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31. 发明授权

US4402978A Gastro-protecting activity of substituted derivatives of 4-phenyl-4-oxo-2-hydroxy-butanoic acid 失效
标题翻译： 4-苯基-4-氧代-2-羟基 - 丁酸的取代衍生物的胃保护活性
公开(公告)号：US4402978A
公开(公告)日：1983-09-06
申请号：US256911
申请日：1981-04-23
申请人： Yani Christidis , Robert Fournex , Colette Tournemine
发明人： Yani Christidis , Robert Fournex , Colette Tournemine
IPC分类号： C07C69/738 , A61K31/19 , A61K31/215 , A61K31/357 , A61K31/36 , A61P1/04 , C07C51/00 , C07C51/353 , C07C51/363 , C07C51/367 , C07C51/373 , C07C59/88 , C07C59/90 , C07C67/00 , C07C201/00 , C07C205/56 , C07D317/60 , C07D317/62 , A61K31/235 , A61K31/24
CPC分类号： C07D317/60 , C07C205/56 , C07C51/353 , C07C51/363 , C07C51/367 , C07C51/373 , C07C59/90 , Y10S514/926 , Y10S514/927
摘要： Diseases and ailments accompanied by gastric and gastroduodenal lesions treated by administering a compound of the formula (I) ##STR1## in which R represents hydrogen or alkyl containing 1 to 5 carbon atoms and R.sub.1 and R.sub.2, identical or different, both represent alkoxy containing 1 to 3 carbon atoms, or both represent halogen, or R.sub.1 represents hydrogen and R.sub.2 represents halogen, nitro or trifluoromethyl, or R.sub.1 and R.sub.2 form a methylenedioxy group at adjacent carbon atoms, in their racemic and optically active forms, as well as pharmaceutically acceptable salts thereof, particularly alkali metal, alkaline earth metal, or amine salts of said acid.
摘要翻译：通过给予其中R表示氢或含有1至5个碳原子的烷基的R 1和R 2相同或不同的式（I）化合物（I）化合物治疗的伴有胃和胃十二指肠损伤的疾病和疾病都代表含有1至3个碳原子的烷氧基，或两者都表示卤素，或R 1表示氢，R 2表示卤素，硝基或三氟甲基，或R 1和R 2在其外消旋和光学活性形式中在相邻碳原子处形成亚甲二氧基，其药学上可接受的盐，特别是所述酸的碱金属，碱土金属或胺盐。

32. 发明授权

US4384137A Process for preparation of hydroxyarylglyoxylic acids and their alkaline salts, and application thereof to preparation of sodium parahydroxyphenylglyoxylate 失效
标题翻译：羟基芳基乙醛酸及其碱式盐的制备方法及其在制备对羟基苯基乙醛酸钠
公开(公告)号：US4384137A
公开(公告)日：1983-05-17
申请号：US375124
申请日：1982-04-20
申请人： Alain Schouteeten , Yani Christidis , Jean-Claude Vallejos
发明人： Alain Schouteeten , Yani Christidis , Jean-Claude Vallejos
IPC分类号： C07C59/90 , B01J27/00 , B01J31/04 , C07C45/39 , C07C47/575 , C07C51/00 , C07C51/235 , C07C51/373 , C07C51/41 , C07C51/487 , C07C67/00 , C07C65/40
CPC分类号： C07C51/412 , C07C45/39 , C07C47/575 , C07C51/373 , C07C51/487
摘要： The invention relates to a process for preparation of hydroxyarylglyoxylic acids starting from hydroxyarylglycolic acids, by catalytic oxidation in an aqueous alkaline medium to pH higher than, or equal to, 11.5, through oxygen or oxygen-containing gas, characterized in that it is carried out in homogeneous phase at a temperature lower than, or equal to, 30.degree. C., and in the presence of cupric ions, and in that at the end of the reaction, the desired acid is isolated from the reactional medium through acidification to pH of about 0.5.The sodium parahydroxyphenylglyoxylate is obtained when acidification is stopped at pH=5, at the end of the reaction.
摘要翻译： PCT No.PCT / FR81 / 00108 Sec。 1982年4月20日 102（e）1982年4月20日PCT PCT日期：1981年8月27日PCT公布。公开号WO82 / 00821 1982年3月18日。本发明涉及由羟基芳基乙醇酸制备羟基芳基乙醛酸的方法，通过在含水碱性介质中通过氧或含氧气体在含水碱性介质中的催化氧化至pH高于或等于11.5，其特征在于其在低于或等于30℃的温度下并且在铜离子存在下在均相中进行，并且在反应结束时，将所需的酸从反应介质通过酸化至约0.5的pH。在反应结束时酸化停止pH = 5时得到对羟基苯基乙醛酸钠。

