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41. 发明申请

WO2007103917A3 SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS 审中-公开
公开(公告)号：WO2007103917A3
公开(公告)日：2007-09-13
申请号：PCT/US2007/063381
申请日：2007-03-06
申请人： INTEGRATED BIOSYSTEMS, INC. , VOUTE, Nicolas , LEE, Eric, K. , YAKOUSHKIN, Dimitry
发明人： VOUTE, Nicolas , LEE, Eric, K. , YAKOUSHKIN, Dimitry
IPC分类号： A01N1/02 , A01N1/00 , F25D25/00 , A61M1/02 , A61J1/16
摘要： A system for use in freezing, storing and thawing biopharmaceutical materials includes a flexible sterile container means for holding biopharmaceutical material therein and a holder more rigid than said container means. The container means is received in a cavity of the holder and the holder extends along a perimeter of the container means. The holder is fixedly connected to the container means. The holder includes opposing sides defining an opening and the container means extends between the opposing sides of the holder defining the opening. The container means includes a substantially smooth exterior surface extending between the opposing sides.

42. 发明申请

WO2007103917A2 SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS 审中-公开
标题翻译：用于冷冻，储存和治疗生物材料的系统和方法
公开(公告)号：WO2007103917A2
公开(公告)日：2007-09-13
申请号：PCT/US2007063381
申请日：2007-03-06
申请人： INTEGRATED BIOSYSTEMS INC , VOUTE NICOLAS , LEE ERIC K , YAKOUSHKIN DIMITRY
发明人： VOUTE NICOLAS , LEE ERIC K , YAKOUSHKIN DIMITRY
CPC分类号： F25D25/005 , A61J1/165 , F25D2331/809
摘要： A system for use in freezing, storing and thawing biopharmaceutical materials includes a flexible sterile container means for holding biopharmaceutical material therein and a holder more rigid than said container means. The container means is received in a cavity of the holder and the holder extends along a perimeter of the container means. The holder is fixedly connected to the container means. The holder includes opposing sides defining an opening and the container means extends between the opposing sides of the holder defining the opening. The container means includes a substantially smooth exterior surface extending between the opposing sides.
摘要翻译：用于冷冻，储存和解冻生物药物材料的系统包括用于在其中保持生物药物材料的柔性无菌容器装置和比所述容器装置更刚性的保持器。容器装置被容纳在保持器的空腔中，并且保持器沿着容器装置的周边延伸。保持器固定地连接到容器装置。保持器包括限定开口的相对侧，并且容器装置在限定开口的保持器的相对侧之间延伸。容器装置包括在相对的侧面之间延伸的基本光滑的外表面。

43. 发明申请

WO03037083A9 SYSTEMS AND METHODS FOR FREEZING AND STORING BIOPHARMACUETICAL MATERIAL 审中-公开
标题翻译：用于冷冻和储存生物材料的系统和方法
公开(公告)号：WO03037083A9
公开(公告)日：2004-01-15
申请号：PCT/US0235137
申请日：2002-11-01
申请人： INTEGRATED BIOSYSTEMS INC , VOUTE NICOLAS , LOK MAXIME , LEONARD LEONIDAS CARTWRIGHT , HUGHES TIMOTHY GERARD , WISNIEWSKI RICHARD
发明人： VOUTE NICOLAS , LOK MAXIME , LEONARD LEONIDAS CARTWRIGHT , HUGHES TIMOTHY GERARD , WISNIEWSKI RICHARD
IPC分类号： A61J3/00 , A01N1/02 , A23L3/36 , A23L3/365 , A61J1/10 , A61M1/02 , B65D81/18 , F25D25/00 , F25D31/00 , A01N1/00
CPC分类号： F25D31/001 , A01N1/02 , A01N1/0257 , A01N1/0263 , A23L3/364 , A23L3/365 , A61M1/0277 , A61M1/0281 , F25B2600/07 , F25D25/00 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , F25D2500/02
摘要： The present invention provides a system for freezing, thawing, and storing biopharmaceutical materials which includes a flexible container, a conduit, and a temperature control unit. The flexible container is adapted to receive a biopharmaceutical material therein for freezing, thawing, and storing. The container is formed of a first substantially flat sheet of flexible material joined together by a seam with a second substantially flat sheet of flexible material so as to lie substantially flat when empty. The container fully encloses an interior portion for receiving the biopharmaceutical material. Also, the container is configured to form a three dimensional shape when filled with the biopharmaceutical material, wherein the three dimensional shape has a first side and a second side opposite the first side. The conduit is connected to the flexible container with the outside of the container being in fluid communication with the interior portion via the conduit. The temperature control unit includes a first surface and a second surface facing the first surface and the temperature control unit is configured to receive the flexible container therein, when the container is filled with the biopharmaceutical material. The container conforms to the shape of the interior of the temperature control unit and the first side and the second side of the container contact the first surface and the second surface of the temperature control unit. The first surface and/or the second surface of temperature control unit include heat transfer surface(s).
摘要翻译：本发明提供一种用于冷冻，解冻和储存包括柔性容器，导管和温度控制单元的生物药物材料的系统。柔性容器适于在其中容纳生物药物用于冷冻，解冻和储存。容器由具有第二基本平坦的柔性材料片的接缝连接在一起的第一基本平坦的柔性材料片形成，以便在空的时基本平坦。容器完全包围用于接收生物药物材料的内部部分。此外，容器被配置为当填充有生物药物材料时形成三维形状，其中三维形状具有与第一侧相对的第一侧和第二侧。导管连接到柔性容器，容器的外部通过导管与内部部分流体连通。温度控制单元包括面向第一表面的第一表面和第二表面，并且温度控制单元构造成当容器填充有生物药物材料时将柔性容器接纳在其中。容器符合温度控制单元的内部形状，并且容器的第一侧和第二侧接触温度控制单元的第一表面和第二表面。温度控制单元的第一表面和/或第二表面包括传热表面。

