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    • 46. 发明授权
    • 흰씀바귀로부터 추출된 세스퀴테르펜 락톤계 화합물 및이를 함유하는 심혈관 질환 및 암 치료용 조성물
    • 흰씀바귀귀로추추된된퀴퀴톤계합물합물합물합물합물이심혈암암암암암
    • KR100469612B1
    • 2005-02-02
    • KR1020030007237
    • 2003-02-05
    • 학교법인 경희학원주식회사 싸이제닉
    • 백남인권병목김대근김성훈이희설정인식
    • C07H17/04
    • PURPOSE: Sesquiterpene lactone compounds extracted from Ixeria dentata forma albiflora and a composition for treating cardiovascular disease and cancer containing the same compounds are provided, which compounds have no toxicity, and have improved ACAT(Acyl-Coa: Cholesterol Acyltransferase) and FPT(Farnesyl Protein Transferase) inhibiting effects. CONSTITUTION: The sesquiterpene lactone compounds, 3β-O-(6'-p-hydroxyphenylacetyl-β-D-glucopyranosyl)-8β-hydroxyguaian-4(15), 10(14), 11(13)-triene-6,12-olide, represented by formula (1), and extracted from Ixeria dentata forma albiflora by using alcohol solvent, preferably methanol are provided. The composition for treating cardiovascular disease and cancer contains the sesquiterpene lactone compounds of formula (1), wherein the cardiovascular disease is arteriosclerosis, hypertension, angina pectoris, hyperlipidemia, myocardial infarction or cardiac failure; and the cancer is pancreatic cancer, bladder cancer, lung cancer or skin cancer.
    • 目的:本发明提供了从牙鲆提取的倍半萜内酯化合物和含有相同化合物的用于治疗心血管疾病和癌症的组合物,该化合物没有毒性,并具有改善的ACAT(酰基-CoA:胆固醇酰基转移酶)和FPT(法尼基蛋白 转移酶)抑制作用。 构成:倍半萜内酯化合物,3β,-O-(6'-对羟基苯乙酰基-β-D-吡喃葡萄糖基)-8β-羟基瓜氨酸-4(15),10(14),11 (1)表示的(13) - 三烯-6,12-内酯,并且通过使用醇溶剂,优选甲醇,从白头叶蝉提取物提取。 用于治疗心血管疾病和癌症的组合物含有式(1)的倍半萜内酯化合物,其中心血管疾病为动脉硬化,高血压,心绞痛,高脂血症,心肌梗塞或心力衰竭; 癌症是胰腺癌,膀胱癌,肺癌或皮肤癌。
    • 47. 发明授权
    • 카나마이신 저항성 유전자를 포함하는 rescuecloning용 식물형질전환벡터 pRCV1
    • 카나마이신저항성유전자를포함하함함rescue rescue rescue cl cl cl p p p p p p p pRCV1
    • KR100468652B1
    • 2005-01-29
    • KR1020010072264
    • 2001-11-20
    • 학교법인 경희학원
    • 박영두김형석
    • C12N15/82
    • PURPOSE: A plant transformation vector pRCV1 containing a kanamycin resistance gene is provided, thereby it can be used for rescue cloning to find the function of a certain gene present in plants. CONSTITUTION: The plant transformation vector pRCV1 contains a kanamycin resistance gene, β-glucuronidase gene, an ampicillin resistance gene and bacterial replication origin. A transgenic plant Agrobacterium tumefaciens LBA4404/pRCV1(KFCC 11282) is produced with the plant transformation vector pRCV1. Primers capable of sequencing the T-border outside of the pRCV1 vector have the nucleotide sequences of SEQ ID NOs: 1 and 2. Primers capable of sequencing the T-border inside of the pRCV1 vector have the nucleotide sequences of SEQ ID NOs: 3 and 4. A method for analysis of a transformant comprises extracting genomic DNA from the transgenic plant with the pRCV1 vector, digesting the genomic DNA with Pst I and ligating the digested DNA to carry out the rescue cloning.
