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31. 发明授权

US08524709B2 Kinase inhibitor compounds 有权
公开(公告)号：US08524709B2
公开(公告)日：2013-09-03
申请号：US13349222
申请日：2012-01-12
申请人： Congxin Liang , Ming Qi , Shu Gao , Zhigang Li
发明人： Congxin Liang , Ming Qi , Shu Gao , Zhigang Li
IPC分类号： A61K31/5377 , A61K31/404 , A61K31/454 , A61K31/506 , A61K31/4545 , C07D401/14 , C07D413/14 , C07D403/06
CPC分类号： C07D493/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C12Q1/485
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.

32. 发明授权

US08513221B2 PI3K isoform selective inhibitors 失效
标题翻译： PI3K同种型选择性抑制剂
公开(公告)号：US08513221B2
公开(公告)日：2013-08-20
申请号：US12999032
申请日：2009-07-07
申请人： Congxin Liang , Zhigang Li
发明人： Congxin Liang , Zhigang Li
IPC分类号： C07D413/14
CPC分类号： C07D487/04 , C07D473/32 , C07D519/00
摘要： 2-Morpholin-4-yl-9H-purine and 5-Morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine derivatives, especially those substituted by 6-heteroaryl, are unexpected PI3 kinase isoform selective inhibitors with good drug properties and are useful in treating disorders related to abnormal PI3K activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.
摘要翻译： 2-吗啉-4-基-9H-嘌呤和5-吗啉-4-基-3H- [1,2,3]三唑并[4,5-d]嘧啶衍生物，特别是被6-杂芳基取代的那些，是意想不到的具有良好药物性质的PI3激酶同种型选择性抑制剂，并且可用于治疗与异常PI3K活性相关的疾病，例如癌症，免疫疾病，心血管疾病，病毒感染，炎症，代谢/内分泌障碍和神经障碍。

33. 发明申请

US20120312809A1 MICROWAVE OVEN 审中-公开
标题翻译：微波炉
公开(公告)号：US20120312809A1
公开(公告)日：2012-12-13
申请号：US13591041
申请日：2012-08-21
申请人： Shouguo WANG , Zhigang Li , Zongyin Ou , Deqiang Tan
发明人： Shouguo WANG , Zhigang Li , Zongyin Ou , Deqiang Tan
IPC分类号： H05B6/64
CPC分类号： H05B6/6426
摘要： A microwave oven includes an oven seat, an oven cover hinged on the oven seat and a cooking chamber enclosed by the oven seat and oven cover. The oven cover comprises, in this order from an inner side to an outer side, a waterproof cover, a microwave shielding cover and an outer cover that are formed respectively in a hemispherical shape and assembled together via an oven cover skeleton and a skeleton frame. The oven cover skeleton includes an annular base body with an assembly groove to allow the waterproof cover to be wedged therein. The waterproof cover has a first flange to be wedged in the assembly groove. The microwave shielding cover has a second flange to be pressed on the base body. The skeleton frame is coupled on the outer side of the microwave shield cover and pressed on the second flange and oven cover skeleton.
摘要翻译：微波炉包括烤箱座，铰接在烤箱座上的烤箱盖和由烤箱座和烘箱盖包围的烹饪室。烤箱盖从内侧到外侧依次包括分别形成为半球状的防水罩，微波屏蔽罩和外盖，并且经由烤箱罩框架和骨架框架组装在一起。烘箱盖骨架包括具有组装槽的环形基体，以允许防水盖楔入其中。防水盖具有楔入组装槽中的第一凸缘。微波屏蔽罩具有被压在基体上的第二凸缘。骨架框架耦合在微波屏蔽罩的外侧，并被压在第二凸缘和烤箱盖骨架上。

34. 发明申请

US20120259361A1 SUTURE ANCHOR WITH IMPROVED TORSIONAL DRIVE HEAD 审中-公开
标题翻译：具有改进的扭转驱动头的SUTURE锚固器
公开(公告)号：US20120259361A1
公开(公告)日：2012-10-11
申请号：US13494395
申请日：2012-06-12
申请人： Joseph H. Contiliano , Yufu Li , Zhigang Li , Nathan Cauldwell
发明人： Joseph H. Contiliano , Yufu Li , Zhigang Li , Nathan Cauldwell
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B2017/00004 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/044
摘要： The present invention provides a suture anchor that includes an elongate shank defining a longitudinal axis and having at least one engaging member for applying the suture anchor within the bone and securing the suture anchor in the bone once implanted formed thereon, and a drive head having a proximal end, a distal end and a radial cross-sectional geometry, where the drive head is mated to the elongate shank, includes at least one suture attachment element formed in a portion thereof and at least one anti-rotational member integral therewith, suture anchor kits utilizing the suture anchors and methods of attaching bone to gone.
摘要翻译：本发明提供了一种缝合锚，其包括限定纵向轴线的细长柄，并且具有至少一个接合构件，用于将缝合锚固件施加在骨骼内，并且一旦植入其中就将缝合锚定固定在骨骼中，并且具有近端，远端和径向横截面几何形状，其中驱动头配合到细长柄部，包括形成在其一部分中的至少一个缝合线附接元件和与其成一体的至少一个抗旋转构件，缝合锚使用缝合锚的工具和附着骨的方法。

