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31. 发明申请

US20110301175A1 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS 有权
标题翻译： 5-（4-（HALOALKOXY）苯基）嘧啶-2-胺化合物和作为激酶抑制剂的组合物
公开(公告)号：US20110301175A1
公开(公告)日：2011-12-08
申请号：US12674416
申请日：2008-08-19
申请人： Valentina Molteni , Xiaolin Li , Xiaodong Liu , Donatella Chianelli , Juliet Nabakka , Jon Loren , Shuli You
发明人： Valentina Molteni , Xiaolin Li , Xiaodong Liu , Donatella Chianelli , Juliet Nabakka , Jon Loren , Shuli You
IPC分类号： A61K31/506 , C07D401/12 , C07D403/12 , C07D413/12 , A61P9/12 , A61P11/06 , A61P17/00 , A61P1/00 , A61P35/00 , C07D239/42 , A61K31/505
CPC分类号： C07D239/42 , C07D401/12 , C07D403/12 , C07D413/12
摘要： The invention provides compounds of formula (1) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, AbI, BCR-AbI, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3. Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, Fms, KDR, c-rapor b-raf kinases.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的式（1）化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit，PDGFRα，PDGFR和bgr，CSF1R，AbI，BCR-AbI，CSK，JNK1，JNK2，p38异常活化的疾病或病症的方法，p70S6K，TGF＆bgr; SRC，EGFR，trkB，FGFR3。 Fes，Lck，Syk，RAF，MKK4，MKK6，SAPK2＆bgr; BRK，Fms，KDR，c-rapor b-raf激酶。

32. 发明申请

US20100190811A1 PYRIMIDINE DERIVATIVES AND COMPOSITIONS AS C-KIT AND PDGFR KINASE INHIBITORS 失效
标题翻译：吡啶衍生物和组合物作为C-kit和PDGFR激酶抑制剂
公开(公告)号：US20100190811A1
公开(公告)日：2010-07-29
申请号：US12598919
申请日：2008-05-01
申请人： Xiaolin Li , Xiaodong Liu , Valentina Molteni
发明人： Xiaolin Li , Xiaodong Liu , Valentina Molteni
IPC分类号： A61K31/506 , C07D401/14 , A61P35/00 , A61P25/36 , A61P25/28 , A61P25/16 , A61P25/00 , A61P3/10 , A61P3/04 , A61P37/06 , A61P19/02
CPC分类号： C07D401/14 , C07D405/14
摘要： The invention provides a novel class of pyrimidine derivatives, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFRα and PDGFRβ kinases.
摘要翻译：本发明提供了一类新颖的嘧啶衍生物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及c-kit，PDGFRα异常活化的疾病或病症和PDGFR＆bgr; 激酶。

33. 发明授权

US07678792B2 Compositions and methods for modulating c-kit and PDGFR receptors 失效
标题翻译：用于调节c-kit和PDGFR受体的组合物和方法
公开(公告)号：US07678792B2
公开(公告)日：2010-03-16
申请号：US11873196
申请日：2007-10-16
申请人： Donatella Chianelli , Christopher Cow , Yun He , Songchun Jiang , Xiaolin Li , Xiaodong Liu , Zuosheng Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Pingda Ren , Taebo Sim , Xiaodong Wang , Shuli You
发明人： Donatella Chianelli , Christopher Cow , Yun He , Songchun Jiang , Xiaolin Li , Xiaodong Liu , Zuosheng Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Pingda Ren , Taebo Sim , Xiaodong Wang , Shuli You
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/497 , A61K31/501 , A61K31/5355 , A61K31/506 , C07D413/14 , C07D213/69 , C07D213/61 , C07D213/74 , C07D213/80 , C07C205/06 , C07C301/00 , C07C255/07 , C07C69/73 , A61P17/10 , A61P29/00 , A61P3/10 , A61P31/00 , A61P27/14
CPC分类号： C07D471/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit，PDGFRα，PDGFR和bgr，CSF1R，Abl，BCR-Abl，CSK，JNK1，JNK2，p38异常活化的疾病或病症的方法，p70S6K，TGF-bgr，SRC，EGFR，trkB，FGFR3，FLT3，Fes，Lck，Syk，RAF，MKK4，MKK6，SAPK2＆bgr，BRK，KDR，c-raf或b-raf激酶或其突变形式。

