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41. 发明专利

AU3866693A Plasma sterilizer and method 未知
公开(公告)号：AU3866693A
公开(公告)日：1993-11-25
申请号：AU3866693
申请日：1993-05-18
申请人： ABTOX INC
发明人： CAMPBELL BRYANT A , MOULTON KERN A
IPC分类号： A61L2/14 , H05H1/46
摘要： A plasma sterilizer and method employ essentially uncharged, highly reactive free radicals, atoms and excited molecules of a gas mixture to sterilize articles. The gas mixture includes oxidizing and/or reducing agents and is ionized into a plasma having ionization products that include highly destructive components in the form of charged particles and ultraviolet radiation. A plasma distribution device blocks the ultra-violet radiation and facilitates the recombination of the charged particles such that essentially uncharged, highly reactive free radicals, atoms and excited molecules of the gas mixture is delivered to the articles.

42. 发明专利

CA2096368A1 PLASMA STERILIZER AND METHOD 未知
公开(公告)号：CA2096368A1
公开(公告)日：1993-11-19
申请号：CA2096368
申请日：1993-05-17
申请人： ABTOX INC
发明人： CAMPBELL BRYANT A , MOULTON KERN A
IPC分类号： A61L2/14 , H05H1/46
摘要： A plasma sterilizer and method employ essentially uncharged, highly reactive free radicals, atoms and excited molecules of a gas mixture to sterilize articles. The gas mixture includes oxidizing and/or reducing agents and is ionized into a plasma having ionization products that include highly destructive components in the form of charged particles and ultraviolet radiation. A plasma distribution device blocks the ultra-violet radiation and facilitates the recombination of the charged particles such that essentially uncharged, highly reactive free radicals, atoms and excited molecules of the gas mixture is delivered to the articles.

43. 发明授权

EP0474137B1 Plasma sterilizing process with pulsed antimicrobial agent treatment 有权
标题翻译：通过等离子体的手段灭菌，并用抗微生物剂治疗的脉冲
公开(公告)号：EP0474137B1
公开(公告)日：1996-06-12
申请号：EP91114652.0
申请日：1991-08-30
申请人： ABTOX, INC.
发明人： Caputo, Ross A. , Campbell, Bryant A. , Moulton, Kern A.
IPC分类号： A61L2/14 , A61L2/20
CPC分类号： A61L2/20 , A61L2/14 , Y10S422/906 , Y10S422/907

44. 发明公开

EP0456134A2 Sterilizing with peracid and plasma 失效
标题翻译：杀菌剂等离子体。
公开(公告)号：EP0456134A2
公开(公告)日：1991-11-13
申请号：EP91107227.0
申请日：1991-05-03
申请人： ABTOX, INC.
发明人： Campbell, Bryant A. , Moulton, Kern A. , Caputo, Ross A.
IPC分类号： A61L2/14 , A61L2/20
CPC分类号： A61L2/14 , A61L2/20
摘要： A process for plasma sterilization comprising exposing an article to be sterilized to pretreatment with a peracid antimicrobial agent and to a plasma generated from gases. The gases can be selected from the group consisting essentially of argon, helium, nitrogen, oxygen, hydrogen and mixtures thereof; and the exposure to the plasma can be carried out at a pressure of from 0.1 to 10 torr and a chamber temperature of less than 80°C. The peracid antimicrobial agent can be a member selected from the group consisting of saturated and unsaturated peralkanoic acids having from 1 to 8 carbon atoms and halogenated derivatives thereof and is preferably peracetic acid.
摘要翻译：一种用于等离子体灭菌的方法，包括将待消毒的物品暴露于用过酸性抗微生物剂预处理，以及由气体产生的血浆。气体可以选自基本上由氩，氦，氮，氧，氢及其混合物组成的组; 并且暴露于等离子体可以在0.1至10托的压力和小于80℃的室温下进行。过酸性抗微生物剂可以是选自饱和和不饱和的全烷基酸的成员，其具有 1至8个碳原子及其卤代衍生物，优选为过乙酸。

