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31. 发明申请

US20100159479A1 TIMP-1 AS A MARKER FOR COLORECTAL CANCER 审中-公开
标题翻译： TIMP-1作为彩色癌的标记
公开(公告)号：US20100159479A1
公开(公告)日：2010-06-24
申请号：US12613760
申请日：2009-11-06
申请人： Wolfgang Rollinger , Johann Karl , Norbert Wild , Herbert Andres , Peter Heiss , Ursula Garczarek , Andrea Geistanger , Friedemann Krause
发明人： Wolfgang Rollinger , Johann Karl , Norbert Wild , Herbert Andres , Peter Heiss , Ursula Garczarek , Andrea Geistanger , Friedemann Krause
IPC分类号： G01N33/573
CPC分类号： G01N33/57419 , G01N2333/8146
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein TIMP-1 (tissue inhibitor of metalloproteinase 1) as a marker molecule in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual, the method involving measuring TIMP-1 in the sample. Measurement of TIMP-1 can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了使用蛋白质TIMP-1（金属蛋白酶1的组织抑制剂）作为结直肠癌诊断中的标记分子。本发明涉及从个体得到的粪便样品中诊断结肠直肠癌的方法，该方法涉及在样品中测量TIMP-1。 TIMP-1的测定可以例如用于结肠直肠癌的早期检测或诊断。

32. 发明申请

US20130344506A1 SEPRASE AS A MARKER FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) 审中-公开
标题翻译： SEPRASE作为慢性阻塞性肺疾病（COPD）的标记
公开(公告)号：US20130344506A1
公开(公告)日：2013-12-26
申请号：US14022309
申请日：2013-09-10
申请人： Johann Karl , Julia Riedlinger , Wolfgang Rollinger
发明人： Johann Karl , Julia Riedlinger , Wolfgang Rollinger
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/6884 , G01N2333/96433 , G01N2800/122 , G01N2800/60
摘要： An in vitro method aiding in the assessment of chronic obstructive pulmonary disease (COPD). The disclosure further relates to a method for assessing COPD from a sample, derived from an individual, by measuring the protein Seprase in said sample in vitro.
摘要翻译：一种协助慢性阻塞性肺疾病（COPD）评估的体外方法。本公开还涉及通过在体外测量所述样品中的蛋白质Seprase，从源自个体的样品中评估COPD的方法。

33. 发明申请

US20130344504A1 NNMT AS A MARKER FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) 审中-公开
标题翻译： NNMT作为慢性阻塞性肺疾病（COPD）的标记
公开(公告)号：US20130344504A1
公开(公告)日：2013-12-26
申请号：US14022285
申请日：2013-09-10
申请人： Johann Karl , Julia Riedlinger , Wolfgang Rollinger
发明人： Johann Karl , Julia Riedlinger , Wolfgang Rollinger
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2333/91017 , G01N2800/122
摘要： An in vitro method aiding in the assessment of chronic obstructive pulmonary disease (COPD). The disclosure further relates to a method for assessing COPD from a sample, derived from an individual, by measuring the protein NNMT in said sample in vitro.
摘要翻译：一种协助慢性阻塞性肺疾病（COPD）评估的体外方法。本公开还涉及通过在体外测量所述样品中的蛋白质NNMT来评估来源于个体的样品的COPD的方法。

34. 发明申请

US20120021929A1 USE OF DPPIV/SEPRASE AS A MARKER FOR CANCER 审中-公开
标题翻译：使用DPPIV / SEPRASE作为癌症标记
公开(公告)号：US20120021929A1
公开(公告)日：2012-01-26
申请号：US13268042
申请日：2011-10-07
申请人： Magdalena Swiatek-de Lange , Johann Karl , Wolfgang Rollinger
发明人： Magdalena Swiatek-de Lange , Johann Karl , Wolfgang Rollinger
IPC分类号： G01N33/574 , C40B30/00 , C40B40/04 , C12Q1/37 , C12Q1/48
CPC分类号： C12Q1/37 , G01N2800/7028
摘要： Described is a method aiding in the assessment of the presence of cancer. The method uses the soluble DPPIV/seprase protein complex (DPPIV/seprase) as a universal marker of different cancer types. Measurement of DPPIV/seprase complex can, e.g., be used in the early detection or diagnosis of cancer or in the surveillance of patients who undergo surgery.
摘要翻译：描述了一种帮助评估癌症存在的方法。该方法使用可溶性DPPIV / seprase蛋白复合物（DPPIV / seprase）作为不同癌症类型的通用标记物。 DPPIV / seprase复合物的测量可以例如用于癌症的早期检测或诊断或用于接受手术的患者的监视。