34. 发明申请

US20100048539A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：US20100048539A1
公开(公告)日：2010-02-25
申请号：US12513498
申请日：2007-11-02
申请人： Donatella Chianelli , Xiaolin Li , Xiaodong Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Laszlo Revesz , Lawrence B. Perez , Clinton Brooks , Wojciech Wrona , Paul William Manley , Werner Breitenstein
发明人： Donatella Chianelli , Xiaolin Li , Xiaodong Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Laszlo Revesz , Lawrence B. Perez , Clinton Brooks , Wojciech Wrona , Paul William Manley , Werner Breitenstein
IPC分类号： A61K31/506 , C07D401/14 , C07D413/14 , C07D405/14 , A61K31/5377 , A61K31/538 , A61K31/55 , C12N5/00 , A61P35/00 , A61P37/00 , A61P3/00 , A61P25/00 , A61P9/00 , A61P37/08
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to beat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFRα and PDGFRβ kinases. Formula (I).
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物来击败或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及c-kit，PDGFRα异常活化的疾病或病症，以及 PDGFR＆bgr 激酶。式（I）。

35. 发明申请

US20090161035A1 COLOR SUBSTRATE, MANUFACTURING METHOD THEREOF AND LIQUID CRYSTAL DISPLAY 有权
标题翻译：彩色底片，其制造方法和液晶显示
公开(公告)号：US20090161035A1
公开(公告)日：2009-06-25
申请号：US12334396
申请日：2008-12-12
申请人： Xibin Shao , Jingwei Liu , Gang Wang , Xiaodong Liu , Jiaheng Wang
发明人： Xibin Shao , Jingwei Liu , Gang Wang , Xiaodong Liu , Jiaheng Wang
IPC分类号： G02F1/13357 , G02B5/30 , G02B5/20 , B05D5/12 , G02F1/1335
CPC分类号： G02F1/133512 , G02F1/133617
摘要： Disclosed are a color substrate, a manufacturing method thereof and a liquid crystal display. The color substrate comprises a substrate; black matrices disposed on the substrate; color pixels whose material is fluorescent material disposed alternately among the black matrices; a flat encapsulation layer covering the black matrices and the color pixel; and a built-in polarizer attached to the flat encapsulation layer. The manufacturing method comprises forming black matrices on a substrate, and forming color pixels of fluorescent material among the black matrices; form a flat encapsulation layer; and form a built-in polarizer. The liquid crystal display by using the color substrate of the present invention further comprises a array substrate, a liquid crystal layer and a back light wherein wavelength of light emitted by the back light is shorter than of equal to stimulated luminescence critical wavelength of fluorescent material of the color pixels on the color substrate. In the present invention, the color fluorescent material is used for replacing the color resin material on the color substrate, the lamination mode is changed and the energy loss resulting from light-absorbing of the resin material is decreased, which could increase the light utilization efficiency and improve the visual angle characteristic of the liquid crystal display.
摘要翻译：公开了彩色基板，其制造方法和液晶显示器。彩色衬底包括衬底; 设置在基板上的黑色矩阵; 其材料是荧光材料的彩色像素交替布置在黑色矩阵之间; 覆盖黑矩阵和彩色像素的平坦封装层; 以及附着在平坦封装层上的内置偏光片。制造方法包括在基板上形成黑色矩阵，并在黑色矩阵之间形成荧光材料的彩色像素; 形成平坦的封装层; 并形成内置的偏光片。通过使用本发明的彩色基板的液晶显示器还包括阵列基板，液晶层和背光，其中由背光发射的光的波长短于等于荧光材料的受激发光临界波长彩色底片上的彩色像素。在本发明中，彩色荧光材料用于替换彩色基板上的着色树脂材料，层压模式改变，并且由于树脂材料的光吸收而导致的能量损失降低，这可能提高光利用效率并提高液晶显示器的视角特性。

