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    • 43. 发明申请
    • DERIVATION OF MIDBRAIN DOPAMINERGIC NEURONS FROM EMBRYONIC STEM CELLS
    • 胚胎干细胞衍化中脑多巴胺能神经元
    • WO0183715A3
    • 2002-05-23
    • PCT/US0114051
    • 2001-05-01
    • US GOV HEALTH & HUMAN SERVLEE SANG HUNLUMELSKY NADYASTUDER LORENZMCKAY RON D G
    • LEE SANG-HUNLUMELSKY NADYASTUDER LORENZMCKAY RON D G
    • A61K35/12A61K48/00A61P25/00C12N5/0793C12N5/06A61K35/30C12N5/08C12N5/10C12Q1/02
    • C12N5/0619A61K35/12A61K48/00C12N2501/115C12N2501/119C12N2501/41C12N2506/02
    • The invention provides a method of culturing cells. The method generally includes five stages: (1) expansion of ES cells; (2) generation of embryoid bodies; (3) selection of CNS precursor cells; (4) expansion of CNS precursor cells; and (5) differentiation of CNS precursor cells. During the expansion phase, the CNS precursor cells are cultured in a media which includes at least one neurologic agent such as bFGF, SHH, and FGF8. The expanded CNS precursors are differentiated by withdrawal of at least one neurologic agent, typically, bFGF. Preferably, the differentiation media includes ascorbic acid. The method of the invention can be used to culture a variety of cells, preferably neuronal cells, including, but not limited to dopaminergic neuron cells, cholinergic neuronal cells and serotonergic neuron cells. The invention also provides a method for treating a neurological disorder, such as Parkinson's disease, a method of introducing a gene product into a brain of a patient, and an assay for neurologically active substances. The invention further provides a cell culture which includes differentiated neuron cells, of which at least about 20 % of the differentiated neurons are dopaminergic neurons.
    • 本发明提供了培养细胞的方法。 该方法通常包括五个阶段:(1)ES细胞的扩增; (2)胚状体的产生; (3)选择CNS前体细胞; (4)CNS前体细胞的扩增; 和(5)CNS前体细胞的分化。 在扩展阶段期间,将CNS前体细胞在包含至少一种神经药剂如bFGF,SHH和FGF8的培养基中培养。 扩大的CNS前体通过撤出至少一种神经药剂(通常为bFGF)而分化。 优选地,分化培养基包含抗坏血酸。 本发明的方法可用于培养各种细胞,优选神经元细胞,包括但不限于多巴胺能神经元细胞,胆碱能神经元细胞和5-羟色胺能神经元细胞。 本发明还提供治疗神经障碍如帕金森病的方法,将基因产物导入患者脑内的方法和神经活性物质的检测方法。 本发明进一步提供了包括分化的神经元细胞的细胞培养物,其中至少约20%的分化的神经元是多巴胺能神经元。
    • 44. 发明申请
    • GAS CONVERSION SYSTEM
    • 气体转换系统
    • WO2013003164A3
    • 2013-04-18
    • PCT/US2012043421
    • 2012-06-21
    • AMARANTE TECHNOLOGIES INCTANIBATA TORUKOO JAE-MOLEE SANG HUN
    • TANIBATA TORUKOO JAE-MOLEE SANG HUN
    • B01J19/12B01J7/00C01B32/50
    • H05H1/46H05H2001/4622
    • A gas conversion system (1) using microwave plasma is provided. The system (1) includes: a microwave waveguide (24); a gas flow tube (26) passing through a microwave waveguide (24) and configured to transmit microwaves therethrough; a temperature controlling means (241) for controlling a temperature of the microwave waveguide (24); a temperature sensor (29) disposed near the gas flow tube (26) and configured to measure a temperature of gas flow tube (26) or microwave waveguide (24); an igniter (28) located near the gas flow tube (26) and configured to ignite a plasma inside the gas flow tube (26) so that the plasma converts a gas flowing through the gas flow tube (26) during operation; and a plasma detector (30) located near the gas flow tube (26) and configured to monitor the plasma.