35. 发明申请

US20090270272A1 ASSESSING RISK OF DISEASE PROGRESSION IN RHEUMATOID ARTHRITIS PATIENTS 有权
标题翻译：评估炎症性疾病患者的疾病进展风险
公开(公告)号：US20090270272A1
公开(公告)日：2009-10-29
申请号：US12412840
申请日：2009-03-27
申请人： Johann Karl , Veit Peter Grunert , Wolfgang Rollinger , Norbert Wild
发明人： Johann Karl , Veit Peter Grunert , Wolfgang Rollinger , Norbert Wild
IPC分类号： C40B30/04 , C40B40/10
CPC分类号： G01N33/564 , G01N33/6869 , G01N33/6893 , G01N2333/4737 , G01N2333/5412 , G01N2800/102
摘要： Disclosed is an in vitro method aiding in the further assessment of patients suffering from rheumatoid arthritis. The method especially is used in assessing whether an RA patient is at risk of disease progression. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of at least C-reactive protein (CRP) and interleukin-6 and correlating the concentrations determined to the likelihood of an underlying rapidly progressing form of RA. A patient at high risk of a rapidly progressing disease might be a patient in need for treatment or if already treated in need for a different and more effective treatment. The invention also relates to the use of a marker panel comprising C-reactive protein and interleukin-6 in the assessment of a patient with rheumatoid arthritis and it teaches a protein array device and kit, respectively, for performing the method of the invention.
摘要翻译：公开了一种辅助进一步评估患有类风湿性关节炎患者的体外方法。该方法特别用于评估RA患者是否处于疾病进展的风险。该方法例如通过分析生物化学标记来实施，包括在样品中测量至少C反应蛋白（CRP）和白细胞介素-6的浓度，并将确定的浓度与RA的潜在快速进展形式的可能性相关联。患有快速进展疾病的高风险患者可能是需要治疗的患者，或者如果已经需要治疗，需要进行不同的和更有效的治疗。本发明还涉及在评估类风湿性关节炎患者中使用包含C-反应蛋白和白细胞介素-6的标记物片，并分别教导了用于实施本发明方法的蛋白质阵列装置和试剂盒。

36. 发明申请

US20080020414A1 CYFRA 21-1 AS A MARKER FOR COLORECTAL CANCER 有权
标题翻译： CYFRA 21-1作为彩色癌症的标记
公开(公告)号：US20080020414A1
公开(公告)日：2008-01-24
申请号：US11764913
申请日：2007-06-19
申请人： Johann Karl , Herbert Andres , Veit Grunert , Wolfgang Rollinger , Werner Zolg
发明人： Johann Karl , Herbert Andres , Veit Grunert , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/68 , C12Q1/00 , C12Q1/34 , C12Q1/48
CPC分类号： G01N33/57419 , G01N2333/4742
摘要： The present invention relates to the assessment of colorectal cancer. It discloses the use of protein CYFRA 21-1 in the assessment of colorectal cancer. It also relates to a method for assessing colorectal cancer in vitro using a liquid sample, derived from an individual by measuring CYFRA 21-1 in said sample. Measurement of CYFRA 21-1 can, e.g., be used in the early detection or in the follow-up of patients with colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的评估。它公开了蛋白质CYFRA 21-1在结肠直肠癌评估中的应用。它还涉及一种通过在所述样品中测量CYFRA 21-1从体外衍生的液体样品体外评估结肠直肠癌的方法。 CYFRA 21-1的测量可以例如用于早期检测或结直肠癌患者的随访。

37. 发明申请

US20130344516A1 ARMET AS A MARKER FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) 审中-公开
公开(公告)号：US20130344516A1
公开(公告)日：2013-12-26
申请号：US14022276
申请日：2013-09-10
申请人： Johann Karl , Julia Riedlinger , Markus Roessler
发明人： Johann Karl , Julia Riedlinger , Markus Roessler
IPC分类号： G01N33/68
CPC分类号： G01N33/6884 , G01N33/6893 , G01N2333/47 , G01N2800/122 , G01N2800/60
摘要： An in vitro method aiding in the assessment of chronic obstructive pulmonary disease (COPD). The disclosure further relates to a method for assessing COPD from a sample, derived from an individual, by measuring the protein ARMET in said sample in vitro.

