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31. 发明授权

EP1891942B1 Opthalmic insert and method for sustained release of medication to the eye 有权
标题翻译：眼科插入物和方法用于连续递送药物到眼睛
公开(公告)号：EP1891942B1
公开(公告)日：2010-03-03
申请号：EP07012726.1
申请日：2000-04-07
申请人： Eyelab Group, LLC
发明人： Cohan, Bruce E. , Diamond, Howard
IPC分类号： A61K9/22 , A61K9/20 , A61F9/00
CPC分类号： A61F9/0017 , A61F9/00772 , A61K9/0051 , Y10S977/904

32. 发明申请

US20130008803A1 Methods and Systems for Measurement of Tear Glucose Levels 审中-公开
标题翻译：用于测量泪液葡萄糖水平的方法和系统
公开(公告)号：US20130008803A1
公开(公告)日：2013-01-10
申请号：US13342634
申请日：2012-01-03
申请人： Mark E. Meyerhoff , Bruce E. Cohan , Qinyi Yan , Bo Peng , Zvi Flanders
发明人： Mark E. Meyerhoff , Bruce E. Cohan , Qinyi Yan , Bo Peng , Zvi Flanders
IPC分类号： G01N27/327
CPC分类号： G01N27/3271 , A61B5/1486
摘要： A sensor system for determining glucose concentration in a tear fluid sample includes a working electrode including an immobilized glucose oxidase enzyme portion for reacting with glucose in the tear fluid sample, and a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample. Alternatively, a vessel for receiving the tear fluid sample may include the enzyme portion on an inner wall thereof. A reference electrode is disposed adjacent the working electrode, wherein the electrochemical reaction of the enzyme portion with glucose in the tear fluid sample generates a current related to the glucose concentration in the tear fluid sample.
摘要翻译：用于测定泪液样品中的葡萄糖浓度的传感器系统包括工作电极，其包括用于与泪液样品中的葡萄糖反应的固定的葡萄糖氧化酶部分和用于提高对泪液中的电活性干扰物种的葡萄糖选择性的选择性部分流体样品。或者，用于接收泪液样品的容器可以包括在其内壁上的酶部分。参考电极设置在工作电极附近，其中酶部分与泪液样品中的葡萄糖的电化学反应产生与泪液样品中的葡萄糖浓度相关的电流。

33. 发明申请

US20080021298A1 Apparatus And Method For Self-Measurement Of Intraocular Pressure 失效
标题翻译：眼压自我测量装置及方法
公开(公告)号：US20080021298A1
公开(公告)日：2008-01-24
申请号：US10598002
申请日：2003-10-20
申请人： Bruce Cohan , Andrew Pearch , Zvi Flanders , Donald Gillespie
发明人： Bruce Cohan , Andrew Pearch , Zvi Flanders , Donald Gillespie
IPC分类号： A61B3/16
CPC分类号： A61B3/16
摘要： An apparatus and method for the self-measurement of intraocular pressure utilize a tonometer disposed within a housing and having a tonometer tip. The apparatus further includes an adjustment mechanism in communication with the tonometer for positioning the tonometer tip in contact with a test eye of the user, and an illuminator mounted within the housing adjacent the tonometer tip. A receiver is aligned with the tonometer tip for receiving an applanation pattern created by contact of the tonometer tip with the test eye, and a display is provided in communication with the receiver for displaying the applanation pattern to an observing eye of the user. The intraocular pressure of the test eye is determined from a force applied by the tonometer tip upon observation of a selected applanation pattern by the observing eye.
摘要翻译：用于眼内自我测量的装置和方法利用设置在壳体内并具有眼压计尖端的眼压计。该装置还包括与眼压计连通的调节机构，用于将眼压计尖端定位成与用户的测试眼接触，以及安装在邻近眼压计尖端的壳体内的照明器。接收器与眼压计尖端对齐，用于接收通过眼压计尖端与测试眼睛的接触而产生的压平图案，并且提供与接收器通信的显示器，用于向用户的观察眼睛显示压平图案。通过观察眼观察选定的压平图案，由眼压计尖端施加的力确定测试眼睛的眼内压。

34. 发明授权

US07133712B2 Method and apparatus for non-invasive monitoring of blood substances using self-sampled tears 有权
公开(公告)号：US07133712B2
公开(公告)日：2006-11-07
申请号：US10404702
申请日：2003-04-01
申请人： Bruce E. Cohan , Geun Sig Cha , Mark E. Meyerhoff , Hakhyun Nam , Donald E. Gillespie , Gang Cui , Jong Sik Kim , Zvi Flanders
发明人： Bruce E. Cohan , Geun Sig Cha , Mark E. Meyerhoff , Hakhyun Nam , Donald E. Gillespie , Gang Cui , Jong Sik Kim , Zvi Flanders
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： C12Q1/006 , A61B5/1486 , A61B2562/0295 , C12Q1/32 , C12Q1/54 , G01N27/3272 , G01N33/528 , G01N2001/1056 , G01N2001/149 , G01N2035/0465 , Y10T436/144444
摘要： A method and apparatus for non-invasively determining the concentration of a substance in blood, such as glucose, include a sample portion arranged for contacting an eye region of a user to obtain a tear fluid sample, a sensor in communication with the sample portion for generating a signal related to the tear substance concentration, and a processor in communication with the sensor for determining a blood substance concentration corresponding to the tear substance concentration.