    • 提供一种使用微波等离子体的气体转换系统(1)。 系统(1)包括:微波波导(24); 气流管(26),其穿过微波波导(24)并且被配置为通过其传输微波; 温度控制装置(241),用于控制微波波导(24)的温度; 设置在所述气流管(26)附近并构造成测量气流管(26)或微波波导(24)的温度的温度传感器(29); 位于气流管(26)附近且配置成点燃气流管(26)内部的等离子体的点火器(28),使得等离子体在操作期间转换流过气流管(26)的气体; 和位于气流管(26)附近并且被配置成监测等离子体的等离子体检测器(30)。
    • 45. 发明申请
    • IMPEDANCE MATCHING APPARATUS
    • 阻抗匹配装置
    • WO2013022237A1
    • 2013-02-14
    • PCT/KR2012/006202
    • 2012-08-03
    • LG INNOTEK CO., LTD.LEE, Sang Hun
    • LEE, Sang Hun
    • H03H7/38H04B1/48
    • H03H7/38H03H7/40H04B1/0458H04B1/18
    • Disclosed is an impedance matching apparatus performing impedance matching between a front end module and an antenna. The impedance matching apparatus includes an RF front end providing a multi-band RF signal, a reflected power measuring module measuring a reflection coefficient for the RF input signal, a matching module adjusting impedance so that the reflection coefficient is minimized, a first switch module provided in the RF front end to selectively switch the RF signal onto a bypass path, and a controller allowing the RF signal to be switched onto the bypass path if a specific frequency range is detected from the reflection coefficient.
    • 公开了一种在前端模块和天线之间执行阻抗匹配的阻抗匹配装置。 阻抗匹配装置包括提供多频带RF信号的RF前端,测量RF输入信号的反射系数的反射功率测量模块,匹配模块调整阻抗以使反射系数最小化,提供第一开关模块 在RF前端中,如果从反射系数检测到特定频率范围,则将RF信号选择性地切换到旁路路径上,以及允许RF信号切换到旁路路径的控制器。
    • 50. 发明申请
    • REMOTE CONTROLLER RECEIVER MODULE AND MOUNTING STRUCTURE FOR SAME
    • 远程控制器接收器模块和安装结构
    • WO2010041890A2
    • 2010-04-15
    • PCT/KR2009005771
    • 2009-10-09
    • KODENSHI KOREA CORPLEE KI YOUNGLEE SANG HUN
    • LEE KI YOUNGLEE SANG HUN
    • H04Q9/04
    • G08C17/00
    • The present invention relates to a remote controller receiver module and mounting structure for same, and comprises a light receiving element that receives and processes the signal of the remote controller; a lead frame whereon is mounted a signal processing element that processes a received signal and is formed by projecting a plurality of lead terminals to one side; a shield case that forms a light receiving window corresponding to the location of said light receiving element, bends left and right sides to form a bent part, and has a plurality of ground terminals formed by being projected outward so that a connection may be made with the lead terminal of said lead frame externally; a mold part molded by an epoxy resin that surrounds said lead frame and shield case and exposes the lead terminal of the lead frame and the ground terminal of the shield case externally; and a hemispherical lens part that is formed on the light receiving face of said mold part. By a technique wherein the ground terminal of said shield case is projected outside of said mold part and connected with said lead terminal upon mounting on a printed circuit board, thereby projecting the ground terminal outside the package without contacting the shield case inside the package, and consequently making connections from the printed circuit board, the number of production workers may be effectively reduced, and production efficiency may be improved.
    • 本发明涉及一种用于其的遥控器接收器模块和安装结构,并且包括接收和处理遥控器的信号的光接收元件; 其上安装有引导框架,其处理接收到的信号并通过将多个引线端子投影到一侧而形成的信号处理元件; 形成与所述光接收元件的位置相对应的受光窗的屏蔽壳体,使左右侧弯曲以形成弯曲部,并且具有通过向外突出而形成的多个接地端子,从而可以以 所述引线框架的引线端子在外部; 由环氧树脂模制的模制部件,其围绕所述引线框架和屏蔽壳体并将引线框架的引线端子和屏蔽壳体的接地端子从外部暴露出来; 以及形成在所述模具部的光接收面上的半球透镜部。 通过一种技术,其中所述屏蔽壳体的接地端子在安装在印刷电路板上时突出到所述模具部件的外部并与所述引线端子连接,从而将接地端子投射到封装外部而不与封装体内的屏蔽壳体接触, 从而从印刷电路板进行连接,可以有效地减少生产工人的数量,并且可以提高生产效率。