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41. 发明申请

WO2014150566A1 REDUCING THE RISK OF AUTOIMMUNE DISEASE 审中-公开
标题翻译：降低自身免疫性疾病的风险
公开(公告)号：WO2014150566A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/023630
申请日：2014-03-11
申请人： MJN U.S. HOLDINGS LLC
发明人： HONDMANN, Dirk, , VAN TOL, Eric A.F., , GROSS, Gabriele, , SCHOEMAKER, Marieke H., , LAMBERS, Teartse Tim,
IPC分类号： A61K38/01 , A61P37/06
CPC分类号： A61K38/018
摘要： The present disclosure provides a method for reducing the risk of autoimmune disease by administering a composition comprising peptides selected from a casein hydrolysate. Such a composition, may reduce the symptoms of autoimmune disease and may be a treatment for autoimmune disease, especially type 1 diabetes. Preferably, the hydrolysate consists of peptides with a molecular weight of more than 500 Da.
摘要翻译：本公开提供了通过施用包含选自酪蛋白水解产物的肽的组合物来降低自身免疫疾病风险的方法。这种组合物可以减少自身免疫疾病的症状，并且可以是自身免疫疾病，特别是1型糖尿病的治疗。优选地，水解产物由分子量大于500Da的肽组成。

42. 发明申请

WO2014143481A1 LOW-BUFFER NUTRITIONAL COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：低缓冲营养组合物及其用途
公开(公告)号：WO2014143481A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/016070
申请日：2014-02-12
申请人： MJN U.S. HOLDINGS LLC
发明人： WITTKE, Anja , BANAVARA, Dattatreya
IPC分类号： A23L1/30 , A23L1/304 , A23L1/308 , A23L1/03 , A23L1/29
CPC分类号： A23L1/296 , A23L29/015 , A23L29/035 , A23L33/16 , A23L33/19 , A23L33/26 , A23L33/40 , A23V2002/00 , A23V2200/32 , A23V2200/06 , A23V2200/3202 , A23V2200/3204 , A23V2250/1578
摘要： The present disclosure is directed to methods for supporting resistance to bacterial growth in the gastrointestinal tract of a subject, particularly in that of a human infant. In certain embodiments, the method comprises administering to a subject a nutritional composition that has a low buffer strength, wherein administration of said nutritional composition decreases the bacterial counts of bacteria selected from the group consisting of Enteropathogenic E. coli (EPEC), Enteroaggregative E. coli (EAEC), Cronobacter sakazakii, Salmonella enterica , and combinations thereof in the subject's gastrointestinal tract. This disclosure further relates to the manufacture and use of low-buffer nutritional compositions in methods for modulating gastric acidity and/or in methods for enhancing the rate of gastric emptying in a subject, each method comprising a step of administering at least one of said low-buffer nutritional compositions to the subject.
摘要翻译：本公开涉及用于支持对受试者的胃肠道中的细菌生长的抗性的方法，特别是对于婴儿。在某些实施方案中，所述方法包括对受试者施用具有低缓冲强度的营养组合物，其中所述营养组合物的施用降低了选自肠病毒性肠杆菌（Enterec病原性大肠杆菌）（Entercathogenic E.coli）（EPEC），肠聚集体E. 大肠杆菌（EAEC），阪崎肠埃布杆菌，肠炎沙门氏菌及其组合在受试者的胃肠道中。本公开还涉及在调节胃酸度的方法中和/或用于增强受试者胃排空速率的方法中制备和使用低缓冲营养组合物，每种方法包括施用至少一种所述低浓度缓冲营养组合物。

