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31. 发明授权

US5320643A Automatic cardiac capture restoration and threshold-seeking method and apparatus 失效
标题翻译：自动心脏捕获恢复和阈值寻求方法和装置
公开(公告)号：US5320643A
公开(公告)日：1994-06-14
申请号：US958194
申请日：1992-10-06
申请人： Glenn M. Roline , Lucy M. Nichols , Tommy D. Bennett , David L. Thompson
发明人： Glenn M. Roline , Lucy M. Nichols , Tommy D. Bennett , David L. Thompson
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3712 , A61N1/36564
摘要： An automatic capture restoration and threshold-seeking method and apparatus for use with a cardiac pacemaker derives control signals for restoring cardiac capture from a cardiac pressure sensor. The pressure sensor also provides input control signals for a threshold-seeking apparatus. Both pulse width and amplitude thresholds can be changed contemporaneously during both capture restoration and threshold seeking.
摘要翻译：与心脏起搏器一起使用的自动捕获恢复和阈值寻求方法和装置导出用于从心脏压力传感器恢复心脏捕获的控制信号。压力传感器还为阈值寻求装置提供输入控制信号。在捕获恢复和阈值寻找期间，脉冲宽度和幅度阈值均可同时改变。

32. 发明授权

US5226413A Rate responsive pacemaker and method for automatically initializing the same 失效
标题翻译：速率反应起搏器和自动初始化相同的方法
公开(公告)号：US5226413A
公开(公告)日：1993-07-13
申请号：US567372
申请日：1990-08-14
申请人： Tommy D. Bennett , Lucy M. Nichols , Glenn M. Roline , David L. Thompson
发明人： Tommy D. Bennett , Lucy M. Nichols , Glenn M. Roline , David L. Thompson
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/37 , A61N1/36585
摘要： A pacemaker system includes a dual sensor implantable pacemaker and an external programmer for automatically and simultaneously optimizing and initializing a plurality of pacing parameters. The pacemaker includes means for automatically initializing a sensitivity threshold, pacing pulse width, pacing pulse amplitude, activity threshold, and pressure rate response gain setting.
摘要翻译：起搏器系统包括双传感器可植入起搏器和用于自动并同时优化和初始化多个起搏参数的外部编程器。起搏器包括自动初始化灵敏度阈值，起搏脉冲宽度，起搏脉冲幅度，活动阈值和压力响应增益设置的手段。

33. 发明授权

US08380295B2 Detection of waveform artifact 有权
标题翻译：检测波形伪影
公开(公告)号：US08380295B2
公开(公告)日：2013-02-19
申请号：US12609455
申请日：2009-10-30
申请人： Saul E. Greenhut , Mustafa Karamanoglu , Karen J. Kleckner , Tommy D. Bennett , Scott W. Davie
发明人： Saul E. Greenhut , Mustafa Karamanoglu , Karen J. Kleckner , Tommy D. Bennett , Scott W. Davie
IPC分类号： A61B5/04
CPC分类号： A61N1/3702
摘要： An implantable medical device system including a physiological sensor detects signal artifact in a signal waveform acquired by the sensor. Features of individual waveforms in the sensor signal are extracted. Sample waveforms are classified by expert observation into at least two classes including an artifact class. A distribution range for each of the extracted features from the sample waveforms is determined for each of the classes. Waveform classification criteria are established in response to the determined distribution ranges.
摘要翻译：包括生理传感器的可植入医疗装置系统检测由传感器获取的信号波形中的信号伪影。提取传感器信号中各波形的特征。通过专家观察将样本波形分类为至少两个类，包括神器类。为每个类别确定来自采样波形的每个提取特征的分布范围。响应于确定的分布范围建立波形分类标准。

