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41. 发明申请

WO2002030444A3 PLASMINOGEN ACTIVATOR TO PREVENT CORNEAL AND SUBEPITHELIAL HAZE AFTER LASER VISION CORRECTION SURGERY 审中-公开
公开(公告)号：WO2002030444A3
公开(公告)日：2002-04-18
申请号：PCT/US2001/031849
申请日：2001-10-12
申请人： THE JOHNS HOPKINS UNIVERSITY , SILVER, David M., , CSUTAK, Adrienne , BERTA, Andras , TOZSER, Jozsef
发明人： SILVER, David M., , CSUTAK, Adrienne , BERTA, Andras , TOZSER, Jozsef
IPC分类号： A61K38/49
摘要： The present invention is directed to a method to prevent or reduce postoperative corneal subepithelial haze after excimer laser photorefractive keratectomy (PRK), laser in situ keratomileusis (LASIK) surgery. According to the method, a therapeutically effective amount of one or more plasminogen activators, most preferably urokinase (uPA), is administered topically to the surface of the affected eye at levels between 0.1 and 2,500 IU/ml, about eight to twelve times on the day of surgery, and four to eight times per day for about the next six to twelve days thereafter. The most preferred therapeutic amount is from about 0.1-1 IU uPA/ml, and also 1-10 IU/ml. Plasminogen activators that can be used in the inventions include urokinase, prourokinase, tissue plasminogen activator, streptokinase and mutants thereof. The invention also covers topical ophthalmic compositions that include one or more plasminogen activators, most preferably uPA, to prevent or reduce postoperative corneal subepithelial haze.

42. 发明申请

WO0104007A8 MULTI-COMPARTMENT PACKAGE 审中-公开
标题翻译：多层包装
公开(公告)号：WO0104007A8
公开(公告)日：2001-09-20
申请号：PCT/US0019073
申请日：2000-07-12
申请人： COMPAK CORP , JOHNSON JIMMIE L , BOWEN RON , SILVER DAVID
发明人： JOHNSON JIMMIE L , BOWEN RON , SILVER DAVID
IPC分类号： B65D25/08 , B65D77/20 , B65D77/24 , B65D81/32
CPC分类号： B65D81/3233 , B65D25/08 , B65D77/245 , B65D81/3216 , B65D2577/2091
摘要： A multi-compartment (28, 30) sealed, container (12) for maintaining separation between two constituents, typically one dry (45) and one wet (44), until mixing of the constituents is desired. The container functions to house the constituents, introduce the constituents, facilitate mixing of the constituents, and serves as a ustensil for the dispensing of the constituent mixture.
摘要翻译：一个多隔室（28,30）密封的容器（12），用于保持两个组分之间的分离，通常一个干燥（45）和一个湿的（44），直到组分混合。容器用于容纳组分，引入组分，促进组分的混合，并用作分散组分混合物的ustensil。

43. 发明申请

WO1995006998A1 TELEPHONE BILLING METHOD 审中-公开
标题翻译：电话费用方式
公开(公告)号：WO1995006998A1
公开(公告)日：1995-03-09
申请号：PCT/US1994000461
申请日：1994-01-13
申请人： KUGELL, Stanley , SILVER, David
IPC分类号： H04M15/08
CPC分类号： H04M15/00
摘要： A method of billing a collect telephone call comprising providing a toll-free or a local telephone number to a customer to access a provider in a toll-free call from a calling party number (10); receiving the originating telephone number in response to the toll-free call (12); obtaining a destination telephone number from the customer (16); billing the call to the destination telephone number as coming from a predetermined other telephone number (29), whereby the calling party telephone number is not provided to the destination telephone number. Alternately, when a toll-free number is provided, billing the call to the destination telephone number as coming from the calling party telephone number (28).
摘要翻译：一种计费收费电话呼叫的方法，包括向客户提供免费电话号码或本地电话号码以从呼叫方号码（10）接收免费电话中的提供商; 响应于免费通话（12）接收始发电话号码; 从客户（16）获取目的地电话号码; 将来自预定的其他电话号码（29）的目的地电话号码的呼叫记账，由此不向目的地电话号码提供呼叫方电话号码。或者，当提供免费电话号码时，将来自主叫方电话号码（28）的呼叫计费到目的地电话号码。

