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41. 发明申请

WO2006055692A3 PULMONARY OCCLUSAL STENT DELIVERY CATHETER, LOADING SYSTEM AND METHODS OF USE 审中-公开
公开(公告)号：WO2006055692A3
公开(公告)日：2006-05-26
申请号：PCT/US2005/041642
申请日：2005-11-16
申请人： PULMONX , WONDKA, Anthony , SOLTESZ, Peter, P. , KOTMEL, Robert , MATOV, Nadia , CROWDER, Thomas
发明人： WONDKA, Anthony , SOLTESZ, Peter, P. , KOTMEL, Robert , MATOV, Nadia , CROWDER, Thomas
IPC分类号： A61M35/00 , A61F2/86
摘要： Methods, systems and devices are provided for performing lung volume reduction in patients suffering from chronic obstructive pulmonary disease or other conditions where isolation of a lung segment or reduction of lung volume is desired. The methods are minimally invasive with instruments being introduced through the mouth (endotracheally) and rely on isolating the target lung tissue segment from other regions of the lung and occluding various lung passageways with the use of occlusal stents. The occlusal stents are delivered with the use of an occlusal stent delivery system which is loaded with the occlusal stent with the use of an occlusal stent loading system.

42. 发明申请

WO2003105941A1 APPARATUS AND METHOD FOR ISOLATED LUNG ACCESS 审中-公开
标题翻译：用于隔离肺吸入的装置和方法
公开(公告)号：WO2003105941A1
公开(公告)日：2003-12-24
申请号：PCT/US2000/029417
申请日：2000-10-24
申请人： PULMONX
发明人： PERKINS, Rodney, A. , SOLTESZ, Peter, P. , KOTMEL, Robert
IPC分类号： A61M29/00
CPC分类号： A61M25/003 , A61M1/0058 , A61M1/0084 , A61M16/0404 , A61M16/0459 , A61M16/0463 , A61M16/0479 , A61M16/0484 , A61M16/0486 , A61M25/0032 , A61M25/0662 , A61M2025/0034 , A61M2025/0036 , A61M2025/1052 , A61M2205/587 , A61M2210/1039
摘要： Apparatus, systems, methods, and kits are provided for isolating a target lung segment and treating that segment, usually by drug delivery or lavage. The systems include at least a lobar or sub-lobar isolation catheter (80) which is introduced beyond a second lung bifurcation (i.e., beyond the first bifurcation in a lobe of the lung) and which can occlude a bronchial passage at that point. An inner catheter (10) is usually introduced through the isolation catheter (80) and used in cooperation with the isolation catheter (80) for delivering and/or removing drugs or washing liquids from the isolated lung region. Optionally, the inner catheter (10) will also have an occluding member (18) near its distal end for further isolation of a target region within the lung.
摘要翻译：提供装置，系统，方法和试剂盒用于分离目标肺段并通常通过药物递送或灌洗来治疗该区段。这些系统至少包括一个延伸或分支的隔离导管（80），该导管（80）被引入超过第二肺分叉（即，在肺的隆起中的第一分叉之外），并且在该点可阻塞支气管通道。内导管（10）通常通过隔离导管（80）引入并与隔离导管（80）配合使用，用于从分离的肺区输送和/或去除药物或洗涤液体。任选地，内导管（10）还将在其远端附近具有闭塞构件（18），用于进一步分离肺内的目标区域。

