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41. 发明专利

AU2012202348A1 Temperature feedback control for solid state gas sensors 未知
公开(公告)号：AU2012202348A1
公开(公告)日：2012-05-10
申请号：AU2012202348
申请日：2012-04-20
申请人： SENSORMATIC ELECTRONICS LLC , UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： DAOUST CLAUDE , GONG JIAN-WEI , CHEN QUAN-FANG , LIU NEN-CHIN , LIAN MING-REN
IPC分类号： G01N27/12 , G01N27/406 , G01N27/407 , G05D23/19
摘要： TEMPERATURE FEEDBACK CONTROL FOR SOLID STATE GAS SENSORS A solid state gas sensor may include gas sensing element coupled to a substrate. The gas sensing element may have a desired operating temperature, which may be between 100 and 400 degrees Celsius. The sensor may further include a temperature sensor coupled to the substrate and configured to sense an operating temperature of the sensing element and provide a feedback signal representative of the operating temperature. The sensor may further include a heater having a heat output. The heater may be responsive to the feedback signal to adjust the heat output to drive the operating temperature to the desired operating temperature. A detector such as a smoke detector or carbon monoxide detector having such a solid state gas sensor is also provided. An associated method is also provided.

42. 发明专利

AU2003274894A1 PLASTID GENETIC ENGINEERING VIA SOMATIC EMBRYOGENESIS 未知
公开(公告)号：AU2003274894A1
公开(公告)日：2004-01-23
申请号：AU2003274894
申请日：2003-07-03
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： DANIELL HENRY
IPC分类号： A01H1/00 , A61K39/00 , C07K14/24 , C07K14/28 , C07K14/32 , C12N5/10 , C12N15/09 , C12N15/82 , C12P21/02 , C12Q1/02 , C12Q1/32
摘要： A plastid transformation vector suitable for transforming a non-green plant cell, in which the plastid vector comprises, as operably linked components, a first flanking sequence, a DNA sequence coding for a foreign gene, and a second flanking sequence.

43. 发明专利

AU2015339447B2 Methods and compositions for natural killer cells 未知
公开(公告)号：AU2015339447B2
公开(公告)日：2021-08-12
申请号：AU2015339447
申请日：2015-10-27
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： COPIK ALICJA J , OYER JEREMIAH L , IGARASHI ROBERT Y , ALTOMARE DEBORAH
IPC分类号： A61K48/00 , C12N15/88
摘要： Disclosed herein are novel compositions and methods for stimulation of and the production or expansion of natural killer (NK) cells. Numbers of NK cells can be increased following contact with exosomes modified with one or more stimulatory peptides. Methods and compositions for the production of exosomes, wherein the exosomes comprises stimulatory peptides are also described. Also described are methods of treating cancer using the disclosed NK-stimulating exosomes or NK cells stimulated by the disclosed methods.

44. 发明专利

AU2019200525B2 Methods and compositions for natural killer cells 未知
公开(公告)号：AU2019200525B2
公开(公告)日：2021-01-21
申请号：AU2019200525
申请日：2019-01-25
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： COPIK ALICJA , REDDY VIJAY , OYER JEREMIAH
IPC分类号： A61K39/395 , C12N5/00 , C12N5/02
摘要： The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

45. 发明专利

SG11202004674VA TECHNIQUES FOR SECURELY EXECUTING CODE THAT OPERATES ON ENCRYPTED DATA ON A PUBLIC COMPUTER 未知
公开(公告)号：SG11202004674VA
公开(公告)日：2020-06-29
申请号：SG11202004674V
申请日：2018-12-17
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC , UNIV BOSTON
发明人： MUCCIOLO EDUARDO , CHAMON CLAUDIO
IPC分类号： G06F21/72 , G06F21/00
摘要： Techniques, for secure processing of encrypted data on public resources, include receiving first data indicating a sequence of reversible q-bit gates including a first segment for decrypting, a second segment for operating on the decrypted data, and a third segment for encrypting the resulting data. Second data indicates rules for replacing a first sequence of two gates operating on at least one shared bit of an input N-bit word with a different second sequence of one or more gates that produce the same output N-bit word. The second data is used to propagate: a gate from the first segment a distance into the second segment or beyond; and, a gate from the third segment a distance into the second segment or before. This produces an obfuscated sequence of reversible gates. Obfuscated instructions based on the obfuscated sequence of gates are sent to the public resources.

