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    • 50. 发明申请
    • DEHYDRATION SENSORS WITH ION-RESPONSIVE AND CHARGED POLYMERIC SURFACTANTS
    • 具有离子反应和带电聚合物表面活性剂的脱水传感器
    • WO2012023071A2
    • 2012-02-23
    • PCT/IB2011/053313
    • 2011-07-25
    • KIMBERLY-CLARK WORLDWIDE, INC.SONG, XuedongWEI, NingPHILLIPS, Ronnie, L.
    • SONG, XuedongWEI, NingPHILLIPS, Ronnie, L.
    • G01N33/493G01N33/52G01N21/80G01N31/22
    • G01N33/558A61F13/42A61F13/84A61F2013/00429A61F2013/0094A61F2013/00948A61F2013/15081A61F2013/15154A61F2013/8473
    • A lateral flow assay device for determining the relative ionic strength of urine is described. The device includes a buffering zone having a polyelectrolyte disposed therein, and an indicator zone having a pH indicator non-diffusively immobilized therein, the indicator zone being separate from the buffering zone and positioned adjacent to and in fluid communication with the buffering zone. A detection zone is part of the buffering zone, and has a buffering component comprising a weak polymeric acid and weak polymeric base with a pKa ≤ 10 -3 , and a class of charged polymeric surfactants that are responsive to relative ion concentrations in a sample solution, and a charged pH indicator with a charge opposite to that of the charged polymeric surfactant. The charged polymeric surfactant is soluble in amounts of greater than or equal to about 1% by weight (≥ 1wt. % solute) in water and aqueous solutions of low ionic concentration of ≤ 0.1 wt. % salts, but insoluble ( 0.1 wt. % salts. The present invention also describes absorbent articles incorporating such an assay device and methods of monitoring dehydration or testing ion strength of a urine sample using such a test format.
    • 描述了用于确定尿液的相对离子强度的侧流测定装置。 该装置包括其中设置有聚电解质的缓冲区和具有非扩散固定在其中的指示剂区的指示剂区,指示剂区与缓冲区分开并且与缓冲区相邻并且与缓冲区流体连通。 检测区是缓冲区的一部分,并且具有包含弱聚合酸和弱聚合物碱的缓冲组分,所述缓冲组分具有pKa≤10-3和一类带电聚合物表面活性剂,其对 样品溶液中的相对离子浓度,以及与带电聚合物表面活性剂的电荷相反的带电荷pH指示剂。 带电聚合物表面活性剂在水中的溶解度大于或等于约1重量%(≥1重量%溶质),并且低离子浓度的水溶液≤0.1重量% %的盐,但是在高离子浓度的水溶液中不溶(<1wt。%溶质) 0.1重量% %的盐。 本发明还描述了包含这种测定装置的吸收制品和使用这种测试形式来监测尿样的脱水或测试离子强度的方法。