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31. 发明专利

JPS58183627A Immunobiological preparation 失效
标题翻译：免疫学准备
公开(公告)号：JPS58183627A
公开(公告)日：1983-10-26
申请号：JP6228182
申请日：1982-04-14
申请人： Sutoka Paru , Sutoka Kurara
发明人： PARU SUTOKA , KURARA SUTOKA
IPC分类号： A61K36/064 , A61K39/00 , A61K39/395 , C12N1/16 , C12P1/02 , C12P21/00 , C12Q1/04 , G01N33/569
CPC分类号： A61K36/064 , A61K39/0002 , C12P1/02 , C12R1/72 , G01N33/56961 , Y10S435/921 , Y10S435/961
摘要： The invention relates to a process for the production of new immunobiological preparations for the diagnosis, prophylaxis and/or treatment of Candida guilliermondii infections. According to the invention one proceeds as follows: (a) a Candida guilliermondii strain is propagated under aerobic conditions at 24-42 DEG C. on a culture medium containing assimilable carbon and nitrogen sources, the resulting population(s) is (are) maintained under identical conditions for a prolonged period, therafter the fungus cells are separated from the culture, washed, ruptured mechanically, extracted, the extract is treated with a polar organic solvent, and the resulting precipitate is converted into an immunobiological preparation either as such or after further purification, or (b) a Candida guilliermondii strain is cultivated for 48-72 hours under aerobic conditions at 24 DEG -42 DEG C. on a culture medium containing assimilable carbon and nitrogen sources, the resulting culture is optionally propagated further to produce two or three new populations, then the fungus cells are separated from the culture, washed, ruptured mechanically, extracted, then, if desired, a polar organic solvent is added to the extract, and the resulting precipitate is converted into an immunobiological preparation either as such or after further purification, or (c) a Candida guilliermondii strain is cultivated for 48-72 hours under aerobic conditions at 24 DEG -42 DEG C. on a culture medium containing assimilable carbon and nitrogen sources, then the culture is killed, the killed cells are separated and converted then into an immunobiological preparation either as such or after purification.

32. 发明专利

JPS576480B2 JPS576480B2 - 失效
公开(公告)号：JPS576480B2
公开(公告)日：1982-02-04
申请号：JP15951778
申请日：1978-12-20
IPC分类号： C12P7/64 , C11C3/06 , C11C3/10
CPC分类号： C11C3/06 , C11C3/10 , Y10S435/917 , Y10S435/921 , Y10S435/937

33. 发明专利

JP4118340B2 Fungal antigen and a method of manufacturing the same 失效
公开(公告)号：JP4118340B2
公开(公告)日：2008-07-16
申请号：JP51202798
申请日：1997-08-29
申请人：タカラバイオ株式会社
发明人：郁之進加藤 , 滋利水谷 , 一任竹迫 , 政博遠藤
IPC分类号： C07K14/37 , G01N33/53 , A61K39/00 , A61K39/35 , A61P31/10 , A61P37/00 , A61P37/04 , A61P37/08 , C07K14/40 , C12N15/09 , C12N15/31 , C12R1/725 , G01N33/569
CPC分类号： C07K14/40 , A61K39/00 , A61K39/0002 , A61K39/35 , C07K14/37 , C12P21/00 , G01N33/56961 , Y10S435/921 , Y10S435/922

35. 发明专利

JPS6128389A Purification of lactase preparation 失效
标题翻译：杀菌剂制剂的纯化
公开(公告)号：JPS6128389A
公开(公告)日：1986-02-08
申请号：JP3623185
申请日：1985-02-25
申请人： Pfizer
发明人： DENISU MAIKERU FUENTON
IPC分类号： C12N9/38
CPC分类号： C12N9/2471 , C12N9/86 , C12Y302/01023 , C12Y305/02006 , Y10S435/814 , Y10S435/911 , Y10S435/921

36. 发明专利

JPS5915625B2 JPS5915625B2 - 失效
公开(公告)号：JPS5915625B2
公开(公告)日：1984-04-10
申请号：JP2423279
申请日：1979-03-01
申请人： Toyo Boseki
发明人： KIKUCHI TOSHIRO , OGAWA MASARU , ANDO MINORU
IPC分类号： C12N9/02 , C12Q1/26
CPC分类号： C12Y103/03006 , C12N9/001 , C12Q1/26 , Y10S435/921

