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41. 发明授权

US07413851B2 Nucleophosmin directed diagnostics and therapeutics for multidrug resistant neoplastic disease 失效
标题翻译： Nucleophosmin定向诊断和治疗多药耐药性肿瘤疾病
公开(公告)号：US07413851B2
公开(公告)日：2008-08-19
申请号：US10737712
申请日：2003-12-15
申请人： Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
发明人： Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
IPC分类号： C12Q1/00
CPC分类号： G01N33/57492 , A61K39/0005 , A61K39/0011 , G01N33/5005 , G01N33/574 , G01N33/6875 , G01N2800/52
摘要： Disclosed are methods for detecting neoplastic or damaged cells and for detecting multidrug resistance in neoplastic or damaged cells by detecting an increase in the cell surface expression of a nucleophosmin (NPM) protein on the surface of such a multidrug resistant neoplastic or damaged cells as compared to the level of expression of the nucleophosmin protein on the surface of a normal cell.
摘要翻译：公开了通过检测这种多药耐药肿瘤或受损细胞的表面上的核磷酸（NPM）蛋白的细胞表面表达的增加来检测肿瘤或损伤的细胞并检测肿瘤或受损细胞中的多药耐药性的方法，正常细胞表面的核磷蛋白表达水平。

42. 发明授权

US07398517B2 Method and system for detecting vulnerabilities in source code 失效
标题翻译：检测源代码漏洞的方法和系统
公开(公告)号：US07398517B2
公开(公告)日：2008-07-08
申请号：US11762475
申请日：2007-06-13
申请人： Ryan J. Berg , Larry Rose , John Peyton , John J. Danahy , Robert Gottlieb , Chris Rehbein
发明人： Ryan J. Berg , Larry Rose , John Peyton , John J. Danahy , Robert Gottlieb , Chris Rehbein
IPC分类号： G06F9/44 , G06F12/14 , G06F21/00
CPC分类号： G06F21/577 , G06F8/43 , G06F11/3604
摘要： A method and system of detecting vulnerabilities in source code. Source code is parsed into an intermediate representation. Models (e.g., in the form of lattices) are derived for the variables in the code and for the variables and/or expressions used in conjunction with routine calls. The models are then analyzed in conjunction with pre-specified rules about the routines to determine if the routine call posses one or more of pre-selected vulnerabilities.
摘要翻译：一种检测源代码漏洞的方法和系统。源代码被解析为中间表示。为代码中的变量以及与常规调用结合使用的变量和/或表达式导出模型（例如，以格子形式）。然后将这些模型与关于例程的预先规定的规则一起进行分析，以确定例程调用是否具有一个或多个预先选择的漏洞。

43. 发明授权

US07398516B2 Method and system for detecting race condition vulnerabilities in source code 失效
标题翻译：检测源代码中的竞争条件漏洞的方法和系统
公开(公告)号：US07398516B2
公开(公告)日：2008-07-08
申请号：US10824685
申请日：2004-04-15
申请人： Ryan James Berg , Larry Rose , John Peyton , John J. Danahy , Robert Gottlieb , Chris Rehbein
发明人： Ryan James Berg , Larry Rose , John Peyton , John J. Danahy , Robert Gottlieb , Chris Rehbein
IPC分类号： G06F9/44 , G06F12/14 , G06F21/00
CPC分类号： G06F11/3604 , G06F11/3624 , G06F21/57
摘要： A method and system of detecting vulnerabilities in source code. Source code is parsed into an intermediate representation. Models are derived for the code and the models are then analyzed in conjunction with pre-specified rules about the routines to determine if the routines posses one or more of pre-selected vulnerabilities.
摘要翻译：一种检测源代码漏洞的方法和系统。源代码被解析为中间表示。为代码派生模型，然后结合预先规定的关于例程的规则来分析模型，以确定例程是否具有一个或多个预先选择的漏洞。

44. 发明授权

US07378232B2 Assay for melanogenesis 失效
标题翻译：测定黑素生成
公开(公告)号：US07378232B2
公开(公告)日：2008-05-27
申请号：US10435439
申请日：2003-05-09
申请人： Seth J. Orlow , Prashiela Manga , Liliana Staleva
发明人： Seth J. Orlow , Prashiela Manga , Liliana Staleva
IPC分类号： C12Q1/00 , C12Q1/02
CPC分类号： G01N33/5011 , G01N33/5008 , G01N33/5014 , G01N33/5044 , G01N33/5097 , G01N33/6872 , G01N2510/00
摘要： The invention provides methods for the identification of agents that modify or mimic P protein function. Cells expressing a P protein are generally more sensitive to toxins, and changes in cell viability and/or cell death after exposure of P protein-expressing cells to an agent and a toxin is an indication that such an agent is a modifier of P protein expression. The invention also provides methods for the treatment of melanoma and other cancers.
摘要翻译：本发明提供用于鉴定修饰或模拟P蛋白功能的试剂的方法。表达P蛋白的细胞通常对毒素更敏感，并且将表达P蛋白的细胞暴露于药物和毒素后，细胞活力和/或细胞死亡的变化表明这样的试剂是P蛋白表达的调节剂。本发明还提供了治疗黑素瘤和其他癌症的方法。

