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31. 发明授权

US06797482B2 Methods for the high-resolution identification of solvent-accessible amide hydrogens in protein binding sites 失效
标题翻译：用于高分辨率鉴定蛋白质结合位点中溶剂可及的酰胺氢的方法
公开(公告)号：US06797482B2
公开(公告)日：2004-09-28
申请号：US09954376
申请日：2001-09-10
申请人： Virgil L. Woods, Jr.
发明人： Virgil L. Woods, Jr.
IPC分类号： G01N3353
CPC分类号： G01N33/53 , G01N33/6878 , G01N2030/027 , G01N2030/8813 , G01N2333/805 , G01N2333/96477 , Y10T436/24 , Y10T436/25 , Y10T436/25125
摘要： The present invention provides methods whereby the positions of peptide amide groups that are labeled with a heavy hydrogen in a polypeptide or protein can be localized at high resolution. The methods are useful for determining which peptide amide groups in a polypeptide or protein are accessible to solvent, mapping the binding site and/or binding surface of a binding protein, and/or studying allosteric or other conformational changes in a polypeptide or protein which alter the rates at which certain peptide amide hydrogens exchange with solvent.
摘要翻译：本发明提供了多肽或蛋白质中用重氢标记的肽酰胺基的位置可以以高分辨率定位的方法。所述方法可用于确定多肽或蛋白质中的哪些肽酰胺基团可溶于溶剂，测定结合蛋白的结合位点和/或结合表面，和/或研究多肽或蛋白质中的变构或其它构象变化，其改变某些肽酰胺氢与溶剂交换的速率。

32. 发明申请

US20020042080A1 Methods for the high-resolution identification of solvent-accessible amide hydrogens in protein binding sites 失效
标题翻译：用于高分辨率鉴定蛋白质结合位点中溶剂可及的酰胺氢的方法
公开(公告)号：US20020042080A1
公开(公告)日：2002-04-11
申请号：US09954376
申请日：2001-09-10
申请人： Carta Proteomics, Inc.
发明人： Virgil L. Woods JR.
IPC分类号： G01N033/53 , C12Q001/37 , G01N033/543
CPC分类号： G01N33/53 , G01N33/6878 , G01N2030/027 , G01N2030/8813 , G01N2333/805 , G01N2333/96477 , Y10T436/24 , Y10T436/25 , Y10T436/25125
摘要： The present invention provides methods whereby the positions of peptide amide groups that are labeled with a heavy hydrogen in a polypeptide or protein can be localized at high resolution. The methods are useful for determining which peptide amide groups in a polypeptide or protein are accessible to solvent, mapping the binding site and/or binding surface of a binding protein, and/or studying allosteric or other conformational changes in a polypeptide or protein which alter the rates at which certain peptide amide hydrogens exchange with solvent.
摘要翻译：本发明提供了多肽或蛋白质中用重氢标记的肽酰胺基的位置可以以高分辨率定位的方法。所述方法可用于确定多肽或蛋白质中的哪些肽酰胺基团可溶于溶剂，测定结合蛋白的结合位点和/或结合表面，和/或研究多肽或蛋白质中的变构或其它构象变化，其改变某些肽酰胺氢与溶剂交换的速率。

33. 发明申请

WO2016135882A1 十二指腸液試料の膵液由来成分検出用試料としての適性評価方法审中-公开
标题翻译：用于检测胰蛋白酶衍生物组分的样品作为样品的适用性评估方法
公开(公告)号：WO2016135882A1
公开(公告)日：2016-09-01
申请号：PCT/JP2015/055403
申请日：2015-02-25
申请人：オリンパス株式会社
发明人：朝倉　正教 , 長岡　智紀 , 島田　奈緒
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N33/582 , G01N2333/96433 , G01N2333/96477
摘要：動物から採取された十二指腸液試料について、当該十二指腸液試料が膵液由来成分の検出用試料として適しているか否かを評価する方法を提供する。すなわち、（ａ）十二指腸液試料とキモトリプシン特異的基質を混合し、前記十二指腸液試料による前記キモトリプシン特異的基質の分解活性を測定する工程と、（ｂ）前記十二指腸液試料とペプシン特異的基質を混合し、前記十二指腸液試料による前記ペプシン特異的基質の分解活性を測定する工程と、（ｃ）前記十二指腸液試料の前記キモトリプシン特異的基質の分解活性及び前記十二指腸液試料の前記ペプシン特異的基質の分解活性に基づき、前記十二指腸液試料が膵液由来成分の検出用試料として適しているか否かを評価する工程と、を有する、十二指腸液試料の膵液由来成分検出用試料としての適性評価方法を提供する。
摘要翻译：提供了用于评价从动物收集的十二指肠液样品是否适合作为用于检测来自胰汁的成分的样品的方法。评价十二指肠液样品作为检测胰液来源成分的样品的适合性的方法包括：（a）将十二指肠液样品与糜蛋白酶特异性底物混合并测量糜蛋白酶特异性底物降解活性的步骤十二指肠汁样品; （b）将十二指肠液样品与胃蛋白酶特异性底物混合并测量十二指肠液样品的胃蛋白酶特异性底物降解活性的步骤; 以及（c）根据十二指肠液样品和胃蛋白酶特异性底物的胰凝乳蛋白酶特异性底物降解活性，评价十二指肠液样品是否适合作为检测胰汁衍生成分的样品的步骤十二指肠液样品的降解活性。