43. 发明申请

WO2014143469A1 NUTRITIONAL COMPOSITIONS CONTAINING AN ENRICHED LIPID FRACTION AND USES THEREOF 审中-公开
标题翻译：含有丰富脂质分解的营养组合物及其用途
公开(公告)号：WO2014143469A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/015775
申请日：2014-02-11
申请人： MJN U.S. HOLDINGS LLC
发明人： BANAVARA, Dattatreya, , JOUNI, Zeina, , ALVEY, John D., , GONZALEZ, Juan M.,
IPC分类号： A23L1/30 , A23L1/305 , A23C9/14 , A23C9/15 , A23L1/29
CPC分类号： A23L1/296 , A23C2240/05 , A23L33/115 , A23L33/12 , A23L33/135 , A23L33/19 , A23L33/40
摘要： The present disclosure relates to a nutritional composition comprising a fat source that includes an enriched lipid fraction derived from milk. The enriched lipid fraction may contain saturated fatty acids, trans-fatty acids, monounsaturated fatty acids, CLAs, BCFAs, cholesterol, milk fat globule membrane proteins, gangliosides, and mixtures thereof. The enriched lipid fraction may exhibit additive or synergistic beneficial health effects when consumed. The disclosure further relates to methods of providing a nutritional composition comprising an enriched lipid fraction to targeted subjects.
摘要翻译：本公开涉及包含脂肪源的营养组合物，其包含来自牛奶的富集的脂质部分。富集的脂质部分可以含有饱和脂肪酸，反式脂肪酸，单不饱和脂肪酸，CLA，BCFA，胆固醇，乳脂肪球膜蛋白，神经节苷脂及其混合物。当消耗时，富集的脂质部分可能表现出增加的或协同的有益的健康影响。本公开还涉及向目标受试者提供包含富集脂质部分的营养组合物的方法。

44. 发明申请

WO2014109862A1 NUTRITIONAL COMPOSITIONS CONTAINING A NEUROLOGIC COMPONENT AND USES THEREOF 审中-公开
标题翻译：含有神经元成分的营养组合物及其用途
公开(公告)号：WO2014109862A1
公开(公告)日：2014-07-17
申请号：PCT/US2013/074521
申请日：2013-12-12
申请人： MJN U.S. HOLDINGS LLC
发明人： KUANG, Chenzhong, , XIAO, Yan, , POELS, Eduard, K. , JOUNI, Zeina, , HONDMANN, Dirk,
IPC分类号： A23L1/30 , A23L1/29 , A61K31/164 , A61K31/685 , A61K31/688 , A61K31/7032 , A61K31/7068 , A61K31/7072
CPC分类号： A61K31/7072 , A23L33/115 , A23L33/12 , A23L33/40 , A61K31/07 , A61K31/164 , A61K31/685 , A61K31/688 , A61K31/7032 , A61K31/7068 , A61K2300/00
摘要： The present disclosure relates to nutritional compositions comprising a neurologic component, wherein, the neurologic component may promote brain and nervous system development and further provide neurological protection and repair. The neurologic component may include phosphatidylethanolamine, sphingomyelin, cytidine diphosphate-choline, ceramide, uridine, at least one ganglioside, and mixtures thereof. The disclosure further relates to methods of promoting brain and nervous system health by providing said nutritional compositions to target subjects, which includes pediatric subjects.
摘要翻译：本公开内容涉及包含神经组分的营养组合物，其中神经学组分可促进脑和神经系统发育并进一步提供神经保护和修复。神经学成分可包括磷脂酰乙醇胺，鞘磷脂，胞苷二磷酸胆碱，神经酰胺，尿苷，至少一种神经节苷脂，及其混合物。本公开还涉及通过向包括儿科受试者在内的目标受试者提供所述营养组合物来促进脑和神经系统健康的方法。

45. 发明申请

WO2014099134A1 MILK-BASED NUTRITIONAL COMPOSITIONS CONTAINING LACTOFERRIN AND USES THEREOF 审中-公开
标题翻译：含有LACTOFERRIN的基于乳汁的营养组合物及其用途
公开(公告)号：WO2014099134A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/067223
申请日：2013-10-29
申请人： MJN U.S. HOLDINGS LLC
发明人： WITTKE, Anja
IPC分类号： A23L1/305 , A23L1/308 , A23J1/20 , A23L1/29 , C07K14/79
CPC分类号： A23J1/20 , A23L33/19 , A23L33/26 , A23L33/40 , A23V2002/00 , A23V2200/00 , C07K14/79 , A23V2250/54248
摘要： The present disclosure relates to milk-based nutritional compositions comprising lactoferrin and/or a prebiotic component, wherein, when combined, the lactoferrin and prebiotic component may exhibit additive or synergistic beneficial effects on the health and development of a pediatric subject. The disclosure further relates to methods comprising the administration of said milk-based nutritional compositions to pediatric subjects.
摘要翻译：本公开内容涉及包含乳铁蛋白和/或益生元组分的基于乳的营养组合物，其中当组合时，乳铁蛋白和益生元组分可以对儿科受试者的健康和发育显示出增加的或协同的有益效果。本公开还涉及包括向儿科受试者施用所述基于乳的营养组合物的方法。

