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41. 发明专利

AU3014801A Chelating compounds, their complexes with paramagnetic metals 未知
公开(公告)号：AU3014801A
公开(公告)日：2001-07-03
申请号：AU3014801
申请日：2000-12-20
申请人： BRACCO SPA
发明人： FRANZINI MAURIZIO , BELTRAMI ANDREA , CALABI LUISELLA , MAIOCCHI ALESSANDRO , VIRTUANI MARIO , ANELLI PIER LUCIO , RAMALINGAM KONDAREDDIAR , RANGANATHAN RAMACHANDRAN S
IPC分类号： A61K49/00 , A61K49/04 , A61K49/06 , A61K49/08 , C07C229/08 , C07F1/00 , C07F9/38 , C07F9/572 , C07F15/02 , C07J51/00
摘要： Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with said metal ions and the physiologically compatible salts thereof, as well as the use thereof as contrast agents in the technique known as "Magnetic Resonance Imaging" (M.R.I.).

42. 发明专利

DE69425572T2 未知
公开(公告)号：DE69425572T2
公开(公告)日：2001-04-26
申请号：DE69425572
申请日：1994-05-25
申请人： BRACCO SPA , DIBRA SPA
发明人： UGGERI FULVIO , ANELLI PIER LUCIO , FEDELI FRANCO , MURRU MARCELLA , DE HAEN CHRISTOPH
IPC分类号： C07D257/02 , A61K49/00 , A61K49/04 , A61K49/08 , A61K51/00 , A61K51/04 , C07C237/04 , C07C237/10
摘要： PCT No. PCT/EP94/01677 Sec. 371 Date May 30, 1995 Sec. 102(e) Date May 30, 1995 PCT Filed May 25, 1994 PCT Pub. No. WO94/27644 PCT Pub. Date Dec. 8, 1994Novel compounds containing a polyiodinated aromatic or heteroaromatic residue and their chelate complexes with ions of metal elements with atomic number from 20 to 31, 39, from 42 to 44, 49 and from 57 to 83, and their salts with physiologically tolerable organic and inorganic bases are useful contrast agents for preparation of diagnostic formulations to obtain images of organs and/or tissues of human and animal body through the use of nuclear magnetic resonance or X-rays or the combination of both nuclear magnetic resonance and X-rays.

43. 发明专利

IL131255D0 A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the derivatives thereof 未知
公开(公告)号：IL131255D0
公开(公告)日：2001-01-28
申请号：IL13125598
申请日：1998-06-08
申请人： BRACCO SPA
IPC分类号： C07D257/02 , C07D
摘要： A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the salts thereof of formula (I) which comprises the following steps: a) carboxymethylation reaction of a suitable precursor in water, with a haloacetic acid, b) hydrolysis reaction in basic conditions by addition of the base added at the previous step.

44. 发明专利

DE69800434D1 未知
公开(公告)号：DE69800434D1
公开(公告)日：2001-01-25
申请号：DE69800434
申请日：1998-05-19
申请人： BRACCO SPA , DIBRA SPA
发明人： DESANTIS NICOLA
IPC分类号： C07C233/00 , C07C229/62 , C07C231/02 , C07C231/08 , C07C233/33 , C07C237/46 , C07C237/52
摘要： A process for the preparation of 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide of formula (I), starting from 5-amino-1,3-benzenedicarboxylic acid of formula (II), comprising the following steps: step a) is the reaction in heterogeneous phase between 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid and thionyl chloride in a solvent selected from the group consisting of: straight or branched (C7-C16) hydrocarbons, (C7-C8) aromatic hydrocarbons, 1,1,1-trichloroethane, n-butyl acetate, diglyme (diethylene glycol dimethyl ether), in the presence of catalytic amounts of a tertiary amine, to give compound (III); step b) is the acetylation reaction of compound (III) with glacial acetic acid both as the solvent and the reagent and thionyl chloride; step c) is the formation of compound (V) by reaction of the compound (IV) with 1-amino-2,3-propanediol, by reaction of compound (IV) in a dipolar aprotic solvent, selected from the group of dimethylformamide (DMF), dimethylacetamide (DMA), dimethylsulfoxide (DMSO) or N-methyl-pyrrolidinone; step d) is the alkylation of the compound (V) in aqueous solution at basic pH, by addition of a sodium hydroxide-calcium hydroxide mixture, with 3-chloro-1,2-propanediol or epichlorohydrin, at a temperature of 40-90 DEG C.