34. 发明申请

WO99009204A1 METHODS FOR THE HIGH-RESOLUTION IDENTIFICATION OF SOLVENT-ACCESSIBLE AMIDE HYDROGENS IN POLYPEPTIDES 审中-公开
标题翻译：多分散溶剂中可溶性酰胺氢化物高分辨率鉴定方法
公开(公告)号：WO99009204A1
公开(公告)日：1999-02-25
申请号：PCT/US1998/017135
申请日：1998-08-18
IPC分类号： G01N30/02 , G01N30/88 , G01N33/53 , G01N33/68 , C12Q1/00 , C12Q1/68
CPC分类号： G01N33/53 , G01N33/6878 , G01N2030/027 , G01N2030/8813 , G01N2333/805 , G01N2333/96477 , Y10T436/24 , Y10T436/25 , Y10T436/25125
摘要： The present invention provides methods whereby the positions of peptide amide groups that are labeled with a heavy hydrogen in a polypeptide or protein can be localized at high resolution. The methods are useful for determining which peptide amide groups in a polypeptide or protein are accessible to solvent, mapping the binding site and/or binding surface of a binding protein, and/or studying allosteric or other conformational changes in a polypeptide or protein which alter the rates at which certain peptide amide hydrogens exchange with solvent.
摘要翻译：本发明提供了多肽或蛋白质中用重氢标记的肽酰胺基的位置可以以高分辨率定位的方法。所述方法可用于确定多肽或蛋白质中的哪些肽酰胺基团可溶于溶剂，测定结合蛋白的结合位点和/或结合表面，和/或研究多肽或蛋白质中的变构或其他构象变化，其改变某些肽酰胺氢与溶剂交换的速率。

35. 发明申请

WO2005085871A1 A METHOD FOR PREDICTING THE STATE OF THE GASTRIC MUCOSA 审中-公开
标题翻译：一种预测胃粘膜状态的方法
公开(公告)号：WO2005085871A1
公开(公告)日：2005-09-15
申请号：PCT/FI2005/050061
申请日：2005-03-03
申请人： BIOHIT OYJ , SARNA, Seppo , TIUSANEN, Tapani , SUOVANIEMI, Osmo
发明人： SARNA, Seppo , TIUSANEN, Tapani , SUOVANIEMI, Osmo
IPC分类号： G01N33/74
CPC分类号： G01N33/6893 , G01N2333/595 , G01N2333/96477 , G01N2800/062
摘要： The present invention is directed to a method for assessing or predicting the state of the gastric mucosa in a subject by determining, in said subject, the probability for the gastric mucosa belonging to at least one gastric mucosa class, the method comprising: measuring, from a sample of said subject, the pepsinogen I (PGI) and gastrin-17 (G-17) analyte concentrations, as well as determining the presence or concentration of a marker for Helicobacter pylori ; entering the data so obtained in a data processing system comprising an operating system, a database and means for transceiving and processing data, the said data processing system being adapted to determine the probability for the gastric mucosa belonging to the at least one gastric mucosa class, based on the data entered as well as on predefined clinical data in the database, the information so generated being indicative of the state of the gastric mucosa in said subject.
摘要翻译：本发明涉及通过在所述受试者中确定属于至少一种胃粘膜类别的胃粘膜的概率来评估或预测受试者胃粘膜状态的方法，所述方法包括：从所述受试者的样品，胃蛋白酶原I（PGI）和胃泌素-17（G-17）分析物浓度，以及确定幽门螺杆菌标记物的存在或浓度; 输入在包括操作系统，数据库和用于收发和处理数据的装置的数据处理系统中获得的数据，所述数据处理系统适于确定属于至少一个胃粘膜类的胃粘膜的概率，基于输入的数据以及数据库中的预定临床数据，所生成的信息指示所述受试者中胃粘膜的状态。

36. 发明授权

EP2315843B1 ENHANCING ENDOTOXIN DETECTION 有权
标题翻译：增强内毒素检测
公开(公告)号：EP2315843B1
公开(公告)日：2016-04-20
申请号：EP09808609.3
申请日：2009-08-11
申请人： BioDtech, Inc.
发明人： PEPE, Michael, G. , CHAMPION, Milton, Keith
IPC分类号： C12Q1/37 , C12R1/01 , G01N33/569
CPC分类号： G01N33/56911 , G01N2333/96477 , G01N2400/50

