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41. 发明申请

WO2019006349A1 HEATED BLOOD PRESSURE CUFF DEVICE, SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2019006349A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/040368
申请日：2018-06-29
申请人： FENWAL INC.
发明人： CASE, Brian, C. , STONIG, Christian
IPC分类号： A61M1/02 , A61B5/022 , A61B5/15
摘要： A system for increasing blood flow through a user's limb during a blood collection procedure includes an inflatable cuff that is worm around the user's limb. A pump and a deflation valve are in fluid communication with the inflatable cuff. A heating element and a temperature sensor are attached to the inflatable cuff. The system also includes a motion sensor. A controller is in communication with the pump, the deflation valve, the heating element and the temperature and motion sensors and detects a blood pressure or blood flow of the user, controls inflation and deflation of the inflatable cuff and controls energization of the heating element based on data from the motion sensor and the temperature sensor.

42. 发明申请

WO2017066447A1 FLUID PROCESSING AND CIRCUIT ARRAY, SYSTEM AND APPARATUS 审中-公开
标题翻译：流体处理和电路阵列，系统和设备
公开(公告)号：WO2017066447A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/056839
申请日：2016-10-13
申请人： FENWAL, INC.
发明人： KUSTERS, Benjamin, E. , BRIERTON, Mark, J.
IPC分类号： A61M1/02 , A61M1/34 , A61M1/26 , A61M1/36
CPC分类号： A61M1/265 , A61M1/0281 , A61M1/3633 , A61M2205/121 , A61M2209/086
摘要： A fluid flow circuit assembly in the form of a molded, disposable cassette for a blood processing device, comprising a housing having a plurality of openings, a spinning membrane separator disposed at least partially within the housing, and a plurality of flow paths communicating between an interior and an exterior of the housing via the plurality of openings, wherein the separator is disposed substantially at the center of the plurality of flow paths. The cassette can be loaded onto a loading platform of a blood processing device. The loading platform comprises a separator drive motor configured to engage the spinning membrane separator and is capable of translational motion to automatically load the cassette onto pumps on the blood processing device.
摘要翻译：一种用于血液处理装置的模制的一次性盒子形式的流体流动回路组件，其包括具有多个开口的壳体，至少部分设置在壳体内的旋转膜分离器，以及多个流动路径，其经由所述多个开口在所述壳体的内部和外部之间连通，其中所述分离器基本上设置在所述多个流动路径的中心。盒可以被加载到血液处理设备的加载平台上。装载平台包括分离器驱动电动机，该分离器驱动电动机构造成接合旋转膜分离器并且能够平移运动以自动将盒装载到血液处理装置上的泵上。

43. 发明申请

WO2017048673A8 APPARATUS, SYSTEMS AND METHODS FOR STORING, TREATING AND/OR PROCESSING BLOOD AND BLOOD COMPONENTS 审中-公开
公开(公告)号：WO2017048673A8
公开(公告)日：2017-03-23
申请号：PCT/US2016/051438
申请日：2016-09-13
申请人： FENWAL, INC.
发明人： CALDERON, Carlos , GASSMAN, Christopher , BROWN, David, S.
IPC分类号： A61M1/02 , A61J1/10
摘要： Apparatus, systems and methods are disclosed relating to certain aspects of blood processing, collecting or storing, including method and system for automated authentication, processing device with scanner, blood container with two dimensional barcode, blood collection containers, blood container label and related tracking method, integrated container system, and processing device with sterile connection device.