37. 发明申请

WO0175446A9 DEVICE AND METHOD FOR CYTOLOGY SLIDE PREPARATION 审中-公开
标题翻译：用于细胞学幻影准备的装置和方法
公开(公告)号：WO0175446A9
公开(公告)日：2002-12-19
申请号：PCT/US0110968
申请日：2001-04-04
申请人： DIGENE CORP
发明人： BOTACINI DAS DORES GERSON , MIELZYNSKA-LOHNAS IWONA , TAROMARU ELIANE , PAYNE WILLIAM J , SLATTERY JOSEPH P , LAZAR JAMES
IPC分类号： G01N33/48 , G01N1/28 , G01N33/543
CPC分类号： G01N33/54386 , Y10S435/921 , Y10S435/922 , Y10S435/923 , Y10S435/924 , Y10S435/962 , Y10S435/97 , Y10S435/973 , Y10S436/81 , Y10T436/25 , Y10T436/25375
摘要： This invention provides a novel device and method for preparing cytology slides. The device comprises a book-like form including an absorbent material (20) and filter (22) attached to the inside surface of a front cover (12) and a cytology slide (40) removeably attached to an inside surface of a back cover (16). A sample is removed from the body of a patient, placed in a liquid-based solution, and then on the filter. When the book-like form is closed, the sample is effectively transferred to the slide. The device can be modified so that a plurality of slides are prepared at the same time.
摘要翻译：本发明提供了一种制备细胞学幻灯片的新型装置和方法。该装置包括书本形式，其包括附接到前盖（12）的内表面的吸收材料（20）和过滤器（22）以及可移除地附接到后盖的内表面的细胞学滑块（40） 16）。将样品从患者体内取出，置于液体溶液中，然后放在过滤器上。当书本形式关闭时，样本被有效地转移到幻灯片。该装置可以被修改，以便同时准备多个幻灯片。

38. 发明申请

WO1997043433A1 ENZYMATIC PROCESS FOR THE MANUFACTURE OF ASCORBIC ACID, 2-KETO-L-GULONIC ACID AND ESTERS OF 2-KETO-L-GULONIC ACID 审中-公开
标题翻译：用于制备抗坏血酸，2-KETO-L-GULONIC酸和2-KETO-L-GULONIC酸的酶的酶学方法
公开(公告)号：WO1997043433A1
公开(公告)日：1997-11-20
申请号：PCT/US1997008668
申请日：1997-05-16
申请人： EASTMAN CHEMICAL COMPANY
发明人： EASTMAN CHEMICAL COMPANY , HUBBS, John, Clark
IPC分类号： C12P17/04
CPC分类号： C12P17/04 , C12P7/60 , Y10S435/836 , Y10S435/847 , Y10S435/913 , Y10S435/921 , Y10S435/933
摘要： The present invention is directed toward efficient, high-yield processes for making ascorbic acid, 2-keto-L-gulonic acid, and esters of 2-keto-L-gulonic acid. The processes comprise reacting the appropriate starting materials with a hydrolase enzyme catalyst such as a protease, an esterase, a lipase or an amidase.
摘要翻译：本发明涉及用于制备抗坏血酸，2-酮-L-古洛糖酸和2-酮-L-古洛糖酸的酯的有效的高产率方法。该方法包括使合适的原料与水解酶催化剂如蛋白酶，酯酶，脂肪酶或酰胺酶反应。

