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31. 发明申请

US20090032468A1 Methods for Removal of Lipids from Fluids 审中-公开
标题翻译：从流体中除去脂质的方法
公开(公告)号：US20090032468A1
公开(公告)日：2009-02-05
申请号：US11868551
申请日：2007-10-08
申请人： David C. Bomberger , Pablo E. Garcia , Eric Hegwer , Thomas P. Low , Ripudaman Malhotra
发明人： David C. Bomberger , Pablo E. Garcia , Eric Hegwer , Thomas P. Low , Ripudaman Malhotra
IPC分类号： B01D11/04
CPC分类号： B01D61/362 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/342 , A61M1/3468 , A61M1/3472 , A61M1/3482 , A61M1/3486 , A61M1/3496 , A61M1/3693 , A61M2202/0456 , A61M2202/08 , A61M2202/203 , A61M2202/206 , A61M2205/3368 , B01D11/043 , B01D11/0492 , B01D61/246 , B01D63/02 , B01D63/046 , B01D2313/50
摘要： This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.
摘要翻译：本发明涉及从流体（例如血浆）或从含脂质生物体中除去脂质的系统和方法。这些系统与提取溶剂接触流体，其使得流体中的脂质与流体分离，或者使用至少一个中空纤维接触器使含脂质生物体中的脂质与含脂质生物体分离。将分离的脂质从流体中除去。将萃取溶剂从流体中除去或至少降低到低于特定阈值的水平，使得能够将流体施用于患者，而患者不经历不期望的后果。一旦液体已经被处理，流体可以被给予捐赠流体的患者，给不同的患者或被储存。

32. 发明申请

US20070246423A1 Systems and Methods Using Multiple Solvents for the Removal of Lipids from Fluids 失效
标题翻译：使用多种溶剂从流体中去除脂质的系统和方法
公开(公告)号：US20070246423A1
公开(公告)日：2007-10-25
申请号：US11769872
申请日：2007-06-28
申请人： David Bomberger , Bryan Chavez , Pablo Garcia , Eric Hegwer , Thomas Low , Ripudaman Malhotra , Jeffrey Shimon
发明人： David Bomberger , Bryan Chavez , Pablo Garcia , Eric Hegwer , Thomas Low , Ripudaman Malhotra , Jeffrey Shimon
IPC分类号： B01D17/00
CPC分类号： B01D61/362 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/342 , A61M1/3468 , A61M1/3472 , A61M1/3482 , A61M1/3486 , A61M1/3496 , A61M1/3693 , A61M2202/0456 , A61M2202/08 , A61M2202/203 , A61M2202/206 , A61M2205/3368 , B01D11/043 , B01D11/0492 , B01D61/246 , B01D63/02 , B01D63/046 , B01D2313/50
摘要： This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.
摘要翻译：本发明涉及从流体或诸如血浆的流体中从含脂质生物体中除去脂质的系统和方法。这些系统将流体与至少一种提取溶剂组合，其引起脂质与流体或含脂质生物分离。将分离的脂质从流体中除去。将至少一种提取溶剂从流体中除去或者至少减少到使得能够向患者施用流体的浓度，而不会产生不期望的后果。一旦流体被处理，流体可以被施用给捐赠流体的患者或不同的患者进行治疗。

33. 发明申请

US20070181485A1 Systems and Methods Using Multiple Solvents for Removal of Lipids from Fluids 失效
标题翻译：使用多种溶剂从流体中除去脂质的系统和方法
公开(公告)号：US20070181485A1
公开(公告)日：2007-08-09
申请号：US11737939
申请日：2007-04-20
申请人： David Bomberger , Bryan Chavez , Pablo Garcia , Eric Hegwer , Thomas Low , Ripudaman Malhotra , Jeffrey Shimon
发明人： David Bomberger , Bryan Chavez , Pablo Garcia , Eric Hegwer , Thomas Low , Ripudaman Malhotra , Jeffrey Shimon
IPC分类号： C02F1/44
CPC分类号： B01D61/362 , A61M1/34 , A61M1/3403 , A61M1/342 , A61M1/3472 , A61M1/3482 , A61M1/3486 , A61M1/3496 , A61M1/3693 , A61M2202/0456 , A61M2202/08 , A61M2202/203 , A61M2202/206 , A61M2205/3306 , A61M2205/3331 , A61M2205/3334
摘要： This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.
摘要翻译：本发明涉及从流体或诸如血浆的流体中从含脂质生物体中除去脂质的系统和方法。这些系统将流体与至少一种提取溶剂组合，其引起脂质与流体或含脂质生物分离。将分离的脂质从流体中除去。将至少一种提取溶剂从流体中除去或者至少减少到使得能够向患者施用流体的浓度，而不会产生不期望的后果。一旦流体被处理，流体可以被施用给捐赠流体的患者或不同的患者进行治疗。