45. 发明专利

ITFI990169A1 未知
公开(公告)号：ITFI990169A1
公开(公告)日：2001-01-22
申请号：ITFI990169
申请日：1999-07-22
申请人： BRACCO SPA
发明人： MACCHIA BRUNO , BALSAMO ALDO , MACCHIA MARCO , DEL TACCA MARIO , DANESI ROMANO
IPC分类号： A61K31/513 , A61K31/7068 , A61P35/00 , C07D239/54 , C07D239/56 , C07H15/26

46. 发明专利

DK0773923T3 未知
公开(公告)号：DK0773923T3
公开(公告)日：2000-09-04
申请号：DK96919779
申请日：1996-05-17
申请人： BRACCO SPA
发明人： MAURO MARINA , CARLO FELICE VISCARDI , GAGNA MASSIMO
IPC分类号： B01J27/10 , C07B61/00 , C07C227/04 , B01J27/02 , C07C227/06 , C07C227/16 , C07C229/62
摘要： The present invention refers to a process for the preparation of 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid, comprising the following steps: a) catalytic hydrogenation of 5-nitro-1,3-benzenedicarboxylic acid in neutral or basic environment, which gives an aqueous solution of 5-amino-1,3-benzenedicarboxylic acid sodium salt; b) direct iodination of the 5-amino-1,3-benzenedicarboxylic acid sodium salt solution deriving from step a), without further purification, with a solution of ICl in HCl, being the 5-amino-1,3-benzenedicarboxylic acid sodium salt solution previously added with HCl and H2SO4.

47. 发明专利

NO20003919D0 未知
公开(公告)号：NO20003919D0
公开(公告)日：2000-08-02
申请号：NO20003919
申请日：2000-08-02
申请人： BRACCO SPA
发明人： THALLER MARIA CRISTINA , ROSSOLINI GIANMARIA , SELAN LAURA , PASSARIELLO CLAUDIO
IPC分类号： C12N1/20 , C12P19/04 , C12Q1/14 , C12R1/445 , G01N33/53 , G01N33/569 , G01N
摘要： A method for the laboratory determination of prosthetic infections is described. This method, performed on biological fluids isolated from patients, is based on the detection of antibodies specific for the polysaccharides produced by bacteria colonizing prosthetic devices.

48. 发明专利

ITMI20001352D0 未知
公开(公告)号：ITMI20001352D0
公开(公告)日：2000-06-16
申请号：ITMI20001352
申请日：2000-06-16
申请人： BRACCO SPA
发明人： CAVAGNA FRIEDRICH , VERONA SANDRA
IPC分类号： A61K20060101 , G01N20060101

49. 发明专利

CZ9903818A3 Process for preparing 1,4,7,10 - tetraazacyclododecane 未知
公开(公告)号：CZ9903818A3
公开(公告)日：2000-04-12
申请号：CZ381899
申请日：1998-04-16
申请人： BRACCO SPA
发明人： RIPA GIORGIO , ARGESE MARIA
IPC分类号： C07D257/02
CPC分类号： C07D257/02

50. 发明专利

ITMI20000193D0 未知
公开(公告)号：ITMI20000193D0
公开(公告)日：2000-02-08
申请号：ITMI20000193
申请日：2000-02-08
申请人： BRACCO SPA
发明人： KNOPP MICHAEL V , GIESEL FREDERIK , VON TENGO-KOBLIGK HENDRIK , RADELEFF JANNIS
IPC分类号： G01N20060101

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