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41. 发明申请

WO2006094673A3 SYNERGISTIC MIXTURES OF C6- TO C12-ALKANEDI0LS AND TROPOLONE (DERIVATIVES) 审中-公开
标题翻译： C6-对C12-烷基和三聚氰胺（衍生物）的协同混合物
公开(公告)号：WO2006094673A3
公开(公告)日：2006-12-14
申请号：PCT/EP2006001800
申请日：2006-02-27
申请人： UNIV MUENCHEN L MAXIMILIANS , UNIV ALBERT LUDWIGS FREIBURG , LICHTENTHALER STEFAN , HAASS CHRISTIAN , NEUMANN STEFANIE , SCHOEBEL SUSANNE , HERTWECK MAREN , BAUMEISTER RALF
发明人： LICHTENTHALER STEFAN , HAASS CHRISTIAN , NEUMANN STEFANIE , SCHOEBEL SUSANNE , HERTWECK MAREN , BAUMEISTER RALF
IPC分类号： C12N15/12 , A01K67/027 , A61K38/17 , A61K39/395 , C07K14/47 , C12N1/15 , C12N5/00 , C12N15/11 , C12N15/62 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/47
摘要： The present invention relates to a polynucleotide encoding a specific novel sorting nexin, SNX-B8/30 and is also related to a polypeptide encoded by said polynucleotides. The invention also relates to specific medical, pharmaceutical and scientific uses of said new member of a herein described sorting nexin (SNX) subgroup consisting of SNX-9, SNX- 18 and the herein described SNX-B8/30. Also provided are specific screening methods for agonists or antagonists influencing the function and/or expression of the SNX-B 8/30 and/or the further members of the herein identified subfamily of sorting nexins. Accordingly, the present invention also relates to novel pharmaceutical compositions. These pharmaceutical compositions may, inter alia, be employed in the treatment of diseases/disorders related to (pathological) APP metabolism and/or the insulin metabolism, like Alzheimer's disease or diabetes. Also provided are non-human transgenic animals comprising a modified and/or altered SNX-B8/30 or expressing a heterologous SNX-B8/30.
摘要翻译：本发明涉及编码特异性新型分选结合蛋白SNX-B8 / 30的多核苷酸，并且还与由所述多核苷酸编码的多肽相关。本发明还涉及本文所述的由SNX-9，SNX-18和本文所述的SNX-B8 / 30组成的本文所述的分选新蛋白（SNX）亚组的新成员的具体医学，药学和科学用途。还提供了影响SNX-B 8/30的功能和/或表达的激动剂或拮抗剂的特异性筛选方法和/或本文确定的分选内毒素亚家族的其它成员。因此，本发明还涉及新的药物组合物。这些药物组合物尤其可以用于治疗与（代谢）APP代谢和/或胰岛素代谢有关的疾病/病症，如阿尔茨海默病或糖尿病。还提供了包含经修饰和/或改变的SNX-B8 / 30或表达异源SNX-B8 / 30的非人转基因动物。

42. 发明申请

WO02082714A3 DEVICE AND METHOD FOR USE IN QUANTUM CRYPTOGRAPHY 审中-公开
标题翻译：装置和方法量子密码
公开(公告)号：WO02082714A3
公开(公告)日：2003-09-25
申请号：PCT/EP0203825
申请日：2002-04-05
申请人： UNIV MUENCHEN L MAXIMILIANS , WEINFURTER HARALD , KURTSIEFER CHRISTIAN
发明人： WEINFURTER HARALD , KURTSIEFER CHRISTIAN
IPC分类号： H04L9/08 , H04L9/00
CPC分类号： H04L9/0852
摘要： The invention relates to a quantum cryptography system for the safe generation of keys, especially using signal sources and analytical channels. The signal sources are arranged spatially separately in such a way that the wave fronts of the light signals emitted by them are partially superimposed on the input of the quantum channel. The analytical channels are arranged in such a way that the wave front of the light signals exiting the quantum channel is spatially split up and at least two of the sections are analyzed in a quantum mechanical state.
摘要翻译：本发明涉及一种用于安全密钥生成量子加密系统中，尤其是与信号源和分析通道。信号源被布置为在空间上分离，由它们发射的光的光信号在量子通道的输入部分重叠的那波前。分析通道被布置为使得从量子信道的光信号的出现的波阵面被空间分割和至少两个部件的一个量子态进行了分析。