34. 发明授权

US08244355B2 Method and apparatus to provide diagnostic index and therapy regulated by subject's autonomic nervous system 有权
标题翻译：提供受试者自主神经系统调节的诊断指标和治疗的方法和装置
公开(公告)号：US08244355B2
公开(公告)日：2012-08-14
申请号：US10977073
申请日：2004-10-29
申请人： Tommy D. Bennett , Edwin G. Duffin , Barbro Kjellstrom
发明人： Tommy D. Bennett , Edwin G. Duffin , Barbro Kjellstrom
IPC分类号： A61N1/00
CPC分类号： A61B5/0205 , A61B5/4035 , A61B5/7239 , A61N1/36535 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/3702
摘要： A system and method are provided for determining an index of autonomic nervous system (ANS) or sympathetic nervous system (SNS) activity for use in patient monitoring or therapy delivery control. An ANS or SNS index is calculated as a function of multiple monitored physiological variables that strongly correlate to changes in autonomic or sympathetic tone. These ANS-influenced variables are derived from selected hemodynamic and/or electrical signals and may include variables relating to any of: the maximum rate of pressure rise (dP/dtmax), the maximum rate of pressure decline (dP/dtmin), pulse pressure (PP), pre-ejection time interval (PEI) and/or systolic time interval (STI), heart rate (HR), heart rate variability (HRV), and baro-reflex gain. Changes in the ANS or SNS index may be used to automatically adjust a device delivered therapy.
摘要翻译：提供了一种用于确定用于患者监测或治疗递送控制的自主神经系统（ANS）或交感神经系统（SNS）活动指数的系统和方法。 ANS或SNS指数被计算为与自主神经或交感神经紧张度变化密切相关的多个被监测的生理变量的函数。这些受ANS影响的变量来源于选定的血液动力学和/或电信号，并且可以包括与以下任何相关的变量：压力升高的最大速率（dP / dtmax），压力下降的最大速率（dP / dtmin），脉压（PP），预喷射时间间隔（PEI）和/或收缩期间隔（STI），心率（HR），心率变异性（HRV）和压力反射增益。可以使用ANS或SNS指数的变化来自动调整设备传递的治疗。

35. 发明申请

US20120197088A1 DETECTION OF WAVEFORM ARTIFACT 有权
标题翻译：检测波浪文艺
公开(公告)号：US20120197088A1
公开(公告)日：2012-08-02
申请号：US13017307
申请日：2011-01-31
申请人： Mustafa Karamanoglu , Karen J. Kleckner , Tommy D. Bennett
发明人： Mustafa Karamanoglu , Karen J. Kleckner , Tommy D. Bennett
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： G06F19/3406 , A61B5/02116 , A61B5/02125 , A61B5/7217 , A61B5/7239 , G06K9/0053 , G16H40/63
摘要： A medical device system including a physiological sensor is configured to perform a method for detecting signal artifact in a signal waveform acquired by the sensor. A signal waveform is sensed in a patient using the physiological sensor and a fiducial point associated with the sensed waveform is identified. A point value is established using the fiducial point. Signal artifact is detected in response to the established point value and an established threshold, and at least a portion of the signal waveform is rejected in response to detecting signal artifact.
摘要翻译：包括生理传感器的医疗装置系统被配置为执行用于检测由传感器获取的信号波形中的信号伪影的方法。使用生理传感器在患者中感测到信号波形，并且识别与感测波形相关联的基准点。使用基准点建立点值。响应于建立的点值和建立的阈值检测信号伪像，并且响应于检测到信号伪影而拒绝信号波形的至少一部分。

