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41. 发明申请

WO2018075977A1 RECOMBINANT VECTORS EXPRESSING ANTIGENS OF AVIAN INFLUENZA VIRUS AND USES THEREOF 审中-公开
标题翻译：表达抗禽流感病毒抗原的重组载体及其应用
公开(公告)号：WO2018075977A1
公开(公告)日：2018-04-26
申请号：PCT/US2017/057741
申请日：2017-10-20
申请人： MERIAL, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
发明人： PRITCHARD, Joyce , MEBATSION, Teshome , SWAYNE, David
IPC分类号： A61K39/145 , A61K39/00
摘要： The present invention provides recombinant viral vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant viral vectors, polyvalent vaccines comprising the recombinant viral vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant viral vectors.
摘要翻译：本发明提供了含有和表达禽类病原体抗原的重组病毒载体，包含重组病毒载体的组合物，包含重组病毒载体的多价疫苗。本发明进一步提供了针对各种禽类病原体的疫苗接种方法和生产重组病毒载体的方法。

42. 发明申请

WO2018071535A1 PESTICIDAL AND PARASITICIDAL VINYL ISOXAZOLINE COMPOUNDS 审中-公开
标题翻译：杀虫剂和杀虫剂乙烯基异恶唑啉化合物
公开(公告)号：WO2018071535A1
公开(公告)日：2018-04-19
申请号：PCT/US2017/056130
申请日：2017-10-11
申请人： MERIAL, INC.
发明人： LONG, Alan , LE HIR DE FALLOIS, Loic Patrick
IPC分类号： A01N43/80 , C07D413/12 , C07D263/16 , A01P7/04
摘要： The present invention relates to pesticidal and parasiticidal isoxazoline of formula (I) and salts thereof: Formula (I) wherein variables B 1 , B 2 , B 3 , R 1 , P 1 , P 2 , Y and Q are described herein are as defined in the description. The invention also relates to parasiticidal and pesticidal compositions comprising the isoxazoline compounds of formula (I), processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.
摘要翻译：本发明涉及式（I）的杀虫和杀寄生虫异恶唑啉及其盐：式（I）其中变量B 1，B 2， B 3，R 1，P 1，P 2，Y和Q在本文中被描述为在说明中定义。本发明还涉及包含式（I）的异恶唑啉化合物的杀寄生物和杀虫组合物，它们的制备方法以及它们用于预防或治疗动物中的寄生虫感染或侵染和作为杀虫剂的用途。

43. 发明申请

WO2018039508A1 METHOD FOR REDUCING UNWANTED EFFECTS IN PARASITICIDAL TREATMENTS 审中-公开
标题翻译：减少寄生虫治疗中的不利影响的方法
公开(公告)号：WO2018039508A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/048527
申请日：2017-08-25
申请人： MERIAL, INC.
发明人： LE HIR DE FALLOIS, Lois, Patrick
IPC分类号： A01N43/80 , A01P7/00
CPC分类号： A01N25/32 , A61K9/0019 , A61K31/42 , A61K47/10 , A61P33/14 , A01N43/80
摘要： The present intention provides for, inter alia, a method for reducing a withdrawal period when treating livestock for parasitic infestations, which comprises administering an effective amount of a parasiticidal composition comprising an (S) enantiomer of an isoxazoline compound of the formula (S)-1 or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein, and an inert carrier or formulation adjuvant; wherein the composition contains less than 10% by weight of an (R) enantiomer of an isoxazoline compound or a pharmaceutically acceptable salt thereof. Moreover, the present invention further provides for method for reducing at least one unwanted effect while treating a non-human animal for a parasitic infestation by administering an effective amount of a parasiticidal composition comprising an (S) enantiomer of an isoxazoline compound of the formula (S)-l or a pharmaceutically acceptable salt thereof and an inert carrier or formulation adjuvant, wherein the composition contains less than 10% by weight of an (R) enantiomer of an isoxazoline compound or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明特别提供了一种用于减少处理家畜寄生虫害时的停药期的方法，该方法包括给予有效量的包含异恶唑啉（S）对映异构体的杀寄生虫组合物式（S）-1化合物或其药学上可接受的盐，其中变量如本文所定义，以及惰性载体或制剂助剂; 其中所述组合物包含小于10重量％的异恶唑啉化合物或其药学上可接受的盐的（R）对映异构体。此外，本发明进一步提供了通过给药有效量的杀虫组合物来减少至少一种不希望的效果，同时治疗非人动物寄生虫侵染的方法，所述组合物包含式（I）的异恶唑啉化合物的（S）对映体 S）-1或其药学上可接受的盐和惰性载体或配制助剂，其中所述组合物包含小于10重量％的异恶唑啉化合物或其药学上可接受的盐的（R）对映体。