46. 发明申请

WO2014092861A1 NUTRITIONAL COMPOSITION FOR PROMOTING SATIETY 审中-公开
标题翻译：营养满意的营养成分
公开(公告)号：WO2014092861A1
公开(公告)日：2014-06-19
申请号：PCT/US2013/065555
申请日：2013-10-18
申请人： MJN U.S. HOLDINGS LLC
发明人： POELS, Eduard K. , RUDOLPH, Colin , VAN DAEL, Peter , WITTKE, Anja , MCMAHON, Robert J.
IPC分类号： A23L1/29
CPC分类号： A23L1/296 , A23L33/17 , A23L33/40 , A23V2002/00 , A23V2200/332
摘要： Provided herein are nutritional compositions comprising a protein source, a fat source, a carbohydrate source, and at least one nucleotide, wherein the protein source comprises at least one free amino acid, wherein the at least one free amino acid comprises a glutamate salt, glutamic acid, taurine, glutamine, alanine, or any combination thereof. Also provided herein are methods of promoting satiety, preventing or reducing the incidence of overweight or obesity, or preventing or reducing the incidence of diabetes in a subject comprising administering to a subject a nutritional composition comprising a protein source, a fat source, a carbohydrate source, and at least one nucleotide, wherein the protein source comprises at least one free amino acid, wherein the at least one free amino acid comprises a glutamate salt, glutamic acid, taurine, glutamine, alanine, or any combination thereof.
摘要翻译：本文提供了包含蛋白质源，脂肪源，碳水化合物源和至少一个核苷酸的营养组合物，其中所述蛋白质来源包含至少一种游离氨基酸，其中所述至少一种游离氨基酸包含谷氨酸盐，谷氨酸酸，牛磺酸，谷氨酰胺，丙氨酸或其任何组合。本文还提供了促进饱腹感，预防或减少超重或肥胖的发生率或预防或减少受试者中糖尿病发病率的方法，包括向受试者施用包含蛋白质来源，脂肪来源，碳水化合物来源的营养组合物和至少一个核苷酸，其中所述蛋白源包含至少一种游离氨基酸，其中所述至少一种游离氨基酸包含谷氨酸盐，谷氨酸，牛磺酸，谷氨酰胺，丙氨酸或其任何组合。

47. 发明申请

WO2012100022A2 THERMAL SOLUTION FOR LED BULBS 审中-公开
标题翻译： LED散热器的热解决方案
公开(公告)号：WO2012100022A2
公开(公告)日：2012-07-26
申请号：PCT/US2012/021827
申请日：2012-01-19
申请人： GRAFTECH INTERNATIONAL HOLDINGS INC. , PETROSKI, James T.
发明人： PETROSKI, James T.
IPC分类号： F21K99/00
CPC分类号： F21V29/773 , F21K9/23 , F21K9/232 , F21V29/70 , F21V29/763 , F21V29/87 , F21Y2115/10
摘要： A light bulb including an outer housing shaped like a standard Edison light bulb. The interior of the bulb includes a circuit board and one or more LEDs. A heat sink is provided inside the bulb housing that draws thermal energy away from the LEDs using graphite based materials.
摘要翻译：一个灯泡，包括外壳，形状像标准的爱迪生灯泡。灯泡的内部包括电路板和一个或多个LED。散热器设置在灯泡外壳内，使用石墨基材料将热能从LED中吸收。

48. 发明申请

WO2012091945A1 USE OF NUTRITIONAL COMPOSITIONS INCLUDING LACTOFERRIN IN SUPPORTING RESISTANCE TO DISEASES AND CONDITIONS 审中-公开
标题翻译：营养成分的使用，包括LACTOFERRIN在抗疾病和病症方面的应用
公开(公告)号：WO2012091945A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/065229
申请日：2011-12-15
申请人： MEAD JOHNSON NUTRITION COMPANY , WITTKE, Anja, , MUNOZ, Cecilia, , BANAVARA, Dattatreya,
发明人： WITTKE, Anja, , MUNOZ, Cecilia, , BANAVARA, Dattatreya,
IPC分类号： A23J1/20 , A23L1/29 , A23L1/305 , A61K35/20 , A61K38/40
CPC分类号： A61K38/40 , A23J1/20 , A23L33/00 , A23L33/19 , A23V2002/00 , A61K35/20 , Y02A50/473 , Y02A50/475 , A23V2200/30 , A23V2250/54248 , A61K2300/00
摘要： The present disclosure relates to the use of nutritional compositions including lactoferrin from a non-human source in supporting resistance to diseases or conditions. The method includes administering to a human a nutritional composition comprising a fat or lipid source, a protein source and lactoferrin produced by a non-human source.
摘要翻译：本公开涉及包括来自非人来源的乳铁蛋白的营养组合物用于支持对疾病或病症的抗性的用途。该方法包括向人施用营养组合物，其包含由非人源产生的脂肪或脂质来源，蛋白质来源和乳铁蛋白。