44. 发明申请

WO2022190096A1 PREDICTING OLFACTORY PROPERTIES OF MOLECULES USING MACHINE LEARNING 审中-公开
公开(公告)号：WO2022190096A1
公开(公告)日：2022-09-15
申请号：PCT/IL2022/050265
申请日：2022-03-09
申请人： MOODIFY LTD , SILVER, David , KIRIYEVSKY, Kiril , HASSON, Giyora , MAMA, Yaniv , SHARON, Yigal
发明人： SILVER, David , KIRIYEVSKY, Kiril , HASSON, Giyora , MAMA, Yaniv , SHARON, Yigal
IPC分类号： G16C20/30
摘要： There are provided system and method of predicting data related to olfactory properties of a molecule characterized by a chemical structure. The method comprises: upon obtaining data informative of a spatial surface representation (SSR) of molecule corresponding to the chemical structure thereof, selecting on SSR a plurality of N surface points; for each selected surface point, obtaining local data informative of spatial location on SSR and local physicochemical properties of the selected surface point, thus giving rise to a surface points representation (SPR); inputting data informative of SPR into a Machine-Learned (ML) model trained to provide, in accordance with SPR, prediction data related to at least one olfactory property; and receiving, as an output of the ML model, prediction data related to the at least one olfactory property of the molecule. There are also provided system and method of predicting molecular chemical structure enabling one or more olfactory properties.

45. 发明申请

WO2017112073A1 AUTO RANGE CONTROL FOR ACTIVE ILLUMINATION DEPTH CAMERA 审中-公开
标题翻译：主动式照明深度相机的自动调光控制
公开(公告)号：WO2017112073A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/058475
申请日：2016-10-24
申请人： INTEL CORPORATION , ZABATANI, Aviad , SPERLING, Erez , MULLA, Ofir , KIMMEL, Ron , BRONSTEIN, Alex , BRONSTEIN, Michael , SILVER, David H. , MENASHE, Ohad , SURAZHSKY, Vitaly
发明人： ZABATANI, Aviad , SPERLING, Erez , KIMMEL, Ron , BRONSTEIN, Alex , BRONSTEIN, Michael , SILVER, David H. , MENASHE, Ohad , SURAZHSKY, Vitaly
IPC分类号： H04N13/02 , H04N9/31
CPC分类号： F16K17/02 , F15B15/063 , F16K1/22 , F16K1/34 , F16K31/363 , G01B11/25 , H04N5/2256 , H04N5/2351 , H04N5/2353 , H04N5/2354 , H04N5/2355 , H04N5/33
摘要： A method and apparatus for auto range control are described. In one embodiment, the apparatus comprises a projector configured to project a sequence of light patterns on an object; a first camera configured to capture a sequence of images of the object illuminated with the projected light patterns; a controller coupled to the projector and first camera and operable to receive the sequence of images and perform range control by controlling power of the sequence of light patterns being projected on the object and exposure time of a camera based on information obtained from the sequence of images captured by the camera.
摘要翻译：描述了用于自动范围控制的方法和设备。在一个实施例中，该设备包括被配置为在对象上投射光图案序列的投影仪; 第一相机，其被配置为捕捉用投影光图案照射的物体的图像序列; 控制器，耦合到所述投影仪和第一相机，并且可操作以接收所述图像序列，并且通过基于从所述图像序列获得的信息控制投射在所述物体上的所述一系列光图案的功率和相机的曝光时间来执行范围控制被相机捕获。