44. 发明申请

WO2017062460A1 LIVE ATTENUATED HETEROLOGOUS VACCINE FOR LEPTOSPIRA 审中-公开
标题翻译： LEPTOSPIRA的灭活异种疫苗
公开(公告)号：WO2017062460A1
公开(公告)日：2017-04-13
申请号：PCT/US2016/055508
申请日：2016-10-05
申请人： MERIAL, INC. , VETAGRO-SUP , INSTITUT PASTEUR
发明人： BOMCHIL, Natalia, Ines , CUPILLARD, Lionel, Pierre Christian , FONTANA, Célia , GUIGAL, Pierre-Michel , BOUVET, Jérôme , PICARDEAU, Mathieu , KODJO, Angeli
IPC分类号： A61K39/02 , A61K39/00
CPC分类号： A61K39/0225 , A61K2039/522 , A61K2039/552
摘要： The present invention provides compositions or vaccines that contain a recombinant or an attenuated Leptospira interrogans that elicit an immune response in animals against Leptospira infection, including compositions comprising said recombinant or attenuated L. interrogans, methods of vaccination against Leptospira, and kits for use with such methods and compositions.
摘要翻译：本发明提供了组合物或疫苗，其含有在动物中引起针对钩端螺旋体感染的免疫应答的重组或减毒的钩端螺旋体钩端螺旋体，包括包含所述重组或减毒的询问问题的组合物，针对钩端螺旋体疫苗接种的方法，以及与其一起使用的试剂盒方法和组成。

45. 发明申请

WO2016210083A2 INACTIVATED CANINE INFLUENZA VACCINES AND METHODS OF MAKING AND USES THEREOF 审中-公开
标题翻译：灭活的犬流感疫苗及其制备方法及用途
公开(公告)号：WO2016210083A2
公开(公告)日：2016-12-29
申请号：PCT/US2016/038944
申请日：2016-06-23
申请人： MERIAL, INC.
发明人： CHIANG, Yu-Wei , CURETON, David , POULET, Herve
IPC分类号： A61K39/12 , A61P31/00
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/552 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C12N2760/16134
摘要： The present invention relates to canine influenza virus strains, and vaccines and compositions. The present invention also relates to reagents and methods allowing their detection, methods of vaccination as well as methods of producing these reagents and vaccines.
摘要翻译：本发明涉及犬流感病毒株，以及疫苗和组合物。本发明还涉及允许其检测的试剂和方法，接种方法以及生产这些试剂和疫苗的方法。

46. 发明申请

WO2016187534A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS 审中-公开
标题翻译：安全性杀虫剂化合物
公开(公告)号：WO2016187534A1
公开(公告)日：2016-11-24
申请号：PCT/US2016/033522
申请日：2016-05-20
申请人： MERIAL, INC.
发明人： DE FALLOIS, Loic, Le Hir , PACOFSKY, Gregory , LONG, Alan , MENG, Charles , LEE, Hyoung, Ik , OGBU, Cyprian, O.
IPC分类号： C07K11/02 , A01N43/72 , C07D273/00
CPC分类号： C07K11/02 , A01N43/72 , A61K38/00 , C07D273/00 , A01N37/46 , A01N43/90
摘要： The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.
摘要翻译：本发明提供式（I）的环状缩肽化合物和包含有效对抗伤害动物的寄生虫的化合物的组合物。化合物和组合物可用于对抗哺乳动物和鸟类中或哺乳动物上的寄生虫。本发明还提供了用于消除，控制和预防鸟类和哺乳动物中的寄生虫感染的改进方法。

47. 发明申请

WO2016161369A1 ANTHELMINTIC COMBINATIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译： ANTHELMINTIC组合及其使用方法
公开(公告)号：WO2016161369A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025714
申请日：2016-04-01
申请人： MERIAL, INC.
发明人： BONDESEN, Brenda
IPC分类号： A61K38/15 , A61K31/7048 , A61P33/00 , A61P33/14
CPC分类号： A61K38/15 , A61K9/0056 , A61K31/365 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61K31/7048 , A61K2300/00
摘要： The present invention relates to a veterinary composition comprising an effective amount of at least one cyclic depsipeptide and at least one macrocyclic lactone; and a pharmaceutically acceptable carrier, for the treatment or prophylaxis of parasitic infection in a mammal wherein the parasite shows resistance to treatment or prophylaxis with the macrocyclic lactone alone.
摘要翻译：本发明涉及一种兽用组合物，其包含有效量的至少一种环状缩肽和至少一种大环内酯; 和药学上可接受的载体，用于治疗或预防哺乳动物的寄生虫感染，其中寄生虫对单独的大环内酯显示出对治疗或预防的抵抗力。

