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31. 发明申请

US20050097756A1 Utility knife with quick release housing 审中-公开
标题翻译：实用刀具快速释放外壳
公开(公告)号：US20050097756A1
公开(公告)日：2005-05-12
申请号：US11014510
申请日：2004-12-16
申请人： Donald Gringer , Yuan Cheng
发明人： Donald Gringer , Yuan Cheng
IPC分类号： B26B5/00 , B26B1/08
CPC分类号： B26B5/003
摘要： A cutting device includes (i) a housing having first and second separable portions, the first portion having a locking aperture, the second portion having an attachment aperture, and (ii) a locking apparatus for removably locking the first and second portions of the housing. The locking apparatus includes an attachment portion for being fixedly attached in the attachment aperture, and a locking arm adapted to be releasably locked into the locking aperture. The attachment aperture and locking aperture are correspondingly positioned so that the locking arm becomes aligned with the locking aperture when the first and second portions of the housing are aligned for assembly. The housing may be constructed of metal, and the locking apparatus constructed of plastic. The locking apparatus may also include a return spring and blade carrier integrally molded therewith. In one embodiment, the locking arm includes i) an upstanding portion oriented generally perpendicular to an axis of the housing, ii) an actuating arm extending laterally from a free end of the upstanding portion, so that downward force on the actuating arm causes a bending of the upstanding portion, and iii) a locking lip toward the free end of the upstanding portion extending laterally in a direction opposite to the direction of bending of the upstanding portion.
摘要翻译：切割装置包括（i）具有第一和第二可分离部分的壳体，第一部分具有锁定孔，第二部分具有附接孔，和（ii）锁定装置，用于可拆卸地锁定壳体的第一和第二部分。锁定装置包括用于固定地附接在附接孔中的附接部分和适于可释放地锁定到锁定孔中的锁定臂。相应地定位安装孔和锁定孔，使得当壳体的第一和第二部分对齐以用于组装时，锁定臂与锁定孔对准。外壳可以由金属构成，锁定装置由塑料构成。锁定装置还可以包括与其一体模制的复位弹簧和刀片架。在一个实施例中，锁定臂包括：i）大致垂直于壳体的轴线定向的直立部分，ii）从直立部分的自由端横向延伸的致动臂，使得致动臂上的向下的力导致弯曲以及iii）朝向直立部分的自由端的锁定唇缘，其在与直立部分的弯曲方向相反的方向上横向延伸。

32. 发明授权

US06642237B1 Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamides and uses thereof 失效
标题翻译： γ-羟基-2-（氟烷基氨基羰基）-1-哌嗪烷酰胺及其用途
公开(公告)号：US06642237B1
公开(公告)日：2003-11-04
申请号：US09718223
申请日：2000-11-21
申请人： James R. Tata , Kevin T. Chapman , Joseph Leslie Duffy , Nancy J. Kevin , Yuan Cheng , Thomas A. Rano , Fengqi Zhang , Tracy Huening , Brian Anthony Kirk , Zhijian Lu , Subharekha Raghavan , Fred J. Fleitz , Daniel E. Petrillo , Joseph D. Armstrong, III , Richard J. Varsolona , David Askin , R. Scott Hoerrner , Robert Purick
发明人： James R. Tata , Kevin T. Chapman , Joseph Leslie Duffy , Nancy J. Kevin , Yuan Cheng , Thomas A. Rano , Fengqi Zhang , Tracy Huening , Brian Anthony Kirk , Zhijian Lu , Subharekha Raghavan , Fred J. Fleitz , Daniel E. Petrillo , Joseph D. Armstrong, III , Richard J. Varsolona , David Askin , R. Scott Hoerrner , Robert Purick
IPC分类号： C07D491048
CPC分类号： C07D401/06 , A61K31/00 , A61K45/06 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/04 , C07D495/04 , A61K2300/00
摘要： &ggr;-Hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamide compounds are inhibitors of HIV protease and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. These compounds are effective against HIV viral mutants which are resistant to HIV protease inhibitors currently used for treating AIDS and HIV infection.
摘要翻译： γ-羟基-2-（氟烷基氨基羰基）-1-哌嗪戊酰胺化合物是HIV蛋白酶和HIV复制抑制剂的抑制剂。这些化合物可用于预防或治疗HV的感染和治疗AIDS，无论是化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒剂，免疫调节剂，抗生素或疫苗结合使用。还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。这些化合物对HIV病毒突变体有效，其对目前用于治疗AIDS和HIV感染的HIV蛋白酶抑制剂具有抗性。