    • 目的:提供含有卡那霉素抗性基因的植物转化载体pRCV1,因此它可用于拯救性克隆以发现植物中存在的某种基因的功能。 组成:植物转化载体pRCV1含有卡那霉素抗性基因,β-葡糖醛酸糖苷酶基因,氨苄青霉素抗性基因和细菌复制起点。 用植物转化载体pRCV1产生转基因植物根瘤农杆菌LBA4404 / pRCV1(KFCC 11282)。 能够测序pRCV1载体外T-边界的引物具有SEQ ID NO:1和2的核苷酸序列。能够测序pRCV1载体内T-边界的引物具有SEQ ID NO:3的核苷酸序列和 4.用于分析转化体的方法包括用pRCV1载体从转基因植物中提取基因组DNA,用Pst I消化基因组DNA并连接消化的DNA以进行拯救克隆。
    • 48. 发明公开
    • 흰씀바귀로부터 추출된 세스퀴테르펜 락톤계 화합물 및이를 함유하는 심혈관 질환 및 암 치료용 조성물
    • 从IXERIA DENTATA FORMA ALBIFLORA提取的SESQUITERPENE LACTONE化合物和用于治疗心血管疾病的组合物和含有其的癌症
    • KR1020040071336A
    • 2004-08-12
    • KR1020030007237
    • 2003-02-05
    • 학교법인 경희학원주식회사 싸이제닉
    • 백남인권병목김대근김성훈이희설정인식
    • C07H17/04
    • PURPOSE: Sesquiterpene lactone compounds extracted from Ixeria dentata forma albiflora and a composition for treating cardiovascular disease and cancer containing the same compounds are provided, which compounds have no toxicity, and have improved ACAT(Acyl-Coa: Cholesterol Acyltransferase) and FPT(Farnesyl Protein Transferase) inhibiting effects. CONSTITUTION: The sesquiterpene lactone compounds, 3β-O-(6'-p-hydroxyphenylacetyl-β-D-glucopyranosyl)-8β-hydroxyguaian-4(15), 10(14), 11(13)-triene-6,12-olide, represented by formula (1), and extracted from Ixeria dentata forma albiflora by using alcohol solvent, preferably methanol are provided. The composition for treating cardiovascular disease and cancer contains the sesquiterpene lactone compounds of formula (1), wherein the cardiovascular disease is arteriosclerosis, hypertension, angina pectoris, hyperlipidemia, myocardial infarction or cardiac failure; and the cancer is pancreatic cancer, bladder cancer, lung cancer or skin cancer.
    • 目的:提供从白念珠菌(Ixeria dentata forma albiflora)提取的倍半萜内酯化合物和用于治疗心血管疾病和含有相同化合物的癌症的组合物,该化合物没有毒性,并且具有改善的ACAT(酰基-Ca:胆固醇酰基转移酶)和FPT(法呢基蛋白 转移酶)抑制作用。 构成:三倍体内酯化合物3β-O-(6'-对羟基苯乙酰-β-D-吡喃葡萄糖基)-8β-羟基瓜亚酮-4(15),10(14),11(13) - 三烯-6,12 (1)表示,并且通过使用醇溶剂,优选甲醇提取来自牙龈dent ata的叶子。 用于治疗心血管疾病和癌症的组合物含有式(1)的倍半萜内酯化合物,其中心血管疾病是动脉硬化,高血压,心绞痛,高脂血症,心肌梗塞或心力衰竭; 癌症是胰腺癌,膀胱癌,肺癌或皮肤癌。
    • 49. 发明授权
    • 과수 바이러스 검정용 프라이머 및 이를 이용한 바이러스검출방법
    • 과수바이러스검정용프라이머및이를이용한바이러스검출방과
    • KR100442987B1
    • 2004-08-04
    • KR1020020038226
    • 2002-07-03
    • 학교법인 경희학원
    • 박홍렬김현란최용문윤재승백광희
    • C12Q1/68
    • PURPOSE: Primers for detecting fruit tree infecting virus and a screening method of fruit tree infecting virus using the same are provided, thereby easily detecting infection of ASGV(apple stem grooving capillovirus), ACLSV(apple chlorotic leafspot trichovirus), CTV(citrus tristeza virus) and CTLV(citrus tatter leaf virus). CONSTITUTION: Primers for detecting fruit tree infecting virus are selected from the group consisting of ASGV-Pf primer having the nucleotide sequence of SEQ ID NO: 1, ASGV-Pr primer having the nucleotide sequence of SEQ ID NO: 2, ACLSV-CPf primer having the nucleotide sequence of SEQ ID NO: 3, ACLSV-CPr primer having the nucleotide sequence of SEQ ID NO: 4, CTLV-CPf primer having the nucleotide sequence of SEQ ID NO: 5, CTLV-CPr primer having the nucleotide sequence of SEQ ID NO: 6, CTV-CPf primer having the nucleotide sequence of SEQ ID NO: 7, and CTV-CPr primer having the nucleotide sequence of SEQ ID NO: 8. A method for screening fruit tree infecting virus comprises the steps of: (a) amplifying RNA extracted from a sample as a template using RT-PCR using one primer selected from ASGV-Pf primer, ASGV-Pr primer, ACLSV-CPf primer, ACLSV-CPr primer, CTLV-CPf primer, CTLV-CPr primer, CTV-CPf primer, and CTV-CPr primer; and (b) analyzing the size of PCR products.