37. 发明授权

EP1012325B1 METHODS FOR THE HIGH-RESOLUTION IDENTIFICATION OF SOLVENT-ACCESSIBLE AMIDE HYDROGENS IN POLYPEPTIDES 有权
标题翻译：方法多肽中的溶剂可AMIDHYDROGENEN高清晰度的识别
公开(公告)号：EP1012325B1
公开(公告)日：2004-04-28
申请号：EP98940979.2
申请日：1998-08-18
申请人： ExSAR Corporation
发明人： Woods, Virgil L., Jr.
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/564 , G01N33/68
CPC分类号： G01N33/53 , G01N33/6878 , G01N2030/027 , G01N2030/8813 , G01N2333/805 , G01N2333/96477 , Y10T436/24 , Y10T436/25 , Y10T436/25125
摘要： The present invention provides methods whereby the positions of peptide amide groups that are labeled with a heavy hydrogen in a polypeptide or protein can be localized at high resolution. The methods are useful for determining which peptide amide groups in a polypeptide or protein are accessible to solvent, mapping the binding site and/or binding surface of a binding protein, and/or studying allosteric or other conformational changes in a polypeptide or protein which alter the rates at which certain peptide amide hydrogens exchange with solvent.

38. 发明公开

EP1725876A1 A METHOD FOR PREDICTING THE STATE OF THE GASTRIC MUCOSA 有权
标题翻译：预测方法胃黏膜的状态
公开(公告)号：EP1725876A1
公开(公告)日：2006-11-29
申请号：EP05717315.5
申请日：2005-03-03
申请人： BIOHIT OYJ
发明人： SARNA, Seppo , TIUSANEN, Tapani , SUOVANIEMI, Osmo
IPC分类号： G01N33/74 , G01N33/573
CPC分类号： G01N33/6893 , G01N2333/595 , G01N2333/96477 , G01N2800/062
摘要： The present invention is directed to a method for assessing or predicting the state of the gastric mucosa in a subject by determining, in said subject, the probability for the gastric mucosa belonging to at least one gastric mucosa class, the method comprising: measuring, from a sample of said subject, the pepsinogen I (PGI) and gastrin-17 (G-17) analyte concentrations, as well as determining the presence or concentration of a marker for Helicobacter pylori; entering the data so obtained in a data processing system comprising an operating system, a database and means for transceiving and processing data, the said data processing system being adapted to determine the probability for the gastric mucosa belonging to the at least one gastric mucosa class, based on the data entered as well as on predefined clinical data in the database, the information so generated being indicative of the state of the gastric mucosa in said subject.

39. 发明公开

US20240230668A1 PRETREATMENT METHOD FOR QUANTITATIVE DETECTION OF UNDENATURED TYPE II COLLAGEN IN COLLAGEN PRODUCT OR CARTILAGE, AND APPLICATION 审中-公开
公开(公告)号：US20240230668A1
公开(公告)日：2024-07-11
申请号：US18557508
申请日：2021-04-26
申请人： Beijing SEMNL BIOTECHNOLOGY CO., LTD.
发明人： Lige LIU , Zheng YAN , Aiqing LIU , Haiyan WANG , Guoqing ZOU
IPC分类号： G01N33/68 , G01N33/12
CPC分类号： G01N33/6887 , G01N33/12 , G01N2333/78 , G01N2333/96477 , G01N2333/966
摘要： A pretreatment method for detection of an undenatured type II collagen in a cartilage collagen product or a cartilage is proposed. The method can separate an undenatured type II collagen from a complex environment system including proteoglycan, a hydrolyzed collagen, open-chain denatured collagen and the like, and present a dissolved state, thereby facilitating subsequent further qualitative and quantitative detection.

40. 发明申请

US20170096699A1 METHOD FOR EVALUATING SUITABILITY OF DUODENAL FLUID SAMPLE AS SAMPLE FOR DETECTING PANCREATIC FLUID-DERIVED COMPONENTS 有权
公开(公告)号：US20170096699A1
公开(公告)日：2017-04-06
申请号：US15382996
申请日：2016-12-19
申请人： OLYMPUS CORPORATION
发明人： Masanori ASAKURA , Tomonori NAGAOKA , Nao SHIMADA
IPC分类号： C12Q1/37 , G01N33/58
CPC分类号： C12Q1/37 , G01N33/582 , G01N2333/96433 , G01N2333/96477
摘要： A method is provided for evaluating the suitability of a duodenal fluid sample collected from an animal as a sample for detecting pancreatic fluid-derived components. The method comprises: (a) mixing a duodenal fluid sample with a chymotrypsin-specific substrate and measuring an amount of degradation the chymotrypsin-specific substrate by of the duodenal fluid sample, (b) mixing the duodenal fluid sample with a pepsin-specific substrate and measuring an amount of degradation of the pepsin-specific substrate by the duodenal fluid sample, and (c) evaluating that the duodenal fluid sample is suitable as a sample for detecting pancreatic fluid-derived components if the amount of degradation of the chymotrypsin-specific substrate by the duodenal fluid sample is higher than a prescribed threshold value and the amount of degradation of the pepsin-specific substrate by the duodenal fluid sample is lower than a prescribed threshold value, as being suitable as a sample for detecting pancreatic fluid-derived components.

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