43. 发明申请

WO02051990A3 PROTEASES OF ENDOGENOUS RETROVIRUSES, SUBSTRATES THEREOF AND METHOD FOR SCREENING INHIBITORS 审中-公开
标题翻译：蛋白酶内源性逆转录病毒，底物体和一种筛选抑制剂
公开(公告)号：WO02051990A3
公开(公告)日：2003-04-17
申请号：PCT/EP0115209
申请日：2001-12-21
申请人： UNIV MUENCHEN L MAXIMILIANS , VON DER HELM KLAUS , BLUSCH JUERGEN HUBERT , SEELMEIR SIGRID
发明人： VON DER HELM KLAUS , BLUSCH JUERGEN HUBERT , SEELMEIR SIGRID
IPC分类号： C07K14/15 , C12N9/50 , C12N15/57 , C07K7/06 , C07K7/08 , C12N5/10 , G01N33/50
CPC分类号： C07K14/005 , C07K2319/00 , C12N9/503 , C12N2740/13022 , G01N2333/15 , G01N2500/04
摘要： The invention relates to a nucleic acid that encodes a retroviral protease, said nucleic acid comprising a sequence that is selected from the group including SEQ. ID. No. 1, SEQ. ID. No. 2 and SEQ. ID. No. 3.
摘要翻译：本发明涉及一种核酸，其编码用于逆转录病毒蛋白酶，其中所述核酸包含选自包括SEQ.ID.中的序列 1，SEQ.ID.NO. 2和SEQ.ID.NO 3包括。

44. 发明申请

WO2012084212A1 A METHOD OF EXAMINING TISSUE GROWTH AND CONDITIONING OF CELLS ON A SCAFFOLD AND A PERFUSION BIOREACTOR 审中-公开
标题翻译：检查组织生长和细胞在SCAFFOLD和PERFUSION BIORACTOR上的调控方法
公开(公告)号：WO2012084212A1
公开(公告)日：2012-06-28
申请号：PCT/EP2011006455
申请日：2011-12-19
申请人： UNIV MUENCHEN L MAXIMILIANS , AKRA BASSIL , HAAS ULRIKE , HOLLWECK TRIXI
发明人： AKRA BASSIL , HAAS ULRIKE , HOLLWECK TRIXI
IPC分类号： C12M3/00 , A61F2/24 , C12N5/00
CPC分类号： C12M41/46 , C12M21/08 , C12M29/10 , C12M35/04 , C12M41/18
摘要： Disclosed herein is a method of examining tissue growth and/or conditioning and/or adhesion properties of cells on a synthetic and/or natural scaffold (30) as well as a perfusion bioreactor (10) for use in this method. The method comprises the following steps: fixing a scaffold (30) to a holding means (28) disposed or disposable in a perfusion bioreactor (10), generating a flow of nutrition solution along the surface of said scaffold (30) held by said holding means (28), generating and/or maintaining physiological conditions in said nutrition solution flowing along said scaffold (30) using heat exchange means (20, 24, 48, 50) and/or gas exchange means (52, 54, 56, 58, 60, 62, 64) associated with said bioreactor (10), such as to allow growth and/or conditioning of cells on said scaffold (30), and optically inspecting, in particular by microscopy, the scaffold (30) held by said holding means (28) through a window (66, 68, 70, 72) provided in said perfusion bioreactor (10) at different times or continuously during tissue growth and/or conditioning of cells on said scaffold (30) while maintaining said physiological conditions in said perfusion bioreactor (10).
摘要翻译：本文公开了一种检查合成和/或天然支架（30）上的细胞的组织生长和/或调理和/或粘附性质以及用于该方法的灌注生物反应器（10）的方法。该方法包括以下步骤：将支架（30）固定到设置或一次性置于灌注生物反应器（10）中的保持装置（28）上，沿所述支架（30）保持的所述支架（30）的表面产生营养液流，（28），使用热交换装置（20,24,48,50）和/或气体交换装置（52,54,56,58）产生和/或维持所述营养溶液中沿着所述支架（30）流动的生理条件，60,62,64），例如允许所述支架（30）上的细胞的生长和/或调理，特别是通过显微镜光学检查由所述生物反应器（10）保持的支架（30），在组织生长和/或调节所述支架（30）上的细胞的同时或连续地设置在所述灌注生物反应器（10）中的窗口（66,68,70,72）的保持装置（28），同时保持所述生理条件在所述灌注生物反应器（10）中。