33. 发明授权

US4196299A Process for manufacturing thienyl-2 acetic acid 失效
标题翻译：制备噻吩-2-乙酸的方法
公开(公告)号：US4196299A
公开(公告)日：1980-04-01
申请号：US892435
申请日：1978-03-31
申请人： Jean Claude Vallejos , Yani Christidis
发明人： Jean Claude Vallejos , Yani Christidis
IPC分类号： C07D333/22 , C07D333/24
CPC分类号： C07D333/24 , C07D333/22
摘要： The process for manufacturing thienyl-2 acetic acid from acetylthiophene comprises condensing acetylthiophene at a temperature below 120.degree. C. with an excess of a C.sub.4 to C.sub.8 aliphatic primary amine or with a cyclic amine, in the presence of an acid catalyst and removing the water formed, so as to obtain the corresponding imine. The imine is reacted with excess sulfur at a temperature equal to or below 100.degree. C. in a basic and aprotic solvent to produce the corresponding thioamide. The thioamide is hydrolyzed by the action of an excess of a strongly alkaline base in a C.sub.4 to C.sub.8 alcohol or in ethylene glycol, if necessary in the presence of water, so as to obtain an alkali salt of thiophene-2 acetic acid. Finally the latter is treated with a strong acid in aqueous solution to liberate the thienyl-2 acetic acid.
摘要翻译：从乙酰噻吩制备噻吩-2-乙酸的方法包括在低于120℃的温度下用过量的C 4至C 8脂族伯胺或与环状胺在酸催化剂存在下将乙酰噻吩缩合并除去水形成，以获得相应的亚胺。亚胺在碱性和非质子溶剂中在等于或低于100℃的温度下与过量的硫反应生成相应的硫代酰胺。如果需要，在水存在下，硫代酰胺通过过量的强碱性碱在C4至C8醇或乙二醇中的作用水解，得到噻吩-2-乙酸的碱金属盐。最后，后者用强酸在水溶液中处理以释放噻吩基-2-乙酸。

34. 发明授权

US4052364A Bis(hydroxy-di-tert.butylphenyl)-alkanoic acid esters 失效
标题翻译： BIS（羟基-D-叔丁基苯基） - 甘油酸酯
公开(公告)号：US4052364A
公开(公告)日：1977-10-04
申请号：US545532
申请日：1975-01-30
申请人： Yani Christidis , Otto Mauz , Eberhard Prinz
发明人： Yani Christidis , Otto Mauz , Eberhard Prinz
IPC分类号： C08L23/00 , C07C69/732 , C08K5/00 , C08K5/10 , C08K5/13 , C08K5/134 , C08L101/00 , C07C69/76
CPC分类号： C08K5/1345 , C08K5/10
摘要： Bis(hydroxyphenyl)-alkanoic acid esters the phenyl radicals of which are alkylated twice are prepared by alkylation of corresponding compounds carrying one alkyl radical at the nucleus, using isobutylene as alkylating agent. The alkanoic acid esters are obtained in crystalline form and are suitable as stabilizers for polyolefins.

35. 发明授权

US5600001A Acetaldehyde derivatives, their preparation process and their use 失效
标题翻译：乙醛衍生物，其制备方法及其用途
公开(公告)号：US5600001A
公开(公告)日：1997-02-04
申请号：US605792
申请日：1996-02-22
申请人： Alain Schouteeten , Yani Christidis
发明人： Alain Schouteeten , Yani Christidis
IPC分类号： C07C249/02 , C07C213/02 , C07C217/40 , C07C251/88 , C07C209/42 , C07C209/00
CPC分类号： C07C213/02 , C07C217/40 , C07C251/88
摘要： Azines of formula (I): ##STR1## in which R and R' either are identical and represent an alkyl radical containing 1 to 4 carbon atoms or an alkenyl radical containing 3 to 5 carbon atoms, or together form a radical of formula (II):--CHR.sub.1 --(CR.sub.2 R.sub.3).sub.n --CHR.sub.4 -- (II)in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4, identical or different, represent a hydrogen atom or an alkyl radical containing 1 to 4 carbon atoms and n represents 0 or 1, in their different stereoisomer forms, their preparation process and their use.
摘要翻译：式（I）的吖嗪：其中R和R'相同并且表示含有1至4个碳原子的烷基或含有3至5个碳原子的烯基，或一起形成基团式（II）：-CHR1-（CR 2 R 3）n -CHR 4 - （II）其中R 1，R 2，R 3和R 4相同或不同表示氢原子或含有1至4个碳原子的烷基，n表示0 或1，以其不同的立体异构体形式，其制备方法及其用途。