35. 发明公开

EP2335030A4 SYSTEM AND METHOD FOR DETERMINING VOLUME-RELATED PARAMETERS OF OCULAR AND OTHER BIOLOGICAL TISSUES 审中-公开
标题翻译：系统和方法测定生物组织和其它目镜量相关的参数
公开(公告)号：EP2335030A4
公开(公告)日：2014-05-07
申请号：EP09767725
申请日：2009-06-18
申请人： EYELAB GROUP LLC
发明人： DILWORTH DAVID S , COHAN BRUCE E , FLANDERS ZVI , PESHKIN HANNAH R
IPC分类号： G01D9/02 , A61B3/00 , A61B3/10 , A61B3/12 , A61B5/00 , A61B5/107
CPC分类号： A61B3/1005 , A61B3/0025 , A61B3/12 , A61B5/0075 , A61B5/1072 , A61B5/1079 , A61B5/7235

36. 发明公开

EP1891942A1 Opthalmic insert and method for sustained release of medication to the eye 有权
标题翻译： Ophthalmischer Einsatz und Verfahren zur stetigenZuführungeines Arzneimittels ins Auge
公开(公告)号：EP1891942A1
公开(公告)日：2008-02-27
申请号：EP07012726.1
申请日：2000-04-07
申请人： Eyelab Group, LLC
发明人： Cohan, Bruce E. , Diamond, Howard
IPC分类号： A61K9/22 , A61K9/20 , A61F9/00
CPC分类号： A61F9/0017 , A61F9/00772 , A61K9/0051 , Y10S977/904
摘要： An ophthalmic insert (24) and method for sustained release of medication to the eye are provided. The insert (24) includes a body portion (30) sized to pass through a lacrimal punctum (14, 16) and be positioned within a lacrimal canaliculus (18, 20) of the eyelid. The insert further includes a collarette (26) connected to the body portion (30) and sized to rest on the exterior of the lacrimal punctum, the collarette having a pore (42) provided therein. A reservoir (34) is contained at least partially within the body portion (30) and in fluid communication with the pore (42), wherein the reservoir (34) is designed to store and release medication through the pore (42) and onto the eye over time in a controlled manner while the insert (24) is positioned in the eyelid. Preferably, the pore (42) is constructed with a specific geometry appropriate to control the rate of release of the medication onto the eye.
摘要翻译：提供了眼用插入物（24）和用于将药物持续释放到眼睛的方法。插入物（24）包括主体部分（30），其尺寸设置成穿过泪点（14,16）并且位于眼睑的泪小管（18,20）内。所述插入件还包括连接到所述主体部分（30）并且尺寸适于搁置在泪点的外部上的围兜（26），所述小口罩具有设置在其中的孔（42）。储存器（34）至少部分地容纳在主体部分（30）内并且与孔（42）流体连通，其中储存器（34）被设计成通过孔（42）存储和释放药物并且到达当插入物（24）位于眼睑中时，以受控的方式随着时间的过去。优选地，孔（42）以适合于控制药物释放到眼睛上的速率的特定几何结构构成。

37. 发明公开

EP1178779A4 OPHTHALMIC INSERT AND METHOD FOR SUSTAINED RELEASE OF MEDICATION TO THE EYE 无效
标题翻译： EYES INSERT和方法为药物EYE延迟释放
公开(公告)号：EP1178779A4
公开(公告)日：2005-01-12
申请号：EP00921783
申请日：2000-04-07
申请人： EYELAB GROUP LLC
发明人： COHAN BRUCE E , DIAMOND HOWARD
IPC分类号： A61F9/00 , A61F9/007 , A61K9/00 , A61K9/22 , A61K9/20
CPC分类号： A61F9/0017 , A61F9/00772 , A61K9/0051 , Y10S977/904
摘要： An ophthalmic insert (24) and method for sustained release of medication to the eye are provided. The insert (24) includes a body portion (30) sized to pass through a lacrimal punctum (14, 16) and be positioned within a lacrimal canaliculus (18, 20) of the eyelid. The insert further includes a collarette (26) connected to the body portion (30) and sized to rest on the exterior of the lacrimal punctum, the collarette having a pore (42) provided therein. A reservoir (34) is contained at least partially within the body portion (30) and in fluid communication with the pore (42), wherein the reservoir (34) is designed to store and release medication through the pore (42) and onto the eye over time in a controlled manner while the insert (24) is positioned in the eyelid. Preferably, the pore (42) is constructed with a specific geometry appropriate to control the rate of release of the medication onto the eye.