43. 发明申请

WO03022221A9 METHOD AND APPARATUS FOR ENDOBRONCHIAL DIAGNOSIS 审中-公开
标题翻译：用于胃肠道内诊断的方法和设备
公开(公告)号：WO03022221A9
公开(公告)日：2003-09-18
申请号：PCT/US0228863
申请日：2002-09-10
申请人： PULMONX
发明人： KOTMEL ROBERT , SOLTESZ PETER , WONDKA ANTHONY , PERKINS RODNEY
IPC分类号： A61B5/055 , A61B5/08 , A61B5/083 , A61B5/087 , A61B8/08 , A61M16/04 , A61B5/00
CPC分类号： A61B5/6853 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/082 , A61B5/083 , A61B5/085 , A61B5/087 , A61B5/7278 , A61B5/742 , A61B6/481 , A61B6/485 , A61B8/12 , A61B2562/0247 , A61M16/04 , A61M16/0404 , A61M16/0434 , A61M16/0459 , A61M16/0486 , A61M25/0026 , A61M25/10 , A61M2016/0413 , A61M2025/1052
摘要： The present invention provides systems, methods, devices and kits for assessing the level of pulmonary disease in individual lung compartments. A lung compartment comprises a subportion of a lung, such as a lobe, a segment or a subsegment, for example. By measuring individual lung compartments, the level of disease of the pulmonary system may be more precisely defined by determining values of disease parameters reflective of individual subportions or compartments of a lung. Likewise, compartments may be separately imaged to provide further measurement information. Once individual compartments are characterized, they may be compared and ranked based on a number of variables reflecting, for example, level of disease or need for treatment. Such comparison may be aided by simultaneous display of such variables or images on a visual display. Further, the same tests may be performed on the lung as a whole or on both lungs and to determine the affect of the diseased lung compartments on the overall lung performance. In addition, the diseased lung compartments may be temporarily isolated and the measurement tests performed to determine the affect of the isolation on overall lung performance. As a result, the most beneficial treatment options may be selected.
摘要翻译：本发明提供了用于评估个体肺部隔室中肺部疾病水平的系统，方法，装置和试剂盒。例如，肺隔室包括肺的子部分，例如肺叶，区段或子区段。通过测量个体肺部隔室，可以通过确定反映个体子部分或肺部隔室的疾病参数的值来更精确地定义肺部系统的疾病水平。同样，隔室可以分开成像以提供进一步的测量信息。一旦对各个区室进行了表征，就可以根据反映例如疾病水平或需要治疗的许多变量对其进行比较和排列。这种比较可以通过在视觉显示器上同时显示这些变量或图像来辅助。此外，可以对肺整体或在两个肺上进行相同的测试，并确定患病肺部隔室对整体肺性能的影响。此外，病变肺室可能会暂时隔离，并进行测量测试以确定隔离对整体肺部表现的影响。因此，可以选择最有利的治疗方案。

44. 发明申请

WO2022026270A1 HIGH RESISTANCE IMPLANTED BRONCHIAL ISOLATION DEVICES AND METHODS 审中-公开
公开(公告)号：WO2022026270A1
公开(公告)日：2022-02-03
申请号：PCT/US2021/042609
申请日：2021-07-21
申请人： PULMONX CORPORATION
发明人： RADHAKRISHNAN, Sri , OLIVERA, Ryan
IPC分类号： A61B17/12 , A61B17/00 , A61B17/24 , A61F2/04 , A61M16/04 , A61M16/20
摘要： Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region. An exemplary flow control device is configured to block fluid flow in the inspiratory direction and the expiratory direction at normal breathing pressures and allow fluid flow in the expiratory direction at higher than normal breathing pressures.

45. 发明申请

WO2022010722A1 METHODS AND SYSTEMS FOR DETERMINING COLLATERAL VENTILATION 审中-公开
公开(公告)号：WO2022010722A1
公开(公告)日：2022-01-13
申请号：PCT/US2021/040000
申请日：2021-06-30
申请人： PULMONX CORPORATION
发明人： RADHAKRISHNAN, Sri , OLIVERA, Ryan
IPC分类号： A61B5/08 , A61B1/267 , A61B5/083 , A61B5/085 , A61B5/087 , A61B5/097 , A61B5/091 , A61B5/4836 , A61B5/6853 , A61B5/742
摘要： Methods and systems for determining collateral ventilation are disclosed. Methods may comprise introducing a diagnostic catheter into a lung compartment via an assisted ventilation device, inflating the occluding member to isolate the lung compartment, and performing a diagnostic procedure with the catheter while the patient is ventilated via the assisted ventilation device. The diagnostic procedure comprises determining an exhaled volume from the isolated lung compartment over a predetermined period of time while the patient is ventilated via the assisted ventilation device. The presence collateral ventilation may be determined based on the exhaled volume from the isolated lung compartment over the predetermined period of time.