44. 发明申请

WO03037082A9 SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIAL 审中-公开
标题翻译：用于冷冻，储存和治疗生物材料的系统和方法
公开(公告)号：WO03037082A9
公开(公告)日：2004-01-15
申请号：PCT/US0235135
申请日：2002-11-01
申请人： INTEGRATED BIOSYSTEMS INC , VOUTE NICOLAS , LOK MAXIME N , BROWN DAVID C , KENDALL JAMES W , GEISELHART EDWARD
发明人： VOUTE NICOLAS , LOK MAXIME N , BROWN DAVID C , KENDALL JAMES W , GEISELHART EDWARD
IPC分类号： A61J3/00 , A01N1/02 , A23L3/36 , A23L3/365 , A61J1/10 , A61M1/02 , B65D81/18 , F25D25/00 , F25D31/00 , A01N1/00 , B65D81/00
CPC分类号： F25D31/001 , A01N1/02 , A01N1/0257 , A01N1/0263 , A23L3/364 , A23L3/365 , A61M1/0277 , A61M1/0281 , F25B2600/07 , F25D25/00 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , F25D2500/02
摘要： A system for controlled freezing, storing and thawing a biopharmaceutical material includes a flexible container and a supporting structure. The flexible container is adapted to receive the biopharmaceutical material therein for freezing, storing and thawing. The container further includes a flange and the supporting structure is engageable with the flange to receive the container. The supporting structure may position the container for freezing and may protect it during transport and storage.
摘要翻译：用于控制冷冻，储存和解冻生物药物材料的系统包括柔性容器和支撑结构。柔性容器适于容纳其中的生物药物用于冷冻，储存和解冻。容器还包括凸缘，并且支撑结构可与凸缘接合以容纳容器。支撑结构可以将容器定位成冷冻并且可以在运输和储存期间保护它。

45. 发明申请

WO2002095306A1 CRYOPRESERVATION SYSTEM WITH CONTROLLED DENDRITIC FREEZING FRONT VELOCITY 审中-公开
标题翻译：控制冷冻正面速度的CRYOPRESERVATION系统
公开(公告)号：WO2002095306A1
公开(公告)日：2002-11-28
申请号：PCT/US2002/016167
申请日：2002-05-22
申请人： INTEGRATED BIOSYSTEMS, INC.
发明人： WISNIEWSKI, Richard
IPC分类号： F25D17/02
CPC分类号： F25C1/04 , F25B2600/07 , F25C2600/04 , G01N1/42 , G01N2001/2255
摘要： Disclosed is a biopharmaceutical material cryopreservation system(100) that includes a flexible sterile container(104) comprising a biocompatible polymeric material, and the flexible sterile container(104) containing biopharmaceuticals materials(110), and a freezing system(122) thermally coupled to the biopharmaceutical materials(110) via the flexible sterile container(104), and the freezing system(122) comprising a temperature sensor(116) that monitors a temperature of the biopharmaceutical materials(110) wherein the freezing system(122) comprises a feedback loop constructed to control a dendritic freezing front(128) velocity, within the biopharmaceutical materials(110), in a range from approximately 5 millimeters per hour to approximately 250 millimeters per hour based on feedback information from the temperature sensor(116).
摘要翻译：公开了一种生物药物材料冷冻保存系统（100），其包括包含生物相容性聚合物材料的柔性无菌容器（104）和包含生物药物材料（110）的柔性无菌容器（104）和冷冻系统（122）所述生物制药材料（110）经由所述柔性无菌容器（104）和所述冷冻系统（122）包括监测所述生物药物材料（110）的温度的温度传感器（116），其中所述冷冻系统（122）包括反馈构造成基于来自温度传感器（116）的反馈信息，在生物药物材料（110）内控制树突状冷冻前（128）速度，其范围从每小时约5毫米至约250毫米。

