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31. 发明授权

US09281171B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US09281171B2
公开(公告)日：2016-03-08
申请号：US11721260
申请日：2005-12-08
申请人： Robert Harold Bateman , Kevin Giles , Jeffery Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Jeffery Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/40 , H01J49/06 , H01J49/00
CPC分类号： H01J49/062 , H01J49/004
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyzer arranged upstream of an ion guide. Ions are scanned out of the mass selective ion trap or mass analyzer and are received in one or more axial potential wells created or formed within the ion guide. One or more transient DC voltages or potentials are preferably applied to the ion guide in order to create a plurality of axial potential wells which are translated along the length of the ion guide. Ions are released in packets from the exit of the ion guide and are orthogonally acceleration into a drift or flight region of an orthogonal acceleration Time of Flight mass analyzer with a relatively high duty cycle.
摘要翻译：公开了一种质谱仪，其包括布置在离子导向器上游的质量选择性离子阱或质量分析器。离子从质量选择性离子阱或质量分析器扫描出来，并被接收在一个或多个在离子导向器内产生或形成的轴向势阱中。优选地将一个或多个瞬态DC电压或电位施加到离子导向器，以便产生沿离子导向件的长度平移的多个轴向势阱。离子从离子导向器的出口释放出来的离子，并且正交加速到相对较高占空比的正交加速时间飞行质量分析器的漂移或飞行区域。

32. 发明授权

US09082596B2 Method of single point internal lock-mobility correction 有权
标题翻译：单点内锁移动校正方法
公开(公告)号：US09082596B2
公开(公告)日：2015-07-14
申请号：US14123532
申请日：2012-06-01
申请人： Jeffery Mark Brown , Kevin Giles
发明人： Jeffery Mark Brown , Kevin Giles
IPC分类号： H01J49/40 , H01J49/02 , H01J49/00 , G01N27/62 , H01J49/26
CPC分类号： H01J49/0031 , G01N27/622 , H01J49/26
摘要： A method of mass spectrometry is disclosed comprising passing ions through an ion mobility spectrometer and acquiring first ion mobility drift time data. A calibration function is applied to the first ion mobility drift time data to determine a physico-chemical property (e.g. CCS) of the ions. Second ion mobility drift time data is then acquired and the calibration function is applied to the second ion mobility drift time data to determine the physico-chemical property of one or more known or reference ions. The calibration function is then adjusted.
摘要翻译：公开了一种质谱法，其包括使离子通过离子迁移谱仪并获得第一离子迁移率漂移时间数据。将校准功能应用于第一离子迁移率漂移时间数据以确定离子的物理化学性质（例如CCS）。然后获取第二离子迁移率漂移时间数据，并且将校准功能应用于第二离子迁移率漂移时间数据，以确定一种或多种已知或参考离子的物理化学性质。然后调整校准功能。

33. 发明申请

US20150034813A1 Controlling Hydrogen-Deuterium Exchange on a Spectrum by Spectrum Basis 有权
标题翻译：通过光谱基础控制光谱上的氢氘交换
公开(公告)号：US20150034813A1
公开(公告)日：2015-02-05
申请号：US13885913
申请日：2011-11-16
申请人： Jeffery Mark Brown , Steven Derek Pringle , Keith Richardson
发明人： Jeffery Mark Brown , Steven Derek Pringle , Keith Richardson
IPC分类号： H01J49/00 , H01J49/26 , H01J49/06
CPC分类号： H01J49/0077 , H01J49/00 , H01J49/0031 , H01J49/0036 , H01J49/0054 , H01J49/0072 , H01J49/06 , H01J49/065 , H01J49/26
摘要： A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.
摘要翻译：公开了一种质谱仪，其包括用于分离离子的液相色谱装置。气相离子中性反应装置设置在下游以进行气相离子 - 中性反应如氢氘交换。控制系统被布置成在第一操作模式和第二操作模式之间来回自动重复地切换反应装置，其中在第一操作模式中，使至少一些母体或前体离子在反应中反应器件，并且其中在第二操作模式中基本上较少或没有使母体或前体离子发生反应。