46. 发明专利

AU2018273963A1 Novel oncolytic viruses for sensitizing tumor cells to killing by natural killer cells 未知
公开(公告)号：AU2018273963A1
公开(公告)日：2020-01-23
申请号：AU2018273963
申请日：2018-05-25
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： PARKS GRIFF , COPIK ALICJA
IPC分类号： C07K14/705 , A61K35/761 , C12N15/86
摘要： Disclosed are engineered oncolytic viruses, related fusion proteins and polynucleotides encoding them, and methods for treating cancer using the engineered viruses. In one aspect, disclosed herein are engineered oncolytic viruses, wherein the oncolytic virus expresses one or more exogenous membrane bound immune cell targeting ligands comprising an uncleaved signal anchor.

47. 发明专利

SG11201907917XA PM21 PARTICLES TO IMPROVE BONE MARROW HOMING OF NK CELLS 未知
公开(公告)号：SG11201907917XA
公开(公告)日：2019-09-27
申请号：SG11201907917X
申请日：2018-02-28
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC , RES INST NATIONWIDE CHILDRENS HOSPITAL
发明人： COPIK ALICJA , OYER JEREMIAH , CHAKRAVARTI NITIN , LEE DEAN ANTHONY
IPC分类号： A61K35/17 , A61K38/20 , C12N5/00
摘要： PMg/injection) PM21 (14/injection) .2 , 0,000 .50,000 Lung r, 60,000 .E 40,000 S 20 , 000 Liver o P=0.0003 o 0 0 o o 0 o° = —41 - o 0 0 o 0 800 0 800 PM21 (µg/injection) PM21 (µg/injection) 4;120% - P=0.012 ••\"100% +- 100% 80%-e 80% 60% _O R s . E 60% s ÷: 40%-o - o ( !1, 161 ig 40% 20 0% -1 30 % o 4tiSt 421t, 20%-g 0%- azt, sca, O 800 0 800 0 o ° o 0 P=0.035 00 1 -o P=0.015 0 120%- P=0.018 1 + -1oo: : '4 1 80% - LI g 40%- oo h o o c, 20% Eb?, 0% - e lm imok 0 800 PM21 (µg/injection) PM21 (vg/injection) PM21 (µg/injection) FIG. 5 - 100% 80% ' 4 ,2 - 60% '4, 40% • 20% 0% 0 0 otio PM21 (µg/injection) 80,000 460,000 .E 40,000 20,000 o Spleen Brain 0 0 800 PM21 (µg/injection) 0 800 PM21 (11g/injection) 120%- + 100% 80% a 60% • 40% c, 20% 0% D iz.xc 800 - 0 4E4 800 la 10,000 1 5,000 4 ' 000 f 2 •, 2,000 Bone marrow P=0.044 00 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIP0 I PCT 011101010 0111 °nolo omiooliolioomll ono voimIE (10) International Publication Number WO 2018/160673 Al (51) International Patent Classification: A61K 35/17 (2015.01) Cl 2N 5/00 (2006.01) A61K 38/20 (2006.01) (21) International Application Number: PCT/US2018/020187 (22) International Filing Date: 28 February 2018 (28.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/464,747 28 February 2017 (28.02.2017) US (71) Applicants: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. [US/US]; 12201 Research Parkway, Ste 501, Orlando, Florida 32826 (US). RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL [US/US]; 700 Children's Dri- ve, Columbus, Ohio 43205 (US). (72) Inventors: COPIK, Alicia; 196 Paul McClure Ct., Cassel- berry, Florida 23707 (US). OYER, Jeremiah; 609 Albany Ct., Longwood, Florida 32779 (US). CHAKRAVARTI, Nitin; 2801 River Park Drive, Columbus, Ohio 43220 (US). LEE, Dean Anthony; 2561 Sitterly Road, Canal Winches- ter, Ohio 43110 (US). (74) Agent: LANIER, Gibson, J. et al.; Meunier Carlin & Curf- man LLC, 999 Peachtree Street, NE, Suite 1300, Atlanta, Georgia 30309 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: PM21 PARTICLES TO IMPROVE BONE MARROW HOMING OF NK CELLS © (57) : Disclosed are compositions and methods for directing NK cells to the bone marrow through the use of PM21 particles. C [Continued on next page] WO 2018/160673 Al MIDEDIMOMMIDIRE1013 0111 VIII 1101 INEHOMOVOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))