45. 发明公开

EP0474137A2 Plasma sterilizing process with pulsed antimicrobial agent treatment 有权
标题翻译：灭菌手套Plasma und gepulster Behandlung mit antimikrobiellen Mitteln。
公开(公告)号：EP0474137A2
公开(公告)日：1992-03-11
申请号：EP91114652.0
申请日：1991-08-30
申请人： ABTOX, INC.
发明人： Caputo, Ross A. , Campbell, Bryant A. , Moulton, Kern A.
IPC分类号： A61L2/14 , A61L2/20
CPC分类号： A61L2/20 , A61L2/14 , Y10S422/906 , Y10S422/907
摘要： A process for plasma sterilization including exposing an article in a sterilizing chamber to at least one combination sterilizing cycle. Each combination sterilizing cycle includes a pulsed treatment with gaseous antimicrobial agent, removal of the gaseous antimicrobial agent, and a plasma treatment. The pulsed treatment includes one or more pulse-vacuum cycles, each pulse-vacuum cycle includes the steps of evacuating the sterilizing chamber and exposing the article to the gaseous antimicrobial agent with a predetermined pressure profile during a predetermined time. The gaseous antimicrobial agent is preferably carried in a gas mixture with a nonreactive carrier gas. In one embodiment, the predetermined pressure is pulsed. In another embodiment, it is ramped. After the pulsed treatment, the antimicrobial agent is removed by evacuating the sterilizing chamber. The plasma treatment includes exposing the article to a plasma having essentially uncharged, highly reactive free radicals and atoms.
摘要翻译：一种用于等离子体灭菌的方法，包括将消毒室中的物品暴露于至少一个组合灭菌循环。每个组合灭菌循环包括用气体抗微生物剂进行脉冲处理，除去气态抗微生物剂和等离子体处理。脉冲处理包括一个或多个脉冲真空循环，每个脉冲真空循环包括在预定时间内以预定的压力分布排空灭菌室并将制品暴露于气态抗微生物剂的步骤。气态抗微生物剂优选与带有非反应性载气的气体混合物携带。在一个实施例中，预定压力是脉冲的。在另一个实施例中，它是斜坡的。脉冲处理后，通过抽空灭菌室除去抗菌剂。等离子体处理包括将制品暴露于具有基本上不带电的，高反应性的自由基和原子的等离子体。

46. 发明公开

EP0387022A2 Plasma sterilizer and method 有权转让
标题翻译：等离子体灭菌器和方法
公开(公告)号：EP0387022A2
公开(公告)日：1990-09-12
申请号：EP90302410.7
申请日：1990-03-07
申请人： ABTOX, INC.
发明人： Campbell, Bryant A. , Moulton, Kern A.
IPC分类号： A61L2/14
CPC分类号： A61L2/14 , H05H1/46
摘要： A method for plasma sterilization comprises exposing an article to be sterilized to a plasma generated from a gas mixture comprising either (a) argon, helium, nitrogen, or mixtures thereof, and oxygen and hydrogen; (b) argon, helium, nitrogen or mixtures thereof, and hydrogen; or (c) argon, helium, nitrogen or mixtures thereof, and oxygen. The exposure of the article to the plasma is carried out at a pressure of from 0.1 to 10 torr and a chamber temperature of less than 63°C for a time period sufficient to effect sterilization. Contaminated articles can be pretreated in a plasma generated from oxygen and optionally argon, helium and/or nitrogen at the same conditions for up to 5 minutes to remove protein. The apparatus for plasma sterilization of articles comprises a plasma generator and a sterilizing chamber. The plasma generator comprises a plurality of generator tubes positioned in one or more electromagnetic field zones defined by one or more waveguides. The outlet of the generator tube preferably has a restriction for maintaining the gas pressure in the plasma generating chamber at from 0.3 to 10 torr.
摘要翻译：一种用于等离子体灭菌的方法包括将要灭菌的物品暴露于由包含（a）氩气，氦气，氮气或其混合物以及氧气和氢气的气体混合物产生的等离子体; （b）氩气，氦气，氮气或其混合物以及氢气; 或（c）氩气，氦气，氮气或其混合物以及氧气。制品暴露于等离子体的压力为0.1至10托，腔室温度低于63℃达足以进行灭菌的时间。受污染的制品可以在由氧气和任选的氩气，氦气和/或氮气在相同条件下产生的等离子体中预处理长达5分钟以除去蛋白质。用于物品等离子体灭菌的设备包括等离子体发生器和消毒室。等离子体发生器包括位于由一个或多个波导限定的一个或多个电磁场区域中的多个发生器管。发生器管的出口优选具有用于将等离子体发生室中的气体压力保持在0.3至10托的限制。