34. 发明授权

US08283626B2 Electron transfer dissociation device 有权
标题翻译：电子转移离解装置
公开(公告)号：US08283626B2
公开(公告)日：2012-10-09
申请号：US12937806
申请日：2009-04-03
申请人： Jeffery Mark Brown , Martin Raymond Green
发明人： Jeffery Mark Brown , Martin Raymond Green
IPC分类号： H01J49/26
CPC分类号： H01J49/28 , H01J49/0072 , H01J49/065
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
摘要翻译：公开了一种质谱仪，其包括电子转移离解装置，其包括离子导向器。控制系统确定离子导向器内的前体离子的碎裂和电荷减少的程度，并且改变离子通过离子导向器传输的速度，以便优化碎裂和电荷还原过程。

35. 发明授权

US08164052B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08164052B2
公开(公告)日：2012-04-24
申请号：US12593006
申请日：2008-03-26
申请人： Martin R. Green , Jason Lee Wildgoose , Jeffery Mark Brown
发明人： Martin R. Green , Jason Lee Wildgoose , Jeffery Mark Brown
IPC分类号： H01J49/26 , H01J49/40
CPC分类号： H01J49/0481 , H01J49/0072 , H01J49/065 , H01J49/40 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell (1). Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell (1). The cell comprises a plurality of ring electrodes (1) which form a spherical trapping volume. Ions experience negligible RF heating over the majority, of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell (1) having an enhanced sensitivity is thereby provided. Fragment ions created within the cell (1) may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译：公开了包含电子转移离解电池（1）的质谱仪。当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子（1）。电池包括形成球形捕获体积的多个环形电极（1）。离子经验可忽略大部分的RF加热，捕集体积使分析物和试剂离子的动能降低到高于热温度。由此提供了具有增强的灵敏度的电子转移解离单元（1）。在细胞（1）内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，能够显着提高质量分析仪的分辨率。

36. 发明申请

US20110189788A1 Glow Discharge Ion Source 有权
标题翻译：辉光放电离子源
公开(公告)号：US20110189788A1
公开(公告)日：2011-08-04
申请号：US13055612
申请日：2009-07-27
申请人： Jeffery Mark Brown , Martin Raymond Green , Steven Derek Pringle
发明人： Jeffery Mark Brown , Martin Raymond Green , Steven Derek Pringle
IPC分类号： G01N24/00 , G01N21/00
CPC分类号： H01J49/12 , G01N24/00 , H01J49/0009 , H01J49/0072 , H01J49/0495 , H01J49/107 , H01J49/165 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode (14) which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
摘要翻译：公开了质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。辉光放电装置可以包括设置在真空室中的隔离阀（15）内的管状电极（14）。可以通过管状电极（14）提供试剂蒸气，然后其随后通过辉光放电电离。所得的试剂离子可用于由大气压离子源产生的分析物离子的电子转移离解。考虑其他实施例，其中由辉光放电装置产生的离子可用于通过质子转移反应来减少分析物离子的电荷状态，或者可以作为锁定质量或参考离子。