45. 发明申请

WO2010026197A3 WAVELENGTH-TUNABLE LIGHT SOURCE 审中-公开
标题翻译：波长可调光源
公开(公告)号：WO2010026197A3
公开(公告)日：2010-09-23
申请号：PCT/EP2009061419
申请日：2009-09-03
申请人： UNIV MUENCHEN L MAXIMILIANS , HUBER ROBERT ALEXANDER , EIGENWILLIG CHRISTOPH , BIEDERMANN BENJAMIN
发明人： HUBER ROBERT ALEXANDER , EIGENWILLIG CHRISTOPH , BIEDERMANN BENJAMIN
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0066 , G02B5/20 , G02B5/284 , G02B26/002 , H01S3/08009 , H01S3/08059 , H01S3/105
摘要： In at least one embodiment, the wavelength-tunable light source (1) comprises an output source (2) suitable for generating an electromagnetic beam (R) during operation. The light source (1) further comprises a wavelength-selective first filter element (5) disposed downstream of the output source (2). The light source (1) also comprises a first amplifier medium (3) disposed downstream of the first filter element (5) and suitable for at least partially amplifying the beam (R) emitted by the output source (2). The light source (1) further comprises at least one wavelength-selective second filter element (6) disposed downstream of the first amplifier medium (3), wherein the second filter element (6) has an optical distance (L) to the first filter element (5). The first (5) and the at least one second filter element (6) can be tuned using a control unit (11) that comprises the light source (1). In the process, the filter elements (5, 6) are tuned such that the first (5) and the second filter element (6) are transparent for part (P) of the beam (R) in a time delay (T) relative to one another, wherein the delay (T) is equal to the quotient of the optical distance (L) and the speed of light in a vacuum (c).
摘要翻译：在波长可调光源（1）的至少一个实施例中，这包括适合于产生电磁辐射（R）的操作期间的输出源（2）。此外，光源（1）具有布置在输出源（2）下游的波长选择性第一滤波器元件（5）。此外，该光源（1）包括：第一放大介质（3），该第一过滤器元件（5）的下游和至少到输出的从所述源（2）辐射（R）是合适的局部增益发射。所述光源（1）还包括至少一个波长选择第二过滤器元件（6），其在第一放大介质的下游侧（3），其中，所述第二过滤器元件（6）连接到第一过滤器元件（5）的光学距离（L）。经由具有光源（1）的控制单元（11），第一（5）和至少一个第二过滤器元件（6）是可调的。过滤器元件（5，6）在这种情况下调整，使得所述第一（5）和第二过滤器元件（6）的辐射（R）中的时间延迟（T）的部分光束（P）是可渗透到彼此，其中所述延迟（T ）等于光学距离（L）和真空光速（c）的商。