36. 发明申请

US20120108984A1 INTEGRATED PATIENT CARE 有权
标题翻译：一体化患者护理
公开(公告)号：US20120108984A1
公开(公告)日：2012-05-03
申请号：US12915992
申请日：2010-10-29
申请人： Tommy D. Bennett , Yong Kyun Cho , Randolph M. Biallas
发明人： Tommy D. Bennett , Yong Kyun Cho , Randolph M. Biallas
IPC分类号： G06Q50/00 , A61B5/021
CPC分类号： G06F19/3481 , A61B5/0022 , A61B5/021 , A61B5/0215 , A61B5/0537 , A61B5/11 , A61B5/4836 , A61B5/4878 , A61B5/743 , A61B5/7435 , A61N1/37247 , G06F19/00 , G06F19/3456 , G06Q50/22 , G16H40/63 , G16H50/20
摘要： A therapy regimen, e.g., a contingent medication prescription, may be created and automatically distributed to a patient via an integrated patient care system. A clinician may create therapy instructions by at least associating patient conditions with one or more therapy regimens, e.g., medication prescriptions. In some examples, the integrated patient care system may present historical condition data to the clinician to aid the clinician with creating and/or updating the therapy instructions specific to the patient. A therapy module of the integrated patient care system may use the therapy instructions to automatically select a therapy regimen from the therapy instructions based on a patient condition detected based on a sensed physiological parameter. The physiological parameter of the patient may be sensed by an implanted or external sensor. In some examples, the therapy regimen can be presented to the patient according to a predetermined schedule or in response to the detected condition.
摘要翻译：可以创建治疗方案，例如或有药物处方，并通过综合的患者护理系统自动分配给患者。临床医生可以通过至少将患者状况与一种或多种治疗方案（例如药物处方）相关联来产生治疗指导。在一些示例中，综合的患者护理系统可向临床医生呈现历史状态数据，以帮助临床医生创建和/或更新患者特有的治疗指导。综合患者护理系统的治疗模块可以使用治疗指令根据基于检测到的生理参数检测到的患者状况从治疗指令中自动选择治疗方案。患者的生理参数可以通过植入或外部传感器来感测。在一些实例中，治疗方案可以根据预定的时间表或响应于检测到的病症呈现给患者。

37. 发明申请

US20110301474A1 Heart Failure Monitor Quicklook Summary for Patient Management Systems 有权
标题翻译：心力衰竭监测病人管理系统的概要
公开(公告)号：US20110301474A1
公开(公告)日：2011-12-08
申请号：US13210527
申请日：2011-08-16
申请人： James D. Webb , Tommy D. Bennett
发明人： James D. Webb , Tommy D. Bennett
IPC分类号： A61B5/0215
CPC分类号： A61B5/02158 , A61B5/0031 , A61B5/02055
摘要： Continuous remote monitoring of patients based on data obtained from an implantable hemodynamic monitor provides an interactive patient management system. Using network systems, patients are remotely monitored to continuously diagnose and treat heart-failure conditions. A screen displayable summary provides continuous feedback and information to physicians, patients and authorized third parties. The quick look summary includes various sites and presentation tailored to match the patients' and physicians' needs. The quick look summary further includes intelligent features that understand and retain the user's interests, preferences and use patterns. Patients, physicians and other caregivers are seamlessly connected to monitor and serve the chronic needs of heart-failure patients in a reliable and economic manner.
摘要翻译：基于从可植入血液动力学监测器获得的数据对患者的连续远程监测提供了交互式患者管理系统。使用网络系统，对患者进行远程监控，以不断诊断和治疗心力衰竭状况。屏幕可显示的摘要为医生，患者和授权的第三方提供持续的反馈和信息。快速查看摘要包括各种网站和演示文稿，以满足患者和医生的需求。快速概述进一步包括了解和保留用户兴趣，偏好和使用模式的智能功能。患者，医生和其他照顾者无缝连接，以可靠和经济的方式监测和服务于心力衰竭患者的长期需求。