46. 发明申请

WO2013059517A1 ONLINE TEMPORAL DIFFERENCE LEARNING FROM INCOMPLETE CUSTOMER INTERACTION HISTORIES 审中-公开
标题翻译：从不完整的客户互动历史中学习的在线时间差异
公开(公告)号：WO2013059517A1
公开(公告)日：2013-04-25
申请号：PCT/US2012/060904
申请日：2012-10-18
申请人： CAUSATA INC. , NEWNHAM, Leonard Michael , MCFALL, Jason Derek , BARKER, David J. , SILVER, David
发明人： NEWNHAM, Leonard Michael , MCFALL, Jason Derek , BARKER, David J. , SILVER, David
IPC分类号： G06Q30/02
CPC分类号： G06Q30/02 , G06N99/005
摘要： In one embodiment, an indication that a decision has been requested, selected, or applied with respect to one or more users may be obtained. After the indication that a decision that has been requested, selected, or applied is obtained, a value function may be updated, where the value function approximates an expected reward associated with the one or more users over time since the decision has been requested, selected, or applied with respect to the one or more users. The value function may be updated by performing or providing one or more updates to the value function, where a time at which each of the one or more updates is performed or provided is independent of activity of the one or more users.
摘要翻译：在一个实施例中，可以获得关于一个或多个用户已经请求，选择或应用决定的指示。在获得已经被请求，选择或应用的决定的指示之后，可以更新值函数，其中值函数近似于从被选择的决定之后随着时间推移与一个或多个用户相关联的预期回报，或相对于一个或多个用户应用。可以通过对值函数执行或提供一个或多个更新来更新值函数，其中执行或提供一个或多个更新中的每一个的时间独立于一个或多个用户的活动。

47. 发明申请

WO2013049633A1 ONLINE ASYNCHRONOUS REINFORCEMENT LEARNING FROM CONCURRENT CUSTOMER HISTORIES 审中-公开
标题翻译：在同一时间的客户历史上在线寻求非同寻常的加强
公开(公告)号：WO2013049633A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/058010
申请日：2012-09-28
申请人： CAUSATA INC. , NEWNHAM, Leonard Michael , MCFALL, Jason Derek , BARKER, David J. , SILVER, David
发明人： NEWNHAM, Leonard Michael , MCFALL, Jason Derek , BARKER, David J. , SILVER, David
IPC分类号： G06F15/18
CPC分类号： G06N99/005
摘要： In one embodiment, an indication of a Decision Request or an Update Request may be received, where the Update Request is activated independent of user activity. A user state pertaining to at least one user may be received, obtained, accessed or constructed. For the Decision Request, one or more actions may be scored according to one or more value functions associated with a computing device, a policy associated with the computing device may be applied to identify one of the scored actions as a decision, and an indication of the decision may be provided or applied. For the Update Request, the one or more value functions and/or the policy may be updated. An indication of updates to the one or more value functions and/or an indication of updates to the policy may be provided.
摘要翻译：在一个实施例中，可以接收到决策请求或更新请求的指示，其中更新请求被独立于用户活动而被激活。可以接收，获取，访问或构造与至少一个用户有关的用户状态。对于决策请求，可以根据与计算设备相关联的一个或多个值函数来对一个或多个动作进行评分，可以应用与计算设备相关联的策略来将所评分的动作中的一个识别为决策，以及指示可以提供或应用该决定。对于更新请求，可以更新一个或多个值函数和/或策略。可以提供对一个或多个价值功能的更新的指示和/或对策略的更新的指示。

48. 发明申请

WO2007106826A2 DOMAIN NAME OWNERSHIP VALIDATION 审中-公开
标题翻译：域名所有权验证
公开(公告)号：WO2007106826A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/063911
申请日：2007-03-13
申请人： MARKMONITOR INC. , CHEN, Allen, Enfant , SHULL, Mark , SHRAIM, Ihab , SILVER, David , COOPER, Elisa
发明人： CHEN, Allen, Enfant , SHULL, Mark , SHRAIM, Ihab , SILVER, David , COOPER, Elisa
IPC分类号： G06F15/16
CPC分类号： H04L63/1441 , H04L29/12066 , H04L29/12594 , H04L61/1511 , H04L61/3015 , H04L63/1483 , H04L63/1491
摘要： Embodiments of the invention provide systems and methods for validating ownership of a domain name. According to one embodiment, a validating ownership of a domain name can comprise retrieving one or more domain name ownership records. For example, the one or more domain name ownership records comprise Who Is records. Validity of the one or more domain name records can be confirmed with a designated domain manager. According to one embodiment, confirming validity of the one or more domain name records with the designated domain manager can comprise authenticating the designated domain manager based on a certificate provided by the designated domain manager.
摘要翻译：本发明的实施例提供用于验证域名所有权的系统和方法。根据一个实施例，验证域名的所有权可以包括检索一个或多个域名所有权记录。例如，一个或多个域名所有权记录包括谁是记录。一个或多个域名记录的有效性可以用指定的域名管理员确认。根据一个实施例，用指定的域管理器确认一个或多个域名记录的有效性可以包括基于由指定域管理器提供的证书来认证指定域管理器。