46. 发明申请

WO2010000372A3 NEW DRUG FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：用于抑制与蛋白质聚集和/或神经干细胞病变相关的疾病相关蛋白聚集的新药
公开(公告)号：WO2010000372A3
公开(公告)日：2010-05-27
申请号：PCT/EP2009004144
申请日：2009-06-09
申请人： UNIV MUENCHEN L MAXIMILIANS , MAX PLANCK GESELLSCHAFT , GIESE ARMIN , BERTSCH UWE , KRETZSCHMAR HANS , HABECK MATHIAS , HIRSCHBERGER THOMAS , TAVAN PAUL , GRIESINGER CHRISTIAN , LEONOV ANDREI , RYAZANOV SERGEY , WEBER PETRA , GEISSEN MARKUS , GROSCHUP MARTIN H , WAGNER JENS
发明人： GIESE ARMIN , BERTSCH UWE , KRETZSCHMAR HANS , HABECK MATHIAS , HIRSCHBERGER THOMAS , TAVAN PAUL , GRIESINGER CHRISTIAN , LEONOV ANDREI , RYAZANOV SERGEY , WEBER PETRA , GEISSEN MARKUS , GROSCHUP MARTIN H , WAGNER JENS
IPC分类号： C07D231/06 , A61K31/415 , A61P25/28 , C07D207/333 , C07D231/12 , C07D233/22 , C07D261/08 , C07D271/06 , C07D405/04
CPC分类号： C07D231/12 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/42 , A61K31/4245 , C07D207/333 , C07D231/06 , C07D233/64 , C07D261/08 , C07D271/06 , C07D405/04 , C07D413/04 , G01N33/6896 , G01N2800/2828
摘要： The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed. Formula (E) wherein X, Y and L are independently nondirectionally selected from -C(R1)(R2)-, -C(R3)=, -N(R4)-, -N=, -N+(R5)=, -O- and -S-; M and Z are independently nondirectionally selected from formula (I) and formula (II).
摘要翻译：本发明涉及由式（E）表示的化合物。本发明还涉及用于治疗或预防与蛋白质聚集和/或神经变性疾病相关的疾病的由式（E）表示的化合物。此外，本发明涉及包含本发明化合物以及试剂盒的药物和诊断组合物。此外，本发明涉及一种成像聚集蛋白沉积物的方法。还公开了用于制备本发明的可检测标记的化合物的试剂盒。式（E）其中X，Y和L分别独立地选自-C（R 1）（R 2） - ， - C（R 3）=， - N（R 4） - ， - N =， - N +（R 5） -O-和-S-; M和Z独立地选自式（I）和式（II）。

47. 发明申请

WO2008052775A2 CLICK CHEMISTRY FOR THE PRODUCTION OF REPORTER MOLECULES 审中-公开
标题翻译：点击生产报告分子的化学品
公开(公告)号：WO2008052775A2
公开(公告)日：2008-05-08
申请号：PCT/EP2007009474
申请日：2007-10-31
申请人： BASF SE , UNIV MUENCHEN L MAXIMILIANS , CARELL THOMAS , SCHWOEGLER ANJA
发明人： CARELL THOMAS , SCHWOEGLER ANJA
IPC分类号： G01N33/50
CPC分类号： C07H19/14 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00
摘要： The present invention relates to methods for producing reporter molecules suitable for the detection of analytes, e.g. nucleic acids. Further, the present invention relates to methods and regions for detecting analytes.
摘要翻译：本发明涉及制备适用于检测分析物的报道分子的方法，例如。核酸。此外，本发明涉及用于检测分析物的方法和区域。

48. 发明申请

WO2007128601A2 METHOD FOR THE PREPARATION OF A COMPOUND OF THE GENERAL FORMULA R1-R1 AND/OR R1-R2 USING HOMO AND HETERO COUPLING REACTIONS 审中-公开
标题翻译：制备通用化合物的方法R1-R1和/或R1-R2使用HOMO和HETERO偶联反应
公开(公告)号：WO2007128601A2
公开(公告)日：2007-11-15
申请号：PCT/EP2007052181
申请日：2007-03-08
申请人： UNIV MUENCHEN L MAXIMILIANS , KNOCHEL PAUL , MAYR HERBERT , KRASOVSKIY ARKADY , KIENLE MARCEL , DUBBAKA SRINIVAS REDDY , DEL AMO VICENTE , TISHKOV ALEXANDER
发明人： KNOCHEL PAUL , MAYR HERBERT , KRASOVSKIY ARKADY , KIENLE MARCEL , DUBBAKA SRINIVAS REDDY , DEL AMO VICENTE , TISHKOV ALEXANDER
IPC分类号： C07B49/00 , C07C1/32 , C07C15/14 , C07C209/66 , C07C211/54
CPC分类号： C07B37/04 , C07B43/04 , C07B49/00 , C07C1/326 , C07C253/30 , C07C15/14
摘要： The present application relates to a method for the preparation of a compound of the general formula R 1 -R 2 (I) and/or R 1 -R 1 (II) comprising providing a compound of the general formula R 1 d M
摘要翻译：本申请涉及一种制备通式R 1〜2（I）和/或R 1〜2（I）的化合物的方法，包括提供通式R 1的化合物，其中R 1，R 2，