36. 发明授权

US5223621A Transvinylation of carboxylic acids 失效
标题翻译：羧酸的转化
公开(公告)号：US5223621A
公开(公告)日：1993-06-29
申请号：US817194
申请日：1992-01-06
申请人： Jean-Claude Vallejos , Yani Christidis
发明人： Jean-Claude Vallejos , Yani Christidis
IPC分类号： C07C67/10
CPC分类号： C07C67/10
摘要： Transvinylation process between vinyl acetate or vinyl propionate and a carboxylic acid of general formula (I),RCOOH (I)in which R represents a substituted or non-substituted alkyl, cycloalkyl, aralkyl or aromatic radical, in the presence of a palladium catalyst, in which the catalyst is obtained in situ, by reacting, in the reaction medium, a derivative of palladium chosen from the group constituted by palladium II acetate, nitrate or hydroxide and palladium deposited on charcoal, with a tertiary amine chosen from the group constituted by 2,2'-bipyridyl, orthophenanthroline or tetramethylethylenediamine, that the quantity of palladium used, expressed in gram-atom of palladium II per 100 moles of carboxylic acid of general formula (I) is between 0.005 and 1 and that the quantity of amine is greater than 1 and less than 10 moles per gram-atom of palladium II used and use for the preparation of certain products.
摘要翻译：乙酸乙烯酯或丙酸乙烯酯与通式（I）的羧酸，其中R表示取代或未取代的烷基，环烷基，芳烷基或芳族基团的RCOOH（I）在钯催化剂存在下的反应，其中通过在反应介质中使选自由钯II乙酸酯，硝酸盐或氢氧化物构成的组的钯衍生物和沉积在活性炭上的钯与选自以下组成的组中的叔胺反应获得催化剂： 2,2'-联吡啶基，邻菲咯啉或四甲基乙二胺，使用的钯的量（以每100摩尔通式（I）的羧酸计）钯II的克原子数为0.005〜1，胺的量为大于1且小于10摩尔/克原子的钯II，并用于制备某些产品。

37. 发明授权

US5053527A Process for the manufacture of alkyl pyruvates 失效
标题翻译：制备亚苄基吡咯烷酮的方法
公开(公告)号：US5053527A
公开(公告)日：1991-10-01
申请号：US525209
申请日：1990-05-18
申请人： Yani Christidis , Jean-Claude Vallejos
发明人： Yani Christidis , Jean-Claude Vallejos
IPC分类号： B01J27/06 , C07B61/00 , C07C67/313 , C07C69/716
CPC分类号： C07C67/313 , C07C69/716
摘要： The invention provides an improved process for the manufacture of alkyl pyruvates having general formula (I):CH.sub.3 --CO--COOR (I)where R represents a C.sub.1 to C.sub.8 alkyl radical, by controlled oxidation of the corresponding alkyl lactate.The process is characterized in that the controlled oxidation is carried out using an aqueous hydrogen peroxide solution in the presence of catalytic quantities of bromium.
摘要翻译：本发明提供了制备具有通式（I）的烷基丙酮酸盐的改进方法：其中R表示C1至C8烷基的CH3-CO-COOR（Ⅰ）通过相应的乳酸烷基酯的受控氧化。该方法的特征在于，在催化量的溴的存在下，使用过氧化氢水溶液进行受控氧化。