46. 发明申请

WO2016118663A1 BRONCHIAL SEALANT DELIVERY METHODS AND SYSTEMS 审中-公开
标题翻译： BRONCHIAL SEALANT交付方法和系统
公开(公告)号：WO2016118663A1
公开(公告)日：2016-07-28
申请号：PCT/US2016/014183
申请日：2016-01-20
申请人： PULMONX CORPORATION
发明人： RADHAKRISHNAN, Sri , OLIVERA, Ryan
IPC分类号： A61B5/08 , A61M25/10 , A61M29/02
CPC分类号： A61M25/10 , A61B17/12104 , A61B17/12186 , A61M16/04 , A61M16/0404 , A61M16/0434 , A61M16/0459 , A61M16/0479 , A61M16/0486 , A61M2016/0027 , A61M2025/1052 , A61M2202/0208 , A61M2202/025 , A61M2205/3334 , A61M2205/3344 , A61M2205/505
摘要： Devices, methods, and systems are provided for sealing a lung region. The target lung compartment is accessed and isolated via an isolation catheter. Fluid is delivered into the target lung compartment such that the target compartment is pressurized and the fluid flows through the collateral flow channel. A sealing agent is injected into the isolated lung compartment such that the agent is carried by the fluid to the collateral flow channel, thereby sealing the collateral flow channel. Variables of air flow may be measured or analyzed prior to injection of the sealing agent, or the sealing agent may be introduced into the region after a suitable time has elapsed.
摘要翻译：提供了用于密封肺部区域的装置，方法和系统。目标肺隔室通过隔离导管进入和隔离。流体被输送到目标肺隔室中，使得目标隔室被加压并且流体流过旁路流动通道。将密封剂注入到隔离的肺隔室中，使得药剂由流体携带到旁路流动通道，从而密封旁路流动通道。可以在注入密封剂之前测量或分析气流的变量，或者在合适的时间过去之后可以将密封剂引入该区域。

47. 发明申请

WO2013177327A1 DEVICES, METHODS, AND SYSTEMS FOR DELIVERING IMPLANTS TO A LUNG REGION 审中-公开
标题翻译：用于将植入物递送到肺区的装置，方法和系统
公开(公告)号：WO2013177327A1
公开(公告)日：2013-11-28
申请号：PCT/US2013/042298
申请日：2013-05-22
申请人： PULMONX CORPORATION , OLIVERA, Ryan , NGUYEN, Hoang , RADHAKRISHNAN, Sri
发明人： OLIVERA, Ryan , NGUYEN, Hoang , RADHAKRISHNAN, Sri
IPC分类号： A61M25/01 , A61B1/267
CPC分类号： A61B1/018 , A61B1/01 , A61B1/2676 , A61M25/01
摘要： Devices, methods, and systems for accessing a lung region are provided. The system includes a delivery catheter having a proximal section, a distal section, and a body disposed in-between, wherein the distal region comprises at least one curved section; and a bronchoscope having a proximal section, a distal section, and a body disposed in-between, wherein the bronchoscope is configured to receive the delivery catheter; wherein the delivery catheter is configured to affect a curvature of the distal section of the bronchoscope when the distal section of the delivery catheter is advanced at least partially through the distal end of the bronchoscope.
摘要翻译：提供了用于访问肺部区域的设备，方法和系统。该系统包括具有近端部分，远侧部分和设置在其间的主体的输送导管，其中远端区域包括至少一个弯曲部分; 以及支气管镜，其具有近端部分，远端部分和设置在其间的主体，其中所述支气管镜构造成接收所述输送导管; 其中所述输送导管被构造成当所述输送导管的远端部分至少部分地穿过所述支气管镜的远端时，影响所述支气管镜的远侧部分的曲率。

48. 发明申请

WO2010030691A1 SYSTEMS AND METHODS FOR INHIBITING SECRETION FLOW INTO A FUNCTIONAL ASSESSMENT CATHETER 审中-公开
标题翻译：用于抑制分泌流入功能评估导管的系统和方法
公开(公告)号：WO2010030691A1
公开(公告)日：2010-03-18
申请号：PCT/US2009/056392
申请日：2009-09-09
申请人： PULMONX CORPORATION , BEYHAN, Niyazi , MANTRI, Surag , NGUYEN, Hoang , GIA, Son , PULIDO, Gregory Alan , SHAH, Dushyant Jivanlal , SURJAN, George , RUHF, Gregory Michael , FREITAG, Lutz
发明人： BEYHAN, Niyazi , MANTRI, Surag , NGUYEN, Hoang , GIA, Son , PULIDO, Gregory Alan , SHAH, Dushyant Jivanlal , SURJAN, George , RUHF, Gregory Michael , FREITAG, Lutz
IPC分类号： A61M16/00
CPC分类号： A61M16/0463 , A61B17/12036 , A61B17/12104 , A61B17/12136 , A61B2017/00809 , A61B2017/22068 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/0067 , A61F2230/008 , A61F2230/0091 , A61M16/0404 , A61M16/0406 , A61M16/0429 , A61M16/0434 , A61M16/0438 , A61M16/0443 , A61M16/0445 , A61M16/0447 , A61M16/0459 , A61M25/007 , A61M25/0074 , A61M25/0082 , A61M2025/0073 , A61M2025/0096 , A61M2025/1047 , A61M2205/0238 , A61M2205/0266 , A61M2205/11 , A61M2205/7536 , B21F45/008
摘要： Devices systems and methods are disclosed for preventing or inhibiting secretions from entering the lumen of a functional assessment catheter for the lungs, or removing collected secretions. The catheter comprises an expandable element, a cover, or an internal component configured to prevent or inhibit secretion flow into the lumen. The catheter alternatively or additionally comprises a distal end configured to facilitate air flow, absorb secretions or repel secretions away from the catheter tip. The catheter alternatively or additionally comprises an internal element such as a coilable wire, or an obturator configured to prevent secretions from being drawn into the lumen, or to actively remove the secretions. The catheter alternatively or additionally comprises an element to dry, aerate or aspirate the lung passageways.
摘要翻译：公开了用于预防或抑制分泌物进入用于肺的功能性评估导管的内腔或去除收集的分泌物的装置系统和方法。该导管包括可扩张元件，盖或构造成防止或抑制分泌物流入内腔的内部部件。替代地或另外地包括导管的导管包括构造成促进空气流动的远端，吸收分泌物或排斥远离导管尖端的分泌物。替代地或另外地，该导管包括内部元件，例如可卷绕的线，或者构造成阻止分泌物被吸入管腔中的闭塞器，或者主动地移除分泌物。替代地或另外地，导管包括用于干燥，充气或吸入肺通道的元件。