33. 发明申请

US20200324775A1 METHOD FOR AUTONOMOUS CARS TO CHANGE LANES ON MOTORWAYS 审中-公开
公开(公告)号：US20200324775A1
公开(公告)日：2020-10-15
申请号：US16383601
申请日：2019-04-13
申请人： Henry Schellhorn , Yuan Cheng
发明人： Henry Schellhorn , Yuan Cheng
IPC分类号： B60W30/18 , G08G1/16 , G05D1/00 , G08G1/01
摘要： A method for autonomous vehicles to change lanes on a motorway may include steps of providing a computer system enabling an incoming vehicle that conducts lane change to negotiate with an incumbent vehicle that stays in its lane; generating first synchronous data on traffic density and traffic speed to the vehicles in both the transversal and longitudinal directions on the motorway; generating second synchronous data on traffic density and traffic speed to said vehicles for vehicles entering on the motorway and exiting the motorway; providing a summary of historical statistics on the first and second synchronous data to the vehicles; calculating a fair price of each lane of the motorway at a predetermined location, at a predetermined time and within a predetermined tolerance; and generating a protocol to change lanes, wherein said incoming vehicle pays said incumbent vehicle the fair price to move in front of the incumbent vehicle.

34. 发明授权

US08822485B2 Amino heteroaryl compounds as beta-secretase modulators and methods of use 有权
标题翻译：氨基杂芳基化合物作为β-分泌酶调节剂和使用方法
公开(公告)号：US08822485B2
公开(公告)日：2014-09-02
申请号：US13511360
申请日：2010-11-19
申请人： Nick A. Paras , Yuan Cheng , Timothy Powers , James Brown , Stephen A. Hitchcock , Ted Judd , Patricia Lopez , Qiufen Xue , Bryant Yang
发明人： Nick A. Paras , Yuan Cheng , Timothy Powers , James Brown , Stephen A. Hitchcock , Ted Judd , Patricia Lopez , Qiufen Xue , Bryant Yang
IPC分类号： A61K31/505
CPC分类号： C07D401/06 , C07D401/12 , C07D401/14
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I, wherein ring A, B1, B2, B3, L, R1, R4, ring Z, m and p of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。在一个实施方案中，化合物具有通式I，其中式I的环A，B 1，B 2，B 3，L，R 1，R 4，环Z，m和p如本文所定义。本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。这些疾病包括例如阿尔茨海默氏病（AD），认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。本发明还包括式I的其它实施方案，可用于制备式I化合物的中间体和方法。

35. 发明授权

US08447013B2 Multibeam x-ray source with intelligent electronic control systems and related methods 有权
标题翻译：具有智能电子控制系统的多光束X射线源及相关方法
公开(公告)号：US08447013B2
公开(公告)日：2013-05-21
申请号：US13069286
申请日：2011-03-22
申请人： Frank Sprenger , Moritz Beckmann , Yuan Cheng , Houman Jafari
发明人： Frank Sprenger , Moritz Beckmann , Yuan Cheng , Houman Jafari
IPC分类号： H01J35/00
CPC分类号： H01J35/065 , A61B6/4028 , A61B6/4064 , H01J35/04 , H01J35/14 , H01J2201/30469 , H01J2235/062 , H01J2235/068 , H05G1/30
摘要： Multibeam field emission x-ray systems and related methods can include cathode elements, an anode assembly spaced from the plurality of cathode elements, and an extraction gate positioned between the plurality of cathode elements and the anode assembly. A potential difference can be applied between the extraction gate and at least one of the cathode elements to cause an emission of electrons from the respective cathode elements. Emission characteristics of the cathode elements can be measured, and the potential difference between the extraction gate and at least one of the cathode elements can be adjusted based on the emission characteristics measured.
摘要翻译：多光束场发射x射线系统和相关方法可以包括阴极元件，与多个阴极元件间隔开的阳极组件，以及位于多个阴极元件和阳极组件之间的提取门。可以在提取栅极和至少一个阴极元件之间施加电位差以引起来自各个阴极元件的电子的发射。可以测量阴极元件的发射特性，并且可以基于测量的发射特性来调节提取栅极和至少一个阴极元件之间的电势差。