45. 发明授权

US07333956B2 Information management system 有权
标题翻译：信息管理系统
公开(公告)号：US07333956B2
公开(公告)日：2008-02-19
申请号：US09923704
申请日：2001-08-07
申请人： Peter Malcolm
发明人： Peter Malcolm
IPC分类号： G06Q99/00
CPC分类号： H04L12/5855 , G06F21/606 , G06F2221/2113 , G06Q10/063 , G06Q10/10 , G06Q20/3674 , G06Q20/382 , G06Q20/3821 , G06Q20/401 , G06Q20/4012 , G06Q30/06 , H04L51/12 , H04L51/14
摘要： An information management system is described including one or more workstations running applications to allow a user of the workstation to connect to a network, such as the Internet. Each application operates in conjunction with an analyzer, which monitors transmission data that the application is about to transmit to the network or about to receive from the network and which determines an appropriate action to take regarding that transmission data. Such actions may be extracting data from the transmission data, such as passwords and usernames, digital certificates or eCommerce transaction details for storage in a database; ensuring that the transmission data is transmitted at an encryption strength appropriate to the contents of the transmission data; determining whether a check needs to be made as to whether a digital certificate received in transmission data is in force, and determining whether a transaction about to be made by a user of one of the workstations needs third party approval before it is made. The analyzer may consult a policy data containing a policy to govern the workstations in order to make its determination. The information management system provides many advantages in the eCommerce environment to on-line trading companies, who may benefit from improvements to record-keeping, security and control over transactions.
摘要翻译：描述了信息管理系统，其包括运行应用以允许工作站的用户连接到诸如因特网的网络的一个或多个工作站。每个应用程序与分析器一起运行，分析器监视应用程序将要传输到网络的传输数据，或者要监控从网络接收的传输数据，并确定要对传输数据采取的适当措施。这样的动作可以是从数据库中存储的传输数据（例如密码和用户名，数字证书或电子商务交易细节）提取数据; 确保以与发送数据的内容相适应的加密强度发送发送数据; 确定是否需要检查在传输数据中接收到的数字证书是否有效，以及确定是否要由其中一个工作站的用户进行的事务在作出之前需要第三方批准。分析仪可以查阅包含政策的政策数据来管理工作站，以便作出决定。信息管理系统在电子商务环境中为在线贸易公司提供了许多优势，他们可以从改进记录保存，安全性和交易控制中受益。

46. 发明授权

US07324209B2 Apparatus and method for ellipsometric measurements with high spatial resolution 失效
标题翻译：用于具有高空间分辨率的椭偏测量的装置和方法
公开(公告)号：US07324209B2
公开(公告)日：2008-01-29
申请号：US10886157
申请日：2004-07-07
申请人： Henry Allen Hill
发明人： Henry Allen Hill
IPC分类号： G01B9/02
CPC分类号： G01N21/9501 , G01N21/211 , G01N2021/214
摘要： A method of detecting non-uniform ellipsometric properties of a substrate surface involving: directing a measurement beam onto a spot at a selected location on or in the substrate; for each orientation of a plurality of different orientations of the reference beam relative to the scattered measurement beam, interfering the scattered measurement beam with the reference beam to produce a corresponding interference beam, wherein each of the different orientations of the reference beam is selected to produce a peak sensitivity for a portion of the scattered measurement beam that emanates from the object at a corresponding different diffraction angle of a plurality of diffraction angles; for each orientation of the reference beam, converting the interference beam into an interference signal; and using the interference signals to determine whether any non-uniform ellipsometric properties are present anywhere within a region on or in the substrate.
摘要翻译：一种检测衬底表面的不均匀椭偏特性的方法，包括：将测量光束引导到衬底上或衬底上的选定位置的点上; 对于参考光束相对于散射测量光束的多个不同取向的每个取向，干扰散射的测量光束与参考光束以产生相应的干涉光束，其中参考光束的不同取向中的每一个被选择以产生对于在多个衍射角的相应不同衍射角处从物体发出的散射测量光束的一部分的峰值灵敏度; 对于参考光束的每个取向，将干涉光束转换成干涉信号; 并且使用干涉信号来确定在衬底上或衬底中的区域内是否存在任何不均匀椭偏特性。

