biospin Agブルーカー バイオシュピン アー・ゲー
    • FLORIN BUTA
    • C22C1/00C22C1/02C22C1/04C22C13/00H01B13/00H01F6/06
    • C22C1/00C22C13/00Y10S420/901Y10T428/12014
    • PROBLEM TO BE SOLVED: To provide an Sn based alloy for Nb 3 Sn superconducting wire comprising a finer compound inclusion(s) with a dopant(s) in order to produce Nb 3 Sn superconductor wire having a superior current carrying capacity, and to provide a method for producing the same. SOLUTION: The compound Sn based alloy is composed of an Sn-containing metal matrix and a fine inclusion(s), and the fine inclusion(s) is used as a dopant(s), and includes at least one element selected from the group consisting of titanium, vanadium, zirconium and hafnium. In the method, the droplets 13 of the melt 11 of a metal matrix and inclusion particles 12 are sprayed onto a target 15, and are mixed and solidified so as to be a compound alloy where a fine inclusion(s) containing a dopant element(s) is uniformly dispersed into an Sn matrix. COPYRIGHT: (C)2011,JPO&INPIT
    • 要解决的问题:为了提供含有掺杂剂的较细化合物夹杂物以制备Nb 3的SnS 3 Sn超导线材的Sn基合金 具有优异的载流能力的Sn超导体线,并提供其制造方法。 解决方案:复合Sn基合金由含Sn金属基体和精细夹杂物构成,精细夹杂物用作掺杂剂,并且包括至少一种元素选择 由钛,钒,锆和铪组成。 在该方法中,将金属基体和夹杂物粒子12的熔融物11的液滴13喷射到靶15上,并将其混合并固化为复合合金,其中含有掺杂剂元素的精细夹杂物( s)均匀分散在Sn基体中。 版权所有(C)2011,JPO&INPIT
    • 47. 发明专利
    • Device and method for positioning small animal for mri measurement
    • 用于定位用于MRI测量的小动物的装置和方法
    • JP2010082439A
    • 2010-04-15
    • JP2009219014
    • 2009-09-24
    • Bruker Biospin Agブルーカー バイオシュピン アー・ゲー
    • WOLKE DIETMARSCHMIDIG DANIEL
    • A61B5/055G01R33/28
    • G01R33/30G01R33/307G01R33/543
    • PROBLEM TO BE SOLVED: To provide a device for the relative positioning of a small animal with respect to an RF antenna for an MRI measurement. SOLUTION: The device used in performing imaging magnetic resonance measurements (=MRI) in a Region of Interest (ROI) (9) of a small animal (3) with an MRI magnet system (7), with a cradle (5) on which the small animal (3) is lying, and with a radio-frequency (=RF) antenna (6), wherein the RF antenna (6) and the small animal (3) can be positioned relative to each other, characterized in that the device comprises a slide (1) on which the cradle together with the small animal immobilized thereupon can be moved both outside and inside the MRI magnet system, and characterized in that the RF antenna is rigidly fixed on the slide. This results in a device for the relative positioning of the small animal with respect to the RF antenna for an MRI measurement, which is easy to retrofit on existing tomography equipment, with which this positioning can be implemented both inside and outside the MRI magnet by simple handling and without great additional technical effort. COPYRIGHT: (C)2010,JPO&INPIT
    • 要解决的问题:提供用于小动物相对于用于MRI测量的RF天线的相对定位的装置。 解决方案:用于在具有MRI磁体系统(7)的小型动物(3)的感兴趣区域(ROI)(9)中进行成像磁共振测量(= MRI)的装置,具有支架(5) ),并且具有射频(= RF)天线(6),其中RF天线(6)和小动物(3)可以相对于彼此定位,其特征在于, 其特征在于,所述装置包括滑动件(1),所述托架与其上固定的小动物一起可移动到所述MRI磁体系统的外部和内部,并且其特征在于,所述RF天线刚性地固定在所述载玻片上。 这导致用于小动物相对于用于MRI测量的RF天线的相对定位的装置,其易于在现有的断层摄影设备上进行改型,通过该方法可以通过简单的方式在MRI磁体内部和外部实现该定位 处理和没有很多额外的技术努力。 版权所有(C)2010,JPO&INPIT
    • 48. 发明专利
    • Magnet coil system with active drift compensation for two independent current paths
    • 具有两个独立电流模式的主动缓冲补偿的磁铁线圈系统
    • JP2008235870A
    • 2008-10-02
    • JP2008027733
    • 2008-02-07
    • Bruker Biospin Agブルーカー バイオシュピン アー・ゲー
    • SPREITER ROLFVONLANTHEN PATRICK
    • H01F6/00H01F6/06
    • H01F6/005G01R33/3815H01F6/008Y10S505/851
    • PROBLEM TO BE SOLVED: To provide a magnet coil system comprising two independent electric circuits, in which effective drift compensation can be performed in a simple manner. SOLUTION: A magnet coil system (2) is at least partially superconducting at a cryogenic temperature and comprises at least two partial coils (3, 4, 5) that are connected in series and are respectively bridged by a superconducting switch (6, 7, 8) so that the partial coils form independent electric loops (11, 12, 13) when the superconducting switches (6, 7, 8) are closed. The magnetic coil system (2) is characterized in that two electric loops (11, 12) have a common section, and a flux pump (10) having a circuit configuration is provided in the common section (14) of the electric loops (11, 12) of two partial coils (3, 4), wherein all of the currents flowing through two partial coils (3, 4) pass through the flux pump (10) in the operating state. In this manner, the drifts of two independent electric loops can be compensated for with a few devices. COPYRIGHT: (C)2009,JPO&INPIT
    • 要解决的问题:提供一种包括两个独立电路的磁体线圈系统,其中可以以简单的方式执行有效的漂移补偿。 解决方案:电磁线圈系统(2)在低温下至少部分地超导,并且包括至少两个部分线圈(3,4,5),其串联连接并分别由超导开关(6)桥接 ,7,8),使得当超导开关(6,7,8)闭合时,部分线圈形成独立的电路(11,12,13)。 电磁线圈系统(2)的特征在于两个电路(11,12)具有公共部分,并且具有电路结构的磁通泵(10)设置在电动回路(11)的公共部分(14)中 两个部分线圈(3,4)的两个部分线圈(3,4)的电流通过两个部分线圈(3,4)的所有电流在操作状态下通过磁通泵(10)。 以这种方式,可以用少量器件来补偿两个独立电路的漂移。 版权所有(C)2009,JPO&INPIT
    • 49. 发明专利
    • Device and method for compensating magnetic field turbulence in highly uniform magnetic field
    • 用于在高均匀磁场中补偿磁场湍流的装置和方法
    • JP2008122363A
    • 2008-05-29
    • JP2007196531
    • 2007-07-27
    • Bruker Biospin Agブルーカー バイオシュピン アー・ゲー
    • SCHENKEL MICHAELHENSEL ROLFTSCHOPP WERNER
    • G01R33/389
    • G01R33/3875G01R33/389G01R33/56509G01R33/56563
    • PROBLEM TO BE SOLVED: To provide a device and method not only capable of compensating a turbulent magnetic field to secure thereby a high signal-to-noise ratio, but also capable improving surely the compensation for a periodic magnetic field turbulence, in particular, having a frequency component with high magnetic field turbulence.