49. 发明申请

WO2007068313A2 TARGETING AND TRACING OF ANTIGENS IN LIVING CELLS 审中-公开
标题翻译：抗生素在生活细胞中的靶向和追踪
公开(公告)号：WO2007068313A2
公开(公告)日：2007-06-21
申请号：PCT/EP2006010872
申请日：2006-11-13
申请人： UNIV MUENCHEN L MAXIMILIANS , ROTHBAUER ULRICH , LEONHARDT HEINRICH
发明人： ROTHBAUER ULRICH , LEONHARDT HEINRICH
IPC分类号： C07K19/00 , C07K16/46
CPC分类号： G01N33/566 , C07K1/22 , C07K14/43595 , C07K16/18 , C07K2317/22 , C07K2317/92 , C07K2319/60
摘要： The present invention relates to a method of detecting the presence, amount or subcellular location of an antigenic structure of interest in a cell, comprising the steps of: (a) (i) expressing a fusion protein directed to the antigenic structure of interest in said cell or (ii) introducing a fusion protein directed to the antigenic structure of interest and coupled to a (poly)peptide capable of transducing into said cell; wherein said fusion protein comprises a first (poly)peptide sequence comprising the variable region of a heavy chain antibody of Camelidae and a second (poly)peptide sequence derivable from a fluorescent or chromophoric protein.
摘要翻译：本发明涉及一种检测感兴趣的抗原结构在细胞中的存在，数量或亚细胞位置的方法，包括以下步骤：（a）（i）（i）表达针对所述抗原结构的融合蛋白，引入针对感兴趣的抗原结构并与能够转导入所述细胞的（多）肽偶联的融合蛋白; 其中所述融合蛋白包含第一（多）肽序列，其包含骆驼科的重链抗体的可变区和可衍生自荧光或发色蛋白的第二（多）肽序列。

50. 发明申请

WO2006133903A3 METHOD, DYE AND MEDICAMENT FOR STAINING THE INTERNAL LIMITING MEMEBRANE, THE VITREOUS AND/OR THE CAPSULE OF AN EYE 审中-公开
标题翻译：用于染色内部限制性眼睛，眼睛和/或眼睛的胶囊的方法，染色和药物
公开(公告)号：WO2006133903A3
公开(公告)日：2007-03-15
申请号：PCT/EP2006005675
申请日：2006-06-13
申请人： UNIV MUENCHEN L MAXIMILIANS , HARITOGLOU CHRISTOS
发明人： HARITOGLOU CHRISTOS
IPC分类号： A61K49/00
CPC分类号： A61K49/0021 , A61K49/0023 , A61K49/006
摘要： The present invention concerns a method of staining the internal limiting membrane, the vitreous and/or the lens capsule of the eye as well as dyes and me- dicaments suitable for this method. Such dyes, medicaments and methods are needed in ophthalmic surgery, in particular in macular and/or cataract surgery and/or vitrectomy. According to the inventive method, at least one of a fluorescent dye, Lightgreen SF, Copper-phtalocyanine- tetrasulfonic acid tetrasodium salt, E68, Bromophe- nolblue and Chicagoblue is administered to the eye .
摘要翻译：本发明涉及一种染色内部限制膜，眼睛的玻璃体和/或晶状体囊以及适用于该方法的染料和药物的方法。在眼科手术中，特别是在黄斑和/或白内障手术和/或玻璃体切割术中需要这样的染料，药物和方法。根据本发明的方法，向眼睛施用荧光染料，浅绿SF，铜 - 酞菁 - 四磺酸四钠盐，E68，溴酚蓝和Chicagoblue中的至少一种。

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