34. 再颁专利

USRE39498E1 Treatment for cardiovascular and related diseases 失效
标题翻译：治疗心血管及相关疾病
公开(公告)号：USRE39498E1
公开(公告)日：2007-02-27
申请号：US09879002
申请日：1995-12-22
申请人： Karim Rouan Cham , Bill Elliot Cham
发明人： Karim Rouan Cham , Bill Elliot Cham
IPC分类号： A61M37/00 , A61M1/36 , B01D11/00 , C02F1/44
CPC分类号： A61M1/3472 , A61M1/3486 , A61M2202/0456
摘要： A method for the removal of cholesterol, triglycerides and other lipids from animal plasma, serum or other suitable blood fractions, as a discontinuous flow system, the method comprising withdrawing blood from a subject, separating the required fraction from the blood and mixing with a solvent mixture which extracts the lipids from the fraction, after which the delipidated fraction is recombined with the blood cells and returned to the subject, wherein the solvent extraction step is carried out separately and remote from the subject. The delipidated fraction is washed with a second solvent before being recombined with the blood cells. To ensure that the delipidated fraction is free from all extraction solvent, the fraction is mixed with an absorbent specific for the solvent that is being removed. The preferred absorbent is a macroporous polymeric bead contained in the pores of a sintered glass or plastic sphere, the being capable of absorbing organic molecules from an aqueous solution. By treating the plasma, serum or other suitable blood fraction of a patient by these methods, the blood rheology of a patient with impaired blood circulation can be improved. Further, a rapid regression of coronary atherosclerosis occurs.
摘要翻译：一种用于从动物血浆，血清或其它合适的血液部分中除去胆固醇，甘油三酯和其它脂质作为不连续流动系统的方法，所述方法包括从受试者中取出血液，将所需部分与血液分离并与溶剂混合从该级分中提取脂质的混合物，然后将脱脂级分与血细胞重组并返回到受试者，其中溶剂提取步骤分开地和远离受试者进行。在与血细胞重组之前，用第二溶剂洗涤脱脂级分。为了确保脱脂级分不含所有提取溶剂，该级分与特定于待除去溶剂的吸收剂混合。优选的吸收剂是包含在烧结玻璃或塑料球体的孔中的大孔聚合物珠粒，其能够从水溶液中吸收有机分子。通过这些方法治疗患者的血浆，血清或其他合适的血液部分，可以改善患有血液循环的患者的血液流变学。此外，发生冠状动脉粥样硬化的快速消退。

35. 发明申请

US20070039887A1 Hollow fiber contactor systems for removal of lipids from fluids 失效
标题翻译：用于从流体中去除脂质的中空纤维接触器系统
公开(公告)号：US20070039887A1
公开(公告)日：2007-02-22
申请号：US11589376
申请日：2006-10-30
申请人： David Bomberger , Pablo Garcia , Eric Hegwer , Thomas Low , Ripudaman Malhotra
发明人： David Bomberger , Pablo Garcia , Eric Hegwer , Thomas Low , Ripudaman Malhotra
IPC分类号： B01D61/00
CPC分类号： B01D61/362 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/342 , A61M1/3468 , A61M1/3472 , A61M1/3482 , A61M1/3486 , A61M1/3496 , A61M1/3693 , A61M2202/0456 , A61M2202/08 , A61M2202/203 , A61M2202/206 , A61M2205/3368 , B01D11/043 , B01D11/0492 , B01D61/246 , B01D63/02 , B01D63/046 , B01D2313/50
摘要： This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.
摘要翻译：本发明涉及从流体（例如血浆）或从含脂质生物体中除去脂质的系统和方法。这些系统与提取溶剂接触流体，其使得流体中的脂质与流体分离，或者使用至少一个中空纤维接触器使含脂质生物体中的脂质与含脂质生物体分离。将分离的脂质从流体中除去。将萃取溶剂从流体中除去或至少降低到低于特定阈值的水平，使得能够将流体施用于患者，而患者不经历不期望的后果。一旦液体已经被处理，流体可以被给予捐赠流体的患者，给不同的患者或被储存。