    • 本发明提供了用于检测果树感染病毒的引物和使用其的果树感染病毒的筛选方法,从而容易地检测ASGV(苹果茎切槽毛细管病毒),ACLSV(苹果褪绿叶斑点病毒),CTV(柑橘三镰孢病毒 )和CTLV(柑橘破烂叶病毒)。 构成:用于检测果树感染病毒的引物选自具有SEQ ID NO:1的核苷酸序列的ASGV-Pf引物,具有SEQ ID NO:2的核苷酸序列的ASGV-Pr引物,ACLSV-CPf引物 具有序列号3的碱基序列的ACLSV-CPr引物,具有序列号5的碱基序列的CTLV-CPf引物,具有序列号5的碱基序列的CTLV-CPr引物, SEQ ID NO:6,具有SEQ ID NO:7的核苷酸序列的CTV-CPf引物和具有SEQ ID NO:8的核苷酸序列的CTV-CPr引物。一种筛选果树感染病毒的方法,包括以下步骤: (a)使用选自ASGV-Pf引物,ASGV-Pr引物,ACLSV-CPf引物,ACLSV-CPr引物,CTLV-CPf引物,CTLV-CPr引物的一种引物,使用RT-PCR扩增从样品提取的RNA作为模板 ,CTV-CPf引物和CTV-CPr引物; 和(b)分析PCR产物的大小。
    • 50. 发明公开
    • 관절염 치료를 위한 초음파 물리치료패드
    • 用于治疗ARTHRITIS的超声波物理治疗垫
    • KR1020040049580A
    • 2004-06-12
    • KR1020020077409
    • 2002-12-06
    • 학교법인 경희학원한승무
    • 한승무
    • A61H39/06
    • PURPOSE: Provided is an ultrasonic physical treatment pad for treating arthritis, which is fixed to the user's diseased part to perform either or both of ultrasonic activity and heating activity. CONSTITUTION: The pad for use in both ultrasonic treatment and heating treatment is connected to a main body to perform a physical treatment operation on the user's diseased part. The pad comprises: a connection unit to the main body, having a heating connector and an ultrasonic wave-generating connector; a heating pad fixed to a diseased part, which comprises a heat wire pad connected to the heating connector and having heat wires fixed to the center thereof, an elastic pad enclosing the heat wire pad, a water-proof pad enclosing the exterior of the elastic pad, and a velcro tape formed on one side of the water-proof pad; and an ultrasonic wave supplying unit(300) having an ultrasonic wave horn(330) and ultrasonic wave piezoelectric device(340) mounted in the horn(330).
    • 目的:提供一种用于治疗关节炎的超声波物理治疗垫,其被固定到使用者的患部,以进行超声活性和加热活性中的任一者或两者。 构成:用于超声波处理和加热处理的垫连接到主体以对使用者的患部进行物理治疗操作。 垫包括:连接到主体的连接单元,具有加热连接器和超声波产生连接器; 固定到患病部分的加热垫,其包括连接到加热连接器并具有固定到其中心的热丝的热丝焊盘,包围热丝焊盘的弹性垫,包围弹性体的外部的防水垫 垫和形成在防水垫的一侧上的尼龙搭扣带; 以及具有安装在喇叭(330)中的超声波波峰(330)和超声波压电装置(340)的超声波供给部(300)。