47. 发明公开

EP0753241A1 PLASMA GAS MIXTURE FOR STERILIZER AND METHOD 失效
标题翻译：混合气产生等离子体消毒设备和消毒过程
公开(公告)号：EP0753241A1
公开(公告)日：1997-01-15
申请号：EP95914814.0
申请日：1995-03-21
申请人： ABTOX, INC.
发明人： MOULTON, Kern, A. , FISHER, Jim
IPC分类号： A61L2 , H05H1
CPC分类号： A61L2/14 , H05H1/46
摘要： A method for plasma sterilization comprises exposing an article to be sterilized to a neutral active species of a plasma generated from a premixed gas mixture comprising oxygen, hydrogen, and a noble gas. The exposure of the article to the plasma is carried out at reduced pressures and a chamber temperature of less than 63 °C for a time period sufficient to effect sterilization. The apparatus for plasma sterilization of articles comprises a plasma generator (10, 12, 14), a sterilizing chamber (60), and a source of pressurized gas mixture in fluid communication with the plasma generator. The source of pressurized gas mixture has a noble gas and a substantially nonflammable mixture of hydrogen and oxygen, which is preferably between about 2.0 to 2.4 (v/v) percent hydrogen and between 2.6 to 3.0 (v/v) percent oxygen.

48. 发明公开

EP0665895A1 $i(BACILLUS CIRCULANS) BASED BIOLOGICAL INDICATOR FOR GASEOUS STERILANTS 失效
标题翻译：生物指示剂基于环状芽孢杆菌气态杀菌资金。
公开(公告)号：EP0665895A1
公开(公告)日：1995-08-09
申请号：EP94919312.0
申请日：1994-06-01
申请人： ABTOX, INC.
发明人： CAPUTO, Ross, A. , MARTENS, Phillip, A.
IPC分类号： C12M1 , C12Q1 , G01N31 , C12R1
CPC分类号： C12Q1/22 , G01N31/226 , Y10S435/832 , Y10S435/835
摘要： Biological indicators are provided for use in validating and routinely monitoring oxidizing gas sterilizations. The biological indicators are based on Bacillus circulans spores that are enclosed in packages with sufficient permeability to admit a sterilizing amount of vapor while being substantially bacteria impermeable.

49. 发明公开

EP0456135A2 Sterilizing with hydrogen peroxide and plasma 失效
标题翻译：灭菌剂Wasserstoffperoxid和einem等离子体。
公开(公告)号：EP0456135A2
公开(公告)日：1991-11-13
申请号：EP91107228.8
申请日：1991-05-03
申请人： ABTOX, INC.
发明人： Campbell, Bryant A. , Moulton, Kern A. , Caputo, Ross A.
IPC分类号： A61L2/14 , A61L2/20
CPC分类号： A61L2/20 , A61L2/14
摘要： A process for plasma sterilization comprising exposing an article to be sterilized to pretreatment with hydrogen peroxide, and optionally a peracid antimicrobial agent, and to a plasma generated from gases. The gases can be selected from the group consisting essentially of argon, helium, nitrogen, oxygen, hydrogen and mixtures thereof; and the exposure to the plasma can be carried out at a pressure of from 0.1 to 10 torr and a chamber temperature of less than 80°C. The peracid antimicrobial agent can be a member selected from the group consisting of saturated and unsaturated peralkanoic acids having from 1 to 8 carbon atoms and halogenated derivatives thereof and is preferably peracetic acid. The article is preferably treated with plasma generated in a plasma generator separate from the sterilizing chamber.
摘要翻译：一种用于等离子体灭菌的方法，包括将待消毒的物品暴露于用过氧化氢预处理，以及任选的过酸性抗微生物剂，以及由气体产生的血浆。气体可以选自基本上由氩，氦，氮，氧，氢及其混合物组成的组; 并且暴露于等离子体可以在0.1至10托的压力和小于80℃的室温下进行。过酸性抗微生物剂可以是选自饱和和不饱和的全烷基酸的成员，其具有 1至8个碳原子及其卤代衍生物，优选为过乙酸。该制品优选用与灭菌室分离的等离子体发生器中产生的等离子体处理。

50. 发明授权

EP0387022B1 Plasma sterilizer and method 有权转让
标题翻译：等离子体灭菌器和方法
公开(公告)号：EP0387022B1
公开(公告)日：1994-11-09
申请号：EP90302410.7
申请日：1990-03-07
申请人： ABTOX, INC.
发明人： Campbell, Bryant A. , Moulton, Kern A.
IPC分类号： A61L2/14
CPC分类号： A61L2/14 , H05H1/46

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