36. 发明申请

US20040256307A1 Systems and methods using multiple solvents for the removal of lipids from fluids 审中-公开
标题翻译：使用多种溶剂从流体中除去脂质的系统和方法
公开(公告)号：US20040256307A1
公开(公告)日：2004-12-23
申请号：US10856211
申请日：2004-05-28
发明人： David C. Bomberger , Bryan Chavez , Pablo E. Garcia , Eric Hegwer , Thomas P. Low , Ripudaman Malhotra , Jeffrey J. Shimon
IPC分类号： B01D063/06
CPC分类号： B01D61/362 , A61M1/34 , A61M1/3403 , A61M1/342 , A61M1/3472 , A61M1/3482 , A61M1/3486 , A61M1/3496 , A61M1/3693 , A61M2202/0456 , A61M2202/08 , A61M2202/203 , A61M2202/206 , A61M2205/3306 , A61M2205/3331 , A61M2205/3334
摘要： This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.
摘要翻译：本发明涉及从流体或诸如血浆的流体中从含脂质生物体中除去脂质的系统和方法。这些系统将流体与至少一种提取溶剂组合，其引起脂质与流体或含脂质生物分离。将分离的脂质从流体中除去。将至少一种提取溶剂从流体中除去或者至少减少到使得能够向患者施用流体的浓度，而不会产生不期望的后果。一旦流体被处理，流体可以被施用给捐赠流体的患者或不同的患者进行治疗。

37. 发明申请

WO2007118051A3 LIPID THERAPY 审中-公开
标题翻译：脂肪疗法
公开(公告)号：WO2007118051A3
公开(公告)日：2008-07-24
申请号：PCT/US2007065791
申请日：2007-04-02
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , KILPATRICK DEBORAH , HOSSAINY SYED FAIYAZ AHMED , ASTAFIEVA IRINA , LUDWIG FLORIAN N , CONSIGNY PAUL M , ELLIS JEFFREY T , LIM FLORENCIA
发明人： KILPATRICK DEBORAH , HOSSAINY SYED FAIYAZ AHMED , ASTAFIEVA IRINA , LUDWIG FLORIAN N , CONSIGNY PAUL M , ELLIS JEFFREY T , LIM FLORENCIA
IPC分类号： A61K38/00 , A61P9/10 , C07K14/755
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/1275 , A61K9/1617 , A61K9/1658 , A61M1/3472 , A61M1/3486 , A61M2202/0456 , A61K2300/00
摘要： A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo Al comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo Al and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCAl) transporter expression in macrophages and protect ABCAl from thiol-mediated degradation.
摘要翻译：一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。一种组合物，其包含Apo A1和选自用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。

38. 发明申请

WO2003000373A1 SYSTEMS AND METHODS USING A SOLVENT FOR THE REMOVAL OF LIPIDS FROM FLUIDS 审中-公开
标题翻译：使用溶剂从流体中去除脂肪的系统和方法
公开(公告)号：WO2003000373A1
公开(公告)日：2003-01-03
申请号：PCT/US2002/019643
申请日：2002-06-21
申请人： LIPID SCIENCES, INC. , BOMBERGER, David C., , CHAVEZ, Bryan , GARCIA, Pablo, E. , HEGWER, Eric , LOW, Thomas, p. , MALHOLTRA, Ripudaman , SHIMON, Jeffrey, j.
发明人： BOMBERGER, David C., , CHAVEZ, Bryan , GARCIA, Pablo, E. , HEGWER, Eric , LOW, Thomas, p. , MALHOLTRA, Ripudaman , SHIMON, Jeffrey, j.
IPC分类号： B01D11/00
CPC分类号： B01D61/362 , A61M1/34 , A61M1/3472 , A61M1/3482 , A61M1/3486 , A61M1/3496 , A61M2202/0456 , A61M2202/08 , A61M2202/203 , A61M2202/206 , A61M2205/3306 , A61M2205/3331 , A61M2205/50
摘要： Systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. A fluid is combined with at least one extraction solvent, which causes the lipids to separate from the fluid or from lipid-containing organisms. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to an acceptable concentration enabling the delipidated fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or stored for later use.
摘要翻译：用于从流体（例如血浆）或从含脂质生物体中除去脂质的系统和方法。流体与至少一种提取溶剂组合，其引起脂质与流体或含脂质生物分离。将分离的脂质从流体中除去。将萃取溶剂从流体中除去或至少降低到可接受的浓度，使得能够将脱脂流体施用于患者，而不会使患者经历不期望的后果。一旦流体被处理，流体可以被给予捐赠流体的患者给不同的患者，或者存储以供以后使用。