48. 发明专利

SG11201903032SA METHODS AND COMPOSITIONS RELATED TO NK CELL AND ANTI-PDL1 CANCER THERAPIES 未知
公开(公告)号：SG11201903032SA
公开(公告)日：2019-05-30
申请号：SG11201903032S
申请日：2017-10-05
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： COPIK ALICJA J , IGARASHI ROBERT Y , OYER JEREMIAH J , ALTOMARE DEBORAH A
IPC分类号： C12N1/15 , C12N1/19 , C12N1/21 , C12N5/078 , C12N5/10 , C12N15/09
摘要： 100% CD 121 80% 71 3 60% 0 40% >, 20% U- 0% FIG. 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 April 2018 (12.04.2018) iiiionomoloionlio1 001110110011101110MOVON (10) International Publication Number WO 2018/067825 Al WIPO I PCT (51) International Patent Classification: C12N 1/15 (2006.01) C12N 5/078 (2010.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 1/21 (2006.01) C12N 15/09 (2006.01) (21) International Application Number: PCT/US2017/055352 (22) International Filing Date: 05 October 2017 (05.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/404,520 05 October 2016 (05.10.2016) US (71) Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. [US/US]; 12201 Re- search Parkway, Suite 501, Orlando, Florida 32826 (US). (72) Inventors: COPIK, Alicia J.; 12201 Research Parkway, Suite 501, Orlando, Florida 32826 (US). IGARASHI, Robert Y.; 12201 Research Parkway, Suite 501, Orlando, Florida 32826 (US). OYER, Jeremiah J.; 12201 Research Parkway, Suite 501, Orlando, Florida 32826 (US). AL- TOMARE, Deborah A.; 12201 Research Parkway, Suite 501, Orlando, Florida 32826 (US). (74) Agent: LANIER, J. Gibson et al.; Meunier Carlin & Curf- man LLC, 999 Peachtree Street, NE, Suite 1300, Atlanta, Georgia 30309 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: METHODS AND COMPOSITIONS RELATED TO NK CELL AND ANTI-PDL1 CANCER THERAPIES IFNI production upon tumor or cytokine stimulation is highly enhanced for PM21 expanded NK cells 1-1 (57) : Disclosed are compositions and methods relating to the treatment of a cancer via the induction of PDL1 and use of ei anti-PDL1 antibodies. o [Continued on next page] cc O WO 2018/067825 Al MIDEDIMOMOIDEIRMOIMEHERIOMMWS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))

49. 发明专利

AU2013232234B2 Compositions having aluminum particles dispersed in a continuous phase 未知
公开(公告)号：AU2013232234B2
公开(公告)日：2017-06-08
申请号：AU2013232234
申请日：2013-03-12
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC , TEXAS A & M UNIV SYS
发明人： REID DAVID L , SEAL SUDIPTA , PETERSEN ERIC
IPC分类号： C06B27/00 , C06B23/00 , C06B33/00 , C06B43/00 , C06D5/00
摘要： A method of forming composite materials includes mixing a first metal precursor with a chelating agent to form a first metal-chelate complex. The first metal-chelate complex is added to a polymer binder having terminating hydroxyl groups to form a polymer binder-first metal-chelate. The polymer binder first metal-chelate complex is mixed with an aluminum precursor. The aluminum precursor decomposes forming aluminum nanoparticles dispersed in a continuous phase material having metallic aluminum cores. At least one of the first metal-chelate complex and the first metal is dissolved in the continuous phase. The aluminum nanoparticles can have a passivating coating layer thereon provided by the polymer binder, or can have a passivating coating layer formed by including an epoxide, alcohol, carboxylic acid, or amine in the adding that forms passivating compound(s) which add further protection that can provide complete protection from oxidation of the metallic aluminum cores by air.

50. 发明专利

AU2015253484A1 Compositions, methods of making a composition, and methods of use 未知
公开(公告)号：AU2015253484A1
公开(公告)日：2016-10-06
申请号：AU2015253484
申请日：2015-04-27
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： SANTRA SWADESHMUKUL , YOUNG MIKAEEL
IPC分类号： A01N59/20
摘要： Embodiments of the present disclosure, in one aspect, relate to compositions including a copper/silica nanocomposite and a polymer, methods of making a composition, methods of using a composition, and the like. An embodiment of the present disclosure provides for a composition, among others, that includes: a copper/silica nanocomposite having a silica gel matrix that includes copper from one or more of copper nanopartides and copper ions, and a polymer selected from the group consisting of: polyvinylpyrrolidone, poryacrylamide, polylactic acid, polyglycolic acid, starch, a quaternary ammonium compound, and a combination thereof.

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