38. 发明授权

US07935062B2 Derivation of flow contour from pressure waveform 有权
标题翻译：从压力波形推导流量轮廓
公开(公告)号：US07935062B2
公开(公告)日：2011-05-03
申请号：US11045574
申请日：2005-01-27
申请人： Mustafa Karamanoglu , Tommy D. Bennett
发明人： Mustafa Karamanoglu , Tommy D. Bennett
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/02108 , A61B5/029 , A61B5/7239
摘要： The present invention provides a system and method for estimating a blood flow waveform contour from a pressure signal. An arterial or ventricular pressure signal is acquired from a pressure sensor. Landmark points are identified on the pressure waveform that correspond to features of a flow waveform. In one embodiment, the landmark pressure waveform points correspond to the onset of flow, the peak flow, and the end of the systolic ejection phase. The landmark pressure waveform points define a contour that approximates the flow contour. Beat-by-beat flow contour estimation can be performed to allow computation of flow-related hemodynamic parameters such as stroke volume or cardiac output for use in patient monitoring and/or therapy management.
摘要翻译：本发明提供一种用于从压力信号估计血流波形轮廓的系统和方法。从压力传感器获取动脉或心室压力信号。在与流量波形的特征对应的压力波形上标识地标点。在一个实施例中，标记压力波形点对应于流动的开始，峰值流动和收缩期喷射阶段的结束。界标压力波形点定义近似流轮廓的轮廓。可以进行逐搏流轮廓估计，以允许计算流动相关的血液动力学参数，例如用于患者监测和/或治疗管理的中风体积或心输出量。

39. 发明授权

US07708693B2 System and method for detecting artifactual hemodynamic waveform data 有权
标题翻译：用于检测人为血液动力波形数据的系统和方法
公开(公告)号：US07708693B2
公开(公告)日：2010-05-04
申请号：US11044618
申请日：2005-01-27
申请人： Tommy D. Bennett , Mark Choi , David A. Igel , Michael R. S. Hill , Teresa A. Whitman
发明人： Tommy D. Bennett , Mark Choi , David A. Igel , Michael R. S. Hill , Teresa A. Whitman
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/02108
摘要： A system and method for cardiovascular analysis includes an implantable medical device capable of generating hemodynamic pressure waveform data based upon sensed pressure. Hemodynamic waveform data is analyzed to identify artifactual data represented in the hemodynamic waveform.
摘要翻译：用于心血管分析的系统和方法包括能够基于检测到的压力产生血流动力压力波形数据的可植入医疗装置。分析血流动力学波形数据以识别在血流动力学波形中表示的人为因素数据。

40. 发明授权

US5134997A Rate responsive pacemaker and pacing method 失效
标题翻译：速率响应起搏器和起搏方法
公开(公告)号：US5134997A
公开(公告)日：1992-08-04
申请号：US567204
申请日：1990-08-14
申请人： Tommy D. Bennett , Lucy M. Nichols , Glenn M. Roline , David L. Thompson
发明人： Tommy D. Bennett , Lucy M. Nichols , Glenn M. Roline , David L. Thompson
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/37 , A61N1/36585
摘要： A rate responsive pacemaker and a pacing method for optimizing the pacing decay curve after a period of increased activity. The pacing method includes the steps of selecting a set of predetermined achievement criteria such as an achievement rate and an achievement time interval. The achievement rate is selected between an upper pacing rate and a first pacing switch rate threshold. The pacing method then determines whether the achievement criterion has been met. If the achievement criterion has been met, then the decay time constant of the decay curve changes from a first value to a second value, as the pacing rate drops below the first pacing switch rate threshold. A second pacing switch rate threshold lower than the first pacing switch rate threshold is then selected, and, if the achievement criteria have been met, then the decay time constant of the decay curve is modified from the second value to a third value, as the pacing rate drops below the second pacing switch rate threshold.
摘要翻译：一种速率响应起搏器和起搏方法，用于在活动增加一段时间后优化起搏衰减曲线。起搏方法包括如下步骤：选择一组预定的成就标准，例如成就率和成就时间间隔。成就率选择在较高起搏速率和第一起搏开关速率阈值之间。然后，起搏方法确定是否满足成就标准。如果满足成就标准，则衰减曲线的衰减时间常数从第一值变为第二值，因为起搏速率降低到第一起搏开关速率阈值以下。然后选择低于第一起搏开关速率阈值的第二起搏开关速率阈值，并且如果满足成就标准已被满足，则衰减曲线的衰减时间常数从第二值修改为第三值，如起搏率降低到第二起搏开关速率阈值以下。

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