44. 发明申请

WO2012151243A3 PLATELET RESUSPENSION METHOD AND APPARATUS 审中-公开
公开(公告)号：WO2012151243A3
公开(公告)日：2014-05-08
申请号：PCT/US2012036062
申请日：2012-05-02
申请人： FENWAL INC , BELT FLETCHER C , KAST MICHAEL J , MIN KYUNGYOON , RADWANSKI KATHERINE , CORK WILLIAM H
发明人： BELT FLETCHER C , KAST MICHAEL J , MIN KYUNGYOON , RADWANSKI KATHERINE , CORK WILLIAM H
IPC分类号： A01N1/02 , C12M1/00
CPC分类号： A61M1/025 , A61M1/0281 , A61M1/3693 , A61M1/3696
摘要： A method is disclosed for resuspending a concentrated blood component collected in a single-use processing chamber that is mounted to a rotatable support of a centrifugal collection system. A resuspension solution is introduced to the single-use processing chamber containing the concentrated blood component. The rotatable support with the single-use processing chamber mounted thereto is removed from the centrifugal collection system and mounted to a resuspension device. The device is then activated for a period of time sufficient to resuspend the concentrated blood component in the resuspension solution. In another aspect, the resuspension device is configured to impart a reciprocating arcuate motion to the support and its associated single-use processing chamber. A frequency of approximately 300 to 325 rpm over a period of time of approximately 1.5 to 2.5 minutes has been found effective for resuspending platelets. Reciprocation through an arc of less than 200° is provided.
摘要翻译：公开了一种用于将收集在一次性处理室中的浓缩血液成分重新悬浮的方法，所述一次性处理室安装在离心收集系统的可旋转支撑件上。将再悬浮溶液引入含有浓缩血液成分的一次性处理室。安装在其上的一次性处理室的可旋转支撑件从离心收集系统中移除并安装到再悬挂装置。然后将该装置激活足以将浓缩血液成分重悬于再悬浮液中的一段时间。在另一方面，再悬浮装置被配置为向支撑件及其相关联的一次性使用处理室施加往复的弓形运动。发现在约1.5至2.5分钟的时间段内约300至325rpm的频率已经被有效用于重悬血小板。提供通过小于200°的弧的往复运动。

45. 发明申请

WO2014035471A1 SPRING-OPEN SHEETING FOR FLUID PROCESSING CASSETTE 审中-公开
标题翻译：用于流体加工CASSETTE的弹簧开启
公开(公告)号：WO2014035471A1
公开(公告)日：2014-03-06
申请号：PCT/US2013/030130
申请日：2013-03-11
申请人： FENWAL, INC.
发明人： MANZELLA, Jr., Salvatore , PIEPER, Gregory, G. , CHUNG, Terry , ROCKWELL, Benjamin
IPC分类号： A61M1/14 , A61M1/34 , A61M1/36
CPC分类号： B01L3/567 , A61M1/14 , A61M1/34 , A61M1/36 , A61M2205/128 , A61M2205/3331 , B01L3/502 , B01L2200/0689 , B01L2300/049 , B01L2300/123 , B01L2400/06
摘要： A sheeting is provided for use with a fluid processing cassette having a valve station with a plurality of fluid flow ports. The sheeting has a generally flexible layer and a biasing member associated with the layer. The sheeting is attached to the cassette such that the biasing member is received within the valve station. The cassette may be used with a fluid processing system having a valve actuator with a piston that is aligned with the cassette during use. In an extended position, the piston presses the sheeting against the port to prevent fluid flow through the valve station. When the piston moves from the extended position to a retracted position, it allows the sheeting to uncover the port, thereby allowing fluid flow through the valve station. The biasing member assists in displacing the sheeting from the port when the piston moves to the retracted position.
摘要翻译：提供了一种用于具有带有多个流体流动端口的阀站的流体处理盒的片材。片材具有通常柔性的层和与层相关联的偏置构件。片材被附接到盒，使得偏置构件被容纳在阀站内。该盒可以与流体处理系统一起使用，所述流体处理系统具有阀致动器，其具有在使用期间与所述盒对准的活塞。在延伸位置，活塞将压片压靠在端口上，以防止流体流过阀站。当活塞从延伸位置移动到缩回位置时，它允许片材露出端口，从而允许流体流过阀站。当活塞移动到缩回位置时，偏置构件有助于从端口移动片材。