36. 发明申请

US20080229278A1 Component-based development 审中-公开
标题翻译：基于组件的开发
公开(公告)号：US20080229278A1
公开(公告)日：2008-09-18
申请号：US11786311
申请日：2007-04-10
申请人： Xiaodong Liu , Colin Combe , Beihu Wang
发明人： Xiaodong Liu , Colin Combe , Beihu Wang
IPC分类号： G06F9/44
CPC分类号： G06F8/36
摘要： A method is provided for adapting a software component. The method includes the steps of extracting a component specification comprising binary code and metadata from a first component; creating a context-oriented adaptation specification; adapting at least part of the first component in accordance with the context-oriented adaptation specification and an adaptation rule; and generating an adapted component on the basis of the adapted and un-adapted parts of the first component. A tool is also provided for carrying out these steps and may be part of a computer program.
摘要翻译：提供了一种用于调整软件组件的方法。该方法包括从第一组件提取包括二进制代码和元数据的组件规范的步骤; 创建一个面向上下文的适应规范; 根据面向上下文的适应规范和适应规则，适应第一部分的至少一部分; 以及基于所述第一部件的适配部件和未适配部件生成适配部件。还提供了用于执行这些步骤的工具，并且可以是计算机程序的一部分。

37. 发明授权

US06873570B2 High resolution bathymetric sonar system and measuring method for measuring the physiognomy of the seabed 有权
标题翻译：高分辨率测深声纳系统和测量海床地貌的测量方法
公开(公告)号：US06873570B2
公开(公告)日：2005-03-29
申请号：US10450944
申请日：2002-02-08
申请人： Weiqing Zhu , Xiaodong Liu , Min Zhu , Feng Pan , Xiangjun Zhang , Changhong Wang , Yuling Wang
发明人： Weiqing Zhu , Xiaodong Liu , Min Zhu , Feng Pan , Xiangjun Zhang , Changhong Wang , Yuling Wang
IPC分类号： G01S15/89
CPC分类号： G01S15/8904
摘要： A high resolution bathymetric sidescan sonar system for measuring micro-geomorphy of the sea bottom having an underwater vehicle, an underwater electronic subsystem mounted on the underwater vehicle and containing a transmitter and a receiver, and two sonar arrays mounted symmetrically on two sides of a lower part of the underwater vehicle and being connected to the underwater electronic subsystem through a cable. Each sonar array has a transmitting linear array and three or more parallel receiving linear arrays. The parallel receiving linear arrays are arranged at equal spaces, and the space d between two adjacent parallel receiving linear arrays is λ>d≧λ/2, in which λ is a wavelength of an acoustic wave, and an operation frequency of the parallel receiving linear arrays ranges from 30 kHz to 1200 kHz.
摘要翻译：一种用于测量具有水下航行器的海底微地貌的高分辨率测深侧视声纳系统，安装在水下航行器上并包含发射器和接收器的水下电子子系统，以及对称地安装在下侧两侧的两个声纳阵列部分水下航行器，并通过电缆连接到水下电子子系统。每个声纳阵列具有发送线性阵列和三个或更多个并行接收线性阵列。平行接收线性阵列被布置成相等的空间，并且两个相邻的并行接收线性阵列之间的空间d是λ> d> =λ/ 2，其中λ是声波的波长，并行的并行接收线性阵列的操作频率接收线性阵列的范围为30 kHz至1200 kHz。