38. 发明申请

US20070184498A1 Protein RS15A as a marker for colorectal cancer 审中-公开
标题翻译：蛋白质RS15A作为结肠直肠癌的标志物
公开(公告)号：US20070184498A1
公开(公告)日：2007-08-09
申请号：US11640520
申请日：2006-12-15
申请人： Michael Tacke , Marie-Luise Hagmann , Johann Karl , Michael Pfeffer , Herbert Andres , Michael Thierolf , Norbert Wild , Werner Zolg
发明人： Michael Tacke , Marie-Luise Hagmann , Johann Karl , Michael Pfeffer , Herbert Andres , Michael Thierolf , Norbert Wild , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein RS15A (ribosomal protein S15a) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring RS15A in said sample. Measurement of RS15A can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质RS15A（核糖体蛋白S15a）在结直肠癌诊断中的应用。本发明涉及通过在所述样品中测量RS15A从个体衍生的来自液体样品的结肠直肠癌诊断方法。 RS15A的测定可以例如用于结肠直肠癌的早期检测或诊断。

39. 发明申请

US20140004543A1 ASC AS A MARKER FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) 有权
标题翻译： ASC作为慢性阻塞性肺疾病（COPD）的标记
公开(公告)号：US20140004543A1
公开(公告)日：2014-01-02
申请号：US14022273
申请日：2013-09-10
申请人： Herbert Andres , Johann Karl , Julia Riedlinger
发明人： Herbert Andres , Johann Karl , Julia Riedlinger
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/6884 , G01N2333/4703 , G01N2800/122
摘要： An in vitro method aiding in the assessment of chronic obstructive pulmonary disease (COPD). The disclosure further relates to a method for assessing COPD from a sample, derived from an individual, by measuring the protein ASC in said sample in vitro.
摘要翻译：一种协助慢性阻塞性肺疾病（COPD）评估的体外方法。本公开还涉及通过在体外测量所述样品中的蛋白质ASC来评估来自个体的样品的COPD的方法。

40. 发明申请

US20110129860A1 CALPROTECTIN AND HEMOGLOBIN/HAPTOGLOBIN COMPLEX FROM STOOL SAMPLE TO ASSESS COLORECTAL CANCER 审中-公开
标题翻译： CALPROTECTIN和HEMOGLOBIN / HAPTOGLOBIN复合物从STOOL样品到评估彩色癌
公开(公告)号：US20110129860A1
公开(公告)日：2011-06-02
申请号：US12783256
申请日：2010-05-19
申请人： Johann Karl , Norbert Wild , Ursula Garczarek
发明人： Johann Karl , Norbert Wild , Ursula Garczarek
IPC分类号： G01N33/68
CPC分类号： G01N33/57419 , G01N33/721 , G01N2333/4727 , G01N2333/805
摘要： The present invention relates to a method aiding in the assessment of colorectal cancer. The method especially is used in assessing the absence or presence of colorectal cancer in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a stool sample the concentration of the hemoglobin/haptoglobin complex and calprotectin and correlating the concentrations determined to the absence or presence of colorectal cancer. To further improve the assessment of colorectal cancer based on a method of this invention the level of one or more additional marker may be determined together with the hemoglobin/haptoglobin complex and calprotectin in a stool sample and be correlated to the absence or presence of colorectal cancer. The invention also relates to the use of a marker panel comprising the hemoglobin/haptoglobin complex and calprotectin in the early diagnosis of colorectal cancer and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估结肠直肠癌的方法。该方法特别用于评估体外存在或不存在结肠直肠癌。该方法例如通过分析生物化学标记来实施，包括在粪便样品中测量血红蛋白/触珠蛋白复合物和钙卫蛋白的浓度，并将确定的浓度与不存在或存在结肠直肠癌相关联。为了进一步改进基于本发明方法的结肠直肠癌的评估，可以在粪便样品中与血红蛋白/触珠蛋白复合物和钙卫蛋白一起测定一种或多种另外的标记物的水平，并与结肠直肠癌的存在或不存在相关。本发明还涉及包含血红蛋白/触珠蛋白复合物和钙卫蛋白的标记物在早期诊断结肠直肠癌中的用途，并且其教导了用于实施本发明方法的试剂盒。

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