36. 发明申请

US20130072483A1 SUBSTITUTED HYDROXYETHYL AMINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE 有权
标题翻译：取代的羟基乙胺化合物作为β-分泌酶调节剂和使用方法
公开(公告)号：US20130072483A1
公开(公告)日：2013-03-21
申请号：US13427802
申请日：2012-03-22
申请人： Wenge ZHONG , Stephen Hitchcock , Vinod F. Patel , Michael Croghan , Thomas Dineen , Daniel Horne , Matthew Kaller , Charles Kreiman , Patricia Lopez , Holger Monenschein , Thomas Nguyen , Lewis Pennington , Qiufen Xue , Bryant Yang , Yuan Cheng
发明人： Wenge ZHONG , Stephen Hitchcock , Vinod F. Patel , Michael Croghan , Thomas Dineen , Daniel Horne , Matthew Kaller , Charles Kreiman , Patricia Lopez , Holger Monenschein , Thomas Nguyen , Lewis Pennington , Qiufen Xue , Bryant Yang , Yuan Cheng
IPC分类号： C07D491/107 , C07D471/10 , C07D311/96
CPC分类号： C07D491/107 , C07D221/06 , C07D311/96 , C07D471/10 , C07D491/10 , C07D493/10 , C07D495/10
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein R1a, R1b, R1c, B, W, R3, R4 and R5 are defined herein. In another embodiment, the invention provides compounds of general Formula II wherein A1, A2, A3, A4, R1a, R1b, R1c, R2, R4, R5, W, X and Z are defined herein.The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits and impairment, schizophrenia and other similar central nervous system conditions. The invention also comprises further embodiments of Formula II, intermediates and processes useful for the preparation of compounds of Formulas I and II.
摘要翻译：本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。在一个实施方案中，化合物具有通式I，其中R 1a，R 1b，R 1c，B，W，R 3，R 4和R 5在本文中定义。在另一个实施方案中，本发明提供通式II的化合物，其中A1，A2，A3，A4，R1a，R1b，R1c，R2，R4，R5，W，X和Z如本文所定义。本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。这些疾病包括例如阿尔茨海默病（AD），认知缺陷和损伤，精神分裂症和其他类似的中枢神经系统疾病。本发明还包括式II的其它实施方案，可用于制备式I和II化合物的中间体和方法。

37. 发明申请

US20110029625A1 METHOD AND SYSTEM FOR PROCESSING EMAIL ATTACHMENTS 审中-公开
标题翻译：处理电子邮件附件的方法和系统
公开(公告)号：US20110029625A1
公开(公告)日：2011-02-03
申请号：US12845111
申请日：2010-07-28
申请人： Yuan Cheng , Yue Ma , Shuang Qin , Min Qu
发明人： Yuan Cheng , Yue Ma , Shuang Qin , Min Qu
IPC分类号： G06F15/16
CPC分类号： G06Q10/107
摘要： The present invention provides a method and system for processing email attachments. The method includes determining that a local file is attached as an email attachment in the email; creating a corresponding relationship record of the email attachment and the local file; determining that the email attachment is modified; and replacing the local file with the modified email attachment according to the corresponding relationship record automatically.
摘要翻译：本发明提供了一种处理邮件附件的方法和系统。该方法包括确定本地文件作为电子邮件附件附加在电子邮件中; 创建电子邮件附件和本地文件的对应关系记录; 确定电子邮件附件被修改; 并根据相应的关系记录自动替换本地文件与修改的电子邮件附件。

38. 发明申请

US20080114875A1 METHODS AND APPARATUS FOR REAL USER MONITORING 有权
标题翻译：用于真实用户监控的方法和设备
公开(公告)号：US20080114875A1
公开(公告)日：2008-05-15
申请号：US11877804
申请日：2007-10-24
申请人： Paul Anastas , William Ryan Breen , Yuan Cheng , Allen Lieberman , Imad Mouline
发明人： Paul Anastas , William Ryan Breen , Yuan Cheng , Allen Lieberman , Imad Mouline
IPC分类号： G06F15/16 , G06F15/173
CPC分类号： G06F17/30896 , G06Q30/02
摘要： A system monitors browser operation on a web page to identify objects referenced by the web page. For objects referenced by the web page, the system tracks a performance metric associated with each object. The system performs post-processing on the performance metrics of objects referenced by the web page to create a performance record for that web page, and transfers the performance record to a remote server for analysis of performance of web page operation in the browser.
摘要翻译：系统监视网页上的浏览器操作，以识别网页引用的对象。对于网页引用的对象，系统会跟踪与每个对象相关联的性能指标。系统对网页引用的对象的性能指标执行后处理，以创建该网页的性能记录，并将性能记录传输到远程服务器，以分析浏览器中网页操作的性能。