49. 发明申请

WO0230444A2 PLASMINOGEN ACTIVATOR TO PREVENT CORNEAL AND SUBEPITHELIAL HAZE AFTER LASER VISION CORRECTION SURGERY 审中-公开
标题翻译：激光视力矫正外科手术后预防角膜和下面的水肿
公开(公告)号：WO0230444A2
公开(公告)日：2002-04-18
申请号：PCT/US0131849
申请日：2001-10-12
申请人： UNIV JOHNS HOPKINS , SILVER DAVID M , CSUTAK ADRIENNE , BERTA ANDRAS , TOZSER JOZSEF
发明人： SILVER DAVID M , CSUTAK ADRIENNE , BERTA ANDRAS , TOZSER JOZSEF
IPC分类号： A61K38/00 , A61K38/16 , A61K38/43 , A61K38/48 , A61K38/49 , A61P27/02 , A61P27/12 , A61P41/00 , A61P43/00
CPC分类号： A61K38/166 , A61K38/49
摘要： The present invention is directed to a method to prevent or reduce postoperative corneal subepithelial haze after excimer laser photorefractive keratectomy (PRK), laser in situ keratomileusis (LASIK) surgery. According to the method, a therapeutically effective amount of one or more plasminogen activators, most preferably urokinase (uPA), is administered topically to the surface of the affected eye at levels between 0.1 and 2,500 IU/ml, about eight to twelve times on the day of surgery, and four to eight times per day for about the next six to twelve days thereafter. The most preferred therapeutic amount is from about 0.1-1 IU uPA/ml, and also 1-10 IU/ml. Plasminogen activators that can be used in the inventions include urokinase, prourokinase, tissue plasminogen activator, streptokinase and mutants thereof. The invention also covers topical ophthalmic compositions that include one or more plasminogen activators, most preferably uPA, to prevent or reduce postoperative corneal subepithelial haze.
摘要翻译：本发明涉及一种在准分子激光屈光角膜切除术（PRK），激光原位角膜磨镶术（LASIK）手术后预防或减少术后角膜上皮下雾的方法。根据该方法，将治疗有效量的一种或多种纤溶酶原激活剂，最优选尿激酶（uPA）以0.1至2,500IU / ml的水平局部施用于受影响眼睛的表面，约8-12倍大约在接下来的六到十二天，每天四到八次。最优选的治疗量为约0.1-1IU uPA / ml，也为1-10IU / ml。可用于本发明的纤溶酶原激活剂包括尿激酶，原尿激酶，组织纤溶酶原激活剂，链激酶及其突变体。本发明还包括局部眼用组合物，其包括一种或多种纤溶酶原激活剂，最优选uPA，以预防或减少术后角膜上皮下浊度。

50. 发明申请

WO0104007A2 MULTI-COMPARTMENT PACKAGE 审中-公开
公开(公告)号：WO0104007A2
公开(公告)日：2001-01-18
申请号：PCT/US0019073
申请日：2000-07-12
申请人： COMPAK CORP , JOHNSON JIMMIE L , BOWEN RON , SILVER DAVID
发明人： JOHNSON JIMMIE L , BOWEN RON , SILVER DAVID
IPC分类号： B65D25/08 , B65D77/20 , B65D77/24 , B65D81/32 , B65D
CPC分类号： B65D81/3233 , B65D25/08 , B65D77/245 , B65D81/3216 , B65D2577/2091
摘要： A multi-compartment (28, 30) sealed, container (12) for maintaining separation between two constituents, typically one dry (45) and one wet (44), until mixing of the constituents is desired. The container functions to house the constituents, introduce the constituents, facilitate mixing of the constituents, and serves as a ustensil for the dispensing of the constituent mixture.

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