47. 发明授权

US07298941B2 Optical coupling to IC chip 失效
标题翻译：光耦合到IC芯片
公开(公告)号：US07298941B2
公开(公告)日：2007-11-20
申请号：US11354267
申请日：2006-02-14
申请人： Edward L. Palen , Gregory L. Wojcik , Lawrence C. West
发明人： Edward L. Palen , Gregory L. Wojcik , Lawrence C. West
IPC分类号： G02B6/32 , B29B11/00
CPC分类号： G02B6/4214 , G02B6/4204 , G02B6/4206 , G02B6/423 , G02B6/4249
摘要： An optoelectronic circuit including: an IC chip made up of a substrate in which an optical waveguide and a mirror have been fabricated, the substrate having a first lens formed thereon, wherein the mirror is aligned with the optical waveguide and the first lens is aligned with the mirror to form an optical path connecting the first lens, the mirror, and the optical waveguide; and an optical coupler including a second lens, the optical coupler affixed to the substrate and positioned to align the second lens with the first lens so as to couple an optical signal into or out of the optical waveguide within the IC chip.
摘要翻译：一种光电子电路，包括：由其上制造有光波导和反射镜的基板构成的IC芯片，所述基板具有形成在其上的第一透镜，其中所述反射镜与所述光波导对准，并且所述第一透镜与所述反射镜形成连接所述第一透镜，所述反射镜和所述光波导的光路; 以及包括第二透镜的光耦合器，所述光耦合器固定到所述基板并且被定位成将所述第二透镜与所述第一透镜对准，以将光信号耦合到所述IC芯片内的光波导中或从所述IC芯片中的所述光波导耦合。

48. 发明授权

US07216084B2 Computer implemented medical integrated decision support system 有权
标题翻译：计算机实施医疗综合决策支持系统
公开(公告)号：US07216084B2
公开(公告)日：2007-05-08
申请号：US10784898
申请日：2004-02-24
申请人： Thomas Brinkman , Wayne Gattinella , William Kleinfelter , Glen Stettin , David Angaran , J. Russel Teagarden
发明人： Thomas Brinkman , Wayne Gattinella , William Kleinfelter , Glen Stettin , David Angaran , J. Russel Teagarden
IPC分类号： G06Q7/00
CPC分类号： G06F19/325 , G06F19/00 , G06F19/326 , G06F19/328 , G06F19/3418 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/60
摘要： A software-based, integrated member decision support system provides a method for corporations, insurance carriers, health maintenance organizations, physicians, physician groups, or other clients to efficiently provide medical, pharmaceutical, and health benefit advice and information for an enrolled population. A caller is, for example, directed to an operator who provides the caller with medical, pharmaceutical, and/or health benefit advice based on an inquiry from the caller and the information stored on the system. The system may automatically alert the caller or the operator of important medical or pharmaceutical information. At the conclusion of the call, the system or the system with the operator's input, may updated the caller's member profile, request written materials, generate referrals, order prescriptions, or generate reports.
摘要翻译：基于软件的综合成员决策支持系统为公司，保险公司，健康维护组织，医师，医师团体或其他客户提供了一种方法，为注册人群提供医疗，制药和健康福利建议和信息。例如，呼叫者被引导到运营商，该运营商基于来自呼叫者的询问和存储在系统上的信息向呼叫者提供医疗，制药和/或健康益处建议。该系统可以自动向呼叫者或者操作者提醒重要的医疗或药物信息。在通话结束时，系统或具有操作员输入的系统可以更新呼叫者的成员资料，请求书面材料，生成转介，订购处方或生成报告。

49. 发明授权

US07214387B2 Sustained release formulations of metformin 有权
标题翻译：二甲双胍的缓释制剂
公开(公告)号：US07214387B2
公开(公告)日：2007-05-08
申请号：US10630239
申请日：2003-07-30
申请人： Pradeep P. Sanghvi , Sara Ketsela
发明人： Pradeep P. Sanghvi , Sara Ketsela
IPC分类号： A61K9/22 , A61K9/20 , A61K9/28 , A61K9/36 , A61K9/34 , A61K9/32 , A61K9/48 , A61K9/14 , A61K9/16
CPC分类号： A61K47/02 , A61K9/2009 , A61K9/2018 , A61K9/205 , A61K9/2054 , A61K9/2866 , A61K31/155 , A61K47/26 , A61K47/36 , A61K47/38
摘要： The invention provides sustained release formulations of metformin or a pharmaceutically acceptable salt thereof, and methods of treating diabetes by administering to a patient a therapeutically effective amount of a sustained release formulation of metformin or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供二甲双胍或其药学上可接受的盐的持续释放制剂，以及通过向患者施用治疗有效量的二甲双胍缓释制剂或其药学上可接受的盐来治疗糖尿病的方法。

50. 发明授权

US07211620B2 Foldable polyolefin films 失效
标题翻译：可折叠聚烯烃薄膜
公开(公告)号：US07211620B2
公开(公告)日：2007-05-01
申请号：US11042987
申请日：2005-01-25
申请人： Carlos Hurtado Arana
发明人： Carlos Hurtado Arana
IPC分类号： C08L23/04 , C08K3/26 , C08K3/34
CPC分类号： C08L23/06 , C08L23/0815 , C08L2205/02 , C08L2666/06
摘要： The present invention relates to foldable polyolefin film compositions, comprising a blend of high density polyethylene, linear low density polyethylene, a magnesium silicate and an alkaline or alkaline earth metal carbonate, to foldable polyolefin films made from such compositions and to a method for producing such.
摘要翻译：本发明涉及可折叠的聚烯烃薄膜组合物，其包含高密度聚乙烯，线性低密度聚乙烯，硅酸镁和碱金属或碱土金属碳酸盐的共混物，由这种组合物制成的可折叠聚烯烃薄膜，以及制备这种聚合物的方法。

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