38. 发明授权

US4948827A Methyl-2-tertiary butyl-5-thiophenol, its preparation process and its use 失效
标题翻译：甲基-2-叔丁基-5-苯硫酚，其制备方法及用途
公开(公告)号：US4948827A
公开(公告)日：1990-08-14
申请号：US426607
申请日：1989-10-25
申请人： Yani Christidis
发明人： Yani Christidis
IPC分类号： C07C319/02 , C07C321/26 , C08F2/38 , C08K5/36 , C08K5/37 , C08L27/00
CPC分类号： C07C321/26
摘要： This new thiophenol, prepared by reduction of tertiary butyl-4-toluenesulfonyl-2-chloride with the zinc-sulphuric acid couple, can be used as a stabilizer for vinyl chloride polymers, as a chain-transfer agent and as a peptizer.
摘要翻译：可以使用通过用硫酸锌偶合还原叔丁基-4-甲苯磺酰基氯化物制备的这种新的苯硫酚作为氯乙烯聚合物的稳定剂，作为链转移剂和胶溶剂。

39. 发明授权

US4493937A 2-Dimethylamino-2-parahydroxyphenyl sodium acetate, preparation process and application thereof to production of parahydroxybenzyl cyanide 失效
标题翻译： 2-二甲基氨基-2-对羟基苯基乙酸钠，其制备方法和应用于生产对羟基苄基氰化物
公开(公告)号：US4493937A
公开(公告)日：1985-01-15
申请号：US448093
申请日：1982-12-09
申请人： Philippe Gallois , Yani Christidis
发明人： Philippe Gallois , Yani Christidis
IPC分类号： C07B61/00 , B01J27/00 , B01J27/02 , C07C67/00 , C07C227/00 , C07C227/06 , C07C227/08 , C07C227/18 , C07C229/36 , C07C253/00 , C07C255/36 , C07C99/00
CPC分类号： C07C229/36 , C07C253/00
摘要： The invention relates to crystallized 2-dimethylamino-2-parahydroxyphenyl sodium acetate, anhydrous or with 2 molecules of water. The process for preparation thereof comprises heating parahydroxy mandelic acid in dimethylformamide in the presence of a catalytic quantity of a strong acid, such reaction being followed by a sodium hydroxide neutralization. Said product is applied to the production of parahydroxybenzyl cyanide by reacting it with 2-hydroxy isobutyronitrile.
摘要翻译：本发明涉及无水或2分子水的结晶的2-二甲基氨基-2-对羟基苯基乙酸钠。其制备方法包括在催化量的强酸存在下，在二甲基甲酰胺中加热对羟基苯基扁桃酸，该反应随后进行氢氧化钠中和。所述产物通过与2-羟基异丁腈反应而用于生产对羟基苄基氰。

40. 发明授权

US4385006A Process for preparing aromatic nitriles 失效
标题翻译：制备芳香腈的方法
公开(公告)号：US4385006A
公开(公告)日：1983-05-24
申请号：US367125
申请日：1982-04-09
申请人： Alain Schouteeten , Yani Christidis
发明人： Alain Schouteeten , Yani Christidis
IPC分类号： C07C255/49 , C07C255/53 , C07C120/08
CPC分类号： C07C253/22
摘要： The invention relates to obtaining aromatic nitriles of general formula: (R).sub.n --C.sub.6 H.sub.4 --CN, where n=1, 2 or 3, and the rest R, identical or different represent an atom of hydrogen, chlorine or bromine or an alkyl, aryl, alkoxy, alkylamino, hydroxy or amino group, by a process comprising decarboxylating ammoxidation reaction, in an alkaline aqueous medium, at a pH higher than, or equal to, 13, in the presence of a catalyst based on one or several transition metals and an alkaline hydroxide, applied to an arylglyoxylic acid free or salified, of the formula: (R).sub.n --C.sub.6 H.sub.4 --CO--COOH (where n and R have the above-mentioned meanings), or to one of its functional derivatives of the lactone, lactame or C.sub.1 -C.sub.3 -alkyl ester type.
摘要翻译：本发明涉及获得通式为（R）n-C6H4-CN的芳族腈，其中n = 1,2或3，其余的R，相同或不同，表示氢原子，氯原子或溴原子或烷基，芳基，烷氧基，烷基氨基，羟基或氨基，在碱性水性介质中，在基于一种或多种过渡金属的催化剂的存在下，在高于或等于13的pH下进行脱羧氨基化反应和（R）n-C 6 H 4 -CO-COOH（其中n和R具有上述含义），或其功能衍生物之一的式（R）n-C6H4-CO-COOH（其中n和R具有上述含义），不溶或盐化的芳基乙醛酸的碱性氢氧化物内酯，内酯或C1-C3-烷基酯类。

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