39. 发明申请

US20070295768A1 MULTIFUNCTION POURING SPOUT WITH PIVOTING HANDLE 有权
标题翻译：多功能甩卖手柄
公开(公告)号：US20070295768A1
公开(公告)日：2007-12-27
申请号：US11778168
申请日：2007-07-16
申请人： Donald Gringer , Yuan Cheng
发明人： Donald Gringer , Yuan Cheng
IPC分类号： A47G19/14 , B65D5/72 , B65D25/40 , B65D25/00
CPC分类号： B44D3/127 , B44D3/128 , B44D3/14 , B65D25/2829 , B65D25/48
摘要： An inventive pouring spout that is selectively attachable to a container and fitted to the opening of the container with which it is used. In a preferred embodiment, the pouring spout is fitted to the dimensions of a one-quart container and includes a wall, a sealing member, a mouth and a handle. The handle is connected to the wall with a hinge that enables the handle to pivot away from the container to allow the sealing member to be appropriately positioned while the container rests flat on a surface. After the sealing member is in place, the handle is then pivoted back in position to securely hold the container. The handle includes a plurality of upwardly extending projections adapted to securely engage the bottom rim of the container. Furthermore, thermoplastic material is applied at the handle area forming a handle cover that is comfortable and easy to grip. Thermoplastic material is also preferably utilized in the construction of the sealing member for forming a seal between the spout and opening of the container.
摘要翻译：一种创造性的倾倒口，其可选择性地附接到容器并且装配到与其一起使用的容器的开口上。在一个优选实施例中，倾倒嘴适应于一夸脱容器的尺寸，并且包括壁，密封构件，口和手柄。手柄通过铰链连接到壁上，该铰链能够使手柄远离容器枢转，以允许密封构件在容器平放在表面上时被适当地定位。在密封构件就位之后，把手然后枢转回到适当位置以牢固地固定容器。手柄包括多个向上延伸的凸起，其适于牢固地接合容器的底部边缘。此外，热塑性材料被施加在手柄区域，形成舒适且易于抓握的手柄盖。热塑性材料也优选用于密封构件的构造，用于在容器的喷口和开口之间形成密封。

40. 发明申请

US20070009081A1 Computed tomography system for imaging of human and small animal 审中-公开
标题翻译：用于人和小动物成像的计算机断层扫描系统
公开(公告)号：US20070009081A1
公开(公告)日：2007-01-11
申请号：US11441281
申请日：2006-05-25
申请人： Otto Zhou , Jianping Lu , Yueh Lee , Weili Lin , Yuan Cheng , Jian Zhang
发明人： Otto Zhou , Jianping Lu , Yueh Lee , Weili Lin , Yuan Cheng , Jian Zhang
IPC分类号： A61B6/00 , G01N23/00 , G21K1/12 , H05G1/60
CPC分类号： B82Y10/00 , A61B6/032 , A61B6/4028 , A61B6/508 , A61B6/541 , G01N23/046 , G01N2223/316 , G01N2223/419 , G01N2223/612 , H01J35/065 , H01J2201/30469 , H01J2235/068
摘要： Computed tomography device comprising an x-ray source and an x-ray detecting unit. The x-ray source comprises a cathode with a plurality of individually programmable electron emitting units that each emit an electron upon an application of an electric field, an anode target that emits an x-ray upon impact by the emitted electron, and a collimator. Each electron emitting unit includes an electron field emitting material. The electron field emitting material includes a nanostructured material or a plurality of nanotubes or a plurality of nanowires. Computed tomography methods are also provided.
摘要翻译：计算机断层摄影装置，包括x射线源和x射线检测单元。 x射线源包括具有多个单独可编程的电子发射单元的阴极，每个单独可编程的电子发射单元在施加电场时发射电子，在被所发射的电子撞击时发射x射线的阳极靶和准直器。每个电子发射单元包括电子场发射材料。电子场发射材料包括纳米结构材料或多个纳米管或多个纳米线。还提供了计算机断层扫描方法。

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