      SOLUTION: The device for compensating the magnetic field turbulence in a magnetic field having high magnetic field uniformity includes a magnetic field detector 31 for detecting an interference signal U
      in to stabilize, in particular, an H0 magnetic field of an MR measuring system, a control loop for processing the detected interference signal U
      in , and at least one compensation coil 34 transferred with a detected and processed output signal U
      out , and for generating a compensation magnetic field for compensating the interference signal U
      in , at least one out of the control loops is provided with a plurality selection filter system 35 including one or a plurality of selection filter elements connected in parallel, and synchronized with a frequency value of the interference signal U
      in with the center frequency to be compensated, and an output part of each filter element is connected to at least one of the compensation coils 34.
      COPYRIGHT: (C)2008,JPO&INPIT
    • 要解决的问题:提供一种不仅能够补偿湍流磁场从而确保高信噪比,而且能够确实地提高周期性磁场湍流补偿的装置和方法, 具体地,具有具有高磁场湍流的频率分量。 解决方案:用于补偿具有高磁场均匀性的磁场中的磁场湍流的装置包括用于检测中的干扰信号U 的磁场检测器31,特别是H0 MR测量系统的磁场,用于处理中检测到的干扰信号U 的控制回路以及用检测和处理的输出信号U SB SB输出的至少一个补偿线圈34 >,并且为了产生用于补偿中的干扰信号U 的补偿磁场,控制回路中的至少一个设置有多个选择过滤器系统35,所述多个选择过滤器系统35包括一个或多个选择过滤器元件 并联并与要补偿的中心频率的中的干扰信号U 的频率值同步,并且每个滤波器元件的输出部分连接到至少一个补偿线圈34 版权所有(C) 2008年,日本特许厅和INPIT
    • 50. 发明专利
    • Flow-through microfluidic nuclear magnetic resonance (nmr) chip and nmr device
    • 流通微流核磁共振(NMR)芯片和NMR装置
    • JP2008107352A
    • 2008-05-08
    • JP2007275204
    • 2007-10-23
    • Bruker Biospin Agブルーカー バイオシュピン アー・ゲー
    • MASSIN CHARLESFEY MICHAEL
    • G01R33/30G01R33/34
    • G01R33/302G01R33/307
    • PROBLEM TO BE SOLVED: To provide flow-through microfluidic nuclear magnetic resonance NMR chip. SOLUTION: The flow-through microfluidic NMR chip contains substrate (5), in which yz plane internally-having sample chamber (2) is flat surface and has slender wall running parallel to z-direction, with x-directional thickness of xyz rectangular coordinates system between 100 μm and 2 mm; and at least one flat type receiving coil and/or transmitter coil (1, 1') having conductor segment (11). The above coil (1, 1') is at least arranged on one plane of the substrate (5), where its extending section along z-direction of the sample chamber (2) exceeds extending section along z-direction of the coil (1). This invented NMR chip is characterized by that the extending section along z-direction of the coil (1, 1') is larger than the extending section along y-direction of the coil (1, 1'), and also advances in resolution, sensitivity and B1 uniformity to make NMR spectrometry easier. COPYRIGHT: (C)2008,JPO&INPIT
    • 要解决的问题:提供流通微流控核磁共振NMR芯片。

      解决方案:流通微流体NMR芯片包含基板(5),其中内部具有样品室(2)的yz平面为平坦表面,并且具有平行于z方向的细长壁,x方向的厚度 xyz直角坐标系在100μm和2mm之间; 以及具有导体段(11)的至少一个扁平型接收线圈和/或发射器线圈(1,1')。 上述线圈(1,1')至少布置在基板(5)的一个平面上,其沿着样品室(2)的z方向的延伸部分超过线圈(1)的z方向的延伸部分 )。 本发明的NMR芯片的特征在于沿着线圈(1,1')的z方向的延伸部分大于沿着线圈(1,1')的y方向的延伸部分,并且还具有前进的分辨率, 灵敏度和B1均匀性使NMR光谱测定更容易。 版权所有(C)2008,JPO&INPIT