49. 发明申请

WO2004059670A1 COMPOSITE ELECTRODE AND CURRENT COLLECTORS AND PROCESSES FOR MAKING THE SAME 审中-公开
标题翻译：复合电极和电流收集器及其制造方法
公开(公告)号：WO2004059670A1
公开(公告)日：2004-07-15
申请号：PCT/US2003/040640
申请日：2003-12-19
申请人： ADVANCED ENERGY TECHNOLOGY INC. , REYNOLDS, Robert, A., III
发明人： REYNOLDS, Robert, A., III
IPC分类号： H01G4/35
CPC分类号： H01G9/016 , B82Y10/00 , C02F1/4691 , H01G9/155 , H01G11/36 , H01G11/38 , H01G11/40 , H01G11/42 , H01G11/44 , H01G11/86 , Y02E60/13 , Y10T29/417
摘要： Composite electrode/current collectors for capacitors, such a flow-through capacitor (9) or electric double layer capacitor are disclosed. Also disclosed are methods for making a composite electrode/current collectors (3) and capacitors having at least one composite electrode/current collector.
摘要翻译：公开了用于电容器的复合电极/集电器，这种流通电容器（9）或双电层电容器。还公开了制造具有至少一个复合电极/集电器的复合电极/集电体（3）和电容器的方法。

50. 发明申请

WO2004050319A1 MANUFACTURE OF CARBON/CARBON COMPOSITES BY HOT PRESSING 审中-公开
标题翻译：通过热压制造碳/碳复合材料
公开(公告)号：WO2004050319A1
公开(公告)日：2004-06-17
申请号：PCT/US2003/037856
申请日：2003-11-25
申请人： UCAR CARBON COMPANY INC. , HUANG, Dai , LEWIS, Richard, T. , LEWIS, Irwin, C. , SNYDER, Dave
发明人： HUANG, Dai , LEWIS, Richard, T. , LEWIS, Irwin, C. , SNYDER, Dave
IPC分类号： B29B11/16
CPC分类号： C04B35/64 , B82Y30/00 , C04B35/521 , C04B35/522 , C04B35/645 , C04B35/83 , C04B2235/3284 , C04B2235/3418 , C04B2235/3826 , C04B2235/3839 , C04B2235/3843 , C04B2235/3847 , C04B2235/402 , C04B2235/407 , C04B2235/421 , C04B2235/48 , C04B2235/526 , C04B2235/5264 , C04B2235/5436 , C04B2235/5454 , C04B2235/604 , C04B2235/608 , C04B2235/616 , C04B2235/652 , C04B2235/661 , C04B2235/666 , C04B2235/77 , C04B2235/80 , C04B2235/96 , C04B2235/9607 , F16D69/023 , F16D2200/0086
摘要： A mixture of carbon-containing fibers, such as mesophase or isotropic pitch fibers, a suitable matrix material, such as a milled pitch is compressed while resistively heating the mixture to form a carbonized composite material. Preferably, the carbonized material has a density of at least about 1.30 g/cm 3 . Preferably, the composite material is formed in less than ten minutes. This is a significantly shorter time than for conventional processes, which typically take several days and achieve a lower density material. A treating component may be impregnated into the composite. Consequently, carbon/carbon composite materials having final densities of about 1.6-1.8 g/cm 3 or higher are readily achieved with one or two infiltration cycles using a pitch or other carbonaceous material to fill voids in the composite and rebaking.
摘要翻译：将含碳纤维如中间相或各向同性沥青纤维，合适的基质材料如研磨沥青的混合物压缩，同时电阻加热混合物以形成碳化复合材料。优选地，碳化材料具有至少约1.30g / cm 3的密度。优选地，复合材料在不到10分钟内形成。这比通常需要几天并实现较低密度材料的常规工艺明显更短的时间。处理组分可以浸渍到复合材料中。因此，通过使用沥青或其他碳质材料填充复合材料中的空隙并进行重新粘合，可以通过一次或两次渗透循环，容易地实现最终密度为约1.6-1.8g / cm 3或更高的碳/碳复合材料。

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