46. 发明申请

WO2013048984A1 OPTICAL MONITORING SYSTEM FOR BLOOD PROCESSING SYSTEM 审中-公开
标题翻译：血液处理系统光学监测系统
公开(公告)号：WO2013048984A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/056992
申请日：2012-09-25
申请人： FENWAL, INC.
发明人： CASE, Brian, C. , KATZ, Steven, R. , CORK, William, H. , PRENDERGAST, Jonathan
IPC分类号： A61M1/02 , A61M1/36
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/3693 , A61M1/3696 , A61M2205/12 , A61M2205/14 , A61M2205/276 , A61M2205/3306 , A61M2205/331 , A61M2205/3313 , A61M2205/3317 , A61M2205/6063 , A61M2205/6072 , B04B5/0442 , B04B2005/045 , B04B2013/006
摘要： An optical monitoring system is provided for use with a blood processing system. The system includes a light source configured to illuminate a disposable flow circuit received in a centrifuge and a light detector configured to receive an image of the disposable flow circuit. A controller combines two or more of the images received by the light detector to generate a two-dimensional output. The output is used to control the separation of blood within the disposable flow circuit. The monitoring system may also be used to verify that the disposable flow circuit is suitable for use with the centrifuge or that the disposable flow circuit is properly aligned within the centrifuge. The monitoring system may be positioned outside of the centrifuge bucket which receives the centrifuge.
摘要翻译：提供了一种与血液处理系统一起使用的光学监测系统。该系统包括被配置为照亮接收在离心机中的一次性流动回路的光源和被配置为接收一次性流动回路的图像的光检测器。控制器组合由光检测器接收的两个或更多个图像以产生二维输出。该输出用于控制一次性流动回路内的血液分离。监测系统还可用于验证一次性流路是否适合与离心机一起使用，或者一次性流路在离心机内适当对准。监测系统可以位于接收离心机的离心机桶的外部。

47. 发明申请

WO2012110895A8 STERILE DOCKING DEVICE, MEDICAL FLUID FLOW SYSTEM WITH STERILE DOCKING DEVICE AND METHOD OF USING SAME 审中-公开
标题翻译：无菌装卸装置，具有无菌装卸装置的医用流体流动系统及使用该装置的方法
公开(公告)号：WO2012110895A8
公开(公告)日：2012-11-29
申请号：PCT/IB2012000387
申请日：2012-03-02
申请人： FENWAL INC , MIN KYUNGYOON , CORK WILLIAM H
发明人： MIN KYUNGYOON , CORK WILLIAM H
IPC分类号： A61M39/14
CPC分类号： A61M39/143 , F04C2270/0421 , F16L29/005 , F16L47/02 , F16L2201/44
摘要： Method and apparatus are disclosed for forming a sealed communication between conduits or conduit subassemblies (14, 12), each of which has a wall (22, 32) with an exterior surface (24, 34), and at least one of the walls includes an electrically conductive portion. The exterior surfaces may be brought into a facing relationship, and each conductive portion is heated sufficiently to sterilize the exterior surfaces of the walls by generating electrical current in the conductive portion, such as by application of a voltage or by induction. An aperture is then provided, as by an aperture - forming member, through the facing walls to provide communication between the conduits or conduit subassemblies.
摘要翻译：公开了用于在导管或导管子组件（14,12）之间形成密封连通的方法和设备，每个导管子组件具有带外表面（24,34）的壁（22,32），并且至少一个壁包括导电部分。可以使外表面成为面对关系，并且每个导电部分被充分加热以通过在导电部分中产生电流（例如通过施加电压或通过感应）来消毒壁的外表面。然后通过孔形成构件提供孔，穿过相对的壁以提供导管或导管子组件之间的连通。