38. 发明授权

US06645378B1 Polar silanes and their use on silica supports 有权
标题翻译：极性硅烷及其在二氧化硅载体上的用途
公开(公告)号：US06645378B1
公开(公告)日：2003-11-11
申请号：US10092024
申请日：2002-03-05
申请人： Xiaodong Liu , Andrei V. Bordunov
发明人： Xiaodong Liu , Andrei V. Bordunov
IPC分类号： B01D1508
CPC分类号： B01J20/291 , B01D15/322 , B01D15/325 , B01D15/361 , B01D15/3828 , B01J20/286 , B01J20/287 , B01J20/288 , B01J20/3204 , B01J20/3217 , B01J20/3227 , B01J20/3259 , B01J2220/54 , C07B2200/11 , C07F7/1804
摘要： A modified silica support having a polar phase bound to its surface and suitable for use for chromatographic separations, having the following formula: wherein, m=0-20; n=0-20; p=1-50; X is sulfonyl, carbonyl, carbamoyl, or oxycarbonyl; R1=H, alkyl, substituted alkyl, aryl or substituted aryl groups; R2=alkyl, substituted alkyl, aryl or substituted aryl groups; and R3 and R4 are alkyl, aryl, hydroxyl, or alkoxyl groups or groups including oxygen atoms cross-linked to silicon atoms. Also, a polar silane intermediate to make this support.
摘要翻译：具有与其表面结合并适用于色谱分离的极性相的改性二氧化硅载体，具有下式：其中m = 0-20; n = 0-20; p = 1-50; X是磺酰基，羰基，氨基甲酰基或氧羰基; R1 = H，烷基，取代的烷基，芳基或取代的芳基; R2 =烷基，取代的烷基，芳基或取代的芳基; 并且R 3和R 4是包括与硅原子交联的氧原子的烷基，芳基，羟基或烷氧基或基团。另外，极性硅烷中间体可以制成这种载体。

39. 发明授权

US10081731B2 Inorganic coating composition which can be cured at low temperature and a preparation method thereof 有权
公开(公告)号：US10081731B2
公开(公告)日：2018-09-25
申请号：US15202238
申请日：2016-07-05
申请人： Xiaodong Liu
发明人： Xiaodong Liu
IPC分类号： C09D183/00 , C09D1/00 , C09D1/02 , C09D1/04 , C08K3/10 , C08K3/36 , C09D183/02 , C09D183/04 , C09D5/00
CPC分类号： C09D1/00 , C08G77/18 , C08K3/10 , C08K3/36 , C09D1/02 , C09D1/04 , C09D4/00 , C09D5/00 , C09D183/00 , C09D183/02 , C09D183/04 , C08K3/22
摘要： The present invention relates to coating composition. And in particular, to an inorganic coating composition which can be cured at low temperature and a preparation method thereof. In order to solve the problems that the organic coating is harmful for the environment, the inorganic coating has bad flexibility, and the traditional ceramic coatings need heat and is inconvenient for curing in prior art, the present invention provide an inorganic coating composition which can be cured at low temperature and a preparation method thereof. The inorganic coating composition comprises the ingredient as below: 70-80 wt % of inorganic solution; 5-10 wt % of functional additives, which are potassium titanate, alumina, or a compound thereof; 10-20 wt % of inorganic pigment; 0.5-2.0 wt % of other functional additives. The said inorganic solution comprises the following ingredients: 30-40 wt % of organic alkoxy-silane, 15-20 wt % of organic solvent, and 25-30 wt % of silica sol. The inorganic coating composition is able to be cured at low temperature, the film formed by it has excellent flexibility, and the film will not release harmful organic gases, and is beneficial to the environmental.

40. 发明申请

US20150011508A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS 审中-公开
标题翻译：化合物和组合物作为C-KIT激酶抑制剂
公开(公告)号：US20150011508A1
公开(公告)日：2015-01-08
申请号：US14241883
申请日：2012-08-28
申请人： Xiaodong Liu , Xiaolin Li , Jon Loren , Valentina Molteni , Juliet Nabakka , Bao Nguyen , Hank Michael James Petrassi , Vince Yeh
发明人： Xiaodong Liu , Xiaolin Li , Jon Loren , Valentina Molteni , Juliet Nabakka , Bao Nguyen , Hank Michael James Petrassi , Vince Yeh
IPC分类号： C07D471/04 , C07F9/6561
CPC分类号： C07D471/04 , A61K31/4245 , C07F9/6561
摘要： The invention provides compounds of formulae (I) and (II) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的式（I）和（II）化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit或c-kit和PDGFR（PDGFRα，PDGFR＆bgr））激酶的异常活化的疾病或病症的方法。

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