46. 发明专利

ES2266857T3 SISTEMAS Y PROCEDIMIENTOS PARA CONGELAR, ALMACENAR, TRANSPORTAR Y DESCONGELAR MATERIAL BIOFARMACEUTICO. 未知
公开(公告)号：ES2266857T3
公开(公告)日：2007-03-01
申请号：ES03759407
申请日：2003-09-23
申请人： INTEGRATED BIOSYSTEMS INC
发明人： VOUTE NICOLAS , LEE ERIC K , DEBEERS JAMES EDWARD , WOODARD BRIAN J , LEE NGEE JENN
IPC分类号： B62B3/10 , A01N1/00 , A01N1/02 , B65D19/44 , F25D25/00
摘要： Un sistema para transportar y almacenar un material biofarmacéutico, comprendiendo el mencionado sistema: una armadura (15, 1315, 1430) configurada para recibir un contenedor (10, 1310) de material farmacéutico en su interior; un canal (297; 397; 1317; 1420; 1520) configurado para recibir la mencionada armadura (15; 1315; 1430) y el mencionado contenedor (10; 1310) de material biofarmacéutico; y al menos un raíl de soporte (292; 1425; 1320) configurado para soportar la mencionada armadura (15; 1315; 1430) en el mencionado canal (297; 397; 1317; 1420; 1520) de forma que la mencionada armadura (15; 1315; 1430) que recibe el contenedor se extienda desde el mencionado al menos un raíl de soporte (292; 1320; 1425) dentro del mencionado canal y el mencionado canal (297; 397; 1317; 1420; 1520) se extienda desde el mencionado a menos un raíl de soporte (292; 1320; 1425) a al menos un extremo inferior de la mencionada armadura (15; 1315; 1430) en respuesta a la mencionada armadura (15; 1315; 1430) que recibe el contenedor (10; 1310) del material biofarmacéutico y la mencionada armadura siendo recibida en el mencionado canal (297; 397; 1317; 1420; 1520).

47. 发明专利

DK1441585T3 未知
公开(公告)号：DK1441585T3
公开(公告)日：2006-10-02
申请号：DK02778702
申请日：2002-11-01
申请人： INTEGRATED BIOSYSTEMS INC
发明人： LOK MAXIME N , BROWN DAVID C , KENDALL JAMES W , VOUTE NICOLAS , GEISELHART EDWARD
IPC分类号： A01N1/00 , A61J3/00 , A01N1/02 , A23L3/36 , A23L3/365 , A61J1/10 , A61M1/02 , B65D81/00 , B65D81/18 , F25D25/00 , F25D31/00

48. 发明专利

DE60211731D1 未知
公开(公告)号：DE60211731D1
公开(公告)日：2006-06-29
申请号：DE60211731
申请日：2002-11-01
申请人： INTEGRATED BIOSYSTEMS INC
发明人： VOUTE NICOLAS , LOK N , BROWN C , KENDALL W , GEISELHART EDWARD
IPC分类号： A01N1/00 , A61J3/00 , A01N1/02 , A23L3/36 , A23L3/365 , A61J1/10 , A61M1/02 , B65D81/00 , B65D81/18 , F25D25/00 , F25D31/00

49. 发明专利

AT309512T 未知
公开(公告)号：AT309512T
公开(公告)日：2005-11-15
申请号：AT98906117
申请日：1998-02-04
申请人： INTEGRATED BIOSYSTEMS INC
发明人： WISNIEWSKI RICHARD , LEONARD LEONIDAS CARTWRIGHT
IPC分类号： A61J3/00 , F25D31/00 , F28D1/06 , F28D7/02 , F28D7/12 , F28F1/02 , F28F1/14

50. 发明专利

DK1246524T3 未知
公开(公告)号：DK1246524T3
公开(公告)日：2004-09-27
申请号：DK01942276
申请日：2001-01-12
申请人： INTEGRATED BIOSYSTEMS INC
发明人： WISNIEWSKI RICHARD
IPC分类号： F25D3/10 , A01N1/02 , A23G9/06 , A23L3/36 , A23L3/375 , A61J1/05 , A61J1/10 , B65D81/24 , C12N1/04 , F25D3/11 , F25D3/12
摘要： Disclosed is a biopharmaceutical product cryopreservation system, for cryopreserving a biopharmaceutical product that includes a cryopreservation compartment; a cryopreservation fluid located within the cryopreservation compartment; and a biopharmaceutical product cryopreservation vial located within the cryopreservation compartment and surrounded by the cryopreservation fluid, and the biopharmaceutical product cryopreservation vial including a body that includes an oblong cross-section defining proximal and distal ends of the body, and at least one nucleating structure, coupled to a distal end of the body, and the body including a cryogenically stable material that is compatible with biopharmaceutical products. Also disclosed are cryopreservation vials and methods of cryopreserving biopharmaceutical products.

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