35. 发明申请

US20110249284A1 AUTOMATED ASSISTIVE TECHNOLOGY FOR THE VISUALLY IMPAIRED 有权
标题翻译：自动辅助技术的视觉受损
公开(公告)号：US20110249284A1
公开(公告)日：2011-10-13
申请号：US13045347
申请日：2011-03-10
申请人： Richard James Seabright , Zhigang Li
发明人： Richard James Seabright , Zhigang Li
IPC分类号： G06F15/00 , G06F3/12
CPC分类号： G06F17/2705 , G06F3/1206 , G06F3/1208 , G06F3/1244 , G06F3/1245 , G06F3/1246 , G06F3/1257 , G06F17/212 , G06F17/218 , G06F17/2247 , G06F17/245 , G06F17/248
摘要： Disclosed are methods and apparatus for generating accessible documents. In one embodiment, an initial document in a print format is obtained. The print format of the initial document is identified as one of a plurality of print formats. A parser corresponding to the one of the plurality of print formats is applied such that the initial document is parsed according to the print format of the initial document. An intermediate document that conforms to an intermediate format is generated based upon results obtained from applying the parser. A template for converting the intermediate document into an accessible document is obtained. The template is then such that an accessible document corresponding to the initial document is generated, wherein the accessible document includes a plurality of tags that designate an order of a plurality of regions of the accessible document.
摘要翻译：公开了用于生成可访问文档的方法和装置。在一个实施例中，获得打印格式的初始文档。初始文档的打印格式被识别为多种打印格式之一。应用与多个打印格式之一相对应的解析器，使得根据初始文档的打印格式解析初始文档。基于从应用解析器获得的结果生成符合中间格式的中间文档。获得用于将中间文档转换为可访问文档的模板。模板然后使得生成与初始文档相对应的可访问文档，其中可访问文档包括指定可访问文档的多个区域的顺序的多个标签。

36. 发明申请

US20110224212A1 KINASE INHIBITOR COMPOUNDS 审中-公开
标题翻译：激酶抑制剂化合物
公开(公告)号：US20110224212A1
公开(公告)日：2011-09-15
申请号：US13108598
申请日：2011-05-16
申请人： Congxin Liang , Ming Qi , Shu Gao , Zhigang Li
发明人： Congxin Liang , Ming Qi , Shu Gao , Zhigang Li
IPC分类号： A61K31/5377 , A61K31/407 , A61K31/454 , A61K31/506 , A61K31/422 , A61P35/00
CPC分类号： C07D493/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C12Q1/485
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.
摘要翻译：本发明涉及化合物，包含该化合物的组合物，以及使用该化合物和化合物组合物的方法。本文所述的化合物，组合物和方法可用于激酶介导的过程的治疗调节，以及疾病和疾病症状的治疗，特别是由某些激酶的介导的那些症状。

37. 发明申请

US20110022007A1 OPHTHALMIC DEVICES FOR THE CONTROLLED RELEASE OF ACTIVE AGENTS 有权
标题翻译：用于控制释放活性剂的透明设备
公开(公告)号：US20110022007A1
公开(公告)日：2011-01-27
申请号：US12779238
申请日：2010-05-13
申请人： Zhigang Li , Michael J. Trezza, II , Maureen J. Borgia , Aruna Nathan , Bret A. Coldren
发明人： Zhigang Li , Michael J. Trezza, II , Maureen J. Borgia , Aruna Nathan , Bret A. Coldren
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61F9/00772 , A61F2250/0068 , A61K9/0043 , A61K9/0051
摘要： The invention provides devices useful for the delivery of active agents to the eye in a controlled manner. In the devices of the invention, the active agent is present within the device in a continuous or discontinuous concentration gradient.
摘要翻译：本发明提供了用于以受控方式将活性剂递送至眼睛的装置。在本发明的装置中，活性剂以连续或不连续的浓度梯度存在于装置内。

