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    • 48. 发明申请
    • MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION
    • 用于与治疗性腐蚀相关的用于输送治疗药物的医疗装置
    • WO2009158333A2
    • 2009-12-30
    • PCT/US2009/048242
    • 2009-06-23
    • BOSTON SCIENTIFIC SCIMED, INC.ATANASOSKA, LilianaWEBER, JanGROSSO, PaulWARNER, Robert, W.SEETHAMRAJU, Kasyap, V.
    • ATANASOSKA, LilianaWEBER, JanGROSSO, PaulWARNER, Robert, W.SEETHAMRAJU, Kasyap, V.
    • A61L31/02A61L31/16
    • A61L31/022A61L31/10A61L31/14A61L31/148A61L31/16A61L2300/00
    • According to an aspect of the present invention, at least one ionic therapeutic agent is delivered from an implantable or insertable medical device that comprises an ion-conductive polymeric region that is disposed on a metallic region. The metallic region is in electrical contact with a dissimilar metallic region, such that a galvanic current is generated by the dissimilar metals when the device is implanted or inserted into a patient. Delivery of the ionic therapeutic agent from the ion-conductive polymeric region may be, for example, either accelerated or retarded by the galvanic current. According to another aspect of the present invention, implantable or insertable medical devices are provided which comprise: (a) a first metallic region having a first corrosion potential, (b) a second metallic region in electrical contact with the first metallic region and having a second corrosion potential that is greater than the first corrosion potential, and (c) a solid ion-conductive polymeric region, comprising an ion conducting polymer and an ionic therapeutic agent, disposed on the first metallic region, the second metallic region, or both.
    • 根据本发明的一个方面,至少一种离子治疗剂从可植入或可插入的医疗装置输送,其包括设置在金属区域上的离子导电聚合物区域。 金属区域与异种金属区域电接触,使得当器件植入或插入患者体内时,异种金属产生电流。 离子导电聚合物区域的离子治疗剂的递送可以例如由电流加速或延迟。 根据本发明的另一方面,提供了可植入或可插入的医疗装置,其包括:(a)具有第一腐蚀电位的第一金属区域,(b)与第一金属区域电接触的第二金属区域, 第二腐蚀电位大于第一腐蚀电位,和(c)固体离子传导聚合物区域,其包含离子导电聚合物和离子治疗剂,设置在第一金属区域,第二金属区域或两者上。
    • 50. 发明申请
    • MEDICAL DEVICES HAVING SUPERHYDROPHOBIC SURFACES,SUPERHYDROPHILIC SURFACES, OR BOTH
    • 具有超级表面的超声波表面或两面的医疗装置
    • WO2006135755A2
    • 2006-12-21
    • PCT/US2006/022497
    • 2006-06-09
    • BOSTON SCIENTIFIC SCIMED, INC.WEBER, JanSCHEWE, ScottBERG, Brian
    • WEBER, JanSCHEWE, ScottBERG, Brian
    • A61L29/14A61M2205/0222A61M2205/0238
    • According to an aspect of the invention, medical devices are provided, which have the following (a) one or more superhydrophobic surface regions, (b) one or more superhydrophilic surface regions having a durometer of at least 4OA, or (c) a combination of one or more superhydrophobic surface regions and one or more superhydrophilic surface regions having a durometer of at least 4OA. Such surfaces are created, for example, to provide reduced resistance to the movement of adjacent materials, including adjacent fluids and solids. Examples of medical device surface regions benefiting from the present invention include, for example, outside and/or inside (luminal) surfaces of the following: vascular catheters, urinary catheters, hydrolyser catheters, guide wires, pullback sheaths, left ventricular assist devices, endoscopes, airway tubes and injection needles, among many other devices.
    • 根据本发明的一个方面,提供了医疗装置,其具有以下(a)一个或多个超疏水表面区域,(b)一个或多个具有至少40A的硬度的超亲水性表面区域,或(c)组合 的一个或多个超疏水表面区域和一个或多个具有至少40A的硬度的超亲水表面区域。 例如,这样的表面被创建以提供对相邻材料,包括相邻流体和固体的运动的降低的阻力。 受益于本发明的医疗器械表面区域的实例包括例如以下的外部和/或内部(腔)表面:血管导管,导尿管,水解导管,引导线,回拉鞘,左心室辅助装置,内窥镜 ,气道管和注射针等。