39. 发明申请

WO1995003840A1 A PLASMA DELIPIDATION SYSTEM 审中-公开
标题翻译：等离子体脱水系统
公开(公告)号：WO1995003840A1
公开(公告)日：1995-02-09
申请号：PCT/AU1994000415
申请日：1994-07-22
申请人： THE UNIVERSITY OF QUEENSLAND , CHAM, Bill, Elliot
发明人： THE UNIVERSITY OF QUEENSLAND
IPC分类号： A61M01/38
CPC分类号： A61M1/36 , A61M1/3451 , A61M1/3472 , A61M1/3692 , A61M1/3695 , A61M1/3696 , A61M2202/0415 , A61M2202/0456 , A61M2202/08 , Y10T436/25375 , Y10T436/255
摘要： An improved separating device for extracting cholesterol from plasma uses a spinner (45) to disperse incoming plasma laterally into an extracting solvent in the form of fine droplets to improve separation efficiency thereby making it suitable for delipidating blood plasma.
摘要翻译：用于从血浆中提取胆固醇的改进的分离装置使用旋转器（45）将进入的血浆横向分散成细小液滴形式的提取溶剂，以提高分离效率，从而使其适合于脱脂血浆。

40. 发明专利

JP2007195997A Plasma delipidation system 审中-公开
标题翻译：等离子体脱水系统
公开(公告)号：JP2007195997A
公开(公告)日：2007-08-09
申请号：JP2007061306
申请日：2007-03-12
申请人： Aruba Internatl Pty Ltd , アルバ・インターナショナル・プロプライアタリ・リミテッド
发明人： CHAM BILL ELLIOT
IPC分类号： A61M1/36 , A61M1/34 , B01D11/04 , B01F3/08 , B01F7/16 , B01F9/10
CPC分类号： A61M1/36 , A61M1/3451 , A61M1/3472 , A61M1/3692 , A61M1/3695 , A61M1/3696 , A61M2202/0415 , A61M2202/0456 , A61M2202/08 , Y10T436/25375 , Y10T436/255
摘要： PROBLEM TO BE SOLVED: To provide a system to continuously extract and remove lipid like cholesterol, etc. from blood plasma. SOLUTION: It is a method to remove cholesterol from animal blood plasma, wherein a solvent extraction process is applied to blood plasma to extract cholesterol from it. The solvent extraction process is characterized in that blood plasma becomes fine drops, and is dispersed into the solvent by a dispersion means. This increases the speed of extraction of cholesterol in blood plasma into the solvent. The cholesterol extraction system uses a rotary device 45 that disperses introduced blood plasma in the form of fine drops sideways into extraction liquid, and thereby improves the plasma separation efficiency. This method can remove fat from blood plasma in a proper way. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供从血浆中连续提取和去除脂质如胆固醇等的系统。解决方案：从动物血浆中除去胆固醇的方法，其中将溶剂提取过程应用于血浆以从其中提取胆固醇。溶剂萃取方法的特征在于，血浆变成细小的液滴，并通过分散装置分散到溶剂中。这增加了将血浆中胆固醇提取到溶剂中的速度。胆固醇提取系统使用旋转装置45，将引入的血浆以细滴的形式侧向分散到提取液中，从而提高血浆分离效率。这种方法可以以正确的方式从血浆中去除脂肪。版权所有（C）2007，JPO＆INPIT

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