48. 发明申请

WO2015196014A1 PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF 审中-公开
标题翻译：包含吲哚衍生物的PARASITICIDAL组合物，其方法和用途
公开(公告)号：WO2015196014A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036580
申请日：2015-06-19
申请人： MERIAL, INC.
发明人： MENG, Charles , LE HIR DE FALLOIS, Loic
IPC分类号： C07D401/04 , C07D401/12 , C07D209/08 , C07D209/10 , A01N43/38 , A01N43/40 , A01P15/00
CPC分类号： A61K31/404 , C07D209/08 , C07D209/10 , C07D401/04 , C07D401/12 , H03K5/04 , H03K7/00
摘要： The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
摘要翻译：本发明涉及用于对抗哺乳动物中的肝吸虫寄生虫的口服，局部或可注射的组合物，其包含至少一种吲哚衍生物活性剂。本发明还提供了用于消除和控制哺乳动物的肝吸虫寄生虫感染和侵染的改进方法，包括将本发明的组合物给予有需要的哺乳动物。

49. 发明申请

WO2015179417A1 METHOD AND DEVICE FOR CONDITIONAL IN OVO INJECTION 审中-公开
标题翻译：在OVO注射条件下的方法和装置
公开(公告)号：WO2015179417A1
公开(公告)日：2015-11-26
申请号：PCT/US2015/031605
申请日：2015-05-19
申请人： MERIAL, INC.
发明人： LESLIE, Christopher, Davis , NGUYEN, Chien, Dinh , BEVENSEE, Erich
IPC分类号： A01K45/00
CPC分类号： A01K45/007 , A01K43/00 , A61D1/02 , A61D7/00 , A61M5/46
摘要： The present invention provides in ovo injection devices, including a novel vaccine/substance conservation valve (VCV), a needle depth adjuster (NDA), and methods for selectively delivering vaccines and other substances to eggs in the context of poultry hatcheries. The valve of the present invention allows for the conditional dispensing of vaccines and other substances dependent upon the presence or absence of an egg. When an egg is present, the valve becomes activated, allowing vaccines or other substances to be injected. When an egg is absent, the valve is not activated, thus vaccines and other valuable substances are conserved. The NDA allows embryonated eggs to be more safely injected by reducing the depth of needle penetration, particularly in smaller eggs.
摘要翻译：本发明提供了包括新型疫苗/物质保存阀（VCV），针深度调节器（NDA）在内的ovo注射装置，以及在家禽孵化场的情况下选择性地将疫苗和其它物质输送到鸡蛋的方法。本发明的阀允许根据蛋的存在或不存在来有条件地分配疫苗和其它物质。当蛋存在时，阀被激活，允许注射疫苗或其他物质。当鸡蛋不存在时，阀门不被激活，因此疫苗和其他有价值的物质是保守的。 NDA通过减少穿刺深度，特别是在较小的鸡蛋中，可以更加安全地注射胚胎蛋。

50. 发明申请

WO2015109312A1 TOPICAL DELIVERY FORMULATION 审中-公开
标题翻译：主题交付配方
公开(公告)号：WO2015109312A1
公开(公告)日：2015-07-23
申请号：PCT/US2015/012031
申请日：2015-01-20
申请人： MERIAL INC.
发明人： PATE, James , SHUB, Natalya
IPC分类号： A61K9/00
CPC分类号： A01N25/10 , A01N43/56 , A01N53/00 , A61K9/0014
摘要： The invention is a pour-on antiparasitic formulation having superior water resistant properties. The pour-on formulation utilizes one or more polymers (water insoluble with or without water soluble) in the range of about 5 to about 40% w/w, one or more solvents in the range of about 50 to about 94%> w/w, with or without additive (e.g., isopropanol or ethanol) in the range of about 5 to about 30% w/w, and optionally a plasticizer in the range of about 0.5 to about 25% w/w. The pour-on antiparasitic formulation features limited spreading when applied to animals (cattle, sheep, dogs and the like). The pour-on antiparasitic formulation further partially evaporates, leaving a water resistant polymer matrix that diffuses at least one active ingredient to the animal's skin.
摘要翻译：本发明是具有优异防水性能的浇注抗寄生虫制剂。倾注配方使用一种或多种聚合物（水溶性或不含水溶性）在约5至约40％w / w的范围内，一种或多种溶剂在约50至约94％> w / w，有或没有添加剂（例如异丙醇或乙醇）在约5至约30％w / w的范围内，和任选的增塑剂在约0.5至约25％w / w的范围内。灌注抗寄生虫制剂在施用于动物（牛，绵羊，狗等）时具有有限的扩散。浇注抗寄生虫制剂进一步部分蒸发，留下将至少一种活性成分扩散至动物皮肤的防水聚合物基质。

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