39. 发明申请

WO1996021741A1 NUCLEIC ACID PROBES FOR THE DETECTION AND IDENTIFICATION OF FUNGI 审中-公开
标题翻译：对真菌的检测和鉴定的核酸探针
公开(公告)号：WO1996021741A1
公开(公告)日：1996-07-18
申请号：PCT/IB1996000026
申请日：1996-01-12
申请人： CIBA CORNING DIAGNOSTICS CORP. , SANDHU, Gurpreet, S. , KLINE, Bruce, C.
发明人： CIBA CORNING DIAGNOSTICS CORP.
IPC分类号： C12Q01/68
CPC分类号： C12N15/1003 , C07K14/37 , C12Q1/6806 , C12Q1/6895 , Y10S435/911 , Y10S435/913 , Y10S435/921 , Y10S435/922 , Y10S435/924 , Y10S435/929 , Y10S435/931 , Y10S435/933 , Y10S435/939 , Y10S435/94 , Y10S435/942 , Y10T436/143333
摘要： Nucleic acid probes and primers are described for detecting fungi that cause disease in humans and animals, as well as spoilage of food and beverages. These probes can detect rRNA, rDNA or polymerase chain reaction products from a majority of fungi in clinical, environmental or food samples. Nucleic acid hybridization assay probes specific for Acremonium sp., Aspergillus clavatus, Aspergillus flavus, Aspergillus fumigatus, Aspergillus glaucus, Aspergillus nidulans, Aspergillus niger, Aspergillus ochraceus, Aspergillus terreus, Aspergillus unguis, Aspergillus ustus, Beauveria sp., Bipolaris sp., Blastoschizomyces sp., Blastomyces dermatitidis, Candida albicans, Candida glabrata, Candida guilliermondii, Candida kefyr, Candida krusei, Candida lusitaniae, Candida parapsilosis, Candida tropicalis, Chrysosporium sp., Cladosporium sp., Coccidioides immitis, Cryptococcus neoformans var gattii serotype B, Cryptococcus neoformans serotype A, Cryptococcus laurentii, Cryptococcus terreus, Curvularia sp., Fusarium sp., Filobasidium capsuligenum, Filobasidiella (Cryptococcus) neoformans var bacillispora serotype C, Filobasidiella (Cryptococcus) neoformans var neoformans serotype D, Filobasidium uniguttulatum, Geotrichum sp., Histoplasma capsulatum, Malbranchea sp., Mucor sp., Paecilomyces sp., Penicillium species, Pseudallescheria boydii, Rhizopus sp., Sporothrix schenkii, Scopulariopsis brevicaulis, Scopulariopsis brumpti, Saccharomyces cerevisiae, and Trichosporon beigelii are also described.
摘要翻译：描述了核酸探针和引物用于检测在人和动物中引起疾病的真菌，以及食物和饮料的腐败。这些探针可以检测临床，环境或食品样品中大多数真菌的rRNA，rDNA或聚合酶链反应产物。核酸杂交测定特异性针对顶孢菌属，曲霉属，黄曲霉，烟曲霉，曲霉，构巢曲霉，黑曲霉，曲霉，土曲霉，非曲霉，白曲霉，白僵菌，双歧杆菌，白僵菌，ium ium ium ium ium ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans ans 血清型A，隐球菌（Cryptococcus laurentii），土曲霉（Tryptococcus terreus），曲霉属（Curvularia sp。），镰刀菌属（Fusarium sp。），，螨属（Filobasidium capsuligenum），弧菌属（隐球菌属）新型隐孢子虫变种杆菌血清型C，弧菌属（隐球菌属）新型隐球菌var neoformans血清型D， Malbranchea sp。，Mucor sp。，Paecilomyc 还可以描述青霉属，青霉菌（Pseudallescheria boydii），根霉属（Rhizopus sp。），Sporothrix schenkii，Scopulariopsis brevicaulis，Scopulariopsis brumpti，酿酒酵母（Saccharomyces cerevisiae）和Trichosporon beigelii。

40. 发明申请

WO1995006133A1 METHOD OF DETECTING AND COUNTING MICROORGANISMS 审中-公开
标题翻译：方法检测和计数微生物
公开(公告)号：WO1995006133A1
公开(公告)日：1995-03-02
申请号：PCT/DE1994000953
申请日：1994-08-17
申请人： BEIERSDORF AG , MEYER, Bianca , SAUERMANN, Gerhard , TRAUPE, Bernd , WOLF, Florian
发明人： BEIERSDORF AG
IPC分类号： C12Q01/04
CPC分类号： C12N1/38 , C12Q1/04 , C12Q2304/46 , Y10S435/848 , Y10S435/849 , Y10S435/882 , Y10S435/883 , Y10S435/884 , Y10S435/921 , Y10S435/922 , Y10S435/923
摘要： The invention concerns a cosmetic or dermatological method for the detection and/or selective quantitative determination of individual microorganisms, or complete groups of microorganisms, on human or animal skin. The method is characterized in that, after taking a sample of the microflora on skin, the sample is mixed with a disinhibition agent. Then placed in a culture medium which offers favourable growth conditions for a particular group of microorganisms but unfavourable growth conditions for other microorganisms, thus initiating selective culture. This selective culture is incubated for a sufficiently long period during which only the group of microorganisms for which the culture medium offers favourable growth condition can multiply, producing metabolic products, in particular CO2, which collect either in the culture medium itself or in a test vessel, provided for the purpose, which contains an indicator. The concentration of the metabolic products is determined from the change in a.c. resistance of the culture medium or the change in the indicator in the test vessel and, after appropriate calibration, can be correlated using computer-based techniques with the number of microorganisms in the culture medium.
摘要翻译：用于检测和/或选择性地在人或动物皮肤的微生物或微生物的整个组，其特征在于，定量个体befindlicher，服用人或动物皮肤的微生物的样品后化妆品或皮肤病学的方法，该样品与去抑制介质混合，从而所制备的样品被放置在培养基中，但其具有用于微生物的特定组有利的生长条件，其它微生物，由此选择性培养产生，和不利的生长条件该选择性培养物温育足够长的时间周期，从而只有该组的微生物为哪些有培养基中有利的生长条件，有机会相乘，和代谢物，特别是CO 2产生它们要么在培养基本身或指定的前含有指示介质，收集和代谢产物的浓度观察测试容器中确定的培养基中或者在由变化的测试容器中的指示介质的交流电阻和，经过适当的校准，通过用微生物的在选择性培养基中的数目的计算方法相关。

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