38. 发明授权

US09050025B2 System and method for determining volume-related parameters of ocular and other biological tissues 有权
标题翻译：用于确定眼部和其他生物组织的体积相关参数的系统和方法
公开(公告)号：US09050025B2
公开(公告)日：2015-06-09
申请号：US12487143
申请日：2009-06-18
申请人： David S. Dilworth , Bruce E. Cohan , Zvi Flanders , Hannah R. Peshkin
发明人： David S. Dilworth , Bruce E. Cohan , Zvi Flanders , Hannah R. Peshkin
IPC分类号： A61B6/00 , A61B3/10 , A61B3/00 , A61B3/12 , A61B5/00 , A61B5/107
CPC分类号： A61B3/1005 , A61B3/0025 , A61B3/12 , A61B5/0075 , A61B5/1072 , A61B5/1079 , A61B5/7235
摘要： A system and method for determining volume-related parameters of a biological tissue, such as ocular tissue, include a light source for projecting light towards the biological tissue, a receiver for receiving light reflected from the biological tissue at two spectral wavelengths, and an image acquisition system in communication with the receiver for forming an image from the reflected light at each wavelength. A processor applies a mathematical model to the image which compares the absorption of light by the biological tissue at a selected image point at each of the two spectral wavelengths to determine the volume-related parameters, such as the relative thickness and material properties, of the biological tissue at that location.
摘要翻译：用于确定诸如眼组织的生物组织的体积相关参数的系统和方法包括用于将光投射到生物组织的光源，用于接收以两个光谱波长从生物组织反射的光的接收器，以及图像与接收器通信的采集系统，用于从每个波长处的反射光形成图像。处理器将数学模型应用于图像，其比较在两个光谱波长中的每一个处的选定图像点处的生物组织对光的吸收，以确定体积相关参数，例如相对厚度和材料性质生物组织在那个位置。

39. 发明申请

US20130317335A1 Applanation Tonometry Apparatus and Case for Transport and Use Thereof 审中-公开
标题翻译：用于运输和使用的测量测量仪器和外壳
公开(公告)号：US20130317335A1
公开(公告)日：2013-11-28
申请号：US13888850
申请日：2013-05-07
申请人： EYELAB GROUP, LLC
发明人： Bruce E. Cohan , John T. Savina , Zvi Flanders
IPC分类号： A61B19/02 , A61B3/16
CPC分类号： A61B3/16 , A61B50/10 , A61B50/13 , A61B50/15 , A61B90/50
摘要： A case for transportation and use of an applanation tonometry apparatus includes a housing including a base and a wall structure extending upwardly therefrom, the housing sized to receive the applanation tonometry apparatus therein. A lid is pivotally connected to an upper rim of the wall structure, the lid having a closed position overlying the housing and an open position rotated away from the housing, the lid supporting the applanation tonometry apparatus in the open position. A handle is pivotally connected to the lid and has a stored position within the lid and a use position rotated away from the lid, the handle supporting the lid in the open position by engagement with a support surface.
摘要翻译：用于输送和使用压扁眼压测量装置的壳体包括壳体，该壳体包括基部和从其向上延伸的壁结构，壳体的尺寸适于在其中容纳压扁眼压测量装置。盖子枢转地连接到壁结构的上边缘，盖子具有覆盖壳体的封闭位置和离开壳体旋转的打开位置，盖子将压平眼压测量装置支撑在打开位置。手柄枢转地连接到盖子并且具有在盖内的存储位置和远离盖旋转的使用位置，手柄通过与支撑表面的接合而将盖子支撑在打开位置。

40. 发明授权

US07556380B2 Apparatus and method for self-measurement of intraocular pressure 失效
标题翻译：眼压自我测量的装置和方法
公开(公告)号：US07556380B2
公开(公告)日：2009-07-07
申请号：US10598002
申请日：2003-10-20
申请人： Bruce E. Cohan , Andrew C. Pearch , Zvi Flanders , Donald E. Gillespie
发明人： Bruce E. Cohan , Andrew C. Pearch , Zvi Flanders , Donald E. Gillespie
IPC分类号： A61B3/02 , A61B3/10
CPC分类号： A61B3/16
摘要： An apparatus and method for the self-measurement of intraocular pressure utilize a tonometer disposed within a housing and having a tonometer tip. The apparatus further includes an adjustment mechanism in communication with the tonometer for positioning the tonometer tip in contact with a test eye of the user, and an illuminator mounted within the housing adjacent the tonometer tip. A receiver is aligned with the tonometer tip for receiving an applanation pattern created by contact of the tonometer tip with the test eye, and a display is provided in communication with the receiver for displaying the applanation pattern to an observing eye of the user. The intraocular pressure of the test eye is determined from a force applied by the tonometer tip upon observation of a selected applanation pattern by the observing eye.
摘要翻译：用于眼内自我测量的装置和方法利用设置在壳体内并具有眼压计尖端的眼压计。该装置还包括与眼压计连通的调节机构，用于将眼压计尖端定位成与用户的测试眼接触，以及安装在邻近眼压计尖端的壳体内的照明器。接收器与眼压计尖端对齐，用于接收通过眼压计尖端与测试眼睛的接触而产生的压平图案，并且提供与接收器通信的显示器，用于向用户的观察眼睛显示压平图案。通过观察眼观察选定的压平图案，由眼压计尖端施加的力确定测试眼睛的眼内压。

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