37. 发明申请

US20090314934A1 MASS SPECTROMETER 有权
标题翻译：质谱仪
公开(公告)号：US20090314934A1
公开(公告)日：2009-12-24
申请号：US12282394
申请日：2007-03-14
申请人： Jeffery Mark Brown
发明人： Jeffery Mark Brown
IPC分类号： H01J49/40
CPC分类号： H01J49/408
摘要： A multi-turn Time of Plight mass analyser is disclosed comprising a first electric sector (5) and a second electric sector (8). The second electric sector (8) is arranged orthogonal to the first electric sector (5). Ions may make multiple loops or circuits of the mass analyser before being detected and mass analysed enabling a high resolution mass analyser to be provided. According to another embodiment the mass analyser may have an open-loop geometry wherein the first electric sector is elongated and further electric sectors are arranged in a staggered manner along the length of the first electric sector. The first and second electric sectors (5,8) may be sub-divided into a plurality of electric sector segments.
摘要翻译：公开了一种多回合时间质量分析器，其包括第一电扇区（5）和第二电扇区（8）。第二电扇区（8）布置成与第一电扇区（5）正交。在检测到质子分析仪之前，离子可能会产生多个回路或质量分析器，并进行质量分析，以提供高分辨率质量分析仪。根据另一个实施例，质量分析器可以具有开环几何形状，其中第一电气部分是细长的，并且进一步的电扇区沿着第一电气部分的长度以交错的方式布置。第一和第二电扇区（5,8）可以被细分成多个电扇区段。

38. 发明申请

US20090114808A1 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20090114808A1
公开(公告)日：2009-05-07
申请号：US11916430
申请日：2006-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Raymond Green , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译：公开了一种质谱法，其中分析了来自离子检测器的电压信号。获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。然后将各种时间和强度数据对被整合以产生平滑的连续质谱。然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。可以确定在连续质谱中观察到的质量峰的开始和结束时间。然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。

39. 发明申请

US20080111071A1 Mass Spectrometer 审中-公开
标题翻译：质谱仪
公开(公告)号：US20080111071A1
公开(公告)日：2008-05-15
申请号：US11876108
申请日：2007-10-22
申请人： Jeffery Mark Brown , Daniel James Kenny
发明人： Jeffery Mark Brown , Daniel James Kenny
IPC分类号： H01J49/28
CPC分类号： H01J49/405 , H01J49/421
摘要： A mass filter is disclosed comprising an orthogonal acceleration electrode 9. Ions entering the mass filter are orthogonally accelerated by the orthogonal acceleration electrode 9 in a primary acceleration region 2 and enter a flight region 3. The ions 6,7,8 are then reflected by a reflectron 4 and are directed towards an exit region of the mass filter. Ions having a desired mass to charge ratio are arranged to arrive in the primary acceleration region 2 at a time when a voltage pulse applied to the orthogonal acceleration electrode 9 falls from a maximum to zero. Ions having a desired mass to charge ratio are orthogonally decelerated such that they have a zero component of velocity in the orthogonal direction. Accordingly, ions having a desired mass to charge ratio exit the mass filter in an axial direction.
摘要翻译：公开了一种包括正交加速电极9的质量过滤器。进入质量过滤器的离子通过正加速电极9在主加速区域2中正交加速并进入飞行区域3。然后离子6,7,8被反射器4反射并且被引向质量过滤器的出口区域。具有期望的质荷比的离子被布置成在施加到正交加速电极9的电压脉冲从最大值降到零的时刻到达主加速区域2。具有期望的质荷比的离子正交减速，使得它们在正交方向上具有零分量的速度。因此，具有期望质荷比的离子沿轴向离开质量过滤器。

40. 发明授权

US09508537B2 Photo-dissociation of proteins and peptides in a mass spectrometer 有权
标题翻译：蛋白质和肽在质谱仪中的光解离
公开(公告)号：US09508537B2
公开(公告)日：2016-11-29
申请号：US14130440
申请日：2012-07-06
申请人： Jeffery Mark Brown , Kevin Giles , Daniel James Kenny , Paul Murray , Keith Richardson
发明人： Jeffery Mark Brown , Kevin Giles , Daniel James Kenny , Paul Murray , Keith Richardson
IPC分类号： H01J49/06 , H01J49/42 , H01J49/00 , H01J49/10 , H01J49/26 , H01J49/40
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analyzed using a Time of Flight mass analyzer.
摘要翻译：公开了一种质谱方法，其包括将来自激光器的第一光子引导到位于2D或线性离子导向器或离子阱内的离子上。扫描第一光子的频率，并检测由离子发射的第一光子和/或第二光子。然后使用飞行时间质量分析仪对离子进行质量分析。

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