48. 发明申请

WO2012151243A2 PLATELET RESUSPENSION METHOD AND APPARATUS 审中-公开
公开(公告)号：WO2012151243A2
公开(公告)日：2012-11-08
申请号：PCT/US2012/036062
申请日：2012-05-02
申请人： FENWAL, INC. , BELT, Fletcher, C. , KAST, Michael, J. , MIN, Kyungyoon , RADWANSKI, Katherine , CORK, William, H.
发明人： BELT, Fletcher, C. , KAST, Michael, J. , MIN, Kyungyoon , RADWANSKI, Katherine , CORK, William, H.
IPC分类号： A61M1/02
CPC分类号： A61M1/025 , A61M1/0281 , A61M1/3693 , A61M1/3696
摘要： A method is disclosed for resuspending a concentrated blood component collected in a single-use processing chamber that is mounted to a rotatable support of a centrifugal collection system. A resuspension solution is introduced to the single-use processing chamber containing the concentrated blood component. The rotatable support with the single-use processing chamber mounted thereto is removed from the centrifugal collection system and mounted to a resuspension device. The device is then activated for a period of time sufficient to resuspend the concentrated blood component in the resuspension solution. In another aspect, the resuspension device is configured to impart a reciprocating arcuate motion to the support and its associated single-use processing chamber. A frequency of approximately 300 to 325 rpm over a period of time of approximately 1.5 to 2.5 minutes has been found effective for resuspending platelets. Reciprocation through an arc of less than 200° is provided.
摘要翻译：公开了一种用于将收集在一次性处理室中的浓缩血液成分重新悬浮的方法，所述一次性处理室安装在离心收集系统的可旋转支撑件上。将再悬浮溶液引入含有浓缩血液成分的一次性处理室。安装在其上的一次性处理室的可旋转支撑件从离心收集系统中移除并安装到再悬挂装置。然后将该装置激活足以将浓缩血液成分重悬于再悬浮液中的一段时间。在另一方面，再悬浮装置被配置为向支撑件及其相关联的一次性使用处理室施加往复的弓形运动。发现在约1.5至2.5分钟的时间段内约300至325rpm的频率已经被有效用于重悬血小板。提供通过小于200°的弧的往复运动。

49. 发明申请

WO2012125472A1 MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2012125472A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/028532
申请日：2012-03-09
申请人： FENWAL, INC. , BLICKHAN, Bryan , MIN, Kyungyoon , CORK, William, H.
发明人： BLICKHAN, Bryan , MIN, Kyungyoon , CORK, William, H.
IPC分类号： B01D17/12 , A61M37/00 , B01D61/00 , B01D24/28 , B01D33/15
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

50. 发明申请

WO2012125470A1 MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME AND DATA MANAGEMENT SYSTEMS AND METHODS 审中-公开
标题翻译：膜分离装置，系统及其使用方法和数据管理系统及方法
公开(公告)号：WO2012125470A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/028522
申请日：2012-03-09
申请人： FENWAL, INC. , WEGENER, Christopher, J. , MIN, Kyungyoon , FORCIOLI, Laurent , BRIERTON, Mark, J. , BOGGS, Daniel, R.
发明人： WEGENER, Christopher, J. , MIN, Kyungyoon , FORCIOLI, Laurent , BRIERTON, Mark, J. , BOGGS, Daniel, R.
IPC分类号： B01D17/12 , B01D61/00 , B01D24/28 , B01D33/15
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
摘要翻译：公开了膜分离装置以及在血液处理程序中采用该装置的系统和方法。在一个实施例中，提供了一种纺丝膜分离器，其中在膜和壳体之间的间隙中形成至少两个区域或区域，使得两个区域之间的流体的混合被与膜相关联的径向肋这减小了膜和壳体之间的间隙，以限定两个流体区域，脊分离两个区域中的流体以最小化两者之间的混合。公开了用于将先前收集的全血单位分离成诸如浓红细胞和血浆的组分的自动系统和方法，用于单次从供体中直接收集红细胞和血浆，以及用于细胞洗涤。还公开了数据管理系统和方法以及启动方法。

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