38. 发明申请

US20080045911A1 PUNCTAL PLUGS FOR THE DELIVERY OF ACTIVE AGENTS 审中-公开
标题翻译：用于交付活性药剂的阴囊
公开(公告)号：US20080045911A1
公开(公告)日：2008-02-21
申请号：US11759281
申请日：2007-06-07
申请人： Maureen Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael Trezza
发明人： Maureen Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael Trezza
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61F9/00772 , A61K9/0004 , A61K9/0051
摘要： The invention provides punctal plugs for the delivery of active agents. The plugs have a body throughout which at least one active agent is dispersed or that is coated with a polymeric material containing at least one active agent.
摘要翻译：本发明提供用于递送活性剂的泪点塞。塞子具有主体，至少一种活性剂分散在其中，或者涂覆有含有至少一种活性剂的聚合材料。

39. 发明授权

US07257897B2 Trimmer for cutting a coiled strand 有权
标题翻译：切割卷曲线的修剪器
公开(公告)号：US07257897B2
公开(公告)日：2007-08-21
申请号：US10302535
申请日：2002-11-22
申请人： Zhigang Li , Yufu Li , Ronald W Marsh , Kevor S. Tenhuisen
发明人： Zhigang Li , Yufu Li , Ronald W Marsh , Kevor S. Tenhuisen
IPC分类号： B26B13/00
CPC分类号： A61B17/8863 , A61B17/0467 , A61B17/32 , A61F2/88 , B21F11/005 , B21F45/008 , B23D29/023 , Y10S83/907
摘要： A cutting device for trimming a coiled strand, such as an arterial, urinary or other intraluminal stent made from metal or plastic wire, has a pair of articulating arms connected at a pivot joint. One of the arms has a holding jaw for holding the coiled strand. A second of the arms has a jaw with a cutter. The holding jaw has a passageway through which the coiled strand may be threaded to aid in holding the coiled strand for cutting by the cutter. The holding jaw preferably has a guide channel formed by a pair of tapered walls that slide between adjacent turns of the coiled strand. In accordance with a method of the invention, an end of the coiled strand is introduced through the passageway in the holding jaw. The coiled strand is rotated to advance the coiled strand through the passageway until the coiled strand is positioned beneath the cutting jaw at the selected location. The lever portions and the jaw portions are then urged together, cutting the coiled strand at the selected location.
摘要翻译：用于修整卷绕股线的切割装置，例如由金属或塑料线制成的动脉，尿液或其他管腔内支架，具有连接在枢转关节处的一对关节臂。其中一个臂具有用于固定线圈的保持爪。第二个手臂有一个钳子与一个钳子。保持爪具有通道，通过该通道可以使卷绕的线可以被螺纹连接以帮助保持卷绕的线以便切割器进行切割。保持夹爪优选地具有由一对锥形壁形成的引导通道，所述一对锥形壁在螺旋绞线的相邻匝之间滑动。根据本发明的方法，卷绕股线的端部通过保持夹爪中的通道被引入。旋转线圈以使线圈股线通过通道，直到线圈股线在选定位置处位于切割钳口下方。杠杆部分和钳口部分然后被推到一起，在所选择的位置切割线圈股。

40. 发明授权

US09521710B2 Door opening structure for microwave oven 有权
标题翻译：微波炉开门结构
公开(公告)号：US09521710B2
公开(公告)日：2016-12-13
申请号：US14117243
申请日：2012-01-30
申请人： Zhigang Li , Zhihua Chen , Jie Li , Cheng Jiang
发明人： Zhigang Li , Zhihua Chen , Jie Li , Cheng Jiang
IPC分类号： H05B6/64 , E05F5/00 , F24C15/02 , E05F1/12 , A47J36/12
CPC分类号： H05B6/6414 , A47J36/12 , E05F1/1215 , E05F5/00 , E05Y2201/20 , E05Y2201/21 , E05Y2201/256 , E05Y2201/264 , E05Y2900/308 , F24C15/023
摘要： A door opening structure for microwave oven includes an upper hinge fastened on a door body assembly, and a lower hinge fastened on a oven body of a microwave oven, wherein the door body assembly is hinged with the oven body by the upper hinge and the lower hinge. An elastic element is provided between the upper hinge and the lower hinge, and the upper hinge is connected with a damper. Both ends of the upper hinge are provided with first connectors that are hinged with the lower hinge, and the middle portion of the upper hinge is provided with second connectors that are hinged with one end of the damper by spring pins.
摘要翻译：用于微波炉的门开口结构包括紧固在门体组件上的上铰链和紧固在微波炉的炉体上的下铰链，其中门体组件通过上铰链和下铰链铰接在烤箱本体上合页。弹性元件设置在上铰链和下铰链之间，上铰链与阻尼器连接。上铰链的两端设置有与下铰链铰接的第一连接器，并且上铰链的中间部分设置有第二连接器，其通过弹簧销与阻尼器的一端铰接。

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