49. 发明申请

WO2009152013A1 METHODS AND SYSTEMS FOR ASSESSING LUNG FUNCTION AND DELIVERING THERAPEUTIC AGENTS 审中-公开
标题翻译：用于评估肺功能和递送治疗药物的方法和系统
公开(公告)号：WO2009152013A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/046138
申请日：2009-06-03
申请人： PULMONX , ALJURI, Nikolai , BEYHAN, Niyazi
发明人： ALJURI, Nikolai , BEYHAN, Niyazi
IPC分类号： A61M25/00 , A61M31/00
CPC分类号： A61B5/0833 , A61B5/14542 , A61B5/4839 , A61M16/04 , A61M2016/0413 , A61M2025/1052 , A61M2210/1039
摘要： Methods and systems for isolating, assessing and treating lung compartments are disclosed. One or more lung compartments are accessed through an isolation catheter, oxygen rich gas is delivered to the compartments, and blood oxygen or exhaled carbon dioxide are monitored to assess lung compartment function. Diseased lung compartments may be treated using therapeutic agents delivered to the diseased compartments through the isolation catheter. Therapeutic agents include carbon monoxide, radioactive agents, chemotherapeutic agents or angiogenesis inhibitors and angiocidal agents.
摘要翻译：公开了用于分离，评估和治疗肺隔室的方法和系统。通过隔离导管接近一个或多个肺隔室，将富氧气体输送到隔室，并监测血氧或呼出的二氧化碳以评估肺隔室功能。可以使用通过隔离导管递送到患病隔室的治疗剂来治疗疾病的肺隔室。治疗剂包括一氧化碳，放射剂，化学治疗剂或血管生成抑制剂和抗血栓形成剂。

50. 发明申请

WO2008112797A3 METHODS AND DEVICES FOR PASSIVE RESIDUAL LUNG VOLUME REDUCTION AND FUNCTIONAL LUNG VOLUME EXPANSION 审中-公开
标题翻译：用于被动肺体积减少和肺功能扩张的方法和装置
公开(公告)号：WO2008112797A3
公开(公告)日：2008-11-06
申请号：PCT/US2008056706
申请日：2008-03-12
申请人： PULMONX , ALJURI NIKOLAI , PERKINS RODNEY C
发明人： ALJURI NIKOLAI , PERKINS RODNEY C
IPC分类号： A61F2/958 , A61M16/00
CPC分类号： A61M16/0434 , A61B1/2676 , A61B5/0084 , A61B5/08 , A61B5/4836 , A61B17/12104 , A61B17/12136 , A61F2002/043 , A61M16/0003 , A61M16/0436 , A61M16/208 , A61M25/10 , A61M2016/0027 , A61M2016/003 , A61M2025/1052 , A61M2202/0208 , A61M2205/3334 , A61M2207/10 , Y10T29/49826
摘要： The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment.
摘要翻译：通过将导管的远端密封在供给肺隔室的气道中来减少过度充气肺部隔室的体积。当患者呼气时，空气通过导管中的通道从肺室排出。与导管相关联的单向流动元件防止空气在患者吸气时重新进入肺部隔室。随着时间的推移，肺部隔室周围区域的压力导致其随着空气体积减少而崩溃。残余体积减少有效地导致肺功能的扩张。任选地，肺部隔室可以被密